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Items: 1 to 50 of 101

1.

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.

Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA.

Blood. 2019 Jan 24;133(4):331-343. doi: 10.1182/blood-2018-09-877787. Epub 2018 Nov 14.

2.

Influenza virus infection causes global RNAPII termination defects.

Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I.

Nat Struct Mol Biol. 2018 Sep;25(9):885-893. doi: 10.1038/s41594-018-0124-7. Epub 2018 Sep 3.

PMID:
30177761
3.

Drawing on disorder: How viruses use histone mimicry to their advantage.

Tarakhovsky A, Prinjha RK.

J Exp Med. 2018 Jul 2;215(7):1777-1787. doi: 10.1084/jem.20180099. Epub 2018 Jun 22. Review.

4.

Signaling function of PRC2 is essential for TCR-driven T cell responses.

Dobenecker MW, Park JS, Marcello J, McCabe MT, Gregory R, Knight SD, Rioja I, Bassil AK, Prinjha RK, Tarakhovsky A.

J Exp Med. 2018 Apr 2;215(4):1101-1113. doi: 10.1084/jem.20170084. Epub 2018 Mar 9.

5.

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA.

Blood. 2018 Mar 8;131(10):1122-1144. doi: 10.1182/blood-2017-02-768077. Epub 2018 Jan 4.

6.

Viral Infection Identifies Micropeptides Differentially Regulated in smORF-Containing lncRNAs.

Razooky BS, Obermayer B, O'May JB, Tarakhovsky A.

Genes (Basel). 2017 Aug 21;8(8). pii: E206. doi: 10.3390/genes8080206.

7.

Epigenetic drug discovery: breaking through the immune barrier.

Tough DF, Tak PP, Tarakhovsky A, Prinjha RK.

Nat Rev Drug Discov. 2016 Dec;15(12):835-853. doi: 10.1038/nrd.2016.185. Epub 2016 Oct 21. Review.

PMID:
27765940
8.

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.

von Schimmelmann M, Feinberg PA, Sullivan JM, Ku SM, Badimon A, Duff MK, Wang Z, Lachmann A, Dewell S, Ma'ayan A, Han MH, Tarakhovsky A, Schaefer A.

Nat Neurosci. 2016 Oct;19(10):1321-30. doi: 10.1038/nn.4360. Epub 2016 Aug 15.

9.

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, Tarakhovsky A, Nutt SL, Jaritz M, Busslinger M.

Nat Immunol. 2016 Mar;17(3):331-43. doi: 10.1038/ni.3349. Epub 2016 Jan 18.

10.

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.

Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A.

J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21.

11.

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.

Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4448-57. doi: 10.1073/pnas.1512081112. Epub 2015 Jul 27.

12.

Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.

Dobenecker MW, Kim JK, Marcello J, Fang TC, Prinjha R, Bosselut R, Tarakhovsky A.

J Exp Med. 2015 Mar 9;212(3):297-306. doi: 10.1084/jem.20141499. Epub 2015 Feb 16.

13.

Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.

Halper-Stromberg A, Lu CL, Klein F, Horwitz JA, Bournazos S, Nogueira L, Eisenreich TR, Liu C, Gazumyan A, Schaefer U, Furze RC, Seaman MS, Prinjha R, Tarakhovsky A, Ravetch JV, Nussenzweig MC.

Cell. 2014 Aug 28;158(5):989-999. doi: 10.1016/j.cell.2014.07.043. Epub 2014 Aug 14.

14.

The roles of individual mammalian argonautes in RNA interference in vivo.

Ruda VM, Chandwani R, Sehgal A, Bogorad RL, Akinc A, Charisse K, Tarakhovsky A, Novobrantseva TI, Koteliansky V.

PLoS One. 2014 Jul 3;9(7):e101749. doi: 10.1371/journal.pone.0101749. eCollection 2014.

15.

Epigenetic control of immunity.

Busslinger M, Tarakhovsky A.

Cold Spring Harb Perspect Biol. 2014 Jun 2;6(6). pii: a019307. doi: 10.1101/cshperspect.a019307.

16.

The "histone mimicry" by pathogens.

