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Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection.

Sakakibara S, Yasui T, Jinzai H, O'Donnell K, Tsai CY, Minamitani T, Takeda K, Belz GT, Tarlinton DM, Kikutani H.

Int Immunol. 2019 Aug 27. pii: dxz057. doi: 10.1093/intimm/dxz057. [Epub ahead of print]


BAFF, IL-4 and IL-21 separably program germinal center-like phenotype acquisition, BCL6 expression, proliferation and survival of CD40L-activated B cells in vitro.

Robinson MJ, Pitt C, Brodie EJ, Valk AM, O'Donnell K, Nitschke L, Jones S, Tarlinton DM.

Immunol Cell Biol. 2019 Oct;97(9):826-839. doi: 10.1111/imcb.12283. Epub 2019 Jul 29.


Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.

Liu R, King A, Bouillet P, Tarlinton DM, Strasser A, Heierhorst J.

Front Immunol. 2018 Mar 22;9:592. doi: 10.3389/fimmu.2018.00592. eCollection 2018.


Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.

Zhang Y, Tech L, George LA, Acs A, Durrett RE, Hess H, Walker LSK, Tarlinton DM, Fletcher AL, Hauser AE, Toellner KM.

J Exp Med. 2018 Apr 2;215(4):1227-1243. doi: 10.1084/jem.20160832. Epub 2018 Mar 16.


Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.

Brodie EJ, Infantino S, Low MSY, Tarlinton DM.

Front Immunol. 2018 Mar 1;9:401. doi: 10.3389/fimmu.2018.00401. eCollection 2018. Review.


Atypical chemokine receptor 4 shapes activated B cell fate.

Kara EE, Bastow CR, McKenzie DR, Gregor CE, Fenix KA, Babb R, Norton TS, Zotos D, Rodda LB, Hermes JR, Bourne K, Gilchrist DS, Nibbs RJ, Alsharifi M, Vinuesa CG, Tarlinton DM, Brink R, Hill GR, Cyster JG, Comerford I, McColl SR.

J Exp Med. 2018 Mar 5;215(3):801-813. doi: 10.1084/jem.20171067. Epub 2018 Jan 31.


Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB.

Willis SN, Tellier J, Liao Y, Trezise S, Light A, O'Donnell K, Garrett-Sinha LA, Shi W, Tarlinton DM, Nutt SL.

Nat Commun. 2017 Nov 10;8(1):1426. doi: 10.1038/s41467-017-01605-1.


Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms.

King A, Li L, Wong DM, Liu R, Bamford R, Strasser A, Tarlinton DM, Heierhorst J.

PLoS Genet. 2017 Sep 18;13(9):e1007010. doi: 10.1371/journal.pgen.1007010. eCollection 2017 Sep.


IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation.

Chevrier S, Kratina T, Emslie D, Tarlinton DM, Corcoran LM.

Immunol Cell Biol. 2017 Nov;95(10):925-932. doi: 10.1038/icb.2017.71. Epub 2017 Oct 3.


The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

Carrington EM, Tarlinton DM, Gray DH, Huntington ND, Zhan Y, Lew AM.

Immunol Cell Biol. 2017 Nov;95(10):870-877. doi: 10.1038/icb.2017.72. Epub 2017 Sep 6. Review.


The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.

Dolezal E, Infantino S, Drepper F, Börsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M.

Nat Immunol. 2017 Aug;18(8):911-920. doi: 10.1038/ni.3774. Epub 2017 Jun 19.


c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses.

Piovesan D, Tempany J, Di Pietro A, Baas I, Yiannis C, O'Donnell K, Chen Y, Peperzak V, Belz GT, Mackay CR, Smyth GK, Groom JR, Tarlinton DM, Good-Jacobson KL.

Cell Rep. 2017 Apr 18;19(3):461-470. doi: 10.1016/j.celrep.2017.03.060.


Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM.

Cell Death Differ. 2017 May;24(5):878-888. doi: 10.1038/cdd.2017.30. Epub 2017 Mar 31.


MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM.

Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237.


Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

Chow KV, Delconte RB, Huntington ND, Tarlinton DM, Sutherland RM, Zhan Y, Lew AM.

J Immunol. 2016 Sep 1;197(5):2000-8. doi: 10.4049/jimmunol.1600181. Epub 2016 Jul 29.


Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.

Gloury R, Zotos D, Zuidscherwoude M, Masson F, Liao Y, Hasbold J, Corcoran LM, Hodgkin PD, Belz GT, Shi W, Nutt SL, Tarlinton DM, Kallies A.

J Exp Med. 2016 May 30;213(6):1095-111. doi: 10.1084/jem.20152003. Epub 2016 May 23.


The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.

Wong DM, Li L, Jurado S, King A, Bamford R, Wall M, Walia MK, Kelly GL, Walkley CR, Tarlinton DM, Strasser A, Heierhorst J.

