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Rib fracture as a complication of erroneous baseplate and inferior screw placement in reverse total shoulder replacement: a case report.

Whitham RDJ, Clifford ZJ, Tasker AJB, Woods DA.

J Shoulder Elbow Surg. 2020 Mar;29(3):e87-e92. doi: 10.1016/j.jse.2019.11.016. No abstract available.


Prevalence and Cellular Distribution of Novel Immune Checkpoint Targets Across Longitudinal Specimens in Treatment-naïve Melanoma Patients: Implications for Clinical Trials.

Edwards J, Tasker A, Pires da Silva I, Quek C, Batten M, Ferguson A, Allen R, Allanson B, Saw RPM, Thompson JF, Menzies AM, Palendira U, Wilmott JS, Long GV, Scolyer RA.

Clin Cancer Res. 2019 Jun 1;25(11):3247-3258. doi: 10.1158/1078-0432.CCR-18-4011. Epub 2019 Feb 18.


Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.

Gide TN, Quek C, Menzies AM, Tasker AT, Shang P, Holst J, Madore J, Lim SY, Velickovic R, Wongchenko M, Yan Y, Lo S, Carlino MS, Guminski A, Saw RPM, Pang A, McGuire HM, Palendira U, Thompson JF, Rizos H, Silva IPD, Batten M, Scolyer RA, Long GV, Wilmott JS.

Cancer Cell. 2019 Feb 11;35(2):238-255.e6. doi: 10.1016/j.ccell.2019.01.003.


Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients.

Lee H, Quek C, Silva I, Tasker A, Batten M, Rizos H, Lim SY, Nur Gide T, Shang P, Attrill GH, Madore J, Edwards J, Carlino MS, Guminski A, Saw RPM, Thompson JF, Ferguson PM, Palendira U, Menzies AM, Long GV, Scolyer RA, Wilmott JS.

Oncoimmunology. 2018 Oct 31;8(2):e1537581. doi: 10.1080/2162402X.2018.1537581. eCollection 2019.


Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

Wang HL, Andrews KL, Booker SK, Canon J, Cee VJ, Chavez F Jr, Chen Y, Eastwood H, Guerrero N, Herberich B, Hickman D, Lanman BA, Laszlo J 3rd, Lee MR, Lipford JR, Mattson B, Mohr C, Nguyen Y, Norman MH, Pettus LH, Powers D, Reed AB, Rex K, Sastri C, Tamayo N, Wang P, Winston JT, Wu B, Wu Q, Wu T, Wurz RP, Xu Y, Zhou Y, Tasker AS.

J Med Chem. 2019 Feb 14;62(3):1523-1540. doi: 10.1021/acs.jmedchem.8b01733. Epub 2019 Jan 17.


Improving analgesia prescription for trauma inpatients.

Stanger S, Dahill M, Hillary C, Whitham R, Tasker A.

BMJ Open Qual. 2018 Dec 16;7(4):e000397. doi: 10.1136/bmjoq-2018-000397. eCollection 2018.


Particle-Stabilized Fluid-Fluid Interfaces: The Impact of Core Composition on Interfacial Structure.

Tasker A, Sainsbury F, Puttick S.

Front Chem. 2018 Aug 30;6:383. doi: 10.3389/fchem.2018.00383. eCollection 2018. Review.


The role of positron emission tomography in the diagnosis, staging and response assessment of non-small cell lung cancer.

Volpi S, Ali JM, Tasker A, Peryt A, Aresu G, Coonar AS.

Ann Transl Med. 2018 Mar;6(5):95. doi: 10.21037/atm.2018.01.25. Review.


CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment.

Edwards J, Wilmott JS, Madore J, Gide TN, Quek C, Tasker A, Ferguson A, Chen J, Hewavisenti R, Hersey P, Gebhardt T, Weninger W, Britton WJ, Saw RPM, Thompson JF, Menzies AM, Long GV, Scolyer RA, Palendira U.

