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Items: 1 to 50 of 77

1.

Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics.

Warren T, Zumbrun E, Weidner JM, Gomba L, Rossi F, Bannister R, Tarrant J, Reed M, Lee E, Raymond JL, Wells J, Shamblin J, Wetzel K, Donnelly G, Van Tongeren S, Lackemeyer N, Steffens J, Kimmel A, Garvey C, Bloomfield H, Blair C, Singh B, Bavari S, Cihlar T, Porter D.

Viruses. 2020 Jan 13;12(1). pii: E92. doi: 10.3390/v12010092.

2.

Filgotinib, a JAK1 Inhibitor, Modulates Disease-Related Biomarkers in Rheumatoid Arthritis: Results from Two Randomized, Controlled Phase 2b Trials.

Tarrant JM, Galien R, Li W, Goyal L, Pan Y, Hawtin R, Zhang W, Van der Aa A, Taylor PC.

Rheumatol Ther. 2020 Jan 7. doi: 10.1007/s40744-019-00192-5. [Epub ahead of print]

3.
4.

Spontaneous Incidental Brain Lesions in C57BL/6J Mice.

Tarrant JC, Savickas P, Omodho L, Spinazzi M, Radaelli E.

Vet Pathol. 2020 Jan;57(1):172-182. doi: 10.1177/0300985819859878. Epub 2019 Jul 4.

PMID:
31272300
5.

Co-occurrence of Nasal Polyps and Neoplasms of the Canine Nasal Cavity.

Tarrant JC, Holt DE, Durham AC.

Vet Pathol. 2019 Nov;56(6):885-888. doi: 10.1177/0300985819854438. Epub 2019 Jun 6.

PMID:
31170873
6.

From ward to washer: The survival of Clostridium difficile spores on hospital bed sheets through a commercial UK NHS healthcare laundry process.

Tarrant J, Jenkins RO, Laird KT.

Infect Control Hosp Epidemiol. 2018 Dec;39(12):1406-1411. doi: 10.1017/ice.2018.255. Epub 2018 Oct 16.

PMID:
30322417
7.

Virtual Reality for Anxiety Reduction Demonstrated by Quantitative EEG: A Pilot Study.

Tarrant J, Viczko J, Cope H.

Front Psychol. 2018 Jul 24;9:1280. doi: 10.3389/fpsyg.2018.01280. eCollection 2018.

8.

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.

Loomba R, Kayali Z, Noureddin M, Ruane P, Lawitz EJ, Bennett M, Wang L, Harting E, Tarrant JM, McColgan BJ, Chung C, Ray AS, Subramanian GM, Myers RP, Middleton MS, Lai M, Charlton M, Harrison SA.

Gastroenterology. 2018 Nov;155(5):1463-1473.e6. doi: 10.1053/j.gastro.2018.07.027. Epub 2018 Jul 27.

9.

Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer.

Jarzabek MA, Proctor WR, Vogt J, Desai R, Dicker P, Cain G, Raja R, Brodbeck J, Stevens D, van der Stok EP, Martens JWM, Verhoef C, Hegde PS, Byrne AT, Tarrant JM.

PLoS One. 2018 Jun 7;13(6):e0198099. doi: 10.1371/journal.pone.0198099. eCollection 2018.

10.

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.

Lawitz EJ, Coste A, Poordad F, Alkhouri N, Loo N, McColgan BJ, Tarrant JM, Nguyen T, Han L, Chung C, Ray AS, McHutchison JG, Subramanian GM, Myers RP, Middleton MS, Sirlin C, Loomba R, Nyangau E, Fitch M, Li K, Hellerstein M.

Clin Gastroenterol Hepatol. 2018 Dec;16(12):1983-1991.e3. doi: 10.1016/j.cgh.2018.04.042. Epub 2018 Apr 26.

PMID:
29705265
11.

Proof of Concept for an Automated Image Analysis Method to Quantify Rat Bone Marrow Hematopoietic Lineages on H&E Sections.

Kozlowski C, Fullerton A, Cain G, Katavolos P, Bravo J, Tarrant JM.

Toxicol Pathol. 2018 Apr;46(3):336-347. doi: 10.1177/0192623318766458.

PMID:
29683092
12.

Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.

Cepa S, Potter D, Wong L, Schutt L, Tarrant J, Pang J, Zhang X, Andaya R, Salphati L, Ran Y, An L, Morgan R, Maher J.

Toxicol Appl Pharmacol. 2018 Jan 1;338:204-213. doi: 10.1016/j.taap.2017.11.007. Epub 2017 Nov 13.

