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Items: 1 to 50 of 82

1.

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance.

Thomas LR, Adams CM, Wang J, Weissmiller AM, Creighton J, Lorey SL, Liu Q, Fesik SW, Eischen CM, Tansey WP.

Proc Natl Acad Sci U S A. 2019 Nov 25. pii: 201910391. doi: 10.1073/pnas.1910391116. [Epub ahead of print]

2.

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.

Macdonald JD, Chacón Simon S, Han C, Wang F, Shaw JG, Howes JE, Sai J, Yuh JP, Camper D, Alicie BM, Alvarado J, Nikhar S, Payne W, Aho ER, Bauer JA, Zhao B, Phan J, Thomas LR, Rossanese OW, Tansey WP, Waterson AG, Stauffer SR, Fesik SW.

J Med Chem. 2019 Dec 5. doi: 10.1021/acs.jmedchem.9b01411. [Epub ahead of print]

PMID:
31724864
3.

Targeting WDR5: A WINning Anti-Cancer Strategy?

Aho ER, Weissmiller AM, Fesik SW, Tansey WP.

Epigenet Insights. 2019 Jul 18;12:2516865719865282. doi: 10.1177/2516865719865282. eCollection 2019.

4.

Inhibition of MYC by the SMARCB1 tumor suppressor.

Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP.

Nat Commun. 2019 May 1;10(1):2014. doi: 10.1038/s41467-019-10022-5.

5.

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.

Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP.

Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047.

6.

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

Wang F, Jeon KO, Salovich JM, Macdonald JD, Alvarado J, Gogliotti RD, Phan J, Olejniczak ET, Sun Q, Wang S, Camper D, Yuh JP, Shaw JG, Sai J, Rossanese OW, Tansey WP, Stauffer SR, Fesik SW.

J Med Chem. 2018 Jul 12;61(13):5623-5642. doi: 10.1021/acs.jmedchem.8b00375. Epub 2018 Jun 29.

7.

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling.

Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E.

J Cell Sci. 2018 May 22;131(10). pii: jcs210575. doi: 10.1242/jcs.210575.

8.

Moonlighting with WDR5: A Cellular Multitasker.

Guarnaccia AD, Tansey WP.

J Clin Med. 2018 Jan 30;7(2). pii: E21. doi: 10.3390/jcm7020021. Review.

9.

BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.

Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS.

Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.

10.

Interaction of Gcn4 with target gene chromatin is modulated by proteasome function.

Howard GC, Tansey WP.

Mol Biol Cell. 2016 Sep 1;27(17):2735-41. doi: 10.1091/mbc.E16-03-0192. Epub 2016 Jul 6.

11.

Antagonistic roles for the ubiquitin ligase Asr1 and the ubiquitin-specific protease Ubp3 in subtelomeric gene silencing.

McCann TS, Guo Y, McDonald WH, Tansey WP.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1309-14. doi: 10.1073/pnas.1518375113. Epub 2016 Jan 19.

12.

Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.

Thomas LR, Foshage AM, Weissmiller AM, Popay TM, Grieb BC, Qualls SJ, Ng V, Carboneau B, Lorey S, Eischen CM, Tansey WP.

Oncogene. 2016 Jul 7;35(27):3613-8. doi: 10.1038/onc.2015.416. Epub 2015 Nov 2.

13.

The MYC-WDR5 Nexus and Cancer.

Thomas LR, Foshage AM, Weissmiller AM, Tansey WP.

Cancer Res. 2015 Oct 1;75(19):4012-5. doi: 10.1158/0008-5472.CAN-15-1216. Epub 2015 Sep 17. Review.

14.

Do changes in the c-MYC coding sequence contribute to tumorigenesis?

Chakraborty AA, Tansey WP.

Mol Cell Oncol. 2014 Oct 30;2(2):e965631. doi: 10.4161/23723548.2014.965631. eCollection 2015 Apr-Jun.

15.

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP.

Mol Cell. 2015 May 7;58(3):440-52. doi: 10.1016/j.molcel.2015.02.028. Epub 2015 Mar 26.

16.

Functions of the proteasome on chromatin.

McCann TS, Tansey WP.

Biomolecules. 2014 Nov 21;4(4):1026-44. doi: 10.3390/biom4041026. Review.

