Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 120

1.

Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7.

Tzakoniati F, Xu H, Li T, Garcia N, Kugel C, Payandeh J, Koth CM, Tate EW.

Cell Chem Biol. 2019 Nov 11. pii: S2451-9456(19)30356-3. doi: 10.1016/j.chembiol.2019.10.011. [Epub ahead of print]

2.

FSP1 is a glutathione-independent ferroptosis suppressor.

Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Grocin AG, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M.

Nature. 2019 Oct 21. doi: 10.1038/s41586-019-1707-0. [Epub ahead of print]

PMID:
31634899
3.

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.

Kryza T, Bock N, Lovell S, Rockstroh A, Lehman ML, Lesner A, Panchadsaram J, Silva LM, Srinivasan S, Snell CE, Williams ED, Fazli L, Gleave M, Batra J, Nelson C, Tate EW, Harris J, Hooper JD, Clements JA.

Mol Oncol. 2019 Oct 20. doi: 10.1002/1878-0261.12587. [Epub ahead of print]

4.

Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry.

Serwa RA, Sekine E, Brown J, Teo SHC, Tate EW, O'Hare P.

PLoS Pathog. 2019 Oct 7;15(10):e1007956. doi: 10.1371/journal.ppat.1007956. eCollection 2019 Oct.

5.

Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes.

Rueda-Zubiaurre A, Yahiya S, Fischer OJ, Hu X, Saunders CN, Sharma S, Straschil U, Shen J, Tate EW, Delves MJ, Baum J, Barnard A, Fuchter MJ.

J Med Chem. 2019 Sep 20. doi: 10.1021/acs.jmedchem.9b00898. [Epub ahead of print]

PMID:
31490680
6.

Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions.

Birtley JR, Alomary M, Zanini E, Antony J, Maben Z, Weaver GC, Von Arx C, Mura M, Marinho AT, Lu H, Morecroft EVN, Karali E, Chayen NE, Tate EW, Jurewicz M, Stern LJ, Recchi C, Gabra H.

Nat Commun. 2019 Jul 17;10(1):3134. doi: 10.1038/s41467-019-10966-8.

7.

Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.

Lim CSQ, Ha KP, Clarke RS, Gavin LA, Cook DT, Hutton JA, Sutherell CL, Edwards AM, Evans LE, Tate EW, Lanyon-Hogg T.

Bioorg Med Chem. 2019 Oct 15;27(20):114962. doi: 10.1016/j.bmc.2019.06.025. Epub 2019 Jun 15.

8.

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA.

Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.

9.

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases.

Kallemeijn WW, Lueg GA, Faronato M, Hadavizadeh K, Goya Grocin A, Song OR, Howell M, Calado DP, Tate EW.

Cell Chem Biol. 2019 Jun 20;26(6):892-900.e4. doi: 10.1016/j.chembiol.2019.03.006. Epub 2019 Apr 18.

10.

Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a.

Jamshidiha M, Pérez-Dorado I, Murray JW, Tate EW, Cota E, Read RJ.

Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):342-353. doi: 10.1107/S2059798318017825. Epub 2019 Feb 28.

11.

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.

Storck EM, Morales-Sanfrutos J, Serwa RA, Panyain N, Lanyon-Hogg T, Tolmachova T, Ventimiglia LN, Martin-Serrano J, Seabra MC, Wojciak-Stothard B, Tate EW.

Nat Chem. 2019 Jun;11(6):552-561. doi: 10.1038/s41557-019-0237-6. Epub 2019 Apr 1.

12.

BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability.

Tapodi A, Clemens DM, Uwineza A, Jarrin M, Goldberg MW, Thinon E, Heal WP, Tate EW, Nemeth-Cahalan K, Vorontsova I, Hall JE, Quinlan RA.

Exp Eye Res. 2019 Aug;185:107585. doi: 10.1016/j.exer.2019.02.001. Epub 2019 Feb 18.

13.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi: 10.1073/pnas.1816585116. Epub 2019 Jan 7.

14.

Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A.

Goya Grocin A, Serwa RA, Morales Sanfrutos J, Ritzefeld M, Tate EW.

Mol Cell Proteomics. 2019 Jan;18(1):115-126. doi: 10.1074/mcp.RA118.001043. Epub 2018 Oct 19.