PMID:
29146462
13.

Viable Mycobacterium avium ssp. paratuberculosis isolated from calf milk replacer.

Grant IR, Foddai ACG, Tarrant JC, Kunkel B, Hartmann FA, McGuirk S, Hansen C, Talaat AM, Collins MT.

J Dairy Sci. 2017 Dec;100(12):9723-9735. doi: 10.3168/jds.2017-13154. Epub 2017 Oct 4.

14.

Biological considerations of plasma-derived and recombinant factor VIII immunogenicity.

Lai J, Hough C, Tarrant J, Lillicrap D.

Blood. 2017 Jun 15;129(24):3147-3154. doi: 10.1182/blood-2016-11-750885. Epub 2017 Apr 21. Review.

PMID:
28432221
15.

Contemporary and Emerging Applications in Clinical Pathology.

Aulbach AD, Jordan H, Tarrant J.

Toxicol Pathol. 2017 Feb;45(2):257-259. doi: 10.1177/0192623316684035. No abstract available.

PMID:
28178897
16.

Balancing Blood Sample Volume with 3Rs: Implementation and Best Practices for Small Molecule Toxicokinetic Assessments in Rats.

Harstad E, Andaya R, Couch J, Ding X, Liang X, Liederer BM, Messick K, Nguyen T, Schweiger M, Tarrant J, Zhong S, Dean B.

ILAR J. 2016 Dec;57(2):157-165. doi: 10.1093/ilar/ilw023. Review.

PMID:
28053069
17.

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson RI, Schutt LK, Tarrant JM, McDowell M, Liu L, Johnson AR, Lewin-Koh SC, Hedehus M, Ross J, Carano RA, Staflin K, Zhong F, Crawford JJ, Zhong S, Reif K, Katewa A, Wong H, Young WB, Dambach DM, Misner DL.

J Pharmacol Exp Ther. 2017 Jan;360(1):226-238. Epub 2016 Nov 7.

PMID:
27821712
18.

Using the Split Squat to Potentiate Bilateral and Unilateral Jump Performance.

Bishop CJ, Tarrant J, Jarvis PT, Turner AN.

J Strength Cond Res. 2017 Aug;31(8):2216-2222. doi: 10.1519/JSC.0000000000001696.

PMID:
27806006
19.

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.

Diaz D, Pai R, Cain G, La N, Dambach D, Schwartz J, Tarrant JM.

Toxicol Pathol. 2017 Feb;45(2):353-361. doi: 10.1177/0192623316664590. Epub 2016 Sep 28.

PMID:
27565173
20.

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.

Pai R, Ma N, Connor AV, Danilenko DM, Tarrant JM, Salvail D, Wong L, Hartley DP, Misner D, Stefanich E, Wu Y, Chen Y, Wang H, Dambach DM.

Toxicol Sci. 2016 Jun;151(2):245-60. doi: 10.1093/toxsci/kfw037. Epub 2016 Feb 25.

PMID:
26917699
21.

Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation.

Couch JA, Zhang G, Beyer JC, de Zafra CL, Gupta P, Kamath AV, Lewin-Koh N, Tarrant J, Allamneni KP, Cain G, Yee S, Ross S, Cook R, Tsai SP, Ruppel J, Ridgway JB, Paluch M, Hass PE, Franklin J, Yan M.

Clin Cancer Res. 2016 Mar 15;22(6):1469-79. doi: 10.1158/1078-0432.CCR-15-1380. Epub 2015 Nov 20.

22.

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.

Tarrant JM, Dhawan P, Singh J, Zabka TS, Clarke E, DosSantos G, Dragovich PS, Sampath D, Lin T, McCray B, La N, Nguyen T, Kauss A, Dambach D, Misner DL, Diaz D, Uppal H.

Toxicol Mech Methods. 2015 Mar;25(3):201-11. doi: 10.3109/15376516.2015.1014080. Epub 2015 Apr 20.

PMID:
25894564
23.

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ.

Sci Transl Med. 2015 Mar 18;7(279):279ra40. doi: 10.1126/scitranslmed.aaa4642.

PMID:
25787766
24.

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.

Fuji RN, Flagella M, Baca M, Baptista MA, Brodbeck J, Chan BK, Fiske BK, Honigberg L, Jubb AM, Katavolos P, Lee DW, Lewin-Koh SC, Lin T, Liu X, Liu S, Lyssikatos JP, O'Mahony J, Reichelt M, Roose-Girma M, Sheng Z, Sherer T, Smith A, Solon M, Sweeney ZK, Tarrant J, Urkowitz A, Warming S, Yaylaoglu M, Zhang S, Zhu H, Estrada AA, Watts RJ.