17.

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.

Bonizec M, Hérissant L, Pokrzywa W, Geng F, Wenzel S, Howard GC, Rodriguez P, Krause S, Tansey WP, Hoppe T, Dargemont C.

Nucleic Acids Res. 2014;42(17):10975-86. doi: 10.1093/nar/gku786. Epub 2014 Sep 2.

18.

Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.

Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ.

J Am Chem Soc. 2014 Aug 27;136(34):11864-6. doi: 10.1021/ja503604t. Epub 2014 Aug 11.

19.

A common functional consequence of tumor-derived mutations within c-MYC.

Chakraborty AA, Scuoppo C, Dey S, Thomas LR, Lorey SL, Lowe SW, Tansey WP.

Oncogene. 2015 Apr 30;34(18):2406-9. doi: 10.1038/onc.2014.186. Epub 2014 Jul 7.

20.

Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.

Geng F, Tansey WP.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6060-5. doi: 10.1073/pnas.1200854109. Epub 2012 Apr 2.

21.

Ubiquitin and proteasomes in transcription.

Geng F, Wenzel S, Tansey WP.

Annu Rev Biochem. 2012;81:177-201. doi: 10.1146/annurev-biochem-052110-120012. Epub 2012 Mar 8. Review.

22.

Letter to the editor. Chemical-genetic strategy for inhibiting proteasome function in Saccharomyces cerevisiae.

Howard GC, Collins GA, Tansey WP.

Yeast. 2012 Feb;29(2):93-4. doi: 10.1002/yea.1919. Epub 2011 Dec 8. No abstract available.

23.

Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma.

Zheng S, Tansey WP, Hiebert SW, Zhao Z.

BMC Med Genomics. 2011 Aug 8;4:62. doi: 10.1186/1755-8794-4-62.

24.

Proteolytic control of the oncoprotein transcription factor Myc.

Thomas LR, Tansey WP.

Adv Cancer Res. 2011;110:77-106. doi: 10.1016/B978-0-12-386469-7.00004-9. Review.

PMID:
21704229
25.

Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.

Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, Tansey WP.

Mol Biol Cell. 2011 Aug 1;22(15):2741-53. doi: 10.1091/mbc.E11-05-0426. Epub 2011 Jun 16.

26.

Epithelial cell organization suppresses Myc function by attenuating Myc expression.

Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP.

Cancer Res. 2011 Jun 1;71(11):3822-30. doi: 10.1158/0008-5472.CAN-10-3782. Epub 2011 May 24.

27.

Romo1 is a negative-feedback regulator of Myc.

Lee SB, Kim JJ, Chung JS, Lee MS, Lee KH, Kim BS, Do Yoo Y.

J Cell Sci. 2011 Jun 1;124(Pt 11):1911-24. doi: 10.1242/jcs.079996. Epub 2011 May 10. Erratum in: J Cell Sci. 2011 Jun 1;124(Pt 11):1911. Tansey, William P [removed].

28.

Combined chemical and genetic approach to inhibit proteolysis by the proteasome.

Collins GA, Gomez TA, Deshaies RJ, Tansey WP.

Yeast. 2010 Nov;27(11):965-74. doi: 10.1002/yea.1805.

29.

Proteolytic instability and the action of nonclassical transcriptional activators.

Wang X, Muratani M, Tansey WP, Ptashne M.

Curr Biol. 2010 May 11;20(9):868-71. doi: 10.1016/j.cub.2010.03.029. Epub 2010 Apr 22.

30.

Gal4 turnover and transcription activation.

Collins GA, Lipford JR, Deshaies RJ, Tansey WP.

Nature. 2009 Oct 8;461(7265):E7; discussion E8. doi: 10.1038/nature08406.

31.

Inference of cell cycle-dependent proteolysis by laser scanning cytometry.

Chakraborty AA, Tansey WP.

Exp Cell Res. 2009 Jun 10;315(10):1772-8. doi: 10.1016/j.yexcr.2009.01.011. Epub 2009 Jan 27.

32.

Damage control: DNA repair, transcription, and the ubiquitin-proteasome system.

Daulny A, Tansey WP.

DNA Repair (Amst). 2009 Apr 5;8(4):444-8. doi: 10.1016/j.dnarep.2009.01.017. Epub 2009 Mar 9. Review.

