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Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.

Wan X, Yang T, Cuesta A, Pang X, Balius TE, Irwin JJ, Shoichet BK, Taunton J.

J Am Chem Soc. 2020 Mar 18;142(11):4960-4964. doi: 10.1021/jacs.9b10377. Epub 2020 Mar 4.


Masters Athlete Screening Study (MASS): Insights Into the Psychological Impact of Cardiovascular Preparticipation Screening.

Morrison BN, Zwaiman I, Isserow S, Taunton J, MacDonald M, Cater C, Velghe J, Hirsch A, Warburton DER, McKinney J.

Clin J Sport Med. 2020 Feb 13. doi: 10.1097/JSM.0000000000000802. [Epub ahead of print]


Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.

Cuesta A, Wan X, Burlingame AL, Taunton J.

J Am Chem Soc. 2020 Feb 19;142(7):3392-3400. doi: 10.1021/jacs.9b09684. Epub 2020 Feb 3.


Consecutive non-training days over a weekend for assessing cardiac parasympathetic variation in response to accumulated exercise stress.

Perrotta AS, Koehle MS, White MD, Taunton JE, Warburton DER.

Eur J Sport Sci. 2019 Nov 13:1-11. doi: 10.1080/17461391.2019.1688397. [Epub ahead of print]


Cartilage recovery in runners with and without knee osteoarthritis: A pilot study.

Esculier JF, Jarrett M, Krowchuk NM, Rauscher A, Wiggermann V, Taunton JE, Wilson DR, Gatti AA, Hunt MA.

Knee. 2019 Oct;26(5):1049-1057. doi: 10.1016/j.knee.2019.07.011. Epub 2019 Aug 18.


Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.

Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI.

JCI Insight. 2019 May 2;4(9). pii: 124867. doi: 10.1172/jci.insight.124867. eCollection 2019 May 2.


MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.

Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT.

JCI Insight. 2019 Apr 4;4(7). pii: 125570. doi: 10.1172/jci.insight.125570. eCollection 2019 Apr 4.


Lysine-Targeted Inhibitors and Chemoproteomic Probes.

Cuesta A, Taunton J.

Annu Rev Biochem. 2019 Jun 20;88:365-381. doi: 10.1146/annurev-biochem-061516-044805. Epub 2019 Jan 11.


Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.

Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI.

Circulation. 2019 Feb 26;139(9):1199-1216. doi: 10.1161/CIRCULATIONAHA.118.036232.


Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ.

Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028.


Real-Time Biofeedback of Performance to Reduce Braking Forces Associated With Running-Related Injury: An Exploratory Study.

Napier C, MacLean CL, Maurer J, Taunton JE, Hunt MA.

J Orthop Sports Phys Ther. 2019 Mar;49(3):136-144. doi: 10.2519/jospt.2019.8587. Epub 2018 Dec 7.


Kinematic Correlates of Kinetic Outcomes Associated With Running-Related Injury.

Napier C, MacLean CL, Maurer J, Taunton JE, Hunt MA.

J Appl Biomech. 2019 Apr 1;35(2):123-130. doi: 10.1123/jab.2018-0203. Epub 2019 Jan 30.


What are the perceptions about running and knee joint health among the public and healthcare practitioners in Canada?

Esculier JF, Krowchuk NM, Li LC, Taunton JE, Hunt MA.

PLoS One. 2018 Oct 1;13(10):e0204872. doi: 10.1371/journal.pone.0204872. eCollection 2018.


Pathological Insights From Quantitative Susceptibility Mapping and Diffusion Tensor Imaging in Ice Hockey Players Pre and Post-concussion.

Weber AM, Pukropski A, Kames C, Jarrett M, Dadachanji S, Taunton J, Li DKB, Rauscher A.

Front Neurol. 2018 Aug 6;9:575. doi: 10.3389/fneur.2018.00575. eCollection 2018.


Assessment of cardiovascular risk and preparticipation screening protocols in masters athletes: the Masters Athlete Screening Study (MASS): a cross-sectional study.

Morrison BN, McKinney J, Isserow S, Lithwick D, Taunton J, Nazzari H, De Souza AM, Heilbron B, Cater C, MacDonald M, Hives BA, Warburton DER.

