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Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA.

Mata-Garrido J, Tapia O, Casafont I, Berciano MT, Cuadrado A, Lafarga M.

Acta Neuropathol Commun. 2018 Jul 26;6(1):68. doi: 10.1186/s40478-018-0573-6.


Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA.

Narcís JO, Tapia O, Tarabal O, Piedrafita L, Calderó J, Berciano MT, Lafarga M.

Sci Rep. 2018 Jun 25;8(1):9646. doi: 10.1038/s41598-018-27821-3.


Messages from the voices within: regulation of signaling by proteins of the nuclear lamina.

Gerace L, Tapia O.

Curr Opin Cell Biol. 2018 Jun;52:14-21. doi: 10.1016/ Epub 2018 Jan 4. Review.


CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN.

Lafarga V, Tapia O, Sharma S, Bengoechea R, Stoecklin G, Lafarga M, Berciano MT.

Cell Mol Life Sci. 2018 Feb;75(3):527-546. doi: 10.1007/s00018-017-2638-2. Epub 2017 Sep 6.


Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus.

Tapia O, Narcís JO, Riancho J, Tarabal O, Piedrafita L, Calderó J, Berciano MT, Lafarga M.

Neurobiol Dis. 2017 Dec;108:83-99. doi: 10.1016/j.nbd.2017.08.004. Epub 2017 Aug 18.


Contralateral R1 and R2 components of the laryngeal adductor reflex in humans under general anesthesia.

Sinclair CF, Téllez MJ, Tapia OR, Ulkatan S.

Laryngoscope. 2017 Dec;127(12):E443-E448. doi: 10.1002/lary.26744. Epub 2017 Aug 4.


SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage.

Brun S, Abella N, Berciano MT, Tapia O, Jaumot M, Freire R, Lafarga M, Agell N.

PLoS One. 2017 Jun 5;12(6):e0178925. doi: 10.1371/journal.pone.0178925. eCollection 2017.


A novel methodology for assessing laryngeal and vagus nerve integrity in patients under general anesthesia.

Sinclair CF, Téllez MJ, Tapia OR, Ulkatan S, Deletis V.

Clin Neurophysiol. 2017 Jul;128(7):1399-1405. doi: 10.1016/j.clinph.2017.03.002. Epub 2017 Mar 14.


Poorly cohesive cell (diffuse-infiltrative/signet ring cell) carcinomas of the gallbladder: clinicopathological analysis of 24 cases identified in 628 gallbladder carcinomas.

Tuncel D, Roa JC, Araya JC, Bellolio E, Villaseca M, Tapia O, Jang KT, Quigley B, Saka B, Basturk O, Sarmiento J, Losada HF, Patel S, Reid MD, Memis B, Adsay V.

Hum Pathol. 2017 Feb;60:24-31. doi: 10.1016/j.humpath.2016.09.008. Epub 2016 Sep 22. No abstract available.


Cajal bodies in neurons.

Lafarga M, Tapia O, Romero AM, Berciano MT.

RNA Biol. 2017 Jun 3;14(6):712-725. doi: 10.1080/15476286.2016.1231360. Epub 2016 Sep 14. Review.


MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis.

Lafita-Navarro MC, Blanco R, Mata-Garrido J, Liaño-Pons J, Tapia O, García-Gutiérrez L, García-Alegría E, Berciano MT, Lafarga M, León J.

Oncotarget. 2016 Oct 25;7(43):69536-69548. doi: 10.18632/oncotarget.11766.


Bilateral Atypical Ductal Hyperplasia with Microcalcifications in a Patient with Gynecomastia.

Vidal P, Berner JE, Klenner A, Tapia Ó.

Arch Plast Surg. 2016 May;43(3):299-301. doi: 10.5999/aps.2016.43.3.299. Epub 2016 May 18. No abstract available.


The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines.

Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM, Roa JC.

Pathol Oncol Res. 2016 Oct;22(4):797-805. doi: 10.1007/s12253-016-0066-5. Epub 2016 May 7.


Analysis of Nuclear Lamina Proteins in Myoblast Differentiation by Functional Complementation.

Tapia O, Gerace L.

Methods Mol Biol. 2016;1411:177-94. doi: 10.1007/978-1-4939-3530-7_11.


Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization.

Mata-Garrido J, Casafont I, Tapia O, Berciano MT, Lafarga M.

Acta Neuropathol Commun. 2016 Apr 22;4:41. doi: 10.1186/s40478-016-0312-9.


New classification scheme for ozone monitoring stations based on frequency distribution of hourly data.

Tapia O, Escudero M, Lozano Á, Anzano J, Mantilla E.

Sci Total Environ. 2016 Feb 15;544:1-9. doi: 10.1016/j.scitotenv.2015.11.081. Epub 2015 Dec 1.


miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway.

Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, Buchegger K, Bizama C, Espinoza JA, Peek RM, Araya JC, Roa JC.

Cell Oncol (Dordr). 2016 Feb;39(1):23-33. doi: 10.1007/s13402-015-0247-3. Epub 2015 Oct 12.


