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Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells.

Calvo-Flores Guzmán B, Kim S, Chawdhary B, Peppercorn K, Tate WP, Waldvogel HJ, Faull RL, Montgomery J, Kwakowsky A.

Molecules. 2020 Feb 6;25(3). pii: E693. doi: 10.3390/molecules25030693.


The Acute Effects of Amyloid-Beta1-42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus.

Yeung JHY, Palpagama TH, Tate WP, Peppercorn K, Waldvogel HJ, Faull RLM, Kwakowsky A.

Front Neurosci. 2020 Jan 17;13:1427. doi: 10.3389/fnins.2019.01427. eCollection 2019.


The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP.

Morrissey JA, Bigus E, Necarsulmer JC, Srinivasan V, Peppercorn K, O'Leary DJ, Mockett BG, Tate WP, Hughes SM, Parfitt KD, Abraham WC.

Front Cell Neurosci. 2019 Oct 18;13:459. doi: 10.3389/fncel.2019.00459. eCollection 2019.


Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.

Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM.

Front Mol Neurosci. 2019 Aug 14;12:198. doi: 10.3389/fnmol.2019.00198. eCollection 2019.


A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease.

Morrissey JA, Mockett BG, Singh A, Kweon D, Ohline SM, Tate WP, Hughes SM, Abraham WC.

Neuropharmacology. 2019 Oct;157:107670. doi: 10.1016/j.neuropharm.2019.107670. Epub 2019 Jun 13.


Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha.

Mockett BG, Guévremont D, Elder MK, Parfitt KD, Peppercorn K, Morrissey J, Singh A, Hintz TJ, Kochen L, Tom Dieck S, Schuman E, Tate WP, Williams JM, Abraham WC.

J Neurosci. 2019 Apr 24;39(17):3188-3203. doi: 10.1523/JNEUROSCI.1826-18.2019. Epub 2019 Feb 25.


'Stop' in protein synthesis is modulated with exquisite subtlety by an extended RNA translation signal.

Tate WP, Cridge AG, Brown CM.

Biochem Soc Trans. 2018 Dec 17;46(6):1615-1625. doi: 10.1042/BST20180190. Epub 2018 Nov 12. Review.


Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease.

Tan VTY, Mockett BG, Ohline SM, Parfitt KD, Wicky HE, Peppercorn K, Schoderboeck L, Yahaya MFB, Tate WP, Hughes SM, Abraham WC.

Mol Brain. 2018 Feb 9;11(1):7. doi: 10.1186/s13041-018-0348-9.


Eukaryotic translational termination efficiency is influenced by the 3' nucleotides within the ribosomal mRNA channel.

Cridge AG, Crowe-McAuliffe C, Mathew SF, Tate WP.

Nucleic Acids Res. 2018 Feb 28;46(4):1927-1944. doi: 10.1093/nar/gkx1315.


Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats.

Xiong M, Jones OD, Peppercorn K, Ohline SM, Tate WP, Abraham WC.

Neurobiol Learn Mem. 2017 Feb;138:291-299. doi: 10.1016/j.nlm.2016.08.002. Epub 2016 Aug 9.


Treatment of beta amyloid 1-42 (Aβ(1-42))-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo.

Kwakowsky A, Potapov K, Kim S, Peppercorn K, Tate WP, Ábrahám IM.

Sci Rep. 2016 Feb 16;6:21101. doi: 10.1038/srep21101.


HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.

Cardno TS, Shimaki Y, Sleebs BE, Lackovic K, Parisot JP, Moss RM, Crowe-McAuliffe C, Mathew SF, Edgar CD, Kleffmann T, Tate WP.

PLoS One. 2015 Oct 8;10(10):e0139036. doi: 10.1371/journal.pone.0139036. eCollection 2015.


The highly conserved codon following the slippery sequence supports -1 frameshift efficiency at the HIV-1 frameshift site.

Mathew SF, Crowe-McAuliffe C, Graves R, Cardno TS, McKinney C, Poole ES, Tate WP.

