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Items: 1 to 50 of 81

1.

A protein quality control pathway regulated by linear ubiquitination.

van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF.

EMBO J. 2019 May 2;38(9). pii: e100730. doi: 10.15252/embj.2018100730. Epub 2019 Mar 18.

PMID:
30886048
2.

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating.

Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R, Haßdenteufel S.

Biol Open. 2019 Mar 5;8(3). pii: bio040691. doi: 10.1242/bio.040691.

3.

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.

Puig B, Altmeppen HC, Linsenmeier L, Chakroun K, Wegwitz F, Piontek UK, Tatzelt J, Bate C, Magnus T, Glatzel M.

PLoS Pathog. 2019 Jan 4;15(1):e1007520. doi: 10.1371/journal.ppat.1007520. eCollection 2019 Jan.

4.

The prion protein in neuroimmune crosstalk.

Salvesen Ø, Tatzelt J, Tranulis MA.

Neurochem Int. 2019 Nov;130:104335. doi: 10.1016/j.neuint.2018.11.010. Epub 2018 Nov 15. Review.

5.

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

Ulbrich S, Janning P, Seidel R, Matschke J, Gonsberg A, Jung S, Glatzel M, Engelhard M, Winklhofer KF, Tatzelt J.

PLoS One. 2018 May 23;13(5):e0197659. doi: 10.1371/journal.pone.0197659. eCollection 2018.

6.

Dimerization of the cellular prion protein inhibits propagation of scrapie prions.

Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J.

J Biol Chem. 2018 May 25;293(21):8020-8031. doi: 10.1074/jbc.RA117.000990. Epub 2018 Apr 10.

7.

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.

Linsenmeier L, Mohammadi B, Wetzel S, Puig B, Jackson WS, Hartmann A, Uchiyama K, Sakaguchi S, Endres K, Tatzelt J, Saftig P, Glatzel M, Altmeppen HC.

Mol Neurodegener. 2018 Apr 6;13(1):18. doi: 10.1186/s13024-018-0248-6.

8.

Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases.

Jung S, Tatzelt J.

Prion. 2018 Mar 4;12(2):88-92. doi: 10.1080/19336896.2018.1435936. Epub 2018 Mar 29.

9.

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

Eigenbrod S, Frick P, Bertsch U, Mitteregger-Kretzschmar G, Mielke J, Maringer M, Piening N, Hepp A, Daude N, Windl O, Levin J, Giese A, Sakthivelu V, Tatzelt J, Kretzschmar H, Westaway D.

PLoS One. 2017 Dec 8;12(12):e0188989. doi: 10.1371/journal.pone.0188989. eCollection 2017.

10.

The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins.

Gonsberg A, Jung S, Ulbrich S, Origi A, Ziska A, Baier M, Koch HG, Zimmermann R, Winklhofer KF, Tatzelt J.

J Biol Chem. 2017 Dec 29;292(52):21383-21396. doi: 10.1074/jbc.M117.788067. Epub 2017 Oct 30.

11.

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA.

Elife. 2017 May 20;6. pii: e23473. doi: 10.7554/eLife.23473.

12.

The RAB GTPase RAB18 modulates macroautophagy and proteostasis.

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A.

Biochem Biophys Res Commun. 2017 May 6;486(3):738-743. doi: 10.1016/j.bbrc.2017.03.112. Epub 2017 Mar 22.

13.

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.

Puig B, Altmeppen HC, Ulbrich S, Linsenmeier L, Krasemann S, Chakroun K, Acevedo-Morantes CY, Wille H, Tatzelt J, Glatzel M.

Sci Rep. 2016 Apr 27;6:24970. doi: 10.1038/srep24970.

14.

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS.

Science. 2016 Jan 8;351(6269):173-6. doi: 10.1126/science.aad2033. Epub 2015 Dec 3.

15.

The Cellular Prion Protein: A Player in Immunological Quiescence.

Bakkebø MK, Mouillet-Richard S, Espenes A, Goldmann W, Tatzelt J, Tranulis MA.

Front Immunol. 2015 Sep 2;6:450. doi: 10.3389/fimmu.2015.00450. eCollection 2015. Review.

16.

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.

Meka DP, Müller-Rischart AK, Nidadavolu P, Mohammadi B, Motori E, Ponna SK, Aboutalebi H, Bassal M, Annamneedi A, Finckh B, Miesbauer M, Rotermund N, Lohr C, Tatzelt J, Winklhofer KF, Kramer ER.