15.

Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.

Wang Z, Grosskurth SE, Cheung T, Petteruti P, Zhang J, Wang X, Wang W, Gharahdaghi F, Wu J, Su N, Howard RT, Mayo M, Widzowski D, Scott DA, Johannes JW, Lamb ML, Lawson D, Dry JR, Lyne PD, Tate EW, Zinda M, Mikule K, Fawell SE, Reimer C, Chen H.

Cancer Res. 2018 Dec 1;78(23):6691-6702. doi: 10.1158/0008-5472.CAN-18-1362. Epub 2018 Oct 8.

16.

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.

De Vita E, Schüler P, Lovell S, Lohbeck J, Kullmann S, Rabinovich E, Sananes A, Heßling B, Hamon V, Papo N, Hess J, Tate EW, Gunkel N, Miller AK.

J Med Chem. 2018 Oct 11;61(19):8859-8874. doi: 10.1021/acs.jmedchem.8b01106. Epub 2018 Sep 28.

PMID:
30212625
17.

Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces.

Furniss RCD, Low WW, Mavridou DAI, Dagley LF, Webb AI, Tate EW, Clements A.

J Biol Chem. 2018 Nov 2;293(44):17188-17199. doi: 10.1074/jbc.RA118.005114. Epub 2018 Sep 6.

18.

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions.

Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H.

Chembiochem. 2019 Jan 18;20(2):134-139. doi: 10.1002/cbic.201800406. Epub 2018 Oct 17.

PMID:
30129686
19.

Activity-Based Protein Profiling for the Study of Parasite Biology.

Benns HJ, Tate EW, Child MA.

Curr Top Microbiol Immunol. 2019;420:155-174. doi: 10.1007/82_2018_123. Review.

PMID:
30105424
20.

High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo.

Beard R, Singh N, Grundschober C, Gee AD, Tate EW.

Chem Commun (Camb). 2018 Jul 17;54(58):8120-8123. doi: 10.1039/c8cc01400k.

21.

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW.

Nat Chem. 2018 Jun;10(6):599-606. doi: 10.1038/s41557-018-0039-2. Epub 2018 May 14.

22.

Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.

Pollard DJ, Berger CN, So EC, Yu L, Hadavizadeh K, Jennings P, Tate EW, Choudhary JS, Frankel G.

MBio. 2018 Apr 10;9(2). pii: e00170-18. doi: 10.1128/mBio.00170-18.

23.

Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.

Beard R, Stucki A, Schmitt M, Py G, Grundschober C, Gee AD, Tate EW.

Bioorg Med Chem. 2018 Jul 15;26(11):3039-3045. doi: 10.1016/j.bmc.2018.03.019. Epub 2018 Mar 12.

24.

High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.

Craven GB, Affron DP, Allen CE, Matthies S, Greener JG, Morgan RML, Tate EW, Armstrong A, Mann DJ.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5257-5261. doi: 10.1002/anie.201711825. Epub 2018 Mar 26.

25.

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadavizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJ.

ACS Infect Dis. 2018 Apr 13;4(4):523-530. doi: 10.1021/acsinfecdis.7b00228. Epub 2018 Feb 5.

26.

N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action.

Schlott AC, Holder AA, Tate EW.

ACS Infect Dis. 2018 Apr 13;4(4):449-457. doi: 10.1021/acsinfecdis.7b00203. Epub 2018 Feb 2. Review.

27.

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.

Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2017 Jan 1;8(1):191-197. doi: 10.1039/c6md00531d. Epub 2016 Nov 11.

28.

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.

Lanyon-Hogg T, Faronato M, Serwa RA, Tate EW.

Trends Biochem Sci. 2017 Jul;42(7):566-581. doi: 10.1016/j.tibs.2017.04.004. Epub 2017 Jun 8. Review.

29.

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW.

Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.

30.

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.

Duluc L, Ahmetaj-Shala B, Mitchell J, Abdul-Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L, Dubois OD, Storck EM, Tate EW, Zhao L, Wilkins MR, Wojciak-Stothard B.

Cardiovasc Res. 2017 Mar 1;113(3):276-287. doi: 10.1093/cvr/cvw258.

31.

Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation.

