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Items: 1 to 50 of 52

1.

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Reisländer T, Lombardi EP, Groelly FJ, Miar A, Porru M, Di Vito S, Wright B, Lockstone H, Biroccio A, Harris A, Londoño-Vallejo A, Tarsounas M.

Nat Commun. 2019 Jul 17;10(1):3143. doi: 10.1038/s41467-019-11048-5.

2.

Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells.

Jackson MR, Bavelaar BM, Waghorn PA, Gill MR, El-Sagheer AH, Brown T, Tarsounas M, Vallis KA.

Cancer Res. 2019 Sep 15;79(18):4627-4637. doi: 10.1158/0008-5472.CAN-18-3594. Epub 2019 Jul 16.

PMID:
31311806
3.

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.

Tacconi EM, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, Folio C, Moore J, Kopp A, Baguña Torres J, Sneddon D, Green M, Dedic S, Lee JW, Batra AS, Rueda OM, Bruna A, Leonetti C, Caldas C, Cornelissen B, Brino L, Ryan A, Biroccio A, Tarsounas M.

EMBO Mol Med. 2019 Jul;11(7):e9982. doi: 10.15252/emmm.201809982. Epub 2019 May 24.

4.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Llobet SG, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie DJ, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andújar-Sánchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S.

Cancer Cell. 2019 Jun 10;35(6):950-952. doi: 10.1016/j.ccell.2019.05.012. No abstract available.

5.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Guerrero Llobet S, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie DJ, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andújar-Sánchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S.

Cancer Cell. 2018 Jun 11;33(6):1078-1093.e12. doi: 10.1016/j.ccell.2018.05.008. Erratum in: Cancer Cell. 2019 Jun 10;35(6):950-952.

6.

Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.

Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.

Nat Commun. 2017 Oct 26;8:16171. doi: 10.1038/ncomms16171.

7.

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.

Tacconi EM, Lai X, Folio C, Porru M, Zonderland G, Badie S, Michl J, Sechi I, Rogier M, Matía García V, Batra AS, Rueda OM, Bouwman P, Jonkers J, Ryan A, Reina-San-Martin B, Hui J, Tang N, Bruna A, Biroccio A, Tarsounas M.

EMBO Mol Med. 2017 Oct;9(10):1398-1414. doi: 10.15252/emmm.201607446.

8.

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.

Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.

Nat Commun. 2017 Jul 17;8:15983. doi: 10.1038/ncomms15983. Erratum in: Nat Commun. 2017 Oct 26;8:16171.

9.

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

Schoonen PM, Talens F, Stok C, Gogola E, Heijink AM, Bouwman P, Foijer F, Tarsounas M, Blatter S, Jonkers J, Rottenberg S, van Vugt MATM.

Nat Commun. 2017 Jul 17;8:15981. doi: 10.1038/ncomms15981.

10.

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

Salvati E, Botta L, Amato J, Di Leva FS, Zizza P, Gioiello A, Pagano B, Graziani G, Tarsounas M, Randazzo A, Novellino E, Biroccio A, Cosconati S.

J Med Chem. 2017 May 11;60(9):3626-3635. doi: 10.1021/acs.jmedchem.6b01563. Epub 2017 May 1.

PMID:
28445046
11.

FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

Michl J, Zimmer J, Buffa FM, McDermott U, Tarsounas M.

Nat Struct Mol Biol. 2016 Aug;23(8):755-757. doi: 10.1038/nsmb.3252. Epub 2016 Jun 20.

12.

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.

Michl J, Zimmer J, Tarsounas M.

EMBO J. 2016 May 2;35(9):909-23. doi: 10.15252/embj.201693860. Epub 2016 Apr 1. Review.

13.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J, Tacconi EMC, Folio C, Badie S, Porru M, Klare K, Tumiati M, Markkanen E, Halder S, Ryan A, Jackson SP, Ramadan K, Kuznetsov SG, Biroccio A, Sale JE, Tarsounas M.

