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Items: 39

1.

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer.

Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ.

ACS Omega. 2019 May 31;4(5):9251-9261. doi: 10.1021/acsomega.9b01093. Epub 2019 May 24.

2.

Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.

Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.

Elife. 2019 Jan 7;8. pii: e44851. doi: 10.7554/eLife.44851.

3.

Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents.

Cieślik P, Woźniak M, Rook JM, Tantawy MN, Conn PJ, Acher F, Tokarski K, Kusek M, Pilc A, Wierońska JM.

Psychopharmacology (Berl). 2018 Oct;235(10):2897-2913. doi: 10.1007/s00213-018-4980-y. Epub 2018 Jul 27.

4.

Brief exposure to obesogenic diet disrupts brain dopamine networks.

Barry RL, Byun NE, Williams JM, Siuta MA, Tantawy MN, Speed NK, Saunders C, Galli A, Niswender KD, Avison MJ.

PLoS One. 2018 Apr 26;13(4):e0191299. doi: 10.1371/journal.pone.0191299. eCollection 2018.

5.

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.

Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, Sanders ME, Manning HC, Balko JM.

Nat Commun. 2018 Jan 16;9(1):248. doi: 10.1038/s41467-017-02630-w.

6.

Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model.

Tantawy MN, Charles Manning H, Peterson TE, Colvin DC, Gore JC, Lu W, Chen Z, Chad Quarles C.

Mol Imaging Biol. 2018 Apr;20(2):200-204. doi: 10.1007/s11307-017-1113-7.

7.

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.

Felts AS, Rodriguez AL, Blobaum AL, Morrison RD, Bates BS, Thompson Gray A, Rook JM, Tantawy MN, Byers FW, Chang S, Venable DF, Luscombe VB, Tamagnan GD, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, Emmitte KA.

J Med Chem. 2017 Jun 22;60(12):5072-5085. doi: 10.1021/acs.jmedchem.7b00410. Epub 2017 May 31.

8.

In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction.

Barry RL, Byun NE, Tantawy MN, Mackey CA, Wilson GH 3rd, Stark AJ, Flom MP, Gee LC, Quarles CC.

Brain Imaging Behav. 2018 Feb;12(1):87-95. doi: 10.1007/s11682-017-9674-2.

PMID:
28108946
9.

In vivo evaluation of IGF1R/IR PET ligand [18F]BMS-754807 in rodents.

Prabhakaran J, Dewey SL, McClure R, Simpson NR, Tantawy MN, Mann JJ, Pham W, Kumar JSD.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):941-943. doi: 10.1016/j.bmcl.2016.12.086. Epub 2017 Jan 7.

10.

Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging.

Tang D, Li J, Buck JR, Tantawy MN, Xia Y, Harp JM, Nickels ML, Meiler J, Manning HC.

Mol Imaging Biol. 2017 Aug;19(4):578-588. doi: 10.1007/s11307-016-1027-9.

11.

18F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma.

Osgood CL, Tantawy MN, Maloney N, Madaj ZB, Peck A, Boguslawski E, Jess J, Buck J, Winn ME, Manning HC, Grohar PJ.

Sci Rep. 2016 Sep 27;6:33926. doi: 10.1038/srep33926.

12.

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.

Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.

Elife. 2016 Jul 13;5. pii: e15828. doi: 10.7554/eLife.15828. Erratum in: Elife. 2019 Jan 07;8:.

13.

Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer.

Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC.

Mol Imaging Biol. 2016 Feb;18(1):18-23. doi: 10.1007/s11307-015-0862-4.

14.

Detection of breast cancer microcalcification using (99m)Tc-MDP SPECT or Osteosense 750EX FMT imaging.

Felix DD, Gore JC, Yankeelov TE, Peterson TE, Barnes S, Whisenant J, Weis J, Shoukouhi S, Virostko J, Nickels M, McIntyre JO, Sanders M, Abramson V, Tantawy MN.

Nucl Med Biol. 2015 Mar;42(3):269-73. doi: 10.1016/j.nucmedbio.2014.11.010. Epub 2014 Dec 6.

