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Items: 1 to 50 of 130

1.

Combining antimalarial drugs and vaccine for malaria elimination campaigns: a randomised safety and immunogenicity trial of RTS,S/AS01 administered with dihydroartemisinin, piperaquine and primaquine in healthy Thai adult volunteers.

von Seidlein L, Hanboonkunupakarn B, Jittamala P, Pongsuwan P, Chotivanich K, Tarning J, Hoglund RM, Winterberg M, Mukaka M, Peerawaranun P, Sirithiranont P, Doran Z, Ockenhouse CF, Ivinson K, Lee C, Birkett AJ, Kaslow DC, Singhasivanon P, Day NPJ, Dondorp AM, White NJ, Pukrittayakamee S.

Hum Vaccin Immunother. 2019 Jul 15. doi: 10.1080/21645515.2019.1643675. [Epub ahead of print]

PMID:
31306084
2.

Sequential open label study of the safety, tolerability and pharmacokinetic interactions between dihydroartemisinin-piperaquine and mefloquine in healthy Thai adults.

Hanboonkunupakarn B, van der Pluijm RW, Hoglund R, Pukrittayakamee S, Winterberg M, Mukaka M, Waithira N, Chotivanich K, Singhasivanon P, White NJ, Dondorp AM, Tarning J, Jittamala P.

Antimicrob Agents Chemother. 2019 Jun 10. pii: AAC.00060-19. doi: 10.1128/AAC.00060-19. [Epub ahead of print]

3.

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria.

Chotsiri P, Denoeud-Ndam L, Baudin E, Guindo O, Diawara H, Attaher O, Smit M, Guerin PJ, Doumbo OK, Wiesner L, Barnes KI, Hoglund RM, Dicko A, Etard JF, Tarning J.

Clin Pharmacol Ther. 2019 Jun 1. doi: 10.1002/cpt.1531. [Epub ahead of print]

PMID:
31152555
4.

Amino acid derangements in adults with severe falciparum malaria.

Leopold SJ, Apinan S, Ghose A, Kingston HW, Plewes KA, Hossain A, Dutta AK, Paul S, Barua A, Sattar A, Day NPJ, Tarning J, Winterberg M, White NJ, Dondorp AM.

Sci Rep. 2019 Apr 29;9(1):6602. doi: 10.1038/s41598-019-43044-6.

5.

Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria.

Chu CS, Phyo AP, Turner C, Win HH, Poe NP, Yotyingaphiram W, Thinraow S, Wilairisak P, Raksapraidee R, Carrara VI, Paw MK, Wiladphaingern J, Proux S, Bancone G, Sriprawat K, Lee SJ, Jeeyapant A, Watson J, Tarning J, Imwong M, Nosten F, White NJ.

Clin Infect Dis. 2019 Apr 8;68(8):1311-1319. doi: 10.1093/cid/ciy735.

6.

High sensitivity methods to quantify chloroquine and its metabolite in human blood samples using LC-MS/MS.

Kaewkhao K, Chotivanich K, Winterberg M, Day NP, Tarning J, Blessborn D.

Bioanalysis. 2019 Mar;11(5):333-347. doi: 10.4155/bio-2018-0202. Epub 2019 Mar 15.

7.

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections.

Meister I, Assawasuwannakit P, Vanobberghen F, Penny MA, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01391-18. doi: 10.1128/AAC.01391-18. Print 2019 Apr.

8.

Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children.

Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J.

Nat Commun. 2019 Jan 29;10(1):480. doi: 10.1038/s41467-019-08297-9.

9.

Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole.

Watson JA, Strub-Wourgraft N, Tarral A, Ribeiro I, Tarning J, White NJ.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02515-18. doi: 10.1128/AAC.02515-18. Print 2019 Apr.

10.

Optimization of dosing regimens of isoniazid and rifampicin in children with tuberculosis in India.

Aruldhas BW, Hoglund RM, Ranjalkar J, Tarning J, Mathew SK, Verghese VP, Bose A, Mathew BS.

Br J Clin Pharmacol. 2019 Mar;85(3):644-654. doi: 10.1111/bcp.13846. Epub 2019 Jan 17.

11.

Identifying the Components of Acidosis in Patients With Severe Plasmodium falciparum Malaria Using Metabolomics.