J Clin Invest. 2015 May;125(5):1873-85. doi: 10.1172/JCI79300. Epub 2015 Mar 30.

17.

Nanomedicine for prion disease treatment: new insights into the role of dendrimers.

McCarthy JM, Appelhans D, Tatzelt J, Rogers MS.

Prion. 2013 May-Jun;7(3):198-202. doi: 10.4161/pri.24431.

18.

Prion disease: a tale of folds and strains.

Kretzschmar H, Tatzelt J.

Brain Pathol. 2013 May;23(3):321-32. doi: 10.1111/bpa.12045. Review.

PMID:
23587138
19.

The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum.

Dirndorfer D, Seidel RP, Nimrod G, Miesbauer M, Ben-Tal N, Engelhard M, Zimmermann R, Winklhofer KF, Tatzelt J.

J Biol Chem. 2013 May 17;288(20):13961-73. doi: 10.1074/jbc.M112.430264. Epub 2013 Mar 26.

20.

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.

Pfeiffer NV, Dirndorfer D, Lang S, Resenberger UK, Restelli LM, Hemion C, Miesbauer M, Frank S, Neutzner A, Zimmermann R, Winklhofer KF, Tatzelt J.

EMBO J. 2013 Apr 3;32(7):1036-51. doi: 10.1038/emboj.2013.46. Epub 2013 Mar 12.

21.

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.

Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF.

Mol Cell. 2013 Mar 7;49(5):908-21. doi: 10.1016/j.molcel.2013.01.036. Epub 2013 Feb 28.

22.

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc).

McCarthy JM, Franke M, Resenberger UK, Waldron S, Simpson JC, Tatzelt J, Appelhans D, Rogers MS.

PLoS One. 2013;8(1):e55282. doi: 10.1371/journal.pone.0055282. Epub 2013 Jan 28.

23.

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

Resenberger UK, Müller V, Munter LM, Baier M, Multhaup G, Wilson MR, Winklhofer KF, Tatzelt J.

J Biol Chem. 2012 Dec 21;287(52):43765-76. doi: 10.1074/jbc.M112.389007. Epub 2012 Oct 31.

24.

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Hassdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J.

J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69. doi: 10.1242/jcs.096727. Epub 2012 Feb 28.

25.

Cellular prion protein mediates toxic signaling of amyloid beta.

Resenberger UK, Winklhofer KF, Tatzelt J.

Neurodegener Dis. 2012;10(1-4):298-300. doi: 10.1159/000332596. Epub 2011 Dec 9.

PMID:
22156337
26.

Prion proteins.

Tatzelt J.

Top Curr Chem. 2011;305:ix-x. No abstract available.

PMID:
22049556
27.

Neuroprotective and neurotoxic signaling by the prion protein.

Resenberger UK, Winklhofer KF, Tatzelt J.

Top Curr Chem. 2011;305:101-19. doi: 10.1007/128_2011_160. Review.

PMID:
21598098
28.

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.

Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J.

EMBO J. 2011 May 18;30(10):2057-70. doi: 10.1038/emboj.2011.86. Epub 2011 Mar 25.

29.

Conserved stress-protective activity between prion protein and Shadoo.

Sakthivelu V, Seidel RP, Winklhofer KF, Tatzelt J.

J Biol Chem. 2011 Mar 18;286(11):8901-8. doi: 10.1074/jbc.M110.185470. Epub 2011 Jan 21.

30.

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

Karpuj MV, Gelibter-Niv S, Tiran A, Rambold A, Tatzelt J, Nunziante M, Schatzl HM.

J Biol Chem. 2011 Mar 4;286(9):6911-7. doi: 10.1074/jbc.M110.194662. Epub 2010 Dec 14.

31.

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF.

Cell Death Differ. 2011 May;18(5):769-82. doi: 10.1038/cdd.2010.142. Epub 2010 Nov 26.

32.

Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing.

Chu NK, Olschewski D, Seidel R, Winklhofer KF, Tatzelt J, Engelhard M, Becker CF.

J Pept Sci. 2010 Oct;16(10):582-8. doi: 10.1002/psc.1227.

PMID:
20862726
33.