Clin Cancer Res. 2018 Jul 1;24(13):3036-3045. doi: 10.1158/1078-0432.CCR-17-2257. Epub 2018 Mar 29.


Adsorption of Catalytic Nanoparticles onto Polymer Substrates for Controlled Deposition of Microcapsule Metal Shells.

Hitchcock JP, Tasker AL, Stark K, Leeson A, Baxter EA, Biggs S, Cayre OJ.

Langmuir. 2018 Jan 30;34(4):1473-1480. doi: 10.1021/acs.langmuir.7b02874. Epub 2018 Jan 16.


Understanding the Mechanisms of Gold Shell Growth onto Polymer Microcapsules to Control Shell Thickness.

Tasker AL, Hitchcock J, Baxter EA, Cayre DOJ, Biggs S.

Chem Asian J. 2017 Jul 4;12(13):1641-1648. doi: 10.1002/asia.201700536. Epub 2017 Jun 21.


Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.

Wurz RP, Sastri C, D'Amico DC, Herberich B, Jackson CLM, Pettus LH, Tasker AS, Wu B, Guerrero N, Lipford JR, Winston JT, Yang Y, Wang P, Nguyen Y, Andrews KL, Huang X, Lee MR, Mohr C, Zhang JD, Reid DL, Xu Y, Zhou Y, Wang HL.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5580-5590. doi: 10.1016/j.bmcl.2016.09.067. Epub 2016 Oct 1.


The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.

Sickmier EA, Kurzeja RJ, Michelsen K, Vazir M, Yang E, Tasker AS.

PLoS One. 2016 Sep 22;11(9):e0163366. doi: 10.1371/journal.pone.0163366. eCollection 2016.


The effect of surfactant chain length on the morphology of poly(methyl methacrylate) microcapsules for fragrance oil encapsulation.

Tasker AL, Hitchcock JP, He L, Baxter EA, Biggs S, Cayre OJ.

J Colloid Interface Sci. 2016 Dec 15;484:10-16. doi: 10.1016/j.jcis.2016.08.058. Epub 2016 Aug 24.


Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

Pettus LH, Andrews KL, Booker SK, Chen J, Cee VJ, Chavez F Jr, Chen Y, Eastwood H, Guerrero N, Herberich B, Hickman D, Lanman BA, Laszlo J 3rd, Lee MR, Lipford JR, Mattson B, Mohr C, Nguyen Y, Norman MH, Powers D, Reed AB, Rex K, Sastri C, Tamayo N, Wang P, Winston JT, Wu B, Wu T, Wurz RP, Xu Y, Zhou Y, Tasker AS, Wang HL.

J Med Chem. 2016 Jul 14;59(13):6407-30. doi: 10.1021/acs.jmedchem.6b00610. Epub 2016 Jun 22.


Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

Cee VJ, Chavez F Jr, Herberich B, Lanman BA, Pettus LH, Reed AB, Wu B, Wurz RP, Andrews KL, Chen J, Hickman D, Laszlo J 3rd, Lee MR, Guerrero N, Mattson BK, Nguyen Y, Mohr C, Rex K, Sastri CE, Wang P, Wu Q, Wu T, Xu Y, Zhou Y, Winston JT, Lipford JR, Tasker AS, Wang HL.

ACS Med Chem Lett. 2016 Feb 12;7(4):408-12. doi: 10.1021/acsmedchemlett.5b00403. eCollection 2016 Apr 14.


Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.

Cee VJ, Volak LP, Chen Y, Bartberger MD, Tegley C, Arvedson T, McCarter J, Tasker AS, Fotsch C.

J Med Chem. 2015 Dec 10;58(23):9171-8. doi: 10.1021/acs.jmedchem.5b01018. Epub 2015 Nov 18.


Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.

