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Items: 1 to 50 of 88


Autophagy Suppresses Breast Cancer Metastasis.

Ostendorf BN, Tavazoie SF.

Dev Cell. 2020 Mar 9;52(5):542-544. doi: 10.1016/j.devcel.2020.02.005.


Comprehensive Genome-wide Perturbations via CRISPR Adaptation Reveal Complex Genetics of Antibiotic Sensitivity.

Jiang W, Oikonomou P, Tavazoie S.

Cell. 2020 Mar 5;180(5):1002-1017.e31. doi: 10.1016/j.cell.2020.02.007. Epub 2020 Feb 27.


Extreme Antibiotic Persistence via Heterogeneity-Generating Mutations Targeting Translation.

Khare A, Tavazoie S.

mSystems. 2020 Jan 21;5(1). pii: e00847-19. doi: 10.1128/mSystems.00847-19.


PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis.

Yamaguchi N, Weinberg EM, Nguyen A, Liberti MV, Goodarzi H, Janjigian YY, Paty PB, Saltz LB, Kingham TP, Loo JM, de Stanchina E, Tavazoie SF.

Elife. 2019 Dec 16;8. pii: e52135. doi: 10.7554/eLife.52135.


Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish.

Vejnar CE, Abdel Messih M, Takacs CM, Yartseva V, Oikonomou P, Christiano R, Stoeckius M, Lau S, Lee MT, Beaudoin JD, Musaev D, Darwich-Codore H, Walther TC, Tavazoie S, Cifuentes D, Giraldez AJ.

Genome Res. 2019 Jul;29(7):1100-1114. doi: 10.1101/gr.245159.118. Epub 2019 Jun 21.


Balancing dual demands on the physician-scientist workforce.

Martin DM, Rathmell WK, Tavazoie SF.

J Clin Invest. 2018 Aug 1;128(8):3204-3205. doi: 10.1172/JCI122099. Epub 2018 Jul 16. No abstract available.


Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity.

Masoudi N, Tavazoie S, Glenwinkel L, Ryu L, Kim K, Hobert O.

PLoS Biol. 2018 Apr 19;16(4):e2004979. doi: 10.1371/journal.pbio.2004979. eCollection 2018 Apr.


Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry.

Freddolino PL, Yang J, Momen-Roknabadi A, Tavazoie S.

Elife. 2018 Apr 5;7. pii: e31867. doi: 10.7554/eLife.31867.


LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.

Tavazoie MF, Pollack I, Tanqueco R, Ostendorf BN, Reis BS, Gonsalves FC, Kurth I, Andreu-Agullo C, Derbyshire ML, Posada J, Takeda S, Tafreshian KN, Rowinsky E, Szarek M, Waltzman RJ, Mcmillan EA, Zhao C, Mita M, Mita A, Chmielowski B, Postow MA, Ribas A, Mucida D, Tavazoie SF.

Cell. 2018 Feb 8;172(4):825-840.e18. doi: 10.1016/j.cell.2017.12.026. Epub 2018 Jan 11.


MicroRNA-203 predicts human survival after resection of colorectal liver metastasis.

Kingham TP, Nguyen HCB, Zheng J, Konstantinidis IT, Sadot E, Shia J, Kuk D, Zhang S, Saltz L, D'Angelica MI, Jarnagin WR, Goodarzi H, Tavazoie SF.

Oncotarget. 2017 Mar 21;8(12):18821-18831. doi: 10.18632/oncotarget.13816.


Cancer: Endothelial-cell killing promotes metastasis.

Alarcón CR, Tavazoie SF.

Nature. 2016 Aug 11;536(7615):154-5. Epub 2016 Aug 3. No abstract available.


TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration and Invasion in Breast Cancer.

Lee H, Goodarzi H, Tavazoie SF, Alarcón CR.

Cancer Res. 2016 Sep 1;76(17):4994-5005. doi: 10.1158/0008-5472.CAN-15-2322. Epub 2016 Jun 21.


Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression.

Goodarzi H, Nguyen HCB, Zhang S, Dill BD, Molina H, Tavazoie SF.

Cell. 2016 Jun 2;165(6):1416-1427. doi: 10.1016/j.cell.2016.05.046.


Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.

Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF.

Nat Commun. 2016 May 3;7:11246. doi: 10.1038/ncomms11246.


PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion.

Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF.

Cancer Cell. 2016 Mar 14;29(3):339-353. doi: 10.1016/j.ccell.2016.02.013.


Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts.

Fish L, Pencheva N, Goodarzi H, Tran H, Yoshida M, Tavazoie SF.

Genes Dev. 2016 Feb 15;30(4):386-98. doi: 10.1101/gad.270645.115.


PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.

Nguyen A, Loo JM, Mital R, Weinberg EM, Man FY, Zeng Z, Paty PB, Saltz L, Janjigian YY, de Stanchina E, Tavazoie SF.

J Clin Invest. 2016 Feb;126(2):681-94. doi: 10.1172/JCI83587. Epub 2016 Jan 19.


Multifactorial Competition and Resistance in a Two-Species Bacterial System.

Khare A, Tavazoie S.

PLoS Genet. 2015 Dec 8;11(12):e1005715. doi: 10.1371/journal.pgen.1005715. eCollection 2015 Dec.


PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling.

Sengelaub CA, Navrazhina K, Ross JB, Halberg N, Tavazoie SF.

EMBO J. 2016 Jan 4;35(1):62-76. doi: 10.15252/embj.201591973. Epub 2015 Nov 30.


HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.

Alarcón CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie SF.

Cell. 2015 Sep 10;162(6):1299-308. doi: 10.1016/j.cell.2015.08.011. Epub 2015 Aug 27.


Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival.

Furlow PW, Zhang S, Soong TD, Halberg N, Goodarzi H, Mangrum C, Wu YG, Elemento O, Tavazoie SF.

Nat Cell Biol. 2015 Jul;17(7):943-52. doi: 10.1038/ncb3194. Epub 2015 Jun 22.


Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement.

Goodarzi H, Liu X, Nguyen HC, Zhang S, Fish L, Tavazoie SF.

Cell. 2015 May 7;161(4):790-802. doi: 10.1016/j.cell.2015.02.053.


Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer.

Ross JB, Huh D, Noble LB, Tavazoie SF.

Nat Cell Biol. 2015 May;17(5):651-64. doi: 10.1038/ncb3148. Epub 2015 Apr 13.


N6-methyladenosine marks primary microRNAs for processing.

Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF.

Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18.


Extracellular metabolic energetics can promote cancer progression.

Loo JM, Scherl A, Nguyen A, Man FY, Weinberg E, Zeng Z, Saltz L, Paty PB, Tavazoie SF.

Cell. 2015 Jan 29;160(3):393-406. doi: 10.1016/j.cell.2014.12.018. Epub 2015 Jan 15.


TARBP2 binding structured RNA elements drives metastasis.

Goodarzi H, Tavazoie SF, Tavazoie S.

Cell Cycle. 2014;13(18):2799-800. doi: 10.4161/15384101.2014.954453. No abstract available.


Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Goodarzi H, Zhang S, Buss CG, Fish L, Tavazoie S, Tavazoie SF.

Nature. 2014 Sep 11;513(7517):256-60. doi: 10.1038/nature13466. Epub 2014 Jul 9.


Systematic identification of regulatory elements in conserved 3' UTRs of human transcripts.

Oikonomou P, Goodarzi H, Tavazoie S.

Cell Rep. 2014 Apr 10;7(1):281-92. doi: 10.1016/j.celrep.2014.03.001. Epub 2014 Mar 20.


Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation.

Pencheva N, Buss CG, Posada J, Merghoub T, Tavazoie SF.

Cell. 2014 Feb 27;156(5):986-1001. doi: 10.1016/j.cell.2014.01.038.


Revealing the genetic basis of natural bacterial phenotypic divergence.

Freddolino PL, Goodarzi H, Tavazoie S.

J Bacteriol. 2014 Feb;196(4):825-39. doi: 10.1128/JB.01039-13. Epub 2013 Dec 6.


Cardiorespiratory response to exercise on a large therapeutic roll.

Gappmaier E, Tavazoie SF, Jacketta MG.

Cardiopulm Phys Ther J. 2013 Sep;24(3):5-13.


Synaptic state matching: a dynamical architecture for predictive internal representation and feature detection.

Tavazoie S.

PLoS One. 2013 Aug 26;8(8):e72865. doi: 10.1371/journal.pone.0072865. eCollection 2013.


