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Items: 1 to 50 of 107

1.

Whole proteome profiling of N-myristoyltransferase activity and inhibition using Sortase-A.

Goya Grocin A, Serwa RA, Morales Sanfrutos J, Ritzefeld M, Tate EW.

Mol Cell Proteomics. 2018 Oct 19. pii: mcp.RA118.001043. doi: 10.1074/mcp.RA118.001043. [Epub ahead of print]

2.

Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.

Wang Z, Grosskurth SE, Cheung T, Petteruti P, Zhang J, Wang X, Wang W, Gharahdaghi F, Wu J, Su N, Howard RT, Mayo M, Widzowski D, Scott DA, Johannes JW, Lamb ML, Lawson D, Dry JR, Lyne PD, Tate EW, Zinda M, Mikule K, Fawell SE, Reimer C, Chen H.

Cancer Res. 2018 Dec 1;78(23):6691-6702. doi: 10.1158/0008-5472.CAN-18-1362. Epub 2018 Oct 8.

PMID:
30297535
3.

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.

De Vita E, Schüler P, Lovell S, Lohbeck J, Kullmann S, Rabinovich E, Sananes A, Heßling B, Hamon V, Papo N, Hess J, Tate EW, Gunkel N, Miller AK.

J Med Chem. 2018 Oct 11;61(19):8859-8874. doi: 10.1021/acs.jmedchem.8b01106. Epub 2018 Sep 28.

PMID:
30212625
4.

Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces.

Furniss RCD, Low WW, Mavridou DAI, Dagley LF, Webb AI, Tate EW, Clements A.

J Biol Chem. 2018 Nov 2;293(44):17188-17199. doi: 10.1074/jbc.RA118.005114. Epub 2018 Sep 6.

5.

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions.

Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H.

Chembiochem. 2018 Aug 21. doi: 10.1002/cbic.201800406. [Epub ahead of print]

PMID:
30129686
6.

Activity-Based Protein Profiling for the Study of Parasite Biology.

Benns HJ, Tate EW, Child MA.

Curr Top Microbiol Immunol. 2018 Aug 14. doi: 10.1007/82_2018_123. [Epub ahead of print]

PMID:
30105424
7.

High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo.

Beard R, Singh N, Grundschober C, Gee AD, Tate EW.

Chem Commun (Camb). 2018 Jul 17;54(58):8120-8123. doi: 10.1039/c8cc01400k.

8.

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW.

Nat Chem. 2018 Jun;10(6):599-606. doi: 10.1038/s41557-018-0039-2. Epub 2018 May 14.

9.

Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.

Pollard DJ, Berger CN, So EC, Yu L, Hadavizadeh K, Jennings P, Tate EW, Choudhary JS, Frankel G.

MBio. 2018 Apr 10;9(2). pii: e00170-18. doi: 10.1128/mBio.00170-18.

10.

Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.

Beard R, Stucki A, Schmitt M, Py G, Grundschober C, Gee AD, Tate EW.

Bioorg Med Chem. 2018 Jul 15;26(11):3039-3045. doi: 10.1016/j.bmc.2018.03.019. Epub 2018 Mar 12.

11.

High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.

Craven GB, Affron DP, Allen CE, Matthies S, Greener JG, Morgan RML, Tate EW, Armstrong A, Mann DJ.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5257-5261. doi: 10.1002/anie.201711825. Epub 2018 Mar 26.

12.

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadavizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJ.

ACS Infect Dis. 2018 Apr 13;4(4):523-530. doi: 10.1021/acsinfecdis.7b00228. Epub 2018 Feb 5.

PMID:
29377668
13.

N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action.

Schlott AC, Holder AA, Tate EW.

ACS Infect Dis. 2018 Apr 13;4(4):449-457. doi: 10.1021/acsinfecdis.7b00203. Epub 2018 Feb 2.

PMID:
29363940
14.

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.

Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2017 Jan 1;8(1):191-197. doi: 10.1039/c6md00531d. Epub 2016 Nov 11.

15.

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.