Mol Cell. 2016 Feb 4;61(3):449-460. doi: 10.1016/j.molcel.2015.12.004. Epub 2015 Dec 31.

14.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M.

EMBO J. 2015 Mar 12;34(6):828. doi: 10.15252/embj.201570610. No abstract available.

15.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M.

EMBO J. 2015 Feb 3;34(3):410-24. doi: 10.15252/embj.201488947. Epub 2015 Jan 12. Erratum in: EMBO J. 2015 Mar 12;34(6):828.

16.

How homologous recombination maintains telomere integrity.

Tacconi EM, Tarsounas M.

Chromosoma. 2015 Jun;124(2):119-30. doi: 10.1007/s00412-014-0497-2. Epub 2014 Nov 29. Review.

PMID:
25430998
17.

Introduction. DNA damage and repair.

Sjögren C, Tarsounas M, Bartek J, Höög C.

Exp Cell Res. 2014 Nov 15;329(1):1. doi: 10.1016/j.yexcr.2014.09.029. Epub 2014 Oct 2. No abstract available.

PMID:
25281305
18.

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.

Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S.

Nat Chem Biol. 2014 Oct;10(10):853-60. doi: 10.1038/nchembio.1629. Epub 2014 Sep 7.

19.

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.

Carlos AR, Escandell JM, Kotsantis P, Suwaki N, Bouwman P, Badie S, Folio C, Benitez J, Gomez-Lopez G, Pisano DG, Jonkers J, Tarsounas M.

Nat Commun. 2013;4:2697. doi: 10.1038/ncomms3697.

PMID:
24162189
20.

Genomes and G-quadruplexes: for better or for worse.

Tarsounas M, Tijsterman M.

J Mol Biol. 2013 Nov 29;425(23):4782-9. doi: 10.1016/j.jmb.2013.09.026. Epub 2013 Sep 25. Review.

PMID:
24076189
21.

It's getting HOT at telomeres.

Tarsounas M.

EMBO J. 2013 Jun 12;32(12):1655-7. doi: 10.1038/emboj.2013.119. Epub 2013 May 17. No abstract available.

22.

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.

Thanasoula M, Escandell JM, Suwaki N, Tarsounas M.

EMBO J. 2012 Aug 15;31(16):3398-410. doi: 10.1038/emboj.2012.191. Epub 2012 Jul 27.

23.

RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.

Suwaki N, Klare K, Tarsounas M.

Semin Cell Dev Biol. 2011 Oct;22(8):898-905. doi: 10.1016/j.semcdb.2011.07.019. Epub 2011 Jul 28. Review.

PMID:
21821141
24.

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.

Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, Blasco MA, Jonkers J, Tarsounas M.

Nat Struct Mol Biol. 2010 Dec;17(12):1461-9. doi: 10.1038/nsmb.1943. Epub 2010 Nov 14.

25.

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.

Martinez P, Thanasoula M, Carlos AR, Gómez-López G, Tejera AM, Schoeftner S, Dominguez O, Pisano DG, Tarsounas M, Blasco MA.

Nat Cell Biol. 2010 Aug;12(8):768-80. doi: 10.1038/ncb2081. Epub 2010 Jul 11.

26.

TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice.

Tejera AM, Stagno d'Alcontres M, Thanasoula M, Marion RM, Martinez P, Liao C, Flores JM, Tarsounas M, Blasco MA.

Dev Cell. 2010 May 18;18(5):775-89. doi: 10.1016/j.devcel.2010.03.011.

27.

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.

Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J.

Nat Struct Mol Biol. 2010 Jun;17(6):688-95. doi: 10.1038/nsmb.1831. Epub 2010 May 9.

28.

p53 prevents entry into mitosis with uncapped telomeres.

Thanasoula M, Escandell JM, Martinez P, Badie S, Muñoz P, Blasco MA, Tarsounas M.

Curr Biol. 2010 Mar 23;20(6):521-6. doi: 10.1016/j.cub.2010.01.046. Epub 2010 Mar 11.

29.