BMJ Open Sport Exerc Med. 2018 Aug 9;4(1):e000370. doi: 10.1136/bmjsem-2018-000370. eCollection 2018.


Efficacy of Hot Yoga as a Heat Stress Technique for Enhancing Plasma Volume and Cardiovascular Performance in Elite Female Field Hockey Players.

Perrotta AS, White MD, Koehle MS, Taunton JE, Warburton DER.

J Strength Cond Res. 2018 Oct;32(10):2878-2887. doi: 10.1519/JSC.0000000000002705.


Kinetic risk factors of running-related injuries in female recreational runners.

Napier C, MacLean CL, Maurer J, Taunton JE, Hunt MA.

Scand J Med Sci Sports. 2018 Oct;28(10):2164-2172. doi: 10.1111/sms.13228. Epub 2018 Jun 28.


Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.

Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP.

Haematologica. 2018 Jul;103(7):1218-1228. doi: 10.3324/haematol.2017.174482. Epub 2018 Apr 5.


Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.

Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE.

Cell Death Dis. 2018 Mar 14;9(3):397. doi: 10.1038/s41419-018-0427-y.


The effects of different passive static stretching intensities on recovery from unaccustomed eccentric exercise - a randomized controlled trial.

Apostolopoulos NC, Lahart IM, Plyley MJ, Taunton J, Nevill AM, Koutedakis Y, Wyon M, Metsios GS.

Appl Physiol Nutr Metab. 2018 Aug;43(8):806-815. doi: 10.1139/apnm-2017-0841. Epub 2018 Mar 12.


Monitoring the Prescribed and Experienced Heart Rate-Derived Training Loads in Elite Field Hockey Players.

Perrotta AS, Taunton JE, Koehle MS, White MD, Warburton DER.

J Strength Cond Res. 2019 May;33(5):1394-1399. doi: 10.1519/JSC.0000000000002474.


Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL.

Roberts KG, Yang YL, Payne-Turner D, Lin W, Files JK, Dickerson K, Gu Z, Taunton J, Janke LJ, Chen T, Loh ML, Hunger SP, Mullighan CG.

Blood Adv. 2017 Aug 30;1(20):1657-1671. doi: 10.1182/bloodadvances.2017011296. eCollection 2017 Sep 12.


IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells.

Smith GA, Taunton J, Weiss A.

Sci Signal. 2017 Dec 19;10(510). pii: eaan4931. doi: 10.1126/scisignal.aan4931.


Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.

Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P.

J Biol Chem. 2017 Dec 15;292(50):20720-20731. doi: 10.1074/jbc.M117.797845. Epub 2017 Oct 20.


JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.

Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML.

Leukemia. 2017 Dec;31(12):2568-2576. doi: 10.1038/leu.2017.136. Epub 2017 May 9.


Medial Patellofemoral Ligament Repair Versus Reconstruction for Recurrent Patellar Instability: Two-Year Results of an Algorithm-Based Approach.

Dragoo JL, Nguyen M, Gatewood CT, Taunton JD, Young S.

Orthop J Sports Med. 2017 Mar 16;5(3):2325967116689465. doi: 10.1177/2325967116689465. eCollection 2017 Mar.


Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.

Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J.

J Am Chem Soc. 2017 Jan 18;139(2):680-685. doi: 10.1021/jacs.6b08536. Epub 2017 Jan 4.


Regulation of B cell fate by chronic activity of the IgE B cell receptor.

Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CD.

Elife. 2016 Dec 9;5. pii: e21238. doi: 10.7554/eLife.21238.


Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.

Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS.

Cell. 2016 Nov 17;167(5):1229-1240.e15. doi: 10.1016/j.cell.2016.10.046.


Mycolactone subverts immunity by selectively blocking the Sec61 translocon.

Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C.

J Exp Med. 2016 Dec 12;213(13):2885-2896. Epub 2016 Nov 7.


Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.

Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD.

Mol Cell. 2016 Oct 20;64(2):347-361. doi: 10.1016/j.molcel.2016.09.026.


Detecting Underlying Cardiovascular Disease in Young Competitive Athletes.

McKinney J, Lithwick DJ, Morrison BN, Nazzari H, Luong M, Fordyce CB, Taunton J, Krahn AD, Heilbron B, Isserow S.

