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Items: 32

1.

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Haythorne E, Rohm M, van de Bunt M, Brereton MF, Tarasov AI, Blacker TS, Sachse G, Silva Dos Santos M, Terron Exposito R, Davis S, Baba O, Fischer R, Duchen MR, Rorsman P, MacRae JI, Ashcroft FM.

Nat Commun. 2019 Jun 6;10(1):2474. doi: 10.1038/s41467-019-10189-x.

2.

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Hastoy B, Godazgar M, Clark A, Nylander V, Spiliotis I, van de Bunt M, Chibalina MV, Barrett A, Burrows C, Tarasov AI, Scharfmann R, Gloyn AL, Rorsman P.

Sci Rep. 2018 Nov 19;8(1):16994. doi: 10.1038/s41598-018-34743-7.

3.

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Knudsen JG, Hamilton A, Ramracheya R, Tarasov AI, Brereton M, Haythorne E, Chibalina MV, Spégel P, Mulder H, Zhang Q, Ashcroft FM, Adam J, Rorsman P.

Cell Metab. 2019 Feb 5;29(2):430-442.e4. doi: 10.1016/j.cmet.2018.10.003. Epub 2018 Nov 8.

4.

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis.

Tarasov AI, Galvanovskis J, Rorsman O, Hamilton A, Vergari E, Johnson PRV, Reimann F, Ashcroft FM, Rorsman P.

Lab Chip. 2018 Sep 11;18(18):2838-2848. doi: 10.1039/c8lc00417j.

5.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI.

Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21.

6.

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.

Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV.

Cell Rep. 2018 Jan 23;22(4):1054-1066. doi: 10.1016/j.celrep.2017.12.089. Epub 2018 Jan 28.

7.

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, Kato K, Igarashi K, Kessler BM, Pugh CW, Tamarit-Rodriguez J, Mulder H, Clark A, Frizzell N, Soga T, Ashcroft FM, Silver A, Pollard PJ, Rorsman P.

Cell Rep. 2017 Sep 26;20(13):3135-3148. doi: 10.1016/j.celrep.2017.08.093.

8.

Angular Approach Scanning Ion Conductance Microscopy.

Shevchuk A, Tokar S, Gopal S, Sanchez-Alonso JL, Tarasov AI, Vélez-Ortega AC, Chiappini C, Rorsman P, Stevens MM, Gorelik J, Frolenkov GI, Klenerman D, Korchev YE.

Biophys J. 2016 May 24;110(10):2252-65. doi: 10.1016/j.bpj.2016.04.017.

9.

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion.

Collins SC, Do HW, Hastoy B, Hugill A, Adam J, Chibalina MV, Galvanovskis J, Godazgar M, Lee S, Goldsworthy M, Salehi A, Tarasov AI, Rosengren AH, Cox R, Rorsman P.

Diabetes. 2016 Jul;65(7):1952-61. doi: 10.2337/db15-1489. Epub 2016 Mar 18.

10.

Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1.

Tarasov AI, Rorsman P.

Cell Metab. 2016 Jan 12;23(1):8-10. doi: 10.1016/j.cmet.2015.12.011.

11.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

12.

Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells.

Tarasov AI, Rutter GA.

Methods Enzymol. 2014;542:289-311. doi: 10.1016/B978-0-12-416618-9.00015-7.

PMID:
24862272
13.

Incretin-modulated beta cell energetics in intact islets of Langerhans.

Hodson DJ, Tarasov AI, Gimeno Brias S, Mitchell RK, Johnston NR, Haghollahi S, Cane MC, Bugliani M, Marchetti P, Bosco D, Johnson PR, Hughes SJ, Rutter GA.

Mol Endocrinol. 2014 Jun;28(6):860-71. doi: 10.1210/me.2014-1038. Epub 2014 Apr 25.

14.

Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells.

Tarasov AI, Semplici F, Li D, Rizzuto R, Ravier MA, Gilon P, Rutter GA.

