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S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.

Amal H, Gong G, Gjoneska E, Lewis SM, Wishnok JS, Tsai LH, Tannenbaum SR.

Transl Psychiatry. 2019 Jan 29;9(1):44. doi: 10.1038/s41398-019-0388-7.


Magnetic silica nanoparticles for use in matrix-assisted laser desorption ionization mass spectrometry of labile biomolecules such as oligosaccharides, amino acids, peptides and nucleosides.

Yang H, Su R, Wishnok JS, Liu N, Chen C, Liu S, Tannenbaum SR.

Mikrochim Acta. 2019 Jan 12;186(2):104. doi: 10.1007/s00604-018-3208-5.


Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wishnok JS, Feng G, Tannenbaum SR.

Mol Psychiatry. 2018 Jul 9. doi: 10.1038/s41380-018-0113-6. [Epub ahead of print]


Nitric oxide induced S-nitrosation causes base excision repair imbalance.

Parrish MC, Chaim IA, Nagel ZD, Tannenbaum SR, Samson LD, Engelward BP.

DNA Repair (Amst). 2018 Aug;68:25-33. doi: 10.1016/j.dnarep.2018.04.008. Epub 2018 May 5.


Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis.

Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR.

J Biol Chem. 2018 Jul 20;293(29):11459-11469. doi: 10.1074/jbc.M117.818542. Epub 2018 May 23.


Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.

Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, Suter E, Shockley M, Velazquez J, Velazquez JJ, Stockdale L, Papps JP, Lee I, Vann N, Gamboa M, LaBarge ME, Zhong Z, Wang X, Boyer LA, Lauffenburger DA, Carrier RL, Communal C, Tannenbaum SR, Stokes CL, Hughes DJ, Rohatgi G, Trumper DL, Cirit M, Griffith LG.

Sci Rep. 2018 Mar 14;8(1):4530. doi: 10.1038/s41598-018-22749-0.


Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection.

Cui L, Pang J, Lee YH, Ooi EE, Ong CN, Leo YS, Tannenbaum SR.

PLoS Negl Trop Dis. 2018 Jan 24;12(1):e0006217. doi: 10.1371/journal.pntd.0006217. eCollection 2018 Jan.


Automated Online Solid-Phase Derivatization for Sensitive Quantification of Endogenous S-Nitrosoglutathione and Rapid Capture of Other Low-Molecular-Mass S-Nitrosothiols.

Wang X, Garcia CT, Gong G, Wishnok JS, Tannenbaum SR.

Anal Chem. 2018 Feb 6;90(3):1967-1975. doi: 10.1021/acs.analchem.7b04049. Epub 2018 Jan 9.


Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection.

Cui L, Hou J, Fang J, Lee YH, Costa VV, Wong LH, Chen Q, Ooi EE, Tannenbaum SR, Chen J, Ong CN.

J Virol. 2017 Jun 26;91(14). pii: e00386-17. doi: 10.1128/JVI.00386-17. Print 2017 Jul 15.


Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.

Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2017 Jul;45(7):855-866. doi: 10.1124/dmd.116.074005. Epub 2017 Apr 27.


Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.

Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH.

Mucosal Immunol. 2017 Nov;10(6):1504-1517. doi: 10.1038/mi.2017.9. Epub 2017 Feb 15.


Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity.

Chan KR, Wang X, Saron WA, Gan ES, Tan HC, Mok DZ, Zhang SL, Lee YH, Liang C, Wijaya L, Ghosh S, Cheung YB, Tannenbaum SR, Abraham SN, St John AL, Low JG, Ooi EE.

Nat Microbiol. 2016 Sep 19:16164. doi: 10.1038/nmicrobiol.2016.164. [Epub ahead of print]


Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies.

Tillberg PW, Chen F, Piatkevich KD, Zhao Y, Yu CC, English BP, Gao L, Martorell A, Suk HJ, Yoshida F, DeGennaro EM, Roossien DH, Gong G, Seneviratne U, Tannenbaum SR, Desimone R, Cai D, Boyden ES.

Nat Biotechnol. 2016 Sep;34(9):987-92. doi: 10.1038/nbt.3625. Epub 2016 Jul 4.


Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia.

Cui L, Zheng D, Lee YH, Chan TK, Kumar Y, Ho WE, Chen JZ, Tannenbaum SR, Ong CN.

Sci Rep. 2016 May 18;6:26076. doi: 10.1038/srep26076.


Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever.

Cui L, Lee YH, Thein TL, Fang J, Pang J, Ooi EE, Leo YS, Ong CN, Tannenbaum SR.

PLoS Negl Trop Dis. 2016 Apr 7;10(4):e0004607. doi: 10.1371/journal.pntd.0004607. eCollection 2016 Apr.


S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Seneviratne U, Nott A, Bhat VB, Ravindra KC, Wishnok JS, Tsai LH, Tannenbaum SR.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4152-7. doi: 10.1073/pnas.1521318113. Epub 2016 Mar 24.


In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line.