Wurz RP, Pettus LH, Ashton K, Brown J, Chen JJ, Herberich B, Hong FT, Hu-Harrington E, Nguyen T, St Jean DJ Jr, Tadesse S, Bauer D, Kubryk M, Zhan J, Cooke K, Mitchell P, Andrews KL, Hsieh F, Hickman D, Kalyanaraman N, Wu T, Reid DL, Lobenhofer EK, Andrews DA, Everds N, Guzman R, Parsons AT, Hedley SJ, Tedrow J, Thiel OR, Potter M, Radinsky R, Beltran PJ, Tasker AS.

ACS Med Chem Lett. 2015 Jul 27;6(9):987-92. doi: 10.1021/acsmedchemlett.5b00193. eCollection 2015 Sep 10.


Long-Term Retention of Small, Volatile Molecular Species within Metallic Microcapsules.

Hitchcock JP, Tasker AL, Baxter EA, Biggs S, Cayre OJ.

ACS Appl Mater Interfaces. 2015 Jul 15;7(27):14808-15. doi: 10.1021/acsami.5b03116. Epub 2015 Jun 26.


Broadening the scope of thoracic oncological intervention: a novel minimally invasive method for the diagnosis of primary cardiac lymphoma.

Sayal K, Ali T, Tasker A, Carroll N.

BMJ Case Rep. 2015 May 14;2015. pii: bcr2014208632. doi: 10.1136/bcr-2014-208632.


Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.

Wu B, Wang HL, Cee VJ, Lanman BA, Nixey T, Pettus L, Reed AB, Wurz RP, Guerrero N, Sastri C, Winston J, Lipford JR, Lee MR, Mohr C, Andrews KL, Tasker AS.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):775-80. doi: 10.1016/j.bmcl.2014.12.091. Epub 2015 Jan 7.


The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.

Wurz RP, Pettus LH, Jackson C, Wu B, Wang HL, Herberich B, Cee V, Lanman BA, Reed AB, Chavez F Jr, Nixey T, Laszlo J 3rd, Wang P, Nguyen Y, Sastri C, Guerrero N, Winston J, Lipford JR, Lee MR, Andrews KL, Mohr C, Xu Y, Zhou Y, Reid DL, Tasker AS.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):847-55. doi: 10.1016/j.bmcl.2014.12.067. Epub 2015 Jan 7.


The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.

Wang HL, Cee VJ, Chavez F Jr, Lanman BA, Reed AB, Wu B, Guerrero N, Lipford JR, Sastri C, Winston J, Andrews KL, Huang X, Lee MR, Mohr C, Xu Y, Zhou Y, Tasker AS.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):834-40. doi: 10.1016/j.bmcl.2014.12.068. Epub 2014 Dec 30.


Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.

Harrington PE, Biswas K, Malwitz D, Tasker AS, Mohr C, Andrews KL, Dellamaggiore K, Kendall R, Beckmann H, Jaeckel P, Materna-Reichelt S, Allen JR, Lipford JR.

ACS Med Chem Lett. 2014 Sep 24;6(1):68-72. doi: 10.1021/ml500315b. eCollection 2015 Jan 8.


Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Cushing TD, Hao X, Shin Y, Andrews K, Brown M, Cardozo M, Chen Y, Duquette J, Fisher B, Gonzalez-Lopez de Turiso F, He X, Henne KR, Hu YL, Hungate R, Johnson MG, Kelly RC, Lucas B, McCarter JD, McGee LR, Medina JC, San Miguel T, Mohn D, Pattaropong V, Pettus LH, Reichelt A, Rzasa RM, Seganish J, Tasker AS, Wahl RC, Wannberg S, Whittington DA, Whoriskey J, Yu G, Zalameda L, Zhang D, Metz DP.

J Med Chem. 2015 Jan 8;58(1):480-511. doi: 10.1021/jm501624r. Epub 2014 Dec 3.


Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.

Lanman BA, Reed AB, Cee VJ, Hong FT, Pettus LH, Wurz RP, Andrews KL, Jiang J, McCarter JD, Mullady EL, San Miguel T, Subramanian R, Wang L, Whittington DA, Wu T, Zalameda L, Zhang N, Tasker AS, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5630-5634. doi: 10.1016/j.bmcl.2014.10.085. Epub 2014 Nov 1.