Sci Transl Med. 2015 Feb 4;7(273):273ra15. doi: 10.1126/scitranslmed.aaa3634.

PMID:
25653221
25.

Rural palliative care transitions from home to hospital: carers' experiences.

Hatcher I, Harms L, Walker B, Stokes S, Lowe A, Foran K, Tarrant J.

Aust J Rural Health. 2014 Aug;22(4):160-4. doi: 10.1111/ajr.12105.

PMID:
25123619
26.

Development of a safety biomarker signature to detect hepatic sinusoidal dilation associated with an anti-DLL4 biotherapeutic.

Tarrant JM, Lewin-Koh SC, Lewin-Koh N.

Biomarkers. 2014 Aug;19(5):391-401. doi: 10.3109/1354750X.2014.919026. Epub 2014 May 19.

PMID:
24842386
27.

Convergence in morphology and masticatory function between the pharyngeal jaws of grass carp, Ctenopharyngodon idella, and oral jaws of amniote herbivores.

Gidmark NJ, Tarrant JC, Brainerd EL.

J Exp Biol. 2014 Jun 1;217(Pt 11):1925-32. doi: 10.1242/jeb.096248. Epub 2014 Feb 27.

28.

iRest yoga-nidra on the college campus: changes in stress, depression, worry, and mindfulness.

Eastman-Mueller H, Wilson T, Jung AK, Kimura A, Tarrant J.

Int J Yoga Therap. 2013;(23):15-24.

PMID:
24165520
29.

Use of optimized aminotransferase methods in regulated preclinical studies.

Tarrant J, Meyer D, Katavolos P.

Vet Clin Pathol. 2013 Dec;42(4):535-8. doi: 10.1111/vcp.12082. Epub 2013 Sep 30. Review.

PMID:
24117473
30.

Spatial assessment of amphibian chytrid fungus (Batrachochytrium dendrobatidis) in South Africa confirms endemic and widespread infection.

Tarrant J, Cilliers D, du Preez LH, Weldon C.

PLoS One. 2013 Jul 22;8(7):e69591. doi: 10.1371/journal.pone.0069591. Print 2013.

31.

Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.

Hornberger KR, Berger DM, Crew AP, Dong H, Kleinberg A, Li AH, Medeiros MR, Mulvihill MJ, Siu K, Tarrant J, Wang J, Weng F, Wilde VL, Albertella M, Bittner M, Cooke A, Gray MJ, Maresca P, May E, Meyn P, Peick W Jr, Romashko D, Tanowitz M, Tokar B.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4517-22. doi: 10.1016/j.bmcl.2013.06.053. Epub 2013 Jun 25.

PMID:
23850198
32.

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, Lin Y, Lin Z, Balazs M, Scearce-Levie K, Ernst JA, Dennis MS, Watts RJ.

Sci Transl Med. 2013 May 1;5(183):183ra57, 1-12. doi: 10.1126/scitranslmed.3005338.

33.

Unexpected hematologic effects of biotherapeutics in nonclinical species and in humans.

Everds NE, Tarrant JM.

Toxicol Pathol. 2013 Feb;41(2):280-302. doi: 10.1177/0192623312467400. Review.

PMID:
23471185
34.

Current practices in preclinical drug development: gaps in hemostasis testing to assess risk of thromboembolic injury.

Schultze AE, Walker DB, Turk JR, Tarrant JM, Brooks MB, Pettit SD.

Toxicol Pathol. 2013;41(3):445-53. doi: 10.1177/0192623312460924. Epub 2012 Sep 18.

PMID:
22991386
35.

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.

Erickson RI, Tarrant J, Cain G, Lewin-Koh SC, Dybdal N, Wong H, Blackwood E, West K, Steigerwalt R, Mamounas M, Flygare JA, Amemiya K, Dambach D, Fairbrother WJ, Diaz D.

Toxicol Sci. 2013 Jan;131(1):247-58. doi: 10.1093/toxsci/kfs265. Epub 2012 Sep 5.

PMID:
22956632
36.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM.

Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5.

PMID:
21976371
37.

Optical and biometric characteristics of anisomyopia in human adults.

Tian Y, Tarrant J, Wildsoet CF.

Ophthalmic Physiol Opt. 2011 Sep;31(5):540-9. doi: 10.1111/j.1475-1313.2011.00858.x. Epub 2011 Jul 29.

38.

Response letter from Clinical Pathology Interest Group of the Society of Toxicologic Pathology (STP) for manuscript entitled International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies by Bolon et al.