Wang J, Zhang J, Zhang CJ, Wong YK, Lim TK, Hua ZC, Liu B, Tannenbaum SR, Shen HM, Lin Q.

Sci Rep. 2016 Feb 26;6:22146. doi: 10.1038/srep22146.


Hydroxyphenylation of Histone Lysines: Post-translational Modification by Quinone Imines.

Ravindra KC, Trudel LJ, Wishnok JS, Wogan GN, Tannenbaum SR, Skipper PL.

ACS Chem Biol. 2016 May 20;11(5):1230-7. doi: 10.1021/acschembio.5b00923. Epub 2016 Feb 18.


Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model.

Rivera-Burgos D, Sarkar U, Lever AR, Avram MJ, Coppeta JR, Wishnok JS, Borenstein JT, Tannenbaum SR.

Drug Metab Dispos. 2016 Feb;44(2):220-6. doi: 10.1124/dmd.115.066365. Epub 2015 Nov 19.


Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.

Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010. Epub 2015 Oct 5.


Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR.

Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.


Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.

Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29.


Protective effects of ascorbic acid against the genetic and epigenetic alterations induced by 3,5-dimethylaminophenol in AA8 cells.

Chao MW, Erkekoglu P, Tseng CY, Ye W, Trudel LJ, Skipper PL, Tannenbaum SR, Wogan GN.

J Appl Toxicol. 2015 May;35(5):466-77. doi: 10.1002/jat.3046. Epub 2014 Sep 1.


Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals.

Darby A, Lertpiriyapong K, Sarkar U, Seneviratne U, Park DS, Gamazon ER, Batchelder C, Cheung C, Buckley EM, Taylor NS, Shen Z, Tannenbaum SR, Wishnok JS, Fox JG.

PLoS One. 2014 Jul 24;9(7):e100542. doi: 10.1371/journal.pone.0100542. eCollection 2014.


Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds.

Erkekoglu P, Chao MW, Ye W, Ge J, Trudel LJ, Skipper PL, Kocer-Gumusel B, Engelward BP, Wogan GN, Tannenbaum SR.

Food Chem Toxicol. 2014 Oct;72:98-110. doi: 10.1016/j.fct.2014.06.031. Epub 2014 Jul 9.


Intracellular generation of ROS by 3,5-dimethylaminophenol: persistence, cellular response, and impact of molecular toxicity.

Chao MW, Erkekoglu P, Tseng CY, Ye W, Trudel LJ, Skipper PL, Tannenbaum SR, Wogan GN.

Toxicol Sci. 2014 Sep;141(1):300-13. doi: 10.1093/toxsci/kfu127. Epub 2014 Jun 27.


Dysregulated sphingolipid metabolism in endometriosis.

Lee YH, Tan CW, Venkatratnam A, Tan CS, Cui L, Loh SF, Griffith L, Tannenbaum SR, Chan JK.

J Clin Endocrinol Metab. 2014 Oct;99(10):E1913-21. doi: 10.1210/jc.2014-1340. Epub 2014 Jun 24.


Metabolomics Reveals Inflammatory-Linked Pulmonary Metabolic Alterations in a Murine Model of House Dust Mite-Induced Allergic Asthma.

Ho WE, Xu YJ, Cheng C, Peh HY, Tannenbaum SR, Wong WS, Ong CN.

J Proteome Res. 2014 Jul 2. [Epub ahead of print]


Molecular analysis of serum and bronchoalveolar lavage in a mouse model of influenza reveals markers of disease severity that can be clinically useful in humans.

Kumar Y, Liang C, Limmon GV, Liang L, Engelward BP, Ooi EE, Chen J, Tannenbaum SR.

PLoS One. 2014 Feb 5;9(2):e86912. doi: 10.1371/journal.pone.0086912. eCollection 2014.


Gut microbiome phenotypes driven by host genetics affect arsenic metabolism.

Lu K, Mahbub R, Cable PH, Ru H, Parry NM, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR.

Chem Res Toxicol. 2014 Feb 17;27(2):172-4. doi: 10.1021/tx400454z. Epub 2014 Feb 3.


Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis.

Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, Swenberg JA, Tannenbaum SR, Fox JG.

Environ Health Perspect. 2014 Mar;122(3):284-91. doi: 10.1289/ehp.1307429. Epub 2014 Jan 10.


Tunable membranes for free-flow zone electrophoresis in PDMS microchip using guided self-assembly of silica microbeads.

Song YA, Wu L, Tannenbaum SR, Wishnok JS, Han J.

Anal Chem. 2013 Dec 17;85(24):11695-9. doi: 10.1021/ac402169x. Epub 2013 Nov 25.


Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation.

Lu K, Cable PH, Abo RP, Ru H, Graffam ME, Schlieper KA, Parry NM, Levine S, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR.

Chem Res Toxicol. 2013 Dec 16;26(12):1893-903. doi: 10.1021/tx4002868. Epub 2013 Nov 18.


Serum metabolome and lipidome changes in adult patients with primary dengue infection.