Lanyon-Hogg T, Faronato M, Serwa RA, Tate EW.

Trends Biochem Sci. 2017 Jul;42(7):566-581. doi: 10.1016/j.tibs.2017.04.004. Epub 2017 Jun 8. Review.

16.

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW.

Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.

17.

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.

Duluc L, Ahmetaj-Shala B, Mitchell J, Abdul-Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L, Dubois OD, Storck EM, Tate EW, Zhao L, Wilkins MR, Wojciak-Stothard B.

Cardiovasc Res. 2017 Mar 1;113(3):276-287. doi: 10.1093/cvr/cvw258.

18.

Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation.

Lanyon-Hogg T, Patel NV, Ritzefeld M, Boxall KJ, Burke R, Blagg J, Magee AI, Tate EW.

SLAS Discov. 2017 Apr;22(4):418-424. doi: 10.1177/2472555216689529. Epub 2017 Jan 31.

19.

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness.

Ritzefeld M, Wright MH, Tate EW.

Parasitology. 2018 Feb;145(2):157-174. doi: 10.1017/S0031182017000282. Epub 2017 Mar 8.

20.

Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.

Görlitz F, Kelly DJ, Warren SC, Alibhai D, West L, Kumar S, Alexandrov Y, Munro I, Garcia E, McGinty J, Talbot C, Serwa RA, Thinon E, da Paola V, Murray EJ, Stuhmeier F, Neil MA, Tate EW, Dunsby C, French PM.

J Vis Exp. 2017 Jan 18;(119). doi: 10.3791/55119.

21.

Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.

Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP.

J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30.

22.

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.

Perdios L, Lowe AR, Saladino G, Bunney TD, Thiyagarajan N, Alexandrov Y, Dunsby C, French PM, Chin JW, Gervasio FL, Tate EW, Katan M.

Sci Rep. 2017 Jan 3;7:39841. doi: 10.1038/srep39841.

23.

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.

Ward JA, McLellan L, Stockley M, Gibson KR, Whitlock GA, Knights C, Harrigan JA, Jacq X, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. Epub 2016 Oct 31.

24.

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. Epub 2016 Oct 25.

25.

Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design.

Zhao W, Jamshidiha M, Lanyon-Hogg T, Recchi C, Cota E, Tate EW.

Curr Top Med Chem. 2017;17(1):16-29. Review.

26.

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.

Wright MH, Paape D, Price HP, Smith DF, Tate EW.

ACS Infect Dis. 2016 Jun 10;2(6):427-441. Epub 2016 Apr 29.

27.

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.

Thinon E, Morales-Sanfrutos J, Mann DJ, Tate EW.

ACS Chem Biol. 2016 Aug 19;11(8):2165-76. doi: 10.1021/acschembio.6b00371. Epub 2016 Jun 7.

28.

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Data Brief. 2016 Feb 10;7:257-81. doi: 10.1016/j.dib.2016.02.012. eCollection 2016 Jun.

29.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI.

Mol Biosyst. 2016 May 24;12(6):1781-9. doi: 10.1039/c6mb00109b.

PMID:
27021930
30.

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.

Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2015 Oct 8;6(10):1767-1772. Epub 2015 Aug 19.

31.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2015 Oct 8;6(10):1761-1766. Epub 2015 Aug 19.

32.

The Rab-binding Profiles of Bacterial Virulence Factors during Infection.

So EC, Schroeder GN, Carson D, Mattheis C, Mousnier A, Broncel M, Tate EW, Frankel G.

J Biol Chem. 2016 Mar 11;291(11):5832-43. doi: 10.1074/jbc.M115.700930. Epub 2016 Jan 11.

33.

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.

Broncel M, Serwa RA, Bunney TD, Katan M, Tate EW.

Mol Cell Proteomics. 2016 Feb;15(2):715-25. doi: 10.1074/mcp.O115.054429. Epub 2015 Nov 24.

34.

Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.

Charlton TM, Kovacs-Simon A, Michell SL, Fairweather NF, Tate EW.