Tripathi NK, Schultze AE, Pearson RC, Everds NE, Elliott GS, Ramaiah L, Wells MY, Latimer KS, Walter GL, Katavolos P, Collins ND, Tarrant J, Walker DB, Topper MJ, Jordan HL, O'Rourke LG, Guilpin VB, Brockus CW, Wilcox AL, Clemo FA, Smith GS, Reagan WJ, McCartney JE.

Exp Toxicol Pathol. 2013 Jan;65(1-2):39. doi: 10.1016/j.etp.2011.05.007. Epub 2011 Jun 15. No abstract available.

PMID:
21676604
39.

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.

Gartlan KH, Belz GT, Tarrant JM, Minigo G, Katsara M, Sheng KC, Sofi M, van Spriel AB, Apostolopoulos V, Plebanski M, Robb L, Wright MD.

J Immunol. 2010 Sep 15;185(6):3158-66. doi: 10.4049/jimmunol.0902867. Epub 2010 Aug 13.

40.

Determining the accommodative response from wavefront aberrations.

Tarrant J, Roorda A, Wildsoet CF.

J Vis. 2010 May 1;10(5):4. doi: 10.1167/10.5.4.

41.

Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: considerations for their use.

Tarrant JM.

Toxicol Sci. 2010 Sep;117(1):4-16. doi: 10.1093/toxsci/kfq134. Epub 2010 May 6. Review.

42.

Emergency medicine and political influence.

Hemphill RR, Sklar DP, Christopher T, Kellermann AL, Tarrant JR.

Acad Emerg Med. 2009 Oct;16(10):1019-24. doi: 10.1111/j.1553-2712.2009.00529.x. Epub 2009 Sep 15.

43.

What are we missing: results of a 13-month active follow-up program at a level I trauma center.

Malhotra AK, Martin N, Jacoby M, Tarrant J, Guilford K, Wolfe LG, Aboutanos MB, Duane TM, Ivatury RR.

J Trauma. 2009 Jun;66(6):1696-702; discussion 1702-3. doi: 10.1097/TA.0b013e31819ea529.

PMID:
19509634
44.

Development of an improved method for the determination of polycyclic aromatic hydrocarbons in mainstream tobacco smoke.

Tarrant JE, Mills K, Williard C.

J Chromatogr A. 2009 Mar 20;1216(12):2227-34. doi: 10.1016/j.chroma.2009.01.009. Epub 2009 Jan 15.

PMID:
19181324
45.

Accommodation in emmetropic and myopic young adults wearing bifocal soft contact lenses.

Tarrant J, Severson H, Wildsoet CF.

Ophthalmic Physiol Opt. 2008 Jan;28(1):62-72. doi: 10.1111/j.1475-1313.2007.00529.x.

46.

An audit of lymphopenia in infants under 3 months of age.

Krishna MT, Tarrant JL, Cheadle EA, Noorani S, Hackett S, Huissoon AP.

Arch Dis Child. 2008 Jan;93(1):90-1. Epub 2007 Sep 7. No abstract available.

PMID:
17827195
47.

Visual performance in emmetropia and low myopia after correction of high-order aberrations.

Rossi EA, Weiser P, Tarrant J, Roorda A.

J Vis. 2007 Jun 27;7(8):14.

PMID:
17685821
48.

Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity.

Lloyd T, Dazzan P, Dean K, Park SB, Fearon P, Doody GA, Tarrant J, Morgan KD, Morgan C, Hutchinson G, Leff J, Harrison G, Murray RM, Jones PB.

Psychol Med. 2008 Jan;38(1):71-7. Epub 2007 Jul 30.

PMID:
17662165
49.

Duration of untreated psychosis and neuropsychological function in first episode psychosis.

Lappin JM, Morgan KD, Morgan C, Dazzan P, Reichenberg A, Zanelli JW, Fearon P, Jones PB, Lloyd T, Tarrant J, Farrant A, Leff J, Murray RM.

Schizophr Res. 2007 Sep;95(1-3):103-10. Epub 2007 Jul 20.

PMID:
17644343
50.

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Mastalerz H, Chang M, Chen P, Fink BE, Gavai A, Han WC, Johnson W, Langley D, Lee FY, Leavitt K, Marathe P, Norris D, Oppenheimer S, Sleczka B, Tarrant J, Tokarski JS, Vite GD, Vyas DM, Wong H, Wong TW, Zhang H, Zhang G.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4947-54. Epub 2007 Jun 10.

PMID:
17606372

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