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Items: 1 to 50 of 162

1.

Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).

D'Alessandro S, Alfano G, Di Cerbo L, Brogi S, Chemi G, Relitti N, Brindisi M, Lamponi S, Novellino E, Campiani G, Gemma S, Basilico N, Taramelli D, Baratto MC, Pogni R, Butini S.

Bioorg Chem. 2019 May 31;89:103020. doi: 10.1016/j.bioorg.2019.103020. [Epub ahead of print]

PMID:
31185392
2.

Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro.

Cullia G, Bruno S, Parapini S, Margiotta M, Tamborini L, Pinto A, Galbiati A, Mozzarelli A, Persico M, Paladino A, Fattorusso C, Taramelli D, Conti P.

ACS Med Chem Lett. 2019 Feb 20;10(4):590-595. doi: 10.1021/acsmedchemlett.8b00592. eCollection 2019 Apr 11.

PMID:
30996801
3.

Malaria pigment accelerates MTT - formazan exocytosis in human endothelial cells.

D'Alessandro S, Corbett Y, Parapini S, Perego F, Cavicchini L, Signorini L, Delbue S, Perego C, Ferrante P, Taramelli D, Basilico N.

Parasitology. 2019 Mar;146(3):399-406. doi: 10.1017/S0031182018001579. Epub 2018 Oct 1.

PMID:
30269694
4.

Corrigendum to 'In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori' [International Journal of Antimicrobial Agents 48/1 (2016) 101-105].

Sisto F, Scaltrito MM, Masia C, Bonomi A, Coccè V, Marano G, Haynes RK, Miani A, Farronato G, Taramelli D.

Int J Antimicrob Agents. 2018 Oct;52(4):528. doi: 10.1016/j.ijantimicag.2018.08.006. Epub 2018 Aug 30. No abstract available.

PMID:
30172701
5.

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Wu Y, Parapini S, Williams ID, Misiano P, Wong HN, Taramelli D, Basilico N, Haynes RK.

Molecules. 2018 Jul 13;23(7). pii: E1713. doi: 10.3390/molecules23071713.

6.

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.

Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug.

7.

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.

Vallone A, D'Alessandro S, Brogi S, Brindisi M, Chemi G, Alfano G, Lamponi S, Lee SG, Jez JM, Koolen KJM, Dechering KJ, Saponara S, Fusi F, Gorelli B, Taramelli D, Parapini S, Caldelari R, Campiani G, Gemma S, Butini S.

Eur J Med Chem. 2018 Apr 25;150:698-718. doi: 10.1016/j.ejmech.2018.03.024. Epub 2018 Mar 10.

8.

HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes.

Colombo I, Sangiovanni E, Maggio R, Mattozzi C, Zava S, Corbett Y, Fumagalli M, Carlino C, Corsetto PA, Scaccabarozzi D, Calvieri S, Gismondi A, Taramelli D, Dell'Agli M.

Mediators Inflamm. 2017;2017:7435621. doi: 10.1155/2017/7435621. Epub 2017 Dec 17.

9.

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65.

Scaccabarozzi D, Deroost K, Corbett Y, Lays N, Corsetto P, Salè FO, Van den Steen PE, Taramelli D.

Malar J. 2018 Jan 9;17(1):18. doi: 10.1186/s12936-017-2159-3.

10.

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.

Basilico N, Parapini S, Sparatore A, Romeo S, Misiano P, Vivas L, Yardley V, Croft SL, Habluetzel A, Lucantoni L, Renia L, Russell B, Suwanarusk R, Nosten F, Dondio G, Bigogno C, Jabes D, Taramelli D.

Molecules. 2017 Dec 1;22(12). pii: E2102. doi: 10.3390/molecules22122102.

11.

Malaria pigment stimulates chemokine production by human microvascular endothelium.

Basilico N, Corbett Y, D' Alessandro S, Parapini S, Prato M, Girelli D, Misiano P, Olliaro P, Taramelli D.

Acta Trop. 2017 Aug;172:125-131. doi: 10.1016/j.actatropica.2017.05.002. Epub 2017 May 2.

PMID:
28476599
12.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

13.

In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori.

Sisto F, Scaltrito MM, Masia C, Bonomi A, Coccè V, Marano G, Haynes RK, Miani A, Farronato G, Taramelli D.

Int J Antimicrob Agents. 2016 Jul;48(1):101-105. doi: 10.1016/j.ijantimicag.2016.03.018. Epub 2016 May 6. Erratum in: Int J Antimicrob Agents. 2018 Oct;52(4):528.

PMID:
27216383
14.