Bacterial adaptation through loss of function.

Hottes AK, Freddolino PL, Khare A, Donnell ZN, Liu JC, Tavazoie S.

PLoS Genet. 2013;9(7):e1003617. doi: 10.1371/journal.pgen.1003617. Epub 2013 Jul 11.


A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T.

Cell Rep. 2013 Jul 25;4(2):385-401. doi: 10.1016/j.celrep.2013.06.018. Epub 2013 Jul 11.


Control of metastatic progression by microRNA regulatory networks.

Pencheva N, Tavazoie SF.

Nat Cell Biol. 2013 Jun;15(6):546-54. doi: 10.1038/ncb2769. Review.


Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.

Pencheva N, Tran H, Buss C, Huh D, Drobnjak M, Busam K, Tavazoie SF.

Cell. 2012 Nov 21;151(5):1068-82. doi: 10.1016/j.cell.2012.10.028. Epub 2012 Nov 8.


microRNA regulation of cancer-endothelial interactions: vesicular microRNAs on the move….

Halberg N, Alarcón C, Tavazoie SF.

EMBO J. 2012 Aug 29;31(17):3509-10. doi: 10.1038/emboj.2012.198. Epub 2012 Jul 24. No abstract available.


The dawn of virtual cell biology.

Freddolino PL, Tavazoie S.

Cell. 2012 Jul 20;150(2):248-50. doi: 10.1016/j.cell.2012.07.001.


Large mutational target size for rapid emergence of bacterial persistence.

Girgis HS, Harris K, Tavazoie S.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12740-5. doi: 10.1073/pnas.1205124109. Epub 2012 Jul 16.


Fitness landscape transformation through a single amino acid change in the rho terminator.

Freddolino PL, Goodarzi H, Tavazoie S.

PLoS Genet. 2012 May;8(5):e1002744. doi: 10.1371/journal.pgen.1002744. Epub 2012 May 31. Erratum in: PLoS Genet. 2015 Mar;11(3):e1004940.


Beyond homeostasis: a predictive-dynamic framework for understanding cellular behavior.

Freddolino PL, Tavazoie S.

Annu Rev Cell Dev Biol. 2012;28:363-84. doi: 10.1146/annurev-cellbio-092910-154129. Epub 2012 May 3. Review.


Systematic discovery of structural elements governing stability of mammalian messenger RNAs.

Goodarzi H, Najafabadi HS, Oikonomou P, Greco TM, Fish L, Salavati R, Cristea IM, Tavazoie S.

Nature. 2012 Apr 8;485(7397):264-8. doi: 10.1038/nature11013.


Accurate proteome-wide protein quantification from high-resolution 15N mass spectra.

Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S.

Genome Biol. 2011 Dec 19;12(12):R122. doi: 10.1186/gb-2011-12-12-r122.


A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

Png KJ, Halberg N, Yoshida M, Tavazoie SF.

Nature. 2011 Dec 14;481(7380):190-4. doi: 10.1038/nature10661.


Newly identified genetic variations in common Escherichia coli MG1655 stock cultures.

Freddolino PL, Amini S, Tavazoie S.

J Bacteriol. 2012 Jan;194(2):303-6. doi: 10.1128/JB.06087-11. Epub 2011 Nov 11.


Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms.

Amini S, Hottes AK, Smith LE, Tavazoie S.

PLoS Pathog. 2011 Oct;7(10):e1002298. doi: 10.1371/journal.ppat.1002298. Epub 2011 Oct 20.


Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.

Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS.

Development. 2011 Nov;138(21):4709-19. doi: 10.1242/dev.067710.


Antibiotics and the post-genome revolution.

Amini S, Tavazoie S.

Curr Opin Microbiol. 2011 Oct;14(5):513-8. doi: 10.1016/j.mib.2011.07.017. Epub 2011 Aug 3. Review.


Microarray-based genetic footprinting strategy to identify strain improvement genes after competitive selection of transposon libraries.

Hottes AK, Tavazoie S.

Methods Mol Biol. 2011;765:83-97. doi: 10.1007/978-1-61779-197-0_6.


Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.

Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massagué J.

Nat Med. 2011 Jun 26;17(7):867-74. doi: 10.1038/nm.2379.

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