Pflugers Arch. 2013 Apr;465(4):543-54. doi: 10.1007/s00424-012-1177-9. Epub 2012 Nov 14.

15.

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

Tarasov AI, Semplici F, Ravier MA, Bellomo EA, Pullen TJ, Gilon P, Sekler I, Rizzuto R, Rutter GA.

PLoS One. 2012;7(7):e39722. doi: 10.1371/journal.pone.0039722. Epub 2012 Jul 19.

16.

Regulation of ATP production by mitochondrial Ca(2+).

Tarasov AI, Griffiths EJ, Rutter GA.

Cell Calcium. 2012 Jul;52(1):28-35. doi: 10.1016/j.ceca.2012.03.003. Epub 2012 Apr 12. Review.

17.

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).

Li D, Chen S, Bellomo EA, Tarasov AI, Kaut C, Rutter GA, Li WH.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21063-8. doi: 10.1073/pnas.1109773109. Epub 2011 Dec 12.

18.

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.

Sun G, Tarasov AI, McGinty JA, French PM, McDonald A, Leclerc I, Rutter GA.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1261-73. doi: 10.1152/ajpendo.00100.2010. Epub 2010 Mar 30.

19.

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.

Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, Rutter GA.

Diabetologia. 2010 May;53(5):924-36. doi: 10.1007/s00125-010-1692-1. Epub 2010 Mar 11.

20.

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.

Meur G, Simon A, Harun N, Virally M, Dechaume A, Bonnefond A, Fetita S, Tarasov AI, Guillausseau PJ, Boesgaard TW, Pedersen O, Hansen T, Polak M, Gautier JF, Froguel P, Rutter GA, Vaxillaire M.

Diabetes. 2010 Mar;59(3):653-61. doi: 10.2337/db09-1091. Epub 2009 Dec 10.

21.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19.

22.

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.

da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.

Diabetes. 2009 Apr;58(4):894-905. doi: 10.2337/db08-1187. Epub 2009 Jan 23.

23.

Recording the activity of ATP-sensitive K(+) channels in open-cell cell-attached configuration.

Tarasov AI.

Methods Mol Biol. 2008;491:151-64. doi: 10.1007/978-1-59745-526-8_12.

PMID:
18998091
24.

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA.

Diabetes. 2008 Jun;57(6):1595-604. doi: 10.2337/db07-1547. Epub 2008 Mar 17.

25.

Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11.

Mlynarski W, Tarasov AI, Gach A, Girard CA, Pietrzak I, Zubcevic L, Kusmierek J, Klupa T, Malecki MT, Ashcroft FM.

Nat Clin Pract Neurol. 2007 Nov;3(11):640-5.

PMID:
17982434
26.

Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes.

Tarasov AI, Girard CA, Larkin B, Tammaro P, Flanagan SE, Ellard S, Ashcroft FM.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:46-55.

PMID:
17919178
27.

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

Haider S, Tarasov AI, Craig TJ, Sansom MS, Ashcroft FM.

EMBO J. 2007 Aug 22;26(16):3749-59. Epub 2007 Aug 2.

28.

A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.

Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM.

Diabetes. 2006 Nov;55(11):3075-82.

29.

Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels.

Heusser K, Yuan H, Neagoe I, Tarasov AI, Ashcroft FM, Schwappach B.

J Cell Sci. 2006 Oct 15;119(Pt 20):4353-63.

30.

ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.

Tarasov AI, Girard CA, Ashcroft FM.

Diabetes. 2006 Sep;55(9):2446-54.

31.

The osmotic characteristics of human fetal liver-derived hematopoietic stem cell candidates.

Tarasov AI, Petrenko AY, Jones DR.

Cryobiology. 2004 Jun;48(3):333-40.

PMID:
15157781
32.

[Incidence and course of tuberculosis of the respiratory organs in persons with different blood groups].

Sozykin VL, Tarasov AI, Efashkina TA.

Probl Tuberk. 1980 Mar;(3):30-3. Russian. No abstract available.

PMID:
7393889

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