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Items: 15

1.

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.

Johnstone AL, Andrade NS, Barbier E, Khomtchouk BB, Rienas CA, Lowe K, Van Booven DJ, Domi E, Esanov R, Vilca S, Tapocik JD, Rodriguez K, Maryanski D, Keogh MC, Meinhardt MW, Sommer WH, Heilig M, Zeier Z, Wahlestedt C.

Addict Biol. 2019 Aug 1:e12816. doi: 10.1111/adb.12816. [Epub ahead of print]

2.

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L.

Mol Psychiatry. 2020 Feb;25(2):461-475. doi: 10.1038/s41380-018-0064-y. Epub 2018 May 4.

3.

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2.

Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, N├Ątt D, Wahlestedt C, Heilig M.

Mol Psychiatry. 2017 Dec;22(12):1746-1758. doi: 10.1038/mp.2016.131. Epub 2016 Aug 30.

4.

MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1.

Tapocik JD, Ceniccola K, Mayo CL, Schwandt ML, Solomon M, Wang BD, Luu TV, Olender J, Harrigan T, Maynard TM, Elmer GI, Lee NH.

Front Mol Neurosci. 2016 Mar 24;9:20. doi: 10.3389/fnmol.2016.00020. eCollection 2016.

5.

Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking.

Schank JR, Nelson BS, Damadzic R, Tapocik JD, Yao M, King CE, Rowe KE, Cheng K, Rice KC, Heilig M.

Neuropharmacology. 2015 Dec;99:106-14. doi: 10.1016/j.neuropharm.2015.07.009. Epub 2015 Jul 15.

6.

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.

Barbier E, Tapocik JD, Juergens N, Pitcairn C, Borich A, Schank JR, Sun H, Schuebel K, Zhou Z, Yuan Q, Vendruscolo LF, Goldman D, Heilig M.

J Neurosci. 2015 Apr 15;35(15):6153-64. doi: 10.1523/JNEUROSCI.4571-14.2015.

7.

Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training.

Augier E, Flanigan M, Dulman RS, Pincus A, Schank JR, Rice KC, Kejun C, Heilig M, Tapocik JD.

Psychopharmacology (Berl). 2014 Dec;231(23):4561-8. doi: 10.1007/s00213-014-3605-3. Epub 2014 May 25.

8.

microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking.

Tapocik JD, Barbier E, Flanigan M, Solomon M, Pincus A, Pilling A, Sun H, Schank JR, King C, Heilig M.

J Neurosci. 2014 Mar 26;34(13):4581-8. doi: 10.1523/JNEUROSCI.0445-14.2014.

9.

FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice.

Huang MC, Schwandt ML, Chester JA, Kirchhoff AM, Kao CF, Liang T, Tapocik JD, Ramchandani VA, George DT, Hodgkinson CA, Goldman D, Heilig M.

Neuropsychopharmacology. 2014 Jul;39(8):2029-38. doi: 10.1038/npp.2014.55. Epub 2014 Mar 7.

10.

Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.

Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD, Yuan Q, Barbier E, Feng A, Flanigan M, Augier E, Enoch MA, Hodgkinson CA, Shen PH, Lovinger DM, Edenberg HJ, Heilig M, Goldman D.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16963-8. doi: 10.1073/pnas.1309839110. Epub 2013 Sep 30.

11.

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.

Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M.

J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013.

12.

Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats.

Schank JR, Tapocik JD, Barbier E, Damadzic R, Eskay RL, Sun H, Rowe KE, King CE, Yao M, Flanigan ME, Solomon MG, Karlsson C, Cheng K, Rice KC, Heilig M.

Biol Psychiatry. 2013 Apr 15;73(8):774-81. doi: 10.1016/j.biopsych.2012.12.027. Epub 2013 Feb 16.

13.

Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior.

Tapocik JD, Luu TV, Mayo CL, Wang BD, Doyle E, Lee AD, Lee NH, Elmer GI.

Addict Biol. 2013 May;18(3):480-95. doi: 10.1111/j.1369-1600.2012.00470.x. Epub 2012 Jul 15.

14.

Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence.

Tapocik JD, Solomon M, Flanigan M, Meinhardt M, Barbier E, Schank JR, Schwandt M, Sommer WH, Heilig M.

Pharmacogenomics J. 2013 Jun;13(3):286-96. doi: 10.1038/tpj.2012.17. Epub 2012 May 22.

15.

Identification of candidate genes and gene networks specifically associated with analgesic tolerance to morphine.

Tapocik JD, Letwin N, Mayo CL, Frank B, Luu T, Achinike O, House C, Williams R, Elmer GI, Lee NH.

J Neurosci. 2009 Apr 22;29(16):5295-307. doi: 10.1523/JNEUROSCI.4020-08.2009.

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