15.

Acetate dependence of tumors.

Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP.

Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020.

16.

Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.

Rook JM, Tantawy MN, Ansari MS, Felts AS, Stauffer SR, Emmitte KA, Kessler RM, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ.

Neuropsychopharmacology. 2015 Feb;40(3):755-65. doi: 10.1038/npp.2014.245. Epub 2014 Sep 22.

17.
18.

An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications Using (18)F-NaF.

Wilson GH 3rd, Gore JC, Yankeelov TE, Barnes S, Peterson TE, True JM, Shokouhi S, McIntyre JO, Sanders M, Abramson V, Ngyuen TQ, Mahadevan-Jansen A, Tantawy MN.

J Nucl Med. 2014 Jul;55(7):1138-43. doi: 10.2967/jnumed.114.139170. Epub 2014 May 15.

19.

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

Perrone MG, Malerba P, Uddin J, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A.

Eur J Med Chem. 2014 Jun 10;80:562-568. doi: 10.1016/j.ejmech.2014.04.074. Epub 2014 Apr 29.

20.

Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease.

Wang F, Jiang RT, Tantawy MN, Borza DB, Takahashi K, Gore JC, Harris RC, Takahashi T, Quarles CC.

J Magn Reson Imaging. 2014 Apr;39(4):866-71. doi: 10.1002/jmri.24242. Epub 2013 Sep 4.

21.

Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia.

Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W.

Gastroenterology. 2013 Dec;145(6):1312-22.e1-8. doi: 10.1053/j.gastro.2013.08.050. Epub 2013 Aug 29.

22.

Convergent synthesis and evaluation of (18)F-labeled azulenic COX2 probes for cancer imaging.

Nolting DD, Nickels M, Tantawy MN, Yu JY, Xie J, Peterson TE, Crews BC, Marnett L, Gore JC, Pham W.

Front Oncol. 2013 Jan 3;2:207. doi: 10.3389/fonc.2012.00207. eCollection 2012.

23.

Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy.

Tantawy MN, Jiang R, Wang F, Takahashi K, Peterson TE, Zemel D, Hao CM, Fujita H, Harris RC, Quarles CC, Takahashi T.

BMC Nephrol. 2012 Dec 10;13:168. doi: 10.1186/1471-2369-13-168.

24.

Detecting peritoneal dissemination of ovarian cancer in mice by DWIBS.

Lee HJ, Luci JJ, Tantawy MN, Lee H, Nam KT, Peterson TE, Price RR.

Magn Reson Imaging. 2013 Feb;31(2):227-34. doi: 10.1016/j.mri.2012.06.016. Epub 2012 Aug 24.

25.

Reproducibility of static and dynamic (18)F-FDG, (18)F-FLT, and (18)F-FMISO MicroPET studies in a murine model of HER2+ breast cancer.

Whisenant JG, Peterson TE, Fluckiger JU, Tantawy MN, Ayers GD, Yankeelov TE.

Mol Imaging Biol. 2013 Feb;15(1):87-96. doi: 10.1007/s11307-012-0564-0.

26.

The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

Johnson KA, Jones CK, Tantawy MN, Bubser M, Marvanova M, Ansari MS, Baldwin RM, Conn PJ, Niswender CM.

Neuropharmacology. 2013 Mar;66:187-95. doi: 10.1016/j.neuropharm.2012.03.029. Epub 2012 Apr 21.

27.

Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide.

Tang D, Hight MR, McKinley ET, Fu A, Buck JR, Smith RA, Tantawy MN, Peterson TE, Colvin DC, Ansari MS, Nickels M, Manning HC.

J Nucl Med. 2012 Feb;53(2):287-94. doi: 10.2967/jnumed.111.095653. Epub 2012 Jan 17.

28.

Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer.

Uddin MJ, Crews BC, Ghebreselasie K, Huda I, Kingsley PJ, Ansari MS, Tantawy MN, Reese J, Marnett LJ.