A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.

D'Alessandro S, Camarda G, Corbett Y, Siciliano G, Parapini S, Cevenini L, Michelini E, Roda A, Leroy D, Taramelli D, Alano P.

J Antimicrob Chemother. 2016 May;71(5):1148-58. doi: 10.1093/jac/dkv493. Epub 2016 Feb 16.

PMID:
26888912
15.

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Terzić N, Konstantinović J, Tot M, Burojević J, Djurković-Djaković O, Srbljanović J, Štajner T, Verbić T, Zlatović M, Machado M, Albuquerque IS, Prudêncio M, Sciotti RJ, Pecic S, D'Alessandro S, Taramelli D, Šolaja BA.

J Med Chem. 2016 Jan 14;59(1):264-81. doi: 10.1021/acs.jmedchem.5b01374. Epub 2015 Dec 18.

PMID:
26640981
16.

Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome.

Scaccabarozzi D, Deroost K, Lays N, Omodeo Salè F, Van den Steen PE, Taramelli D.

PLoS One. 2015 Dec 1;10(12):e0143195. doi: 10.1371/journal.pone.0143195. eCollection 2015.

17.

D-Glucose-Derived 1,2,4-Trioxepanes: Synthesis, Conformational Study, and Antimalarial Activity.

Sonawane DP, Corbett Y, Dhavale DD, Taramelli D, Trombini C, Quintavalla A, Lombardo M.

Org Lett. 2015 Aug 21;17(16):4074-7. doi: 10.1021/acs.orglett.5b01996. Epub 2015 Aug 3.

PMID:
26237035
18.

Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.

Tasso B, Novelli F, Tonelli M, Barteselli A, Basilico N, Parapini S, Taramelli D, Sparatore A, Sparatore F.

ChemMedChem. 2015 Sep;10(9):1570-83. doi: 10.1002/cmdc.201500195. Epub 2015 Jul 24.

PMID:
26213237
19.

Modified quaternary ammonium salts as potential antimalarial agents.

Basilico N, Migotto M, Ilboudo DP, Taramelli D, Stradi R, Pini E.

Bioorg Med Chem. 2015 Aug 1;23(15):4681-7. doi: 10.1016/j.bmc.2015.05.055. Epub 2015 Jun 3.

PMID:
26081764
20.

Salinomycin and other ionophores as a new class of antimalarial drugs with transmission-blocking activity.

D'Alessandro S, Corbett Y, Ilboudo DP, Misiano P, Dahiya N, Abay SM, Habluetzel A, Grande R, Gismondo MR, Dechering KJ, Koolen KM, Sauerwein RW, Taramelli D, Basilico N, Parapini S.

Antimicrob Agents Chemother. 2015 Sep;59(9):5135-44. doi: 10.1128/AAC.04332-14. Epub 2015 Jun 8.

21.

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.

Ramdani G, Naissant B, Thompson E, Breil F, Lorthiois A, Dupuy F, Cummings R, Duffier Y, Corbett Y, Mercereau-Puijalon O, Vernick K, Taramelli D, Baker DA, Langsley G, Lavazec C.

PLoS Pathog. 2015 May 7;11(5):e1004815. doi: 10.1371/journal.ppat.1004815. eCollection 2015 May.

22.

Stability of the antimalarial drug dihydroartemisinin under physiologically relevant conditions: implications for clinical treatment and pharmacokinetic and in vitro assays.

Parapini S, Olliaro P, Navaratnam V, Taramelli D, Basilico N.

Antimicrob Agents Chemother. 2015 Jul;59(7):4046-52. doi: 10.1128/AAC.00183-15. Epub 2015 Apr 27.

23.

Clofazimine analogs with antileishmanial and antiplasmodial activity.

Barteselli A, Casagrande M, Basilico N, Parapini S, Rusconi CM, Tonelli M, Boido V, Taramelli D, Sparatore F, Sparatore A.

Bioorg Med Chem. 2015 Jan 1;23(1):55-65. doi: 10.1016/j.bmc.2014.11.028. Epub 2014 Nov 26.

PMID:
25497962
24.

Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.

Corbett Y, Parapini S, D'Alessandro S, Scaccabarozzi D, Rocha BC, Egan TJ, Omar A, Galastri L, Fitzgerald KA, Golenbock DT, Taramelli D, Basilico N.

Microbes Infect. 2015 Mar;17(3):184-94. doi: 10.1016/j.micinf.2014.11.001. Epub 2014 Nov 21.

PMID:
25462568
25.

Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives.