Cystatin D locates in the nucleus at sites of active transcription and modulates gene and protein expression.

Ferrer-Mayorga G, Alvarez-Díaz S, Valle N, De Las Rivas J, Mendes M, Barderas R, Canals F, Tapia O, Casal JI, Lafarga M, Muñoz A.

J Biol Chem. 2015 Oct 30;290(44):26533-48. doi: 10.1074/jbc.M115.660175. Epub 2015 Sep 13.


Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases.

Tapia O, Fong LG, Huber MD, Young SG, Gerace L.

PLoS One. 2015 Mar 19;10(3):e0116196. doi: 10.1371/journal.pone.0116196. eCollection 2015.


Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.

Aguilera Ó, González-Sancho JM, Zazo S, Rincón R, Fernández AF, Tapia O, Canals F, Morte B, Calvanese V, Orgaz JL, Niell N, Aguilar S, Freije JM, Graña O, Pisano DG, Borrero A, Martínez-Useros J, Jiménez B, Fraga MF, García-Foncillas J, López-Otín C, Lafarga M, Rojo F, Muñoz A.

Oncotarget. 2015 Mar 20;6(8):5903-17.


[Mediastinal Castleman's disease: report of one case].

Bellolio J E, Tapia O, Iriarte C M.

Rev Med Chil. 2014 Jun;142(6):782-5. doi: 10.4067/S0034-98872014000600013. Spanish.


The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance.

Tapia O, Riquelme I, Leal P, Sandoval A, Aedo S, Weber H, Letelier P, Bellolio E, Villaseca M, Garcia P, Roa JC.

Virchows Arch. 2014 Jul;465(1):25-33. doi: 10.1007/s00428-014-1588-4. Epub 2014 May 21.


Quantum photonic base states: concept and molecular modeling. Managing chemical process descriptions beyond semi-classic schemes.

Tapia O.

J Mol Model. 2014 Feb;20(2):2110. doi: 10.1007/s00894-014-2110-2. Epub 2014 Feb 14.


The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis.

Tapia O, Lafarga V, Bengoechea R, Palanca A, Lafarga M, Berciano MT.

J Cell Sci. 2014 Mar 1;127(Pt 5):939-46. doi: 10.1242/jcs.138537. Epub 2014 Jan 10.


Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population.

Brebi P, Maldonado L, Noordhuis MG, Ili C, Leal P, Garcia P, Brait M, Ribas J, Michailidi C, Perez J, Soudry E, Tapia O, Guzman P, Muñoz S, Van Neste L, Van Criekinge W, Irizarry R, Sidransky D, Roa JC, Guerrero-Preston R.

Epigenetics. 2014 Feb;9(2):308-17. doi: 10.4161/epi.27120. Epub 2013 Nov 15.


Immunohistochemical expression of vascular endothelial growth factor A in advanced gallbladder carcinoma.

Letelier P, Garcia P, Leal P, Ili C, Buchegger K, Riquelme I, Sandoval A, Tapia O, Roa JC.

Appl Immunohistochem Mol Morphol. 2014 Aug;22(7):530-6. doi: 10.1097/PAI.0b013e3182a318a9.


AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines.

Leal P, Garcia P, Sandoval A, Buchegger K, Weber H, Tapia O, Roa JC.

Onco Targets Ther. 2013 Oct 3;6:1373-84. doi: 10.2147/OTT.S46897. eCollection 2013.


Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor.

Roa JC, Tapia O, Manterola C, Villaseca M, Guzman P, Araya JC, Bagci P, Saka B, Adsay V.

Virchows Arch. 2013 Nov;463(5):651-61. Epub 2013 Sep 11. Erratum in: Virchows Arch. 2013 Dec;463(6):851.


Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma.

Leal P, García P, Sandoval A, Letelier P, Brebi P, Ili C, Álvarez H, Tapia O, Roa JC.

Arch Pathol Lab Med. 2013 Apr;137(4):552-7. doi: 10.5858/arpa.2012-0032-OA.


Cellular FLICE-like inhibitory protein long form (c-FLIPL) overexpression is related to cervical cancer progression.

Ili CG, Brebi P, Tapia O, Sandoval A, Lopez J, Garcia P, Leal P, Sidransky D, Guerrero-Preston R, Roa JC.

Int J Gynecol Pathol. 2013 May;32(3):316-22. doi: 10.1097/PGP.0b013e31825d8064.


Connective tissue growth factor immunohistochemical expression is associated with gallbladder cancer progression.

Garcia P, Leal P, Alvarez H, Brebi P, Ili C, Tapia O, Roa JC.

Arch Pathol Lab Med. 2013 Feb;137(2):245-50. doi: 10.5858/arpa.2011-0628-OA.


DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer.

Letelier P, Brebi P, Tapia O, Roa JC.

Clin Epigenetics. 2012 Jul 13;4(1):11. doi: 10.1186/1868-7083-4-11.


[Intravascular large B cell lymphoma: report of one case].

Tapia OE, Jiménez PP.

