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Items: 38


VEGF-mTOR signaling links obesity and endometrial cancer.

Sahoo SS, Tanwar PS.

Oncoscience. 2018 Jun 27;5(5-6):150-151. doi: 10.18632/oncoscience.430. eCollection 2018 May. No abstract available.


Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/β-catenin signalling.

Goad J, Ko YA, Kumar M, Jamaluddin MFB, Tanwar PS.

Carcinogenesis. 2018 Jun 15. doi: 10.1093/carcin/bgy079. [Epub ahead of print]


Proteomic Characterization of the Extracellular Matrix of Human Uterine Fibroids.

Jamaluddin MFB, Nahar P, Tanwar PS.

Endocrinology. 2018 Jul 1;159(7):2656-2669. doi: 10.1210/en.2018-00151.


Proteomic Analysis Identifies Tenascin-C Expression Is Upregulated in Uterine Fibroids.

Jamaluddin MFB, Nagendra PB, Nahar P, Oldmeadow C, Tanwar PS.

Reprod Sci. 2018 Jan 1:1933719118773420. doi: 10.1177/1933719118773420. [Epub ahead of print]


Proteomic Profiling of Human Uterine Fibroids Reveals Upregulation of the Extracellular Matrix Protein Periostin.

Jamaluddin MFB, Ko YA, Kumar M, Brown Y, Bajwa P, Nagendra PB, Skerrett-Byrne DA, Hondermarck H, Baker MA, Dun MD, Scott RJ, Nahar P, Tanwar PS.

Endocrinology. 2018 Feb 1;159(2):1106-1118. doi: 10.1210/en.2017-03018.


Adipose-Derived VEGF-mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women.

Sahoo SS, Lombard JM, Ius Y, O'Sullivan R, Wood LG, Nahar P, Jaaback K, Tanwar PS.

Mol Cancer Res. 2018 Feb;16(2):309-321. doi: 10.1158/1541-7786.MCR-17-0466. Epub 2017 Nov 13.


Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis.

Sahoo SS, Quah MY, Nielsen S, Atkins J, Au GG, Cairns MJ, Nahar P, Lombard JM, Tanwar PS.

Oncotarget. 2017 May 22;8(42):71400-71417. doi: 10.18632/oncotarget.18069. eCollection 2017 Sep 22.


Extracellular matrix (ECM) activates β-catenin signaling in uterine fibroids.

Ko YA, Jamaluddin MFB, Adebayo M, Bajwa P, Scott RJ, Dharmarajan AM, Nahar P, Tanwar PS.

Reproduction. 2018 Jan;155(1):61-71. doi: 10.1530/REP-17-0339. Epub 2017 Oct 24.


Canonical Wnt/β-Catenin Signaling Regulates Postnatal Mouse Epididymal Development But Does Not Affect Epithelial Cell Differentiation.

Kumar M, Tanwar PS.

Endocrinology. 2017 Dec 1;158(12):4286-4299. doi: 10.1210/en.2017-00519.


In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells.

Ghosh A, Syed SM, Tanwar PS.

Development. 2017 Sep 1;144(17):3031-3041. doi: 10.1242/dev.149989. Epub 2017 Jul 25.


Data on the mRNA expression by in situ hybridization of Wnt signaling pathway members in the mouse uterus.

Goad J, Ko YA, Syed SM, Crossingham YJ, Tanwar PS.

Data Brief. 2017 Apr 8;12:208-212. doi: 10.1016/j.dib.2017.03.047. eCollection 2017 Jun.


Specific deletion of LKB1/Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice.

George JW, Patterson AL, Tanwar PS, Kajdacsy-Balla A, Prins GS, Teixeira JM.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3445-3450. doi: 10.1073/pnas.1612284114. Epub 2017 Mar 13.


Age-related mTOR in gynaecological cancers.

Bajwa P, Sahoo SS, Tanwar PS.

Aging (Albany NY). 2017 Feb 28;9(2):301-302. doi: 10.18632/aging.101190. No abstract available.


Differential Wnt signaling activity limits epithelial gland development to the anti-mesometrial side of the mouse uterus.

Goad J, Ko YA, Kumar M, Syed SM, Tanwar PS.

Dev Biol. 2017 Mar 15;423(2):138-151. doi: 10.1016/j.ydbio.2017.01.015. Epub 2017 Jan 30.


Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs.

Kumar M, Atkins J, Cairns M, Ali A, Tanwar PS.

Oncotarget. 2016 Dec 27;7(52):85709-85727. doi: 10.18632/oncotarget.13920.


Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice.

Bajwa P, Nielsen S, Lombard JM, Rassam L, Nahar P, Rueda BR, Wilkinson JE, Miller RA, Tanwar PS.

Oncotarget. 2017 Jan 31;8(5):7265-7275. doi: 10.18632/oncotarget.13919.


Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions.

Nagendra PB, Goad J, Nielsen S, Rassam L, Lombard JM, Nahar P, Tanwar PS.