Magenta D, Sangiovanni E, Basilico N, Haynes RK, Parapini S, Colombo E, Bosisio E, Taramelli D, Dell'Agli M.

Acta Trop. 2014 Dec;140:77-83. doi: 10.1016/j.actatropica.2014.08.008. Epub 2014 Aug 19.

PMID:
25149353
26.

Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes.

Chianese G, Persico M, Yang F, Lin HW, Guo YW, Basilico N, Parapini S, Taramelli D, Taglialatela-Scafati O, Fattorusso C.

Bioorg Med Chem. 2014 Sep 1;22(17):4572-80. doi: 10.1016/j.bmc.2014.07.034. Epub 2014 Jul 27.

PMID:
25115700
27.

CRIMALDDI: platform technologies and novel anti-malarial drug targets.

Vial H, Taramelli D, Boulton IC, Ward SA, Doerig C, Chibale K.

Malar J. 2013 Nov 5;12:396. doi: 10.1186/1475-2875-12-396.

28.

Further optimization of plakortin pharmacophore: structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity.

Persico M, Parapini S, Chianese G, Fattorusso C, Lombardo M, Petrizza L, Quintavalla A, Rondinelli F, Basilico N, Taramelli D, Trombini C, Fattorusso E, Taglialatela-Scafati O.

Eur J Med Chem. 2013;70:875-86. doi: 10.1016/j.ejmech.2013.10.050. Epub 2013 Oct 27.

PMID:
24262380
29.

Antiplasmodial and anti-inflammatory activities of Canthium henriquesianum (K. Schum), a plant used in traditional medicine in Burkina Faso.

Ilboudo DP, Basilico N, Parapini S, Corbett Y, D'Alessandro S, Dell'Agli M, Coghi P, Karou SD, Sawadogo R, Gnoula C, Simpore J, Nikiema JB, Monti D, Bosisio E, Taramelli D.

J Ethnopharmacol. 2013 Jul 30;148(3):763-9. doi: 10.1016/j.jep.2013.04.049. Epub 2013 May 13.

PMID:
23680158
30.

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection.

D'Alessandro S, Silvestrini F, Dechering K, Corbett Y, Parapini S, Timmerman M, Galastri L, Basilico N, Sauerwein R, Alano P, Taramelli D.

J Antimicrob Chemother. 2013 Sep;68(9):2048-58. doi: 10.1093/jac/dkt165. Epub 2013 May 3.

PMID:
23645588
31.

In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso.

Sanon S, Gansane A, Ouattara LP, Traore A, Ouedraogo IN, Tiono A, Taramelli D, Basilico N, Sirima SB.

Afr J Lab Med. 2013 Mar 8;2(1):81. doi: 10.4102/ajlm.v2i1.81. eCollection 2013.

32.

Pathogenesis of malaria in tissues and blood.

Autino B, Corbett Y, Castelli F, Taramelli D.

Mediterr J Hematol Infect Dis. 2012;4(1):e2012061. doi: 10.4084/MJHID.2012.061. Epub 2012 Oct 4.

33.

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S.

J Med Chem. 2012 Dec 13;55(23):10387-404. doi: 10.1021/jm300831b. Epub 2012 Nov 21.

PMID:
23145816
34.

Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline.

Casagrande M, Barteselli A, Basilico N, Parapini S, Taramelli D, Sparatore A.

Bioorg Med Chem. 2012 Oct 1;20(19):5965-79. doi: 10.1016/j.bmc.2012.07.040. Epub 2012 Aug 2.

PMID:
22917857
35.

Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline.

Rusconi C, Vaiana N, Casagrande M, Basilico N, Parapini S, Taramelli D, Romeo S, Sparatore A.

Bioorg Med Chem. 2012 Oct 1;20(19):5980-5. doi: 10.1016/j.bmc.2012.07.041. Epub 2012 Jul 31.

PMID:
22901673
36.

Antiplasmodial activities of 4-aminoquinoline-statine compounds.

Vaiana N, Marzahn M, Parapini S, Liu P, Dell'Agli M, Pancotti A, Sangiovanni E, Basilico N, Bosisio E, Dunn BM, Taramelli D, Romeo S.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5915-8. doi: 10.1016/j.bmcl.2012.07.069. Epub 2012 Jul 27.

PMID:
22884991
37.

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.

Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S.

J Med Chem. 2012 Aug 9;55(15):6948-67. doi: 10.1021/jm300802s. Epub 2012 Jul 27.

PMID:
22783984
38.

Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area.

Dell'Agli M, Sanna C, Rubiolo P, Basilico N, Colombo E, Scaltrito MM, Ndiath MO, Maccarone L, Taramelli D, Bicchi C, Ballero M, Bosisio E.