Can J Cardiol. 2017 Jan;33(1):155-161. doi: 10.1016/j.cjca.2016.06.007. Epub 2016 Jun 23.


Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.

Rodríguez-Molina JB, Tseng SC, Simonett SP, Taunton J, Ansari AZ.

Mol Cell. 2016 Aug 4;63(3):433-44. doi: 10.1016/j.molcel.2016.06.036. Epub 2016 Jul 28.


Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.

Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO.

Cell Chem Biol. 2016 May 19;23(5):561-566. doi: 10.1016/j.chembiol.2016.04.008.


Phase separation of signaling molecules promotes T cell receptor signal transduction.

Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD.

Science. 2016 Apr 29;352(6285):595-9. doi: 10.1126/science.aad9964. Epub 2016 Apr 7.


Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.

Smith GA, Uchida K, Weiss A, Taunton J.

Nat Chem Biol. 2016 May;12(5):373-9. doi: 10.1038/nchembio.2056. Epub 2016 Mar 28.


The Health Benefits of a 12-Week Home-Based Interval Training Cardiac Rehabilitation Program in Patients With Heart Failure.

Safiyari-Hafizi H, Taunton J, Ignaszewski A, Warburton DE.

Can J Cardiol. 2016 Apr;32(4):561-7. doi: 10.1016/j.cjca.2016.01.031. Epub 2016 Feb 4.


Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury--A Prospective Cohort Study in Collegiate Hockey Players.

Wright AD, Jarrett M, Vavasour I, Shahinfard E, Kolind S, van Donkelaar P, Taunton J, Li D, Rauscher A.

PLoS One. 2016 Feb 25;11(2):e0150215. doi: 10.1371/journal.pone.0150215. eCollection 2016.


A Prospective Pilot Investigation of Brain Volume, White Matter Hyperintensities, and Hemorrhagic Lesions after Mild Traumatic Brain Injury.

Jarrett M, Tam R, Hernández-Torres E, Martin N, Perera W, Zhao Y, Shahinfard E, Dadachanji S, Taunton J, Li DK, Rauscher A.

Front Neurol. 2016 Feb 12;7:11. doi: 10.3389/fneur.2016.00011. eCollection 2016.


Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I.

Immunity. 2016 Jan 19;44(1):46-58. doi: 10.1016/j.immuni.2015.12.017. Erratum in: Immunity. 2016 Feb 16;44(2):438. Sachs, David H [corrected to Sachs, David].


Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J.

Elife. 2015 Dec 10;4. pii: e10222. doi: 10.7554/eLife.10222.


Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.

Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6436-45. doi: 10.1073/pnas.1510876112. Epub 2015 Nov 9.


Corrigendum: The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. No abstract available.


The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added]. Nat Chem Biol. 2015 Nov;11(11):887.


Gait modifications to change lower extremity gait biomechanics in runners: a systematic review.

Napier C, Cochrane CK, Taunton JE, Hunt MA.

Br J Sports Med. 2015 Nov;49(21):1382-8. doi: 10.1136/bjsports-2014-094393. Epub 2015 Jun 23. Review.


Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, Brameld KA, Hill RJ, Goldstein DM, Taunton J.

Nat Chem Biol. 2015 Jul;11(7):525-31. doi: 10.1038/nchembio.1817. Epub 2015 May 25.


Erratum: Covalent docking of large libraries for the discovery of chemical probes.

London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermančič P, Bonnet R, Shoichet BK, Taunton J.

Nat Chem Biol. 2015 Mar;11(3):235. doi: 10.1038/nchembio0315-235b. No abstract available.


Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.

Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J.

J Clin Invest. 2015 Mar 2;125(3):1299-310. doi: 10.1172/JCI76453. Epub 2015 Feb 17.


Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.

Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM.

Oncogene. 2015 Oct 8;34(41):5288-94. doi: 10.1038/onc.2014.455. Epub 2015 Jan 26.


Targeting protein kinases with selective and semipromiscuous covalent inhibitors.

Miller RM, Taunton J.

Methods Enzymol. 2014;548:93-116. doi: 10.1016/B978-0-12-397918-6.00004-5. Review.

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