Cui L, Lee YH, Kumar Y, Xu F, Lu K, Ooi EE, Tannenbaum SR, Ong CN.

PLoS Negl Trop Dis. 2013 Aug 15;7(8):e2373. doi: 10.1371/journal.pntd.0002373. eCollection 2013.


Chemistry meets biology in colitis-associated carcinogenesis.

Mangerich A, Dedon PC, Fox JG, Tannenbaum SR, Wogan GN.

Free Radic Res. 2013 Nov;47(11):958-86. doi: 10.3109/10715762.2013.832239. Epub 2013 Oct 4. Review.


Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease.

Knutson CG, Mangerich A, Zeng Y, Raczynski AR, Liberman RG, Kang P, Ye W, Prestwich EG, Lu K, Wishnok JS, Korzenik JR, Wogan GN, Fox JG, Dedon PC, Tannenbaum SR.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2332-41. doi: 10.1073/pnas.1222669110. Epub 2013 Jun 10.


Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs.

Seneviratne U, Godoy LC, Wishnok JS, Wogan GN, Tannenbaum SR.

J Am Chem Soc. 2013 May 22;135(20):7693-704. doi: 10.1021/ja401565w. Epub 2013 May 8.


Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissue.

Louissaint NA, Cao YJ, Skipper PL, Liberman RG, Tannenbaum SR, Nimmagadda S, Anderson JR, Everts S, Bakshi R, Fuchs EJ, Hendrix CW.

AIDS Res Hum Retroviruses. 2013 Nov;29(11):1443-50. doi: 10.1089/AID.2013.0044. Epub 2013 May 29.


Serum proteome and cytokine analysis in a longitudinal cohort of adults with primary dengue infection reveals predictive markers of DHF.

Kumar Y, Liang C, Bo Z, Rajapakse JC, Ooi EE, Tannenbaum SR.

PLoS Negl Trop Dis. 2012;6(11):e1887. doi: 10.1371/journal.pntd.0001887. Epub 2012 Nov 29.


Transimination of quinone imines: a mechanism for embedding exogenous redox activity into the nucleosome.

Ye W, Seneviratne UI, Chao MW, Ravindra KC, Wogan GN, Tannenbaum SR, Skipper PL.

Chem Res Toxicol. 2012 Dec 17;25(12):2627-9. doi: 10.1021/tx3004517. Epub 2012 Dec 3.


Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study.

Chen J, Flexner C, Liberman RG, Skipper PL, Louissaint NA, Tannenbaum SR, Hendrix CW, Fuchs EJ.

J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):593-9. doi: 10.1097/QAI.0b013e3182717c98.


Metabolomics reveals altered metabolic pathways in experimental asthma.

Ho WE, Xu YJ, Xu F, Cheng C, Peh HY, Tannenbaum SR, Wong WS, Ong CN.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):204-11. doi: 10.1165/rcmb.2012-0246OC. Epub 2012 Nov 9.


Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiation.

Cui L, Ye W, Prestwich EG, Wishnok JS, Taghizadeh K, Dedon PC, Tannenbaum SR.

Chem Res Toxicol. 2013 Feb 18;26(2):195-202. doi: 10.1021/tx300294d. Epub 2013 Jan 24.


In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra.

Lim KS, Cui L, Taghizadeh K, Wishnok JS, Chan W, DeMott MS, Babu IR, Tannenbaum SR, Dedon PC.

J Am Chem Soc. 2012 Oct 31;134(43):18053-64. doi: 10.1021/ja307525h. Epub 2012 Oct 22.


Infection, inflammation and colon carcinogenesis.

Wogan GN, Dedon PC, Tannenbaum SR, Fox JG.

Oncotarget. 2012 Aug;3(8):737-8. No abstract available.


Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism.

Lu K, Knutson CG, Wishnok JS, Fox JG, Tannenbaum SR.

J Proteome Res. 2012 Oct 5;11(10):4916-26. doi: 10.1021/pr300429x. Epub 2012 Sep 27.


Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.

Chao MW, Kim MY, Ye W, Ge J, Trudel LJ, Belanger CL, Skipper PL, Engelward BP, Tannenbaum SR, Wogan GN.

Toxicol Sci. 2012 Nov;130(1):48-59. doi: 10.1093/toxsci/kfs229. Epub 2012 Jul 24.


Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.

Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1820-9. doi: 10.1073/pnas.1207829109. Epub 2012 Jun 11.


Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma.

Ho WE, Cheng C, Peh HY, Xu F, Tannenbaum SR, Ong CN, Wong WS.

Free Radic Biol Med. 2012 Aug 1;53(3):498-507. doi: 10.1016/j.freeradbiomed.2012.05.021. Epub 2012 May 23.


Richard Loeppky (1937-2012).

Eisenbrand G, Gates KS, Hecht SS, Janzowski C, Keefer LK, Marnett LJ, Tannenbaum SR.

Chem Res Toxicol. 2012 Jun 18;25(6):1155-6. doi: 10.1021/tx300219b. Epub 2012 May 25. No abstract available.


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