The influence of rotator cuff pathology on functional outcome in total shoulder replacement.

Ahearn N, McCann PA, Tasker A, Sarangi PP.

Int J Shoulder Surg. 2013 Oct;7(4):127-31. doi: 10.4103/0973-6042.123509.


Minimally invasive total knee arthroplasty; a pragmatic randomised controlled trial reporting outcomes up to 2 year follow up.

Tasker A, Hassaballa M, Murray J, Lancaster S, Artz N, Harries W, Porteous A.

Knee. 2014 Jan;21(1):189-93. doi: 10.1016/j.knee.2013.07.010. Epub 2013 Aug 2. Erratum in: Knee. 2014 Jun;21(3):798.


Multidetector CT findings in patients with mesenteric ischaemia following cardiopulmonary bypass surgery.

Barrett T, Upponi S, Benaglia T, Tasker AD.

Br J Radiol. 2013 Oct;86(1030):20130277. doi: 10.1259/bjr.20130277. Epub 2013 Aug 21.


Effect of silencing the two major tomato fruit pectin methylesterase isoforms on cell wall pectin metabolism.

Wen B, Ström A, Tasker A, West G, Tucker GA.

Plant Biol (Stuttg). 2013 Nov;15(6):1025-32. doi: 10.1111/j.1438-8677.2012.00714.x. Epub 2013 Apr 10.


Detection of pulmonary nodules at paediatric CT: maximum intensity projections and axial source images are complementary.

Kilburn-Toppin F, Arthurs OJ, Tasker AD, Set PA.

Pediatr Radiol. 2013 Jul;43(7):820-6. doi: 10.1007/s00247-012-2597-6. Epub 2013 Jan 24.


Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, Mullady EL, Nishimura N, Pettus LH, Reed AB, Miguel TS, Smith AL, Stec MM, Tadesse S, Tasker A, Aidasani D, Zhu X, Subramanian R, Tamayo NA, Wang L, Whittington DA, Wu B, Wu T, Wurz RP, Yang K, Zalameda L, Zhang N, Hughes PE.

J Med Chem. 2012 Sep 13;55(17):7796-816. doi: 10.1021/jm300846z. Epub 2012 Aug 30. Erratum in: J Med Chem. 2012 Oct 25;55(20):8975.


Shoulder arthroplasty. Part 2: normal and abnormal radiographic findings.

Sheridan BD, Ahearn N, Tasker A, Wakeley C, Sarangi P.

Clin Radiol. 2012 Jul;67(7):716-21. doi: 10.1016/j.crad.2011.05.021. Epub 2012 Feb 4.


Shoulder arthroplasty. Part 1: Prosthesis terminology and classification.

Sheridan BD, Ahearn N, Tasker A, Wakeley C, Sarangi P.

Clin Radiol. 2012 Jul;67(7):709-15. doi: 10.1016/j.crad.2011.11.014. Epub 2012 Jan 31. Review.


Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.

Reed AB, Lanman BA, Neira S, Harrington PE, Sham KK, Frohn M, Pickrell AJ, Tasker AS, Gore A, Fiorino M, Itano A, McElvain M, Middleton S, Morrison H, Xu H, Xu Y, Wong M, Cee VJ.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1779-83. doi: 10.1016/j.bmcl.2011.12.073. Epub 2011 Dec 21.


Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.

Harrington PE, Croghan MD, Fotsch C, Frohn M, Lanman BA, Pennington LD, Pickrell AJ, Reed AB, Sham KK, Tasker A, Arnett HA, Fiorino M, Lee MR, McElvain M, Morrison HG, Xu H, Xu Y, Zhang X, Wong M, Cee VJ.

ACS Med Chem Lett. 2011 Nov 23;3(1):74-8. doi: 10.1021/ml200252b. eCollection 2012 Jan 12.


Identification of triazolopyridazinones as potent p38α inhibitors.