Lanyon-Hogg T, Patel NV, Ritzefeld M, Boxall KJ, Burke R, Blagg J, Magee AI, Tate EW.

SLAS Discov. 2017 Apr;22(4):418-424. doi: 10.1177/2472555216689529. Epub 2017 Jan 31.

32.

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness.

Ritzefeld M, Wright MH, Tate EW.

Parasitology. 2018 Feb;145(2):157-174. doi: 10.1017/S0031182017000282. Epub 2017 Mar 8. Review.

33.

Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.

Görlitz F, Kelly DJ, Warren SC, Alibhai D, West L, Kumar S, Alexandrov Y, Munro I, Garcia E, McGinty J, Talbot C, Serwa RA, Thinon E, da Paola V, Murray EJ, Stuhmeier F, Neil MA, Tate EW, Dunsby C, French PM.

J Vis Exp. 2017 Jan 18;(119). doi: 10.3791/55119.

34.

Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.

Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP.

J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30.

35.

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.

Perdios L, Lowe AR, Saladino G, Bunney TD, Thiyagarajan N, Alexandrov Y, Dunsby C, French PM, Chin JW, Gervasio FL, Tate EW, Katan M.

Sci Rep. 2017 Jan 3;7:39841. doi: 10.1038/srep39841.

36.

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.

Ward JA, McLellan L, Stockley M, Gibson KR, Whitlock GA, Knights C, Harrigan JA, Jacq X, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. Epub 2016 Oct 31.

37.

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. Epub 2016 Oct 25.

38.

Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design.

Zhao W, Jamshidiha M, Lanyon-Hogg T, Recchi C, Cota E, Tate EW.

Curr Top Med Chem. 2017;17(1):16-29. Review.

39.

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.

Wright MH, Paape D, Price HP, Smith DF, Tate EW.

ACS Infect Dis. 2016 Jun 10;2(6):427-441. Epub 2016 Apr 29.

40.

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.

Thinon E, Morales-Sanfrutos J, Mann DJ, Tate EW.

ACS Chem Biol. 2016 Aug 19;11(8):2165-76. doi: 10.1021/acschembio.6b00371. Epub 2016 Jun 7.

41.

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Data Brief. 2016 Feb 10;7:257-81. doi: 10.1016/j.dib.2016.02.012. eCollection 2016 Jun.

42.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI.

Mol Biosyst. 2016 May 24;12(6):1781-9. doi: 10.1039/c6mb00109b.

PMID:
27021930
43.

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.

Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2015 Oct 8;6(10):1767-1772. Epub 2015 Aug 19.

44.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2015 Oct 8;6(10):1761-1766. Epub 2015 Aug 19.

45.

The Rab-binding Profiles of Bacterial Virulence Factors during Infection.

So EC, Schroeder GN, Carson D, Mattheis C, Mousnier A, Broncel M, Tate EW, Frankel G.

J Biol Chem. 2016 Mar 11;291(11):5832-43. doi: 10.1074/jbc.M115.700930. Epub 2016 Jan 11.

46.

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.

Broncel M, Serwa RA, Bunney TD, Katan M, Tate EW.

Mol Cell Proteomics. 2016 Feb;15(2):715-25. doi: 10.1074/mcp.O115.054429. Epub 2015 Nov 24.

47.

Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.

Charlton TM, Kovacs-Simon A, Michell SL, Fairweather NF, Tate EW.

Chem Biol. 2015 Nov 19;22(11):1562-1573. doi: 10.1016/j.chembiol.2015.10.006. Epub 2015 Nov 12.

48.

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

Perdios L, Bunney TD, Warren SC, Dunsby C, French PMW, Tate EW, Katan M.

Adv Biol Regul. 2016 Jan;60:6-13. doi: 10.1016/j.jbior.2015.09.002. Epub 2015 Sep 26.

49.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Anal Biochem. 2015 Dec 1;490:66-72. doi: 10.1016/j.ab.2015.08.025. Epub 2015 Sep 1.

50.

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.

Serwa RA, Abaitua F, Krause E, Tate EW, O'Hare P.

Chem Biol. 2015 Aug 20;22(8):1008-17. doi: 10.1016/j.chembiol.2015.06.024. Epub 2015 Aug 6.

Supplemental Content

Support Center