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

Martínez P, Thanasoula M, Muñoz P, Liao C, Tejera A, McNees C, Flores JM, Fernández-Capetillo O, Tarsounas M, Blasco MA.

Genes Dev. 2009 Sep 1;23(17):2060-75. doi: 10.1101/gad.543509. Epub 2009 Aug 13.

30.

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.

Badie S, Liao C, Thanasoula M, Barber P, Hill MA, Tarsounas M.

J Cell Biol. 2009 May 18;185(4):587-600. doi: 10.1083/jcb.200811079.

31.

Telomere regulation and function during meiosis.

Siderakis M, Tarsounas M.

Chromosome Res. 2007;15(5):667-79. Review.

32.

Role of RAD51C and XRCC3 in genetic recombination and DNA repair.

Liu Y, Tarsounas M, O'regan P, West SC.

J Biol Chem. 2007 Jan 19;282(3):1973-9. Epub 2006 Nov 17.

33.

Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation.

Tarsounas M, West SC.

Cell Cycle. 2005 May;4(5):672-4. Epub 2005 May 25. Review.

PMID:
15846103
34.

Telomere maintenance requires the RAD51D recombination/repair protein.

Tarsounas M, Muñoz P, Claas A, Smiraldo PG, Pittman DL, Blasco MA, West SC.

Cell. 2004 Apr 30;117(3):337-47.

35.

RAD51 localization and activation following DNA damage.

Tarsounas M, Davies AA, West SC.

Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):87-93.

36.

PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis.

Madsen B, Tarsounas M, Burchell JM, Hall D, Poulsom R, Taylor-Papadimitriou J.

Chromosoma. 2003 Oct;112(3):124-32. Epub 2003 Sep 10.

PMID:
14579128
37.

BRCA2-dependent and independent formation of RAD51 nuclear foci.

Tarsounas M, Davies D, West SC.

Oncogene. 2003 Feb 27;22(8):1115-23.

PMID:
12606939
39.

Identification and purification of two distinct complexes containing the five RAD51 paralogs.

Masson JY, Tarsounas MC, Stasiak AZ, Stasiak A, Shah R, McIlwraith MJ, Benson FE, West SC.

Genes Dev. 2001 Dec 15;15(24):3296-307.

40.

CLIP-50 immunolocalization during mouse spermiogenesis suggests a role in shaping the sperm nucleus.

Tarsounas M, Pearlman RE, Moens PB.

Dev Biol. 2001 Aug 15;236(2):400-10.

41.

The genomic structure of SYCP3, a meiosis-specific gene encoding a protein of the chromosome core.

Botelho RJ, DiNicolo L, Tsao N, Karaiskakis A, Tarsounas M, Moens PB, Pearlman RE.

Biochim Biophys Acta. 2001 Apr 16;1518(3):294-9.

PMID:
11311943
42.

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.

Constantinou A, Tarsounas M, Karow JK, Brosh RM, Bohr VA, Hickson ID, West SC.

EMBO Rep. 2000 Jul;1(1):80-4.

43.

Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes.

Tarsounas M, Moens PB.

Curr Top Dev Biol. 2001;51:109-34. Review.

PMID:
11236712
44.
45.
46.

RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes.

Tarsounas M, Morita T, Pearlman RE, Moens PB.

J Cell Biol. 1999 Oct 18;147(2):207-20.

47.

The association of ATR protein with mouse meiotic chromosome cores.

Moens PB, Tarsounas M, Morita T, Habu T, Rottinghaus ST, Freire R, Jackson SP, Barlow C, Wynshaw-Boris A.

Chromosoma. 1999 May;108(2):95-102.

PMID:
10382071
49.

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.

Barlow C, Liyanage M, Moens PB, Tarsounas M, Nagashima K, Brown K, Rottinghaus S, Jackson SP, Tagle D, Ried T, Wynshaw-Boris A.

Development. 1998 Oct;125(20):4007-17.

50.

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.

Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP.

Genes Dev. 1998 Aug 15;12(16):2560-73.

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