Herberich B, Jackson C, Wurz RP, Pettus LH, Sherman L, Liu Q, Henkle B, Saris CJ, Wong LM, Chmait S, Lee MR, Mohr C, Hsieh F, Tasker AS.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1226-9. doi: 10.1016/j.bmcl.2011.11.067. Epub 2011 Nov 23.


Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.

Pennington LD, Croghan MD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, Morrison HG, Arnett HA, Fotsch C, Tasker AS, Wong M, Cee VJ.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):527-31. doi: 10.1016/j.bmcl.2011.10.085. Epub 2011 Nov 4.


TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.

Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA.

Mol Cell. 2011 Feb 18;41(4):458-70. doi: 10.1016/j.molcel.2011.01.019.


The clinical impact of high resolution computed tomography in patients with respiratory disease.

Screaton NJ, Miller FN, Patel BD, Groves A, Tasker AD, Lomas DA, Flower CD.

Eur Radiol. 2011 Feb;21(2):225-31. doi: 10.1007/s00330-010-1923-3. Epub 2010 Aug 24.


Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.

Wu B, Wang HL, Pettus L, Wurz RP, Doherty EM, Henkle B, McBride HJ, Saris CJ, Wong LM, Plant MH, Sherman L, Lee MR, Hsieh F, Tasker AS.

J Med Chem. 2010 Sep 9;53(17):6398-411. doi: 10.1021/jm100567y.


The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.

Harrington PE, St Jean DJ Jr, Clarine J, Coulter TS, Croghan M, Davenport A, Davis J, Ghiron C, Hutchinson J, Kelly MG, Lott F, Lu JY, Martin D, Morony S, Poon SF, Portero-Larragueta E, Reagan JD, Regal KA, Tasker A, Wang M, Yang Y, Yao G, Zeng Q, Henley C 3rd, Fotsch C.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5544-7. doi: 10.1016/j.bmcl.2010.07.060. Epub 2010 Aug 12.


Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors.

Caenepeel S, Renshaw-Gegg L, Baher A, Bush TL, Baron W, Juan T, Manoukian R, Tasker AS, Polverino A, Hughes PE.

J Exp Clin Cancer Res. 2010 Jul 15;29:96. doi: 10.1186/1756-9966-29-96.


Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.

Pettus LH, Wurz RP, Xu S, Herberich B, Henkle B, Liu Q, McBride HJ, Mu S, Plant MH, Saris CJ, Sherman L, Wong LM, Chmait S, Lee MR, Mohr C, Hsieh F, Tasker AS.

J Med Chem. 2010 Apr 8;53(7):2973-85. doi: 10.1021/jm100095x.


Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.

Wurz RP, Pettus LH, Henkle B, Sherman L, Plant M, Miner K, McBride HJ, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1680-4. doi: 10.1016/j.bmcl.2010.01.059. Epub 2010 Jan 21.


2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics.

Zeng Q, Bourbeau MP, Wohlhieter GE, Yao G, Monenschein H, Rider JT, Lee MR, Zhang S, Lofgren J, Freeman D, Li C, Tominey E, Huang X, Hoffman D, Yamane H, Tasker AS, Dominguez C, Viswanadhan VN, Hungate R, Zhang X.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1652-6. doi: 10.1016/j.bmcl.2010.01.046. Epub 2010 Jan 20.


Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.

Wurz RP, Pettus LH, Xu S, Henkle B, Sherman L, Plant M, Miner K, McBride H, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4724-8. doi: 10.1016/j.bmcl.2009.06.058. Epub 2009 Jun 17.


Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation.

Sundaram S, Tasker AD, Morrell NW.

Eur Respir J. 2009 Jun;33(6):1510-2. doi: 10.1183/09031936.00062608.


Vein graft pseudoaneurysm.

Hoey ET, Ganesh V, Gopalan D, Tasker AD.

Postgrad Med J. 2009 Mar;85(1001):166. doi: 10.1136/pgmj.2008.075630. No abstract available.


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