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Items: 24

1.
2.

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.

Loomba R, Kayali Z, Noureddin M, Ruane P, Lawitz EJ, Bennett M, Wang L, Harting E, Tarrant JM, McColgan BJ, Chung C, Ray AS, Subramanian GM, Myers RP, Middleton MS, Lai M, Charlton M, Harrison SA.

Gastroenterology. 2018 Nov;155(5):1463-1473.e6. doi: 10.1053/j.gastro.2018.07.027. Epub 2018 Jul 27.

PMID:
30059671
3.

Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer.

Jarzabek MA, Proctor WR, Vogt J, Desai R, Dicker P, Cain G, Raja R, Brodbeck J, Stevens D, van der Stok EP, Martens JWM, Verhoef C, Hegde PS, Byrne AT, Tarrant JM.

PLoS One. 2018 Jun 7;13(6):e0198099. doi: 10.1371/journal.pone.0198099. eCollection 2018.

4.

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.

Lawitz EJ, Coste A, Poordad F, Alkhouri N, Loo N, McColgan BJ, Tarrant JM, Nguyen T, Han L, Chung C, Ray AS, McHutchison JG, Subramanian GM, Myers RP, Middleton MS, Sirlin C, Loomba R, Nyangau E, Fitch M, Li K, Hellerstein M.

Clin Gastroenterol Hepatol. 2018 Dec;16(12):1983-1991.e3. doi: 10.1016/j.cgh.2018.04.042. Epub 2018 Apr 26.

PMID:
29705265
5.

Proof of Concept for an Automated Image Analysis Method to Quantify Rat Bone Marrow Hematopoietic Lineages on H&E Sections.

Kozlowski C, Fullerton A, Cain G, Katavolos P, Bravo J, Tarrant JM.

Toxicol Pathol. 2018 Apr;46(3):336-347. doi: 10.1177/0192623318766458.

PMID:
29683092
6.

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson RI, Schutt LK, Tarrant JM, McDowell M, Liu L, Johnson AR, Lewin-Koh SC, Hedehus M, Ross J, Carano RA, Staflin K, Zhong F, Crawford JJ, Zhong S, Reif K, Katewa A, Wong H, Young WB, Dambach DM, Misner DL.

J Pharmacol Exp Ther. 2017 Jan;360(1):226-238. Epub 2016 Nov 7.

PMID:
27821712
7.

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.

Diaz D, Pai R, Cain G, La N, Dambach D, Schwartz J, Tarrant JM.

Toxicol Pathol. 2017 Feb;45(2):353-361. doi: 10.1177/0192623316664590. Epub 2016 Sep 28.

PMID:
27565173
8.

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.

Pai R, Ma N, Connor AV, Danilenko DM, Tarrant JM, Salvail D, Wong L, Hartley DP, Misner D, Stefanich E, Wu Y, Chen Y, Wang H, Dambach DM.

Toxicol Sci. 2016 Jun;151(2):245-60. doi: 10.1093/toxsci/kfw037. Epub 2016 Feb 25.

PMID:
26917699
9.

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.

Tarrant JM, Dhawan P, Singh J, Zabka TS, Clarke E, DosSantos G, Dragovich PS, Sampath D, Lin T, McCray B, La N, Nguyen T, Kauss A, Dambach D, Misner DL, Diaz D, Uppal H.

Toxicol Mech Methods. 2015 Mar;25(3):201-11. doi: 10.3109/15376516.2015.1014080. Epub 2015 Apr 20.

PMID:
25894564
10.

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ.

Sci Transl Med. 2015 Mar 18;7(279):279ra40. doi: 10.1126/scitranslmed.aaa4642.

PMID:
25787766
11.

Development of a safety biomarker signature to detect hepatic sinusoidal dilation associated with an anti-DLL4 biotherapeutic.

Tarrant JM, Lewin-Koh SC, Lewin-Koh N.

Biomarkers. 2014 Aug;19(5):391-401. doi: 10.3109/1354750X.2014.919026. Epub 2014 May 19.

PMID:
24842386
12.

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, Lin Y, Lin Z, Balazs M, Scearce-Levie K, Ernst JA, Dennis MS, Watts RJ.

Sci Transl Med. 2013 May 1;5(183):183ra57, 1-12. doi: 10.1126/scitranslmed.3005338.

13.

Unexpected hematologic effects of biotherapeutics in nonclinical species and in humans.

Everds NE, Tarrant JM.

Toxicol Pathol. 2013 Feb;41(2):280-302. doi: 10.1177/0192623312467400. Review.

PMID:
23471185
14.

Current practices in preclinical drug development: gaps in hemostasis testing to assess risk of thromboembolic injury.

Schultze AE, Walker DB, Turk JR, Tarrant JM, Brooks MB, Pettit SD.

Toxicol Pathol. 2013;41(3):445-53. doi: 10.1177/0192623312460924. Epub 2012 Sep 18.

PMID:
22991386
15.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM.

Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5.

PMID:
21976371
16.

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.

Gartlan KH, Belz GT, Tarrant JM, Minigo G, Katsara M, Sheng KC, Sofi M, van Spriel AB, Apostolopoulos V, Plebanski M, Robb L, Wright MD.

J Immunol. 2010 Sep 15;185(6):3158-66. doi: 10.4049/jimmunol.0902867. Epub 2010 Aug 13.

17.

Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: considerations for their use.

Tarrant JM.

Toxicol Sci. 2010 Sep;117(1):4-16. doi: 10.1093/toxsci/kfq134. Epub 2010 May 6. Review.

18.

The role of flow cytometry in companion animal diagnostic medicine.

Tarrant JM.

Vet J. 2005 Nov;170(3):278-88. Review.

PMID:
16266842
19.

Tetraspanins: molecular organisers of the leukocyte surface.

Tarrant JM, Robb L, van Spriel AB, Wright MD.

Trends Immunol. 2003 Nov;24(11):610-7. Review.

PMID:
14596886
20.

The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.

Tarrant JM, Groom J, Metcalf D, Li R, Borobokas B, Wright MD, Tarlinton D, Robb L.

Mol Cell Biol. 2002 Jul;22(14):5006-18.

21.

Diagnosis of chronic myelogenous leukemia in a dog using morphologic, cytochemical, and flow cytometric techniques.

Tarrant JM, Stokol T, Blue JT, McDonough SP, Farrell P.

Vet Clin Pathol. 2001;30(1):19-24.

PMID:
12024326
22.

Overestimation of canine albumin concentration with the bromcresol green method in heparinized plasma samples.

Stokol T, Tarrant JM, Scarlett JM.

Vet Clin Pathol. 2001;30(4):170-176.

PMID:
12024297
23.

Hyperlipaemia in a donkey.

Tarrant JM, Campbell TM, Parry BW.

Aust Vet J. 1998 Jul;76(7):466-9. No abstract available.

PMID:
9700398
24.

MOORFIELDS EYE HOSPITAL IN THE "BLITZ".

Tarrant JM.

Br J Ophthalmol. 1943 Jul;27(7):312-9. No abstract available.

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