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S3-Leitlinie Magenkarzinom – Diagnostik und Therapie der Adenokarzinome des Magens und des ösophagogastralen Übergangs – Langversion 2.0 – August 2019. AWMF-Registernummer: 032/009OL.

Moehler M, Al-Batran SE, Andus T, Arends J, Arnold D, Baretton G, Bornschein J, Budach W, Daum S, Dietrich C, Ebert M, Fischbach W, Flentje M, Gockel I, Grenacher L, Haier J, Höcht S, Jakobs R, Jenssen C, Kade B, Kanzler S, Langhorst J, Link H, Lordick F, Lorenz D, Lorenzen S, Lutz M, Messmann H, Meyer HJ, Mönig S, Ott K, Quante M, Röcken C, Schlattmann P, Schmiegel WH, Schreyer A, Tannapfel A, Thuss-Patience P, Weimann A, Unverzagt S.

Z Gastroenterol. 2019 Dec;57(12):1517-1632. doi: 10.1055/a-1018-2516. Epub 2019 Dec 11. German. No abstract available.


18F-FDG PET-MR enterography in predicting histological active disease using the Nancy index in ulcerative colitis: a randomized controlled trial.

Li Y, Schaarschmidt B, Umutlu L, Forsting M, Demircioglu A, Koch AK, Martin O, Herrmann K, Juette H, Tannapfel A, Langhorst J.

Eur J Nucl Med Mol Imaging. 2019 Oct 24. doi: 10.1007/s00259-019-04535-w. [Epub ahead of print]


Investigating the association between occupational exposure to asbestos and ovarian carcinoma: results from a pilot study in Germany.

Rajput Z, Hering KG, Kraus T, Tannapfel A, Sonnenschein G, Centmayer A, Radon K, Nowak D, Weinmann T.

BMC Public Health. 2019 Oct 22;19(1):1341. doi: 10.1