PLoS One. 2015 Mar 25;10(3):e0122176. doi: 10.1371/journal.pone.0122176. eCollection 2015.


Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing-activated transfer of a mobile genetic element.

Ramsay JP, Tester LG, Major AS, Sullivan JT, Edgar CD, Kleffmann T, Patterson-House JR, Hall DA, Tate WP, Hynes MF, Ronson CW.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4104-9. doi: 10.1073/pnas.1501574112. Epub 2015 Mar 18.


Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus.

Ryan MM, Morris GP, Mockett BG, Bourne K, Abraham WC, Tate WP, Williams JM.

BMC Genomics. 2013 Jun 6;14:376. doi: 10.1186/1471-2164-14-376.


The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.

Imhoff FM, Yang D, Mathew SF, Clarkson AN, Kawagishi Y, Tate WP, Koishi K, McLennan IS.

FEBS Lett. 2013 Jun 19;587(12):1749-53. doi: 10.1016/j.febslet.2013.04.014. Epub 2013 Apr 25.


Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo.

Ryan MM, Ryan B, Kyrke-Smith M, Logan B, Tate WP, Abraham WC, Williams JM.

PLoS One. 2012;7(7):e40538. doi: 10.1371/journal.pone.0040538. Epub 2012 Jul 10.


Primordial soup or vinaigrette: did the RNA world evolve at acidic pH?

Bernhardt HS, Tate WP.

Biol Direct. 2012 Jan 20;7:4. doi: 10.1186/1745-6150-7-4.


Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells.

Baratchi S, Evans J, Tate WP, Abraham WC, Connor B.

Hippocampus. 2012 Jul;22(7):1517-27. doi: 10.1002/hipo.20988. Epub 2011 Dec 7.


Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells.

Morgan NV, Goddard S, Cardno TS, McDonald D, Rahman F, Barge D, Ciupek A, Straatman-Iwanowska A, Pasha S, Guckian M, Anderson G, Huissoon A, Cant A, Tate WP, Hambleton S, Maher ER.

J Clin Invest. 2011 Feb;121(2):695-702. doi: 10.1172/JCI41931. Epub 2011 Jan 4.


The codon specificity of eubacterial release factors is determined by the sequence and size of the recognition loop.

Young DJ, Edgar CD, Poole ES, Tate WP.

RNA. 2010 Aug;16(8):1623-33. doi: 10.1261/rna.2117010. Epub 2010 Jun 28.


Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria.

Young DJ, Edgar CD, Murphy J, Fredebohm J, Poole ES, Tate WP.

RNA. 2010 Jun;16(6):1146-55. doi: 10.1261/rna.1970310. Epub 2010 Apr 26.


Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo.

Ryan MM, Mason-Parker SE, Tate WP, Abraham WC, Williams JM.

Hippocampus. 2011 May;21(5):541-53. doi: 10.1002/hipo.20770.


A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons.

Cardno TS, Poole ES, Mathew SF, Graves R, Tate WP.

RNA. 2009 Aug;15(8):1614-21. doi: 10.1261/rna.1586709. Epub 2009 Jun 17.


Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism.

Claasen AM, Guévremont D, Mason-Parker SE, Bourne K, Tate WP, Abraham WC, Williams JM.

Neurosci Lett. 2009 Aug 21;460(1):92-6. doi: 10.1016/j.neulet.2009.05.040. Epub 2009 May 20.


Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code.

Bernhardt HS, Tate WP.

Biol Direct. 2008 Dec 17;3:53. doi: 10.1186/1745-6150-3-53.


Transterm: a database to aid the analysis of regulatory sequences in mRNAs.

Jacobs GH, Chen A, Stevens SG, Stockwell PA, Black MA, Tate WP, Brown CM.

Nucleic Acids Res. 2009 Jan;37(Database issue):D72-6. doi: 10.1093/nar/gkn763. Epub 2008 Nov 4.


Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory.