Malar J. 2012 Jul 2;11:219. doi: 10.1186/1475-2875-11-219.

39.

Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle.

Finaurini S, Basilico N, Corbett Y, D'Alessandro S, Parapini S, Olliaro P, Haynes RK, Taramelli D.

Toxicology. 2012 Oct 9;300(1-2):57-66. doi: 10.1016/j.tox.2012.05.024. Epub 2012 Jun 5.

PMID:
22677887
40.

Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages.

Mimche PN, Thompson E, Taramelli D, Vivas L.

J Antimicrob Chemother. 2012 Aug;67(8):1895-904. doi: 10.1093/jac/dks132. Epub 2012 Apr 17.

PMID:
22511637
41.

A new class of antimalarial dioxanes obtained through a simple two-step synthetic approach: rational design and structure-activity relationship studies.

Persico M, Quintavalla A, Rondinelli F, Trombini C, Lombardo M, Fattorusso C, Azzarito V, Taramelli D, Parapini S, Corbett Y, Chianese G, Fattorusso E, Taglialatela-Scafati O.

J Med Chem. 2011 Dec 22;54(24):8526-40. doi: 10.1021/jm201056j. Epub 2011 Nov 23.

PMID:
22054038
42.

Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.

Gemma S, Kunjir S, Coccone SS, Brindisi M, Moretti V, Brogi S, Novellino E, Basilico N, Parapini S, Taramelli D, Campiani G, Butini S.

J Med Chem. 2011 Aug 25;54(16):5949-53. doi: 10.1021/jm200686d. Epub 2011 Jul 29.

PMID:
21761935
43.

Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium.

Prato M, D'Alessandro S, Van den Steen PE, Opdenakker G, Arese P, Taramelli D, Basilico N.

Cell Microbiol. 2011 Aug;13(8):1275-85. doi: 10.1111/j.1462-5822.2011.01620.x. Epub 2011 Jun 27.

PMID:
21707906
44.

Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.

Chadwick J, Amewu RK, Marti F, Garah FB, Sharma R, Berry NG, Stocks PA, Burrell-Saward H, Wittlin S, Rottmann M, Brun R, Taramelli D, Parapini S, Ward SA, O'Neill PM.

ChemMedChem. 2011 Aug 1;6(8):1357-61. doi: 10.1002/cmdc.201100196. Epub 2011 Jun 20. No abstract available.

PMID:
21692184
45.

Hypoxia modulates the effect of dihydroartemisinin on endothelial cells.

D'Alessandro S, Basilico N, Corbett Y, Scaccabarozzi D, Omodeo-Salè F, Saresella M, Marventano I, Vaillant M, Olliaro P, Taramelli D.

Biochem Pharmacol. 2011 Sep 1;82(5):476-84. doi: 10.1016/j.bcp.2011.06.002. Epub 2011 Jun 13.

PMID:
21684264
46.

The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria.

Mimche PN, Taramelli D, Vivas L.

Malar J. 2011 Mar 15;10 Suppl 1:S10. doi: 10.1186/1475-2875-10-S1-S10. Review.

47.

Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria.

Bertinaria M, Guglielmo S, Rolando B, Giorgis M, Aragno C, Fruttero R, Gasco A, Parapini S, Taramelli D, Martins YC, Carvalho LJ.

Eur J Med Chem. 2011 May;46(5):1757-67. doi: 10.1016/j.ejmech.2011.02.029. Epub 2011 Feb 22.

PMID:
21396743
48.

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Opsenica I, Burnett JC, Gussio R, Opsenica D, Todorović N, Lanteri CA, Sciotti RJ, Gettayacamin M, Basilico N, Taramelli D, Nuss JE, Wanner L, Panchal RG, Solaja BA, Bavari S.

J Med Chem. 2011 Mar 10;54(5):1157-69. doi: 10.1021/jm100938u. Epub 2011 Jan 25.

49.

Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies.

Fattorusso C, Persico M, Basilico N, Taramelli D, Fattorusso E, Scala F, Taglialatela-Scafati O.

Bioorg Med Chem. 2011 Jan 1;19(1):312-20. doi: 10.1016/j.bmc.2010.11.014. Epub 2010 Nov 11.

PMID:
21123074
50.

Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines.

Casagrande M, Basilico N, Rusconi C, Taramelli D, Sparatore A.

Bioorg Med Chem. 2010 Sep 15;18(18):6625-33. doi: 10.1016/j.bmc.2010.08.001. Epub 2010 Aug 6.

PMID:
20797868

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