PMID:
19272841
33.

Transcriptional control and the ubiquitin-proteasome system.

Leung A, Geng F, Daulny A, Collins G, Guzzardo P, Tansey WP.

Ernst Schering Found Symp Proc. 2008;(1):75-97. Review.

PMID:
19198065
34.

Adenoviral E1A function through Myc.

Chakraborty AA, Tansey WP.

Cancer Res. 2009 Jan 1;69(1):6-9. doi: 10.1158/0008-5472.CAN-08-3026. Review.

35.

Modulation of RNA polymerase II subunit composition by ubiquitylation.

Daulny A, Geng F, Muratani M, Geisinger JM, Salghetti SE, Tansey WP.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19649-54. doi: 10.1073/pnas.0809372105. Epub 2008 Dec 8.

36.

Polyubiquitylation of histone H2B.

Geng F, Tansey WP.

Mol Biol Cell. 2008 Sep;19(9):3616-24. doi: 10.1091/mbc.E08-01-0050. Epub 2008 Jun 18.

37.

Myc-mediated transcriptional repression by recruitment of histone deacetylase.

Kurland JF, Tansey WP.

Cancer Res. 2008 May 15;68(10):3624-9. doi: 10.1158/0008-5472.CAN-07-6552.

38.

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6103-8. doi: 10.1073/pnas.0802095105. Epub 2008 Apr 14.

39.

Denaturing protein immunoprecipitation from yeast.

Tansey WP.

CSH Protoc. 2007 Jan 1;2007:pdb.prot4643. doi: 10.1101/pdb.prot4643.

PMID:
21356925
40.

Yeast Chromatin Immunoprecipitation (ChIP) Assay.

Tansey WP.

CSH Protoc. 2007 Jan 1;2007:pdb.prot4642. doi: 10.1101/pdb.prot4642.

PMID:
21356924
41.

Pulse-chase assay for measuring protein stability in yeast.

Tansey WP.

CSH Protoc. 2007 Jan 1;2007:pdb.prot4641. doi: 10.1101/pdb.prot4641.

PMID:
21356923
42.

Nondenaturing protein immunoprecipitation from Mammalian cells.

Tansey WP.

CSH Protoc. 2007 Jan 1;2007:pdb.prot4620. doi: 10.1101/pdb.prot4620.

PMID:
21356922
43.

Denaturing protein immunoprecipitation from Mammalian cells.

Tansey WP.

CSH Protoc. 2007 Jan 1;2007:pdb.prot4619. doi: 10.1101/pdb.prot4619.

PMID:
21356921
44.

SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae.

Pal B, Chan NC, Helfenbaum L, Tan K, Tansey WP, Gething MJ.

Mol Biol Cell. 2007 Feb;18(2):426-40. Epub 2006 Nov 15.

45.

The proteasome: a utility tool for transcription?

Collins GA, Tansey WP.

Curr Opin Genet Dev. 2006 Apr;16(2):197-202. Epub 2006 Feb 28. Review.

PMID:
16503126
46.

Detection of ubiquitylated proteins in mammalian cells.

Tansey WP.

CSH Protoc. 2006 Nov 1;2006(6). pii: pdb.prot4616. doi: 10.1101/pdb.prot4616.

PMID:
22485991
47.

Detection of ubiquitylated proteins in yeast.

Tansey WP.

CSH Protoc. 2006 Dec 1;2006(7). pii: pdb.prot4615. doi: 10.1101/pdb.prot4615.

PMID:
22484671
48.

Freeze-thaw lysis for extraction of proteins from Mammalian cells.

Tansey WP.

CSH Protoc. 2006 Dec 1;2006(7). pii: pdb.prot4614. doi: 10.1101/pdb.prot4614.

PMID:
22484670
49.

6-azauracil sensitivity assay for yeast.

Tansey WP.

CSH Protoc. 2006 Dec 1;2006(7). pii: pdb.prot4613. doi: 10.1101/pdb.prot4613.

PMID:
22484669
50.

The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators.

Lee D, Ezhkova E, Li B, Pattenden SG, Tansey WP, Workman JL.

Cell. 2005 Nov 4;123(3):423-36.

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