Leopold SJ, Ghose A, Allman EL, Kingston HWF, Hossain A, Dutta AK, Plewes K, Chotivanich K, Day NPJ, Tarning J, Winterberg M, White NJ, Llinás M, Dondorp AM.

J Infect Dis. 2019 May 5;219(11):1766-1776. doi: 10.1093/infdis/jiy727.

12.

A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting-high coverage and safety, but no significant impact on transmission.

Morris U, Msellem MI, Mkali H, Islam A, Aydin-Schmidt B, Jovel I, Shija SJ, Khamis M, Ali SM, Hodzic L, Magnusson E, Poirot E, Bennett A, Sachs MC, Tarning J, Mårtensson A, Ali AS, Björkman A.

BMC Med. 2018 Dec 10;16(1):215. doi: 10.1186/s12916-018-1202-8.

13.

Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.

Walimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, Amara A, Gini J, Winterberg M, Chiong J, Tarning J, Khoo SH.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01310-18. doi: 10.1128/AAC.01310-18. Print 2019 Feb.

14.

Complex interactions between malaria and malnutrition: a systematic literature review.

Das D, Grais RF, Okiro EA, Stepniewska K, Mansoor R, van der Kam S, Terlouw DJ, Tarning J, Barnes KI, Guerin PJ.

BMC Med. 2018 Oct 29;16(1):186. doi: 10.1186/s12916-018-1177-5.

15.

Quantitation of paracetamol by liquid chromatography-mass spectrometry in human plasma in support of clinical trial.

Kam RK, Chan MH, Wong HT, Ghose A, Dondorp AM, Plewes K, Tarning J.

Future Sci OA. 2018 Aug 15;4(8):FSO331. doi: 10.4155/fsoa-2018-0039. eCollection 2018 Sep.

16.

Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs.

Chairat K, Jittamala P, Hanboonkunupakarn B, Pukrittayakamee S, Hanpithakpong W, Blessborn D, White NJ, Day NPJ, Tarning J.

J Antimicrob Chemother. 2018 Nov 1;73(11):3102-3113. doi: 10.1093/jac/dky297.

17.

Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria.

Lohy Das J, Rulisa S, de Vries PJ, Mens PF, Kaligirwa N, Agaba S, Tarning J, Karlsson MO, Dorlo TPC.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00518-18. doi: 10.1128/AAC.00518-18. Print 2018 Oct.

18.

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing.

Ali AM, Penny MA, Smith TA, Workman L, Sasi P, Adjei GO, Aweeka F, Kiechel JR, Jullien V, Rijken MJ, McGready R, Mwesigwa J, Kristensen K, Stepniewska K, Tarning J, Barnes KI, Denti P; WWARN Amodiaquine PK Study Group.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e02193-17. doi: 10.1128/AAC.02193-17. Print 2018 Oct.

19.

Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group.

Thriemer K, Bobogare A, Ley B, Gudo CS, Alam MS, Anstey NM, Ashley E, Baird JK, Gryseels C, Jambert E, Lacerda M, Laihad F, Marfurt J, Pasaribu AP, Poespoprodjo JR, Sutanto I, Taylor WR, van den Boogaard C, Battle KE, Dysoley L, Ghimire P, Hawley B, Hwang J, Khan WA, Mudin RNB, Sumiwi ME, Ahmed R, Aktaruzzaman MM, Awasthi KR, Bardaji A, Bell D, Boaz L, Burdam FH, Chandramohan D, Cheng Q, Chindawongsa K, Culpepper J, Das S, Deray R, Desai M, Domingo G, Duoquan W, Duparc S, Floranita R, Gerth-Guyette E, Howes RE, Hugo C, Jagoe G, Sariwati E, Jhora ST, Jinwei W, Karunajeewa H, Kenangalem E, Lal BK, Landuwulang C, Le Perru E, Lee SE, Makita LS, McCarthy J, Mekuria A, Mishra N, Naket E, Nambanya S, Nausien J, Duc TN, Thi TN, Noviyanti R, Pfeffer D, Qi G, Rahmalia A, Rogerson S, Samad I, Sattabongkot J, Satyagraha A, Shanks D, Sharma SN, Sibley CH, Sungkar A, Syafruddin D, Talukdar A, Tarning J, Ter Kuile F, Thapa S, Theodora M, Huy TT, Waramin E, Waramori G, Woyessa A, Wongsrichanalai C, Xa NX, Yeom JS, Hermawan L, Devine A, Nowak S, Jaya I, Supargiyono S, Grietens KP, Price RN.