Schaefer U, Ho JS, Prinjha RK, Tarakhovsky A.

Cold Spring Harb Symp Quant Biol. 2013;78:81-90. doi: 10.1101/sqb.2013.78.020339. Epub 2014 Apr 14.

17.

Chromatin contributions to the regulation of innate immunity.

Smale ST, Tarakhovsky A, Natoli G.

Annu Rev Immunol. 2014;32:489-511. doi: 10.1146/annurev-immunol-031210-101303. Epub 2014 Feb 6. Review.

PMID:
24555473
18.

Chromatin targeting drugs in cancer and immunity.

Prinjha R, Tarakhovsky A.

Genes Dev. 2013 Aug 15;27(16):1731-8. doi: 10.1101/gad.221895.113. Review.

19.

Logic of the inflammation-associated transcriptional response.

Tarakhovsky A.

Adv Immunol. 2013;119:107-33. doi: 10.1016/B978-0-12-407707-2.00004-7. Review.

PMID:
23886066
20.

Quantitative functions of Argonaute proteins in mammalian development.

Wang D, Zhang Z, O'Loughlin E, Lee T, Houel S, O'Carroll D, Tarakhovsky A, Ahn NG, Yi R.

Genes Dev. 2012 Apr 1;26(7):693-704. doi: 10.1101/gad.182758.111.

21.

Suppression of the antiviral response by an influenza histone mimic.

Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A.

Nature. 2012 Mar 14;483(7390):428-33. doi: 10.1038/nature10892.

22.

Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.

Fang TC, Schaefer U, Mecklenbrauker I, Stienen A, Dewell S, Chen MS, Rioja I, Parravicini V, Prinjha RK, Chandwani R, MacDonald MR, Lee K, Rice CM, Tarakhovsky A.

J Exp Med. 2012 Apr 9;209(4):661-9. doi: 10.1084/jem.20112343. Epub 2012 Mar 12.

23.

Innate immunity.

Tarakhovsky AS, Kroemer G.

Curr Opin Immunol. 2012 Feb;24(1):1-2. doi: 10.1016/j.coi.2012.01.004. Epub 2012 Jan 23. No abstract available.

PMID:
22277983
24.

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.

Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG.

Nat Genet. 2012 Jan 22;44(3):343-7. doi: 10.1038/ng.1068.

25.

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.

Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, Kruger M, Jacobs EY, Unger A, Zieseniss A, Dobenecker MW, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, Tarakhovsky A, Linke WA.

Genes Dev. 2012 Jan 15;26(2):114-9. doi: 10.1101/gad.177758.111. Epub 2012 Jan 12.

26.

MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF.

Hwang CI, Choi J, Zhou Z, Flesken-Nikitin A, Tarakhovsky A, Nikitin AY.

Cell Cycle. 2011 Nov 15;10(22):3834-40. doi: 10.4161/cc.10.22.18294. Epub 2011 Nov 15.

27.

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.

Calado DP, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, Rodig S, Kutok J, Tarakhovsky A, Schmidt-Supprian M, Rajewsky K.

Cancer Cell. 2010 Dec 14;18(6):580-9. doi: 10.1016/j.ccr.2010.11.024.

28.

BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma.

Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R.

Cancer Cell. 2010 Dec 14;18(6):568-79. doi: 10.1016/j.ccr.2010.10.030.

29.

Epigenetic mechanisms of mental retardation.

Schaefer A, Tarakhovsky A, Greengard P.

Prog Drug Res. 2011;67:125-46. Review.

PMID:
21141728
30.

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.

Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O.

Nat Immunol. 2011 Jan;12(1):29-36. doi: 10.1038/ni.1968. Epub 2010 Dec 5.

31.

Suppression of inflammation by a synthetic histone mimic.

Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A.

Nature. 2010 Dec 23;468(7327):1119-23. doi: 10.1038/nature09589. Epub 2010 Nov 10.

32.

Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs.

Andersson T, Rahman S, Sansom SN, Alsiö JM, Kaneda M, Smith J, O'Carroll D, Tarakhovsky A, Livesey FJ.