Taylor CJ, Ireland DR, Ballagh I, Bourne K, Marechal NM, Turner PR, Bilkey DK, Tate WP, Abraham WC.

Neurobiol Dis. 2008 Aug;31(2):250-60. doi: 10.1016/j.nbd.2008.04.011. Epub 2008 May 10.


Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals.

Williams JM, Guévremont D, Mason-Parker SE, Luxmanan C, Tate WP, Abraham WC.

J Neurosci. 2007 Dec 19;27(51):14171-8.


Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues.

Clark MB, Jänicke M, Gottesbühren U, Kleffmann T, Legge M, Poole ES, Tate WP.

J Biol Chem. 2007 Dec 28;282(52):37359-69. Epub 2007 Oct 16.


Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome.

Poole ES, Young DJ, Askarian-Amiri ME, Scarlett DJ, Tate WP.

Cell Res. 2007 Jul;17(7):591-607. Review.


Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents.

Turner PR, Bourne K, Garama D, Carne A, Abraham WC, Tate WP.

J Neurosci Methods. 2007 Aug 15;164(1):68-74. Epub 2007 Apr 6.


Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms.

Cridge AG, Major LL, Mahagaonkar AA, Poole ES, Isaksson LA, Tate WP.

Nucleic Acids Res. 2006 Apr 13;34(7):1959-73. Print 2006.


Transterm--extended search facilities and improved integration with other databases.

Jacobs GH, Stockwell PA, Tate WP, Brown CM.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D37-40.


Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus.

Mockett BG, Brooks WM, Tate WP, Abraham WC.

Brain Res. 2004 Sep 17;1021(1):92-100.


Maintaining the ribosomal reading frame: the influence of the E site during translational regulation of release factor 2.

Márquez V, Wilson DN, Tate WP, Triana-Alonso F, Nierhaus KH.

Cell. 2004 Jul 9;118(1):45-55.


The ribosome: lifting the veil from a fascinating organelle.

Tate WP, Poole ES.

Bioessays. 2004 May;26(5):582-8.


Molecular mimicry in the decoding of translational stop signals.

Poole ES, Askarian-Amiri ME, Major LL, McCaughan KK, Scarlett DJ, Wilson DN, Tate WP.

Prog Nucleic Acid Res Mol Biol. 2003;74:83-121. Review.


Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory.

Turner PR, O'Connor K, Tate WP, Abraham WC.

Prog Neurobiol. 2003 May;70(1):1-32. Review.


Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity.

Williams JM, Guévremont D, Kennard JT, Mason-Parker SE, Tate WP, Abraham WC.

Neuroscience. 2003;118(4):1003-13.


Tandem termination signals: myth or reality?

Major LL, Edgar TD, Yee Yip P, Isaksson LA, Tate WP.

FEBS Lett. 2002 Mar 6;514(1):84-9.


Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.

Abraham WC, Mason-Parker SE, Bear MF, Webb S, Tate WP.

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10924-9. Epub 2001 Aug 21.


Codon bias at the 3'-side of the initiation codon is correlated with translation initiation efficiency in Escherichia coli.

Stenström CM, Jin H, Major LL, Tate WP, Isaksson LA.

Gene. 2001 Jan 24;263(1-2):273-84.


Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation.

Williams JM, Beckmann AM, Mason-Parker SE, Abraham WC, Wilce PA, Tate WP.

Brain Res Mol Brain Res. 2000 May 5;77(2):258-66.


Functional characterization of yeast mitochondrial release factor 1.

Askarian-Amiri ME, Pel HJ, Guévremont D, McCaughan KK, Poole ES, Sumpter VG, Tate WP.

J Biol Chem. 2000 Jun 9;275(23):17241-8.


UGA: a dual signal for 'stop' and for recoding in protein synthesis.

Tate WP, Mansell JB, Mannering SA, Irvine JH, Major LL, Wilson DN.

Biochemistry (Mosc). 1999 Dec;64(12):1342-53. Review.

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