Malar J. 2018 Jun 20;17(1):241. doi: 10.1186/s12936-018-2380-8.

20.

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.

Kloprogge F, Workman L, Borrmann S, Tékété M, Lefèvre G, Hamed K, Piola P, Ursing J, Kofoed PE, Mårtensson A, Ngasala B, Björkman A, Ashton M, Friberg Hietala S, Aweeka F, Parikh S, Mwai L, Davis TME, Karunajeewa H, Salman S, Checchi F, Fogg C, Newton PN, Mayxay M, Deloron P, Faucher JF, Nosten F, Ashley EA, McGready R, van Vugt M, Proux S, Price RN, Karbwang J, Ezzet F, Bakshi R, Stepniewska K, White NJ, Guerin PJ, Barnes KI, Tarning J.

PLoS Med. 2018 Jun 12;15(6):e1002579. doi: 10.1371/journal.pmed.1002579. eCollection 2018 Jun.

21.

Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria.

Chu CS, Phyo AP, Lwin KM, Win HH, San T, Aung AA, Raksapraidee R, Carrara VI, Bancone G, Watson J, Moore KA, Wiladphaingern J, Proux S, Sriprawat K, Winterberg M, Cheah PY, Chue AL, Tarning J, Imwong M, Nosten F, White NJ.

Clin Infect Dis. 2018 Oct 30;67(10):1543-1549. doi: 10.1093/cid/ciy319.

22.

Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Ippolito MM, Jacobson JM, Lederman MM, Winterberg M, Tarning J, Shapiro TA, Flexner C.

Clin Infect Dis. 2018 Oct 30;67(10):1617-1620. doi: 10.1093/cid/ciy405.

PMID:
29771277
23.

Characterizing Blood-Stage Antimalarial Drug MIC Values In Vivo Using Reinfection Patterns.

Watson J, Chu CS, Tarning J, White NJ.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e02476-17. doi: 10.1128/AAC.02476-17. Print 2018 Jul.

24.

Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures.

Gilder ME, Hanpithakphong W, Hoglund RM, Tarning J, Win HH, Hilda N, Chu CS, Bancone G, Carrara VI, Singhasivanon P, White NJ, Nosten F, McGready R.

Clin Infect Dis. 2018 Sep 14;67(7):1000-1007. doi: 10.1093/cid/ciy235.

25.

Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar.

Lohy Das JP, Kyaw MP, Nyunt MH, Chit K, Aye KH, Aye MM, Karlsson MO, Bergstrand M, Tarning J.

Malar J. 2018 Mar 23;17(1):126. doi: 10.1186/s12936-018-2278-5.

26.

Acidosis and acute kidney injury in severe malaria.

Sriboonvorakul N, Ghose A, Hassan MMU, Hossain MA, Faiz MA, Pukrittayakamee S, Chotivanich K, Sukthana Y, Leopold SJ, Plewes K, Day NPJ, White NJ, Tarning J, Dondorp AM.

Malar J. 2018 Mar 23;17(1):128. doi: 10.1186/s12936-018-2274-9.

27.

Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.

Plewes K, Kingston HWF, Ghose A, Wattanakul T, Hassan MMU, Haider MS, Dutta PK, Islam MA, Alam S, Jahangir SM, Zahed ASM, Sattar MA, Chowdhury MAH, Herdman MT, Leopold SJ, Ishioka H, Piera KA, Charunwatthana P, Silamut K, Yeo TW, Lee SJ, Mukaka M, Maude RJ, Turner GDH, Faiz MA, Tarning J, Oates JA, Anstey NM, White NJ, Day NPJ, Hossain MA, Roberts Ii LJ, Dondorp AM.

Clin Infect Dis. 2018 Sep 14;67(7):991-999. doi: 10.1093/cid/ciy213.

28.

Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: a Pooled Analysis To Inform Optimal Dosing in African Children with Uncomplicated Malaria.

de Kock M, Tarning J, Workman L, Allen EN, Tekete MM, Djimde AA, Bell DJ, Ward SA, Barnes KI, Denti P.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01370-17. doi: 10.1128/AAC.01370-17. Print 2018 May.

29.