Cell Rep. 2016 Feb 16;14(6):1488-1499. doi: 10.1016/j.celrep.2016.01.012. Epub 2016 Jan 28.


Regulation of germinal center responses, memory B cells and plasma cell formation-an update.

Corcoran LM, Tarlinton DM.

Curr Opin Immunol. 2016 Apr;39:59-67. doi: 10.1016/j.coi.2015.12.008. Epub 2016 Jan 20. Review.


Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus.

Jones SA, Toh AE, Odobasic D, Oudin MA, Cheng Q, Lee JP, White SJ, Russ BE, Infantino S, Light A, Tarlinton DM, Harris J, Morand EF.

Ann Rheum Dis. 2016 Apr;75(4):739-47. doi: 10.1136/annrheumdis-2015-207744. Epub 2015 Nov 26.


Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall.

Kato Y, Zaid A, Davey GM, Mueller SN, Nutt SL, Zotos D, Tarlinton DM, Shortman K, Lahoud MH, Heath WR, Caminschi I.

J Immunol. 2015 Aug 1;195(3):1006-14. doi: 10.4049/jimmunol.1500767. Epub 2015 Jun 22.


How many memories does it take to make an SLE flare?

Tarlinton DM, Smith KG.

Nat Immunol. 2015 Jul;16(7):685-7. doi: 10.1038/ni.3209. No abstract available.


c-Myb is required for plasma cell migration to bone marrow after immunization or infection.

Good-Jacobson KL, O'Donnell K, Belz GT, Nutt SL, Tarlinton DM.

J Exp Med. 2015 Jun 29;212(7):1001-9. doi: 10.1084/jem.20150191. Epub 2015 Jun 15.


Manipulation of B-cell responses with histone deacetylase inhibitors.

Waibel M, Christiansen AJ, Hibbs ML, Shortt J, Jones SA, Simpson I, Light A, O'Donnell K, Morand EF, Tarlinton DM, Johnstone RW, Hawkins ED.

Nat Commun. 2015 Apr 27;6:6838. doi: 10.1038/ncomms7838.


Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.

Shi W, Liao Y, Willis SN, Taubenheim N, Inouye M, Tarlinton DM, Smyth GK, Hodgkin PD, Nutt SL, Corcoran LM.

Nat Immunol. 2015 Jun;16(6):663-73. doi: 10.1038/ni.3154. Epub 2015 Apr 20.


Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells.

Carrington EM, Zhang JG, Sutherland RM, Vikstrom IB, Brady JL, Soo P, Vremec D, Allison C, Lee EF, Fairlie WD, Bouillet P, Grabow S, Ottina E, Herold MJ, Pellegrini M, Huang DC, Tarlinton DM, Strasser A, Lew AM, Zhan Y.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4044-9. doi: 10.1073/pnas.1417620112. Epub 2015 Mar 16.


The generation of antibody-secreting plasma cells.

Nutt SL, Hodgkin PD, Tarlinton DM, Corcoran LM.

Nat Rev Immunol. 2015 Mar;15(3):160-71. doi: 10.1038/nri3795. Epub 2015 Feb 20. Review.


The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.

Carotta S, Willis SN, Hasbold J, Inouye M, Pang SH, Emslie D, Light A, Chopin M, Shi W, Wang H, Morse HC 3rd, Tarlinton DM, Corcoran LM, Hodgkin PD, Nutt SL.

J Exp Med. 2014 Oct 20;211(11):2169-81. doi: 10.1084/jem.20140425. Epub 2014 Oct 6.


IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, Tarlinton DM, Tybulewicz VL, Ley SC.

J Exp Med. 2014 Sep 22;211(10):2085-101. doi: 10.1084/jem.20132019. Epub 2014 Sep 15.


The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.

Infantino S, Jones SA, Walker JA, Maxwell MJ, Light A, O'Donnell K, Tsantikos E, Peperzak V, Phesse T, Ernst M, Mackay F, Hibbs ML, Fairfax KA, Tarlinton DM.

Sci Signal. 2014 Aug 12;7(338):ra77. doi: 10.1126/scisignal.2005105.


CD19 differentially regulates BCR signalling through the recruitment of PI3K.

Xu Y, Fairfax K, Light A, Huntington ND, Tarlinton DM.

Autoimmunity. 2014 Nov;47(7):430-7. doi: 10.3109/08916934.2014.921810. Epub 2014 Jun 23.


Immunology: To affinity and beyond.

Tarlinton DM.

Nature. 2014 May 29;509(7502):573-4. doi: 10.1038/509573a. No abstract available.


Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism.

Willis SN, Good-Jacobson KL, Curtis J, Light A, Tellier J, Shi W, Smyth GK, Tarlinton DM, Belz GT, Corcoran LM, Kallies A, Nutt SL.

J Immunol. 2014 Apr 1;192(7):3200-6. doi: 10.4049/jimmunol.1303216. Epub 2014 Mar 3.


Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.

