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Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation.
Lu P, ElMallah MK, Liu Z, Wu C, Chen J, Lifshitz LM, ZhuGe R. Lu P, et al. J Cell Physiol. 2021 Sep;236(9):6407-6423. doi: 10.1002/jcp.30315. Epub 2021 Feb 8. J Cell Physiol. 2021. PMID: 33559206 Free PMC article.
Here, we employed the CRISPR/Cas9 gene-editing technique to delete three bitter taste receptors-Tas2r143/Tas2r135/Tas2r126 (i.e., Tas2r triple knockout [TKO]) in mice. ...
Here, we employed the CRISPR/Cas9 gene-editing technique to delete three bitter taste receptors-Tas2r143/Tas2r135/Tas2r126 (i.e., Tas …
Salicin alleviates periodontitis via Tas2r143/gustducin signaling in fibroblasts.
Zhang Z, Zhou Z, Liu J, Zheng L, Peng X, Zhao L, Zheng X, Xu X. Zhang Z, et al. Front Immunol. 2024 Mar 28;15:1374900. doi: 10.3389/fimmu.2024.1374900. eCollection 2024. Front Immunol. 2024. PMID: 38605968 Free PMC article.
The anti-inflammatory effects of salicin against LPS-induced MGFs were investigated in cell cultures, and were further validated with a ligature-induced periodontitis mouse model using Ga-gustducin-null (Gnat3(-/-)) mice. RESULTS: The expression of Tas2r143, Gnat3, Plcb2, …
The anti-inflammatory effects of salicin against LPS-induced MGFs were investigated in cell cultures, and were further validated with a liga …
Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues.
Liu S, Lu S, Xu R, Atzberger A, Günther S, Wettschureck N, Offermanns S. Liu S, et al. Front Physiol. 2017 Oct 30;8:849. doi: 10.3389/fphys.2017.00849. eCollection 2017. Front Physiol. 2017. PMID: 29163195 Free PMC article.
Previous studies indicated that the Tas2r143/Tas2r135/Tas2r126 cluster is expressed in the heart, but other organs had not been systematically analyzed. In order to investigate the expression of this bitter taste receptor gene cluster in non-gustatory tissues, we generated …
Previous studies indicated that the Tas2r143/Tas2r135/Tas2r126 cluster is expressed in the heart, but other organs had not been syste …
Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway.
Kobayashi D, Watarai T, Ozawa M, Kanda Y, Saika F, Kiguchi N, Takeuchi A, Ikawa M, Matsuzaki S, Katakai T. Kobayashi D, et al. Front Immunol. 2022 Aug 18;13:973880. doi: 10.3389/fimmu.2022.973880. eCollection 2022. Front Immunol. 2022. PMID: 36059440 Free PMC article.
However, the role of Tas2Rs in immune cells remains controversial. Here, we demonstrate that Tas2R126, Tas2R135, and Tas2R143 are expressed in mouse neutrophils, but not in other immune cells such as macrophages or T and B lymphocytes. ...
However, the role of Tas2Rs in immune cells remains controversial. Here, we demonstrate that Tas2R126, Tas2R135, and Tas2R143 are exp …
Taste 2 Receptor Is Involved in Differentiation of 3T3-L1 Preadipocytes.
Kimura S, Tsuruma A, Kato E. Kimura S, et al. Int J Mol Sci. 2022 Jul 23;23(15):8120. doi: 10.3390/ijms23158120. Int J Mol Sci. 2022. PMID: 35897692 Free PMC article.
The white adipose tissue of mice has been shown to express Tas2r108, Tas2r126, Tas2r135, Tas2r137, and Tas2r143, but the function of T2Rs in adipocytes remains unclear. Here, we show that fasting and stimulation by bitter compounds both increased Tas2r expression in mouse …
The white adipose tissue of mice has been shown to express Tas2r108, Tas2r126, Tas2r135, Tas2r137, and Tas2r143, but the function of …
Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.
Moine F, Brechbühl J, Nenniger Tosato M, Beaumann M, Broillet MC. Moine F, et al. BMC Biol. 2018 Jan 18;16(1):12. doi: 10.1186/s12915-017-0479-y. BMC Biol. 2018. PMID: 29347925 Free PMC article.
Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, Tas2r131, Tas2r143 and their associated G protein alpha-gustducin (Gnat3). We were further able to confirm their expression at the p …
Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, …
Distinct Cell Types With the Bitter Receptor Tas2r126 in Different Compartments of the Stomach.
Widmayer P, Partsch V, Pospiech J, Kusumakshi S, Boehm U, Breer H. Widmayer P, et al. Front Physiol. 2020 Feb 7;11:32. doi: 10.3389/fphys.2020.00032. eCollection 2020. Front Physiol. 2020. PMID: 32116750 Free PMC article.
Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective responses to potentially harmful or even antiinflammatory or antimicrobial compounds. In a previous study the activity of the Tas2R143 …
Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective r …
Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart.
Foster SR, Blank K, See Hoe LE, Behrens M, Meyerhof W, Peart JN, Thomas WG. Foster SR, et al. FASEB J. 2014 Oct;28(10):4497-508. doi: 10.1096/fj.14-256305. Epub 2014 Jul 1. FASEB J. 2014. PMID: 25002118
Five Tas2rs cloned from heart tissue were screened against a panel of 102 natural or synthetic bitter compounds in a heterologous expression system. We identified agonists for Tas2r108, Tas2r137, and Tas2r143 that were then tested in Langendorff-perfused mouse hearts (from …
Five Tas2rs cloned from heart tissue were screened against a panel of 102 natural or synthetic bitter compounds in a heterologous expression …