Promising approach to reducing Malaria transmission by ivermectin: Sporontocidal effect against Plasmodium vivax in the South American vectors Anopheles aquasalis and Anopheles darlingi.

Pinilla YT, C P Lopes S, S Sampaio V, Andrade FS, Melo GC, Orfanó AS, Secundino NFC, Guerra MGVB, Lacerda MVG, Kobylinski KC, Escobedo-Vargas KS, López-Sifuentes VM, Stoops CA, Baldeviano GC, Tarning J, Vasquez GM, Pimenta PFP, Monteiro WM.

PLoS Negl Trop Dis. 2018 Feb 14;12(2):e0006221. doi: 10.1371/journal.pntd.0006221. eCollection 2018 Feb.

30.

Treatment of uncomplicated and severe malaria during pregnancy.

D'Alessandro U, Hill J, Tarning J, Pell C, Webster J, Gutman J, Sevene E.

Lancet Infect Dis. 2018 Apr;18(4):e133-e146. doi: 10.1016/S1473-3099(18)30065-3. Epub 2018 Jan 31. Review.

31.

Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria.

Leitgeb AM, Charunwatthana P, Rueangveerayut R, Uthaisin C, Silamut K, Chotivanich K, Sila P, Moll K, Lee SJ, Lindgren M, Holmer E, Färnert A, Kiwuwa MS, Kristensen J, Herder C, Tarning J, Wahlgren M, Dondorp AM.

PLoS One. 2017 Dec 15;12(12):e0188754. doi: 10.1371/journal.pone.0188754. eCollection 2017.

32.

Response to "Lactation Status and Studies of Pyrimethamine Pharmacokinetics in Pregnancy".

de Kock M, Tarning J, Barnes KI, Denti P.

CPT Pharmacometrics Syst Pharmacol. 2017 Nov;6(11):731. doi: 10.1002/psp4.12256. Epub 2017 Oct 20. No abstract available.

33.

Model-Informed Drug Development for Malaria Therapeutics.

Andrews KA, Wesche D, McCarthy J, Möhrle JJ, Tarning J, Phillips L, Kern S, Grasela T.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:567-582. doi: 10.1146/annurev-pharmtox-010715-103429. Epub 2017 Oct 6. Review.

PMID:
28992431
34.

Population Pharmacokinetic and Pharmacodynamic Modeling of Artemisinin Resistance in Southeast Asia.

Lohy Das J, Dondorp AM, Nosten F, Phyo AP, Hanpithakpong W, Ringwald P, Lim P, White NJ, Karlsson MO, Bergstrand M, Tarning J.

AAPS J. 2017 Nov;19(6):1842-1854. doi: 10.1208/s12248-017-0141-1. Epub 2017 Sep 11.

PMID:
28895080
35.

Quantification of the antimalarial drug pyronaridine in whole blood using LC-MS/MS - Increased sensitivity resulting from reduced non-specific binding.

Blessborn D, Kaewkhao K, Song L, White NJ, Day NPJ, Tarning J.

J Pharm Biomed Anal. 2017 Nov 30;146:214-219. doi: 10.1016/j.jpba.2017.08.023. Epub 2017 Aug 26.

36.

In vitro antioxidant and antimalarial activities of leaves, pods and bark extracts of Acacia nilotica (L.) Del.

Sadiq MB, Tharaphan P, Chotivanich K, Tarning J, Anal AK.

BMC Complement Altern Med. 2017 Jul 18;17(1):372. doi: 10.1186/s12906-017-1878-x.

37.

Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers.

Chotsiri P, Wattanakul T, Hoglund RM, Hanboonkunupakarn B, Pukrittayakamee S, Blessborn D, Jittamala P, White NJ, Day NPJ, Tarning J.

Br J Clin Pharmacol. 2017 Dec;83(12):2752-2766. doi: 10.1111/bcp.13372. Epub 2017 Aug 16.

38.

Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles.

Kobylinski KC, Ubalee R, Ponlawat A, Nitatsukprasert C, Phasomkulsolsil S, Wattanakul T, Tarning J, Na-Bangchang K, McCardle PW, Davidson SA, Richardson JH.

Malar J. 2017 Jul 7;16(1):280. doi: 10.1186/s12936-017-1923-8.

39.