Rev Med Chil. 2012 Feb;140(2):225-30. doi: 10.4067/S0034-98872012000200012. Spanish.


Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.


Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type I spinal muscular atrophy.

Tapia O, Bengoechea R, Palanca A, Arteaga R, Val-Bernal JF, Tizzano EF, Berciano MT, Lafarga M.

Histochem Cell Biol. 2012 May;137(5):657-67. doi: 10.1007/s00418-012-0921-8. Epub 2012 Feb 1.


Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy.

Bengoechea R, Tapia O, Casafont I, Berciano J, Lafarga M, Berciano MT.

Neurobiol Dis. 2012 Apr;46(1):118-29. doi: 10.1016/j.nbd.2011.12.052. Epub 2012 Jan 10.


A novel GRK2/HDAC6 interaction modulates cell spreading and motility.

Lafarga V, Aymerich I, Tapia O, Mayor F Jr, Penela P.

EMBO J. 2012 Feb 15;31(4):856-69. doi: 10.1038/emboj.2011.466. Epub 2011 Dec 23.


Oxygenation of the phenylhalocarbenes. Are they spin-allowed or spin-forbidden reactions?

Lamsabhi AM, Corral I, Pérez P, Tapia O, Yáñez M.

J Mol Model. 2012 Jun;18(6):2813-21. doi: 10.1007/s00894-011-1283-1. Epub 2011 Nov 27.


[Prognostic factors for gastric cancer without lymph node involvement].

Tapia O, Villaseca M, Bellolio E, Araya JC, Roa JC.

Rev Med Chil. 2011 Apr;139(4):432-8. doi: /S0034-98872011000400003. Epub 2011 Aug 25. Spanish.


[Concordance between Gleason scores of trans rectal biopsies and the surgical piece of radical prostatectomy].

Tapia O, Bellolio E, Roa JC, Guzmán P, Villaseca M, Araya JC.

Rev Med Chil. 2011 Feb;139(2):171-6. doi: /S0034-98872011000200005. Epub 2011 Jul 11. Spanish.


Hyalinizing cholecystitis and associated carcinomas: clinicopathologic analysis of a distinctive variant of cholecystitis with porcelain-like features and accompanying diagnostically challenging carcinomas.

Patel S, Roa JC, Tapia O, Dursun N, Bagci P, Basturk O, Cakir A, Losada H, Sarmiento J, Adsay V.

Am J Surg Pathol. 2011 Aug;35(8):1104-13. doi: 10.1097/PAS.0b013e31822179cc.


Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas.

Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D, Saka B, Losada H, Bagci P, Adsay NV.

Mod Pathol. 2011 Aug;24(8):1069-78. doi: 10.1038/modpathol.2011.68. Epub 2011 Apr 29.


[Mesenteric cryptococcal lymphadenitis: report of one case].

Tapia O, Villaseca M, Araya JC.

Rev Med Chil. 2010 Dec;138(12):1535-8. doi: /S0034-98872010001300010. Epub 2011 Feb 7. Spanish.


[Duodenal villous atrophy associated with Mycophenolate mofetil: report of one case].

Tapia O, Villaseca M, Sierralta A, Roa JC.

Rev Med Chil. 2010 May;138(5):590-4. doi: /S0034-98872010000500010. Epub 2010 Jul 12. Spanish.


Nucleolar targeting of coilin is regulated by its hypomethylation state.

Tapia O, Bengoechea R, Berciano MT, Lafarga M.

Chromosoma. 2010 Oct;119(5):527-40. doi: 10.1007/s00412-010-0276-7. Epub 2010 May 7.


The disposition of free and niosomally encapsulated Rac-flurbiprofen in dairy bovines.

Confalonieri EO, Soraci AL, Becaluba M, Denzoin L, Rodriguez E, Riccio B, Tapia O.

J Vet Pharmacol Ther. 2010 Feb;33(1):9-14. doi: 10.1111/j.1365-2885.2009.01095.x.


Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.

Abella N, Brun S, Calvo M, Tapia O, Weber JD, Berciano MT, Lafarga M, Bachs O, Agell N.

Traffic. 2010 Jun;11(6):743-55. doi: 10.1111/j.1600-0854.2010.01063.x. Epub 2010 Mar 19.


Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and molecular dynamics studies.

Iribarne F, Paulino M, Aguilera S, Tapia O.

J Mol Graph Model. 2009 Nov;28(4):371-81. doi: 10.1016/j.jmgm.2009.09.003. Epub 2009 Sep 23.


TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.

Casafont I, Bengoechea R, Tapia O, Berciano MT, Lafarga M.

J Struct Biol. 2009 Sep;167(3):235-41. doi: 10.1016/j.jsb.2009.06.006. Epub 2009 Jun 16.


Cajal's contribution to the knowledge of the neuronal cell nucleus.

Lafarga M, Casafont I, Bengoechea R, Tapia O, Berciano MT.

Chromosoma. 2009 Aug;118(4):437-43. doi: 10.1007/s00412-009-0212-x. Epub 2009 Apr 29. Review.


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