Chem Biol. 2015 Nov 19;22(11):1562-1573. doi: 10.1016/j.chembiol.2015.10.006. Epub 2015 Nov 12.

35.

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

Perdios L, Bunney TD, Warren SC, Dunsby C, French PMW, Tate EW, Katan M.

Adv Biol Regul. 2016 Jan;60:6-13. doi: 10.1016/j.jbior.2015.09.002. Epub 2015 Sep 26.

36.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Anal Biochem. 2015 Dec 1;490:66-72. doi: 10.1016/j.ab.2015.08.025. Epub 2015 Sep 1.

37.

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.

Serwa RA, Abaitua F, Krause E, Tate EW, O'Hare P.

Chem Biol. 2015 Aug 20;22(8):1008-17. doi: 10.1016/j.chembiol.2015.06.024. Epub 2015 Aug 6.

38.

Myristoylation profiling in human cells and zebrafish.

Broncel M, Serwa RA, Ciepla P, Krause E, Dallman MJ, Magee AI, Tate EW.

Data Brief. 2015 Jul 2;4:379-83. doi: 10.1016/j.dib.2015.06.010. eCollection 2015 Sep.

39.

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.

Schroeder GN, Aurass P, Oates CV, Tate EW, Hartland EL, Flieger A, Frankel G.

Infect Immun. 2015 Oct;83(10):3989-4002. doi: 10.1128/IAI.00785-15. Epub 2015 Jul 27.

40.

Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid.

Nickel S, Serwa RA, Kaschani F, Ninck S, Zweerink S, Tate EW, Kaiser M.

Chemistry. 2015 Jul 20;21(30):10721-8. doi: 10.1002/chem.201500934. Epub 2015 Jun 16.

41.

Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors.

So EC, Mattheis C, Tate EW, Frankel G, Schroeder GN.

Can J Microbiol. 2015 Sep;61(9):617-35. doi: 10.1139/cjm-2015-0166. Epub 2015 May 6.

PMID:
26059316
42.

Cholesterylation: a tail of hedgehog.

Ciepla P, Magee AI, Tate EW.

Biochem Soc Trans. 2015 Apr;43(2):262-7. doi: 10.1042/BST20150032. Review.

PMID:
25849927
43.

Membrane bound O-acyltransferases and their inhibitors.

Masumoto N, Lanyon-Hogg T, Rodgers UR, Konitsiotis AD, Magee AI, Tate EW.

Biochem Soc Trans. 2015 Apr;43(2):246-52. doi: 10.1042/BST20150018. Review.

44.

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

Broncel M, Serwa RA, Ciepla P, Krause E, Dallman MJ, Magee AI, Tate EW.

Angew Chem Int Ed Engl. 2015 May 11;54(20):5948-51. doi: 10.1002/anie.201500342. Epub 2015 Mar 25.

45.

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA.

J Biol Chem. 2015 May 8;290(19):12147-64. doi: 10.1074/jbc.M115.637694. Epub 2015 Mar 23.

46.

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.

Wright MH, Paape D, Storck EM, Serwa RA, Smith DF, Tate EW.

Chem Biol. 2015 Mar 19;22(3):342-54. doi: 10.1016/j.chembiol.2015.01.003. Epub 2015 Feb 26.

47.

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.

Lanyon-Hogg T, Ritzefeld M, Masumoto N, Magee AI, Rzepa HS, Tate EW.

J Org Chem. 2015 May 1;80(9):4370-7. doi: 10.1021/acs.joc.5b00205. Epub 2015 Apr 9.

48.

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics.

Kalesh KA, Clulow JA, Tate EW.

Chem Commun (Camb). 2015 Mar 28;51(25):5497-500. doi: 10.1039/c4cc09527h.

49.

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.

Ciepla P, Konitsiotis AD, Serwa RA, Masumoto N, Leong WP, Dallman MJ, Magee AI, Tate EW.

Chem Sci. 2014 May 1;5(11):4249-4259. Epub 2014 Aug 15.

50.

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF.

PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3363. doi: 10.1371/journal.pntd.0003363. eCollection 2014 Dec.

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