Parkin is protective against proteotoxic stress in a transgenic zebrafish model.

Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF.

PLoS One. 2010 Jul 30;5(7):e11783. doi: 10.1371/journal.pone.0011783.

34.

Synthesis of a GPI anchor module suitable for protein post-translational modification.

Schumacher MC, Resenberger U, Seidel RP, Becker CF, Winklhofer KF, Oesterhelt D, Tatzelt J, Engelhard M.

Biopolymers. 2010;94(4):457-64. doi: 10.1002/bip.21380.

PMID:
20593476
35.

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.

Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF.

J Biol Chem. 2010 Jul 2;285(27):20664-74. doi: 10.1074/jbc.M109.055608. Epub 2010 Apr 28.

36.

Targeting of the prion protein to the cytosol: mechanisms and consequences.

Miesbauer M, Rambold AS, Winklhofer KF, Tatzelt J.

Curr Issues Mol Biol. 2010;12(2):109-18. Epub 2009 Sep 18. Review.

37.

The prion protein: friend and foe.

Tatzelt J.

Curr Issues Mol Biol. 2010;12(2):49. Epub 2009 Sep 18. No abstract available.

38.

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum.

Miesbauer M, Pfeiffer NV, Rambold AS, Müller V, Kiachopoulos S, Winklhofer KF, Tatzelt J.

J Biol Chem. 2009 Sep 4;284(36):24384-93. doi: 10.1074/jbc.M109.023135. Epub 2009 Jun 26.

39.

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.

Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF.

J Biol Chem. 2009 Aug 21;284(34):22938-51. doi: 10.1074/jbc.M109.035774. Epub 2009 Jun 22.

40.

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

Rambold AS, Miesbauer M, Olschewski D, Seidel R, Riemer C, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Baier M, Becker CF, Engelhard M, Winklhofer KF, Tatzelt J.

J Neurochem. 2008 Oct;107(1):218-29. doi: 10.1111/j.1471-4159.2008.05611.x. Epub 2008 Aug 7.

41.

Stress-protective signalling of prion protein is corrupted by scrapie prions.

Rambold AS, Müller V, Ron U, Ben-Tal N, Winklhofer KF, Tatzelt J.

EMBO J. 2008 Jul 23;27(14):1974-84. doi: 10.1038/emboj.2008.122. Epub 2008 Jun 19.

42.

Genes contributing to prion pathogenesis.

Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB.

J Gen Virol. 2008 Jul;89(Pt 7):1777-88. doi: 10.1099/vir.0.2008/001255-0.

43.

Aberrant folding of pathogenic Parkin mutants: aggregation versus degradation.

Schlehe JS, Lutz AK, Pilsl A, Lämmermann K, Grgur K, Henn IH, Tatzelt J, Winklhofer KF.

J Biol Chem. 2008 May 16;283(20):13771-9. doi: 10.1074/jbc.M707494200. Epub 2008 Mar 24.

44.

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.

Winklhofer KF, Tatzelt J, Haass C.

EMBO J. 2008 Jan 23;27(2):336-49. doi: 10.1038/sj.emboj.7601930. Review.

45.

Observing fibrillar assemblies on scrapie-infected cells.

Wegmann S, Miesbauer M, Winklhofer KF, Tatzelt J, Muller DJ.

Pflugers Arch. 2008 Apr;456(1):83-93. doi: 10.1007/s00424-007-0433-x. Epub 2008 Jan 3.

PMID:
18175144
46.

Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes.

Olschewski D, Seidel R, Miesbauer M, Rambold AS, Oesterhelt D, Winklhofer KF, Tatzelt J, Engelhard M, Becker CF.

Chem Biol. 2007 Sep;14(9):994-1006.

47.

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.

Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J, Winklhofer KF.

J Neurosci. 2007 Feb 21;27(8):1868-78.

48.

Molecular basis of cerebral neurodegeneration in prion diseases.

Tatzelt J, Schätzl HM.

FEBS J. 2007 Feb;274(3):606-11. Review.

49.

Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

Rambold AS, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer KF, Tatzelt J.

Mol Biol Cell. 2006 Aug;17(8):3356-68. Epub 2006 May 17.

50.

The role of chaperones in Parkinson's disease and prion diseases.

Winklhofer KF, Tatzelt J.

Handb Exp Pharmacol. 2006;(172):221-58. Review.

PMID:
16610362

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