Oncotarget. 2016 Oct 4;7(40):64836-64853. doi: 10.18632/oncotarget.11711.


Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development.

Kumar M, Camlin NJ, Holt JE, Teixeira JM, McLaughlin EA, Tanwar PS.

Sci Rep. 2016 Jun 6;6:27273. doi: 10.1038/srep27273.


Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.

Bajwa P, Nagendra PB, Nielsen S, Sahoo SS, Bielanowicz A, Lombard JM, Wilkinson JE, Miller RA, Tanwar PS.

Oncotarget. 2016 Apr 12;7(15):19214-27. doi: 10.18632/oncotarget.8468.


Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.

Kumar M, Syed SM, Taketo MM, Tanwar PS.

Dev Biol. 2016 Apr 15;412(2):234-49. doi: 10.1016/j.ydbio.2016.02.025. Epub 2016 Mar 2.


Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.

Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, Ohguchi Y, Birrer MJ, Teixeira JM.

Carcinogenesis. 2014 Mar;35(3):546-53. doi: 10.1093/carcin/bgt357. Epub 2013 Oct 29.


PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.

Tanwar PS, Kaneko-Tarui T, Lee HJ, Zhang L, Teixeira JM.

Carcinogenesis. 2013 Apr;34(4):893-901. doi: 10.1093/carcin/bgs405. Epub 2012 Dec 31.


The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signaling.

Tanwar PS, Commandeur AE, Zhang L, Taketo MM, Teixeira JM.

Carcinogenesis. 2012 Dec;33(12):2351-61. doi: 10.1093/carcin/bgs281. Epub 2012 Sep 7.


Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.

Tanwar PS, Kaneko-Tarui T, Zhang L, Tanaka Y, Crum CP, Teixeira JM.

PLoS Genet. 2012;8(8):e1002906. doi: 10.1371/journal.pgen.1002906. Epub 2012 Aug 16.


Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.

Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM.

Hum Mol Genet. 2012 Oct 15;21(20):4394-405. Epub 2012 Jul 12.


Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance.

Meirelles K, Benedict LA, Dombkowski D, Pepin D, Preffer FI, Teixeira J, Tanwar PS, Young RH, MacLaughlin DT, Donahoe PK, Wei X.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2358-63. doi: 10.1073/pnas.1120733109. Epub 2012 Jan 27.


Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.

Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Lee HJ, Teixeira JM.

Endocrinology. 2012 Jan;153(1):404-16. doi: 10.1210/en.2011-1191. Epub 2011 Nov 29.


Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium.

Tanwar PS, Zhang L, Teixeira JM.

Mol Endocrinol. 2011 Oct;25(10):1725-39. doi: 10.1210/me.2011-0057. Epub 2011 Aug 4.


Dynamic expression of bone morphogenetic protein 4 in reproductive organs of female mice.

Tanwar PS, McFarlane JR.

Reproduction. 2011 Oct;142(4):573-9. doi: 10.1530/REP-10-0299. Epub 2011 Aug 2.


Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN.

Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, Roberts DJ, Teixeira JM.

PLoS One. 2011;6(6):e20715. doi: 10.1371/journal.pone.0020715. Epub 2011 Jun 9.


Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer.

Tanwar PS, Zhang L, Roberts DJ, Teixeira JM.

Cancer Res. 2011 Mar 1;71(5):1584-96. doi: 10.1158/0008-5472.CAN-10-3166.


Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.

Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira JM.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16142-7. doi: 10.1073/pnas.1011606107. Epub 2010 Aug 30.


Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis.

Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J.

Biol Reprod. 2010 Feb;82(2):422-32. doi: 10.1095/biolreprod.109.079335. Epub 2009 Sep 30.


Lin28 promotes transformation and is associated with advanced human malignancies.

Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ.

Nat Genet. 2009 Jul;41(7):843-8. doi: 10.1038/ng.392. Epub 2009 May 31.


Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice.

Tanwar PS, Lee HJ, Zhang L, Zukerberg LR, Taketo MM, Rueda BR, Teixeira JM.

Biol Reprod. 2009 Sep;81(3):545-52. doi: 10.1095/biolreprod.108.075648. Epub 2009 Apr 29.


The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.

Wu X, Yamada-Mabuchi M, Morris EJ, Tanwar PS, Dobens L, Gluderer S, Khan S, Cao J, Stocker H, Hafen E, Dyson NJ, Raftery LA.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5414-9. doi: 10.1073/pnas.0800945105. Epub 2008 Mar 28.


Drosophila follicle cells: morphogenesis in an eggshell.

Wu X, Tanwar PS, Raftery LA.

Semin Cell Dev Biol. 2008 Jun;19(3):271-82. doi: 10.1016/j.semcdb.2008.01.004. Epub 2008 Jan 20. Review.


In vivo evidence of role of bone morphogenetic protein-4 in the mouse ovary.

Tanwar PS, O'Shea T, McFarlane JR.

Anim Reprod Sci. 2008 Jul;106(3-4):232-40. Epub 2007 May 3.


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