Afshar-Sterle S, Zotos D, Bernard NJ, Scherger AK, Rödling L, Alsop AE, Walker J, Masson F, Belz GT, Corcoran LM, O'Reilly LA, Strasser A, Smyth MJ, Johnstone R, Tarlinton DM, Nutt SL, Kallies A.

Nat Med. 2014 Mar;20(3):283-90. doi: 10.1038/nm.3442. Epub 2014 Feb 2.


Evolution of B cell responses to Clec9A-targeted antigen.

Park HY, Light A, Lahoud MH, Caminschi I, Tarlinton DM, Shortman K.

J Immunol. 2013 Nov 15;191(10):4919-25. doi: 10.4049/jimmunol.1301947. Epub 2013 Oct 11.


Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.

Tsantikos E, Maxwell MJ, Putoczki T, Ernst M, Rose-John S, Tarlinton DM, Hibbs ML.

Arthritis Rheum. 2013 Oct;65(10):2691-702. doi: 10.1002/art.38061.


Feeling a little SYK after mixing BAFF with BCR.

Infantino S, Tarlinton DM.

Immunity. 2013 Mar 21;38(3):406-8. doi: 10.1016/j.immuni.2013.03.001.


Mcl-1 is essential for the survival of plasma cells.

Peperzak V, Vikström I, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM.

Nat Immunol. 2013 Mar;14(3):290-7. doi: 10.1038/ni.2527. Epub 2013 Feb 3. Erratum in: Nat Immunol. 2013 Aug;14(8):877.


The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.

van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Reinieren-Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD.

Sci Signal. 2012 Nov 13;5(250):ra82. doi: 10.1126/scisignal.2003113.


B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.

Karnowski A, Chevrier S, Belz GT, Mount A, Emslie D, D'Costa K, Tarlinton DM, Kallies A, Corcoran LM.

J Exp Med. 2012 Oct 22;209(11):2049-64. doi: 10.1084/jem.20111504. Epub 2012 Oct 8.


High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency.

Taubenheim N, Tarlinton DM, Crawford S, Corcoran LM, Hodgkin PD, Nutt SL.

J Immunol. 2012 Oct 1;189(7):3328-38. Epub 2012 Aug 27.


The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

Jurado S, Gleeson K, O'Donnell K, Izon DJ, Walkley CR, Strasser A, Tarlinton DM, Heierhorst J.

J Exp Med. 2012 Aug 27;209(9):1629-39. doi: 10.1084/jem.20120785. Epub 2012 Aug 13.


Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background.

Lau M, Tsantikos E, Maxwell MJ, Tarlinton DM, Anderson GP, Hibbs ML.

J Autoimmun. 2012 Dec;39(4):388-97. doi: 10.1016/j.jaut.2012.06.003. Epub 2012 Aug 4.


Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development.

Tsantikos E, Maxwell MJ, Kountouri N, Harder KW, Tarlinton DM, Hibbs ML.

J Immunol. 2012 Aug 15;189(4):1726-36. doi: 10.4049/jimmunol.1103427. Epub 2012 Jul 13.


Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase.

Xu Y, Huntington ND, Harder KW, Nandurkar H, Hibbs ML, Tarlinton DM.

Immunol Cell Biol. 2012 Oct;90(9):903-11. doi: 10.1038/icb.2012.31. Epub 2012 Jul 10.


Determining germinal centre B cell fate.

Zotos D, Tarlinton DM.

Trends Immunol. 2012 Jun;33(6):281-8. doi: 10.1016/ Epub 2012 May 16. Review.


Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.

Maxwell MJ, Tsantikos E, Kong AM, Vanhaesebroeck B, Tarlinton DM, Hibbs ML.

J Autoimmun. 2012 Jun;38(4):381-91. doi: 10.1016/j.jaut.2012.04.001. Epub 2012 Apr 25.


Through a glass less darkly: apoptosis and the germinal center response to antigen.

Peperzak V, Vikstrom IB, Tarlinton DM.

Immunol Rev. 2012 May;247(1):93-106. doi: 10.1111/j.1600-065X.2012.01123.x. Review.


Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells.

Krebs DL, Chehal MK, Sio A, Huntington ND, Da ML, Ziltener P, Inglese M, Kountouri N, Priatel JJ, Jones J, Tarlinton DM, Anderson GP, Hibbs ML, Harder KW.

J Immunol. 2012 May 15;188(10):5094-105. doi: 10.4049/jimmunol.1103395. Epub 2012 Apr 9.


The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.

Lüthje K, Kallies A, Shimohakamada Y, Belz GT, Light A, Tarlinton DM, Nutt SL.

Nat Immunol. 2012 May;13(5):491-8. doi: 10.1038/ni.2261.


Multiple routes to B-cell memory.

Good-Jacobson KL, Tarlinton DM.

Int Immunol. 2012 Jul;24(7):403-8. doi: 10.1093/intimm/dxs050. Epub 2012 Mar 26. Review.


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