Pharmacokinetics of Sulfadoxine and Pyrimethamine for Intermittent Preventive Treatment of Malaria During Pregnancy and After Delivery.

de Kock M, Tarning J, Workman L, Nyunt MM, Adam I, Barnes KI, Denti P.

CPT Pharmacometrics Syst Pharmacol. 2017 Jul;6(7):430-438. doi: 10.1002/psp4.12181. Epub 2017 Jun 9.

40.

Treatment Failure of Dihydroartemisinin/Piperaquine for Plasmodium falciparum Malaria, Vietnam.

Phuc BQ, Rasmussen C, Duong TT, Dong LT, Loi MA, Ménard D, Tarning J, Bustos D, Ringwald P, Galappaththy GL, Thieu NQ.

Emerg Infect Dis. 2017 Apr;23(4):715-717. doi: 10.3201/eid2304.161872.

41.

Prediction of Improved Antimalarial Chemoprevention with Weekly Dosing of Dihydroartemisinin-Piperaquine.

Permala J, Tarning J, Nosten F, White NJ, Karlsson MO, Bergstrand M.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02491-16. doi: 10.1128/AAC.02491-16. Print 2017 May.

42.

Antibacterial Activities and Possible Modes of Action of Acacia nilotica (L.) Del. against Multidrug-Resistant Escherichia coli and Salmonella.

Sadiq MB, Tarning J, Aye Cho TZ, Anal AK.

Molecules. 2017 Jan 14;22(1). pii: E47. doi: 10.3390/molecules22010047.

43.

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.

Hoglund RM, Workman L, Edstein MD, Thanh NX, Quang NN, Zongo I, Ouedraogo JB, Borrmann S, Mwai L, Nsanzabana C, Price RN, Dahal P, Sambol NC, Parikh S, Nosten F, Ashley EA, Phyo AP, Lwin KM, McGready R, Day NP, Guerin PJ, White NJ, Barnes KI, Tarning J.

PLoS Med. 2017 Jan 10;14(1):e1002212. doi: 10.1371/journal.pmed.1002212. eCollection 2017 Jan.

44.

Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria.

Hien TT, White NJ, Thuy-Nhien NT, Hoa NT, Thuan PD, Tarning J, Nosten F, Magnusson B, Jain JP, Hamed K.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01940-16. doi: 10.1128/AAC.01940-16. Print 2017 Feb.

45.

Clinical presentations, diagnosis, mortality and prognostic markers of tuberculous meningitis in Vietnamese children: a prospective descriptive study.

Bang ND, Caws M, Truc TT, Duong TN, Dung NH, Ha DT, Thwaites GE, Heemskerk D, Tarning J, Merson L, Van Toi P, Farrar JJ, Wolbers M, Pouplin T, Day JN.

BMC Infect Dis. 2016 Oct 18;16(1):573.

46.

Population Pharmacokinetic Modeling of Tribendimidine Metabolites in Opisthorchis viverrini-Infected Adults.

Vanobberghen F, Penny MA, Duthaler U, Odermatt P, Sayasone S, Keiser J, Tarning J.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5695-704. doi: 10.1128/AAC.00655-16. Print 2016 Oct.

47.

Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria.

Wattanakul T, Teerapong P, Plewes K, Newton PN, Chierakul W, Silamut K, Chotivanich K, Ruengweerayut R, White NJ, Dondorp AM, Tarning J.

Malar J. 2016 Apr 27;15:244. doi: 10.1186/s12936-016-1283-9.

48.

Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis.

Pouplin T, Bang ND, Toi PV, Phuong PN, Dung NH, Duong TN, Caws M, Thwaites GE, Tarning J, Day JN.

BMC Infect Dis. 2016 Apr 2;16:144. doi: 10.1186/s12879-016-1470-x.

49.

Treatment of Malaria in Pregnancy.

Tarning J.

N Engl J Med. 2016 Mar 10;374(10):981-2. doi: 10.1056/NEJMe1601193. No abstract available.

50.

Clinical trials of artesunate plus sulfadoxine-pyrimethamine for Plasmodium falciparum malaria in Afghanistan: maintained efficacy a decade after introduction.

Awab GR, Imwong M, Pukrittayakamee S, Alim F, Hanpithakpong W, Tarning J, Dondorp AM, Day NP, White NJ, Woodrow CJ.

Malar J. 2016 Feb 25;15:121. doi: 10.1186/s12936-016-1167-z.

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