Cancer Prev Res (Phila). 2011 Oct;4(10):1536-45. doi: 10.1158/1940-6207.CAPR-11-0120. Epub 2011 Sep 7.

29.

Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot.

Tantawy MN, Peterson TE, Jones CK, Johnson K, Rook JM, Conn PJ, Baldwin RM, Ansari MS, Kessler RM.

Synapse. 2011 Nov;65(11):1173-80. doi: 10.1002/syn.20955. Epub 2011 Jun 17.

30.

Evaluation of an intraperitoneal ovarian cancer syngeneic mouse model using 18F-FDG MicroPET imaging.

Lee HJ, Tantawy MN, Nam KT, Choi I, Peterson TE, Price RR.

Int J Gynecol Cancer. 2011 Jan;21(1):22-7. doi: 10.1097/IGC.0b013e3182021bda.

PMID:
21321526
31.

[I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.

Uddin MJ, Crews BC, Ghebreselasie K, Tantawy MN, Marnett LJ.

ACS Med Chem Lett. 2011 Feb 10;2(2):160-164. Epub 2010 Nov 12.

32.

Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline.

Buck JR, McKinley ET, Hight MR, Fu A, Tang D, Smith RA, Tantawy MN, Peterson TE, Colvin D, Ansari MS, Baldwin RM, Zhao P, Guleryuz S, Manning HC.

J Nucl Med. 2011 Jan;52(1):107-14. doi: 10.2967/jnumed.110.081703. Epub 2010 Dec 13.

33.
34.

[(18)F]Fallypride dopamine D2 receptor studies using delayed microPET scans and a modified Logan plot.

Tantawy MN, Jones CK, Baldwin RM, Ansari MS, Conn PJ, Kessler RM, Peterson TE.

Nucl Med Biol. 2009 Nov;36(8):931-40. doi: 10.1016/j.nucmedbio.2009.06.007. Epub 2009 Oct 3.

35.

Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer.

Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, McKinley ET, Xie J, Mutic NJ, Washington MK, LaFleur B, Tantawy MN, Peterson TE, Ansari MS, Baldwin RM, Rothenberg ML, Bornhop DJ, Gore JC, Coffey RJ.

Clin Cancer Res. 2008 Nov 15;14(22):7413-22. doi: 10.1158/1078-0432.CCR-08-0239.

36.

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ.

J Neurosci. 2008 Oct 8;28(41):10422-33. doi: 10.1523/JNEUROSCI.1850-08.2008.

37.

Radiation-guided P-selectin antibody targeted to lung cancer.

Hariri G, Zhang Y, Fu A, Han Z, Brechbiel M, Tantawy MN, Peterson TE, Mernaugh R, Hallahan D.

Ann Biomed Eng. 2008 May;36(5):821-30. doi: 10.1007/s10439-008-9444-9. Epub 2008 Feb 14.

38.

Discovery of 109Xe and 105Te: superallowed alpha decay near doubly magic 100Sn.

Liddick SN, Grzywacz R, Mazzocchi C, Page RD, Rykaczewski KP, Batchelder JC, Bingham CR, Darby IG, Drafta G, Goodin C, Gross CJ, Hamilton JH, Hecht AA, Hwang JK, Ilyushkin S, Joss DT, Korgul A, Królas W, Lagergren K, Li K, Tantawy MN, Thomson J, Winger JA.

Phys Rev Lett. 2006 Aug 25;97(8):082501. Epub 2006 Aug 21.

PMID:
17026296
39.

Fine structure in proton emission from 145Tm discovered with digital signal processing.

Karny M, Grzywacz RK, Batchelder JC, Bingham CR, Gross CJ, Hagino K, Hamilton JH, Janas Z, Kulp WD, McConnell JW, Momayezi M, Piechaczek A, Rykaczewski KP, Semmes PA, Tantawy MN, Winger JA, Yu CH, Zganjar EF.

Phys Rev Lett. 2003 Jan 10;90(1):012502. Epub 2003 Jan 7.

PMID:
12570604

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