PLoS One. 2010 Oct 18;5(10):e13453. doi: 10.1371/journal.pone.0013453.

33.

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.

Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15957-62. doi: 10.1073/pnas.1002530107. Epub 2010 Aug 23.

34.

Therapeutic targeting of Syk in autoimmune diabetes.

Colonna L, Catalano G, Chew C, D'Agati V, Thomas JW, Wong FS, Schmitz J, Masuda ES, Reizis B, Tarakhovsky A, Clynes R.

J Immunol. 2010 Aug 1;185(3):1532-43. doi: 10.4049/jimmunol.1000983. Epub 2010 Jul 2. Erratum in: J Immunol. 2011 Aug 1;187(3):1516.

35.

Tools and landscapes of epigenetics.

Tarakhovsky A.

Nat Immunol. 2010 Jul;11(7):565-8. doi: 10.1038/ni0710-565. No abstract available.

PMID:
20562839
36.

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.

Maze I, Covington HE 3rd, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ.

Science. 2010 Jan 8;327(5962):213-6. doi: 10.1126/science.1179438.

37.

Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.

Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P.

Neuron. 2009 Dec 10;64(5):678-91. doi: 10.1016/j.neuron.2009.11.019.

38.

Role of the translocation partner in protection against AID-dependent chromosomal translocations.

Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):187-92. doi: 10.1073/pnas.0908946107. Epub 2009 Dec 4.

39.

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK.

Genes Dev. 2009 Apr 15;23(8):975-85. doi: 10.1101/gad.1742509.

40.

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E.

Cell. 2009 Mar 20;136(6):1122-35. doi: 10.1016/j.cell.2008.12.043.

41.

Dicer-dependent microRNA pathway safeguards regulatory T cell function.

Liston A, Lu LF, O'Carroll D, Tarakhovsky A, Rudensky AY.

J Exp Med. 2008 Sep 1;205(9):1993-2004. doi: 10.1084/jem.20081062. Epub 2008 Aug 25.

42.

BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.

Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12435-8. doi: 10.1073/pnas.0805460105. Epub 2008 Aug 19.

43.

The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src.

Oneyama C, Hikita T, Enya K, Dobenecker MW, Saito K, Nada S, Tarakhovsky A, Okada M.

Mol Cell. 2008 May 23;30(4):426-36. doi: 10.1016/j.molcel.2008.03.026.

44.

MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo.

Tang F, Hajkova P, O'Carroll D, Lee C, Tarakhovsky A, Lao K, Surani MA.

Biochem Biophys Res Commun. 2008 Jul 18;372(1):24-9. doi: 10.1016/j.bbrc.2008.04.137. Epub 2008 May 12.

PMID:
18474225
45.

MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis.

Hayashi K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O'Carroll D, Das PP, Tarakhovsky A, Miska EA, Surani MA.

PLoS One. 2008 Mar 5;3(3):e1738. doi: 10.1371/journal.pone.0001738.

46.

Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.

Sampath SC, Marazzi I, Yap KL, Sampath SC, Krutchinsky AN, Mecklenbräuker I, Viale A, Rudensky E, Zhou MM, Chait BT, Tarakhovsky A.

Mol Cell. 2007 Aug 17;27(4):596-608.

47.

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway.

O'Carroll D, Mecklenbrauker I, Das PP, Santana A, Koenig U, Enright AJ, Miska EA, Tarakhovsky A.

Genes Dev. 2007 Aug 15;21(16):1999-2004. Epub 2007 Jul 12.

48.

Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk.

Honda K, Sakaguchi T, Sakai K, Schmedt C, Ramirez A, Jorcano JL, Tarakhovsky A, Kamisoyama H, Sakai T.

Carcinogenesis. 2007 Oct;28(10):2074-81. Epub 2007 May 10.

PMID:
17494055
49.

Maternal microRNAs are essential for mouse zygotic development.

Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA.

Genes Dev. 2007 Mar 15;21(6):644-8.

50.

BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism.

Patke A, Mecklenbräuker I, Erdjument-Bromage H, Tempst P, Tarakhovsky A.

J Exp Med. 2006 Oct 30;203(11):2551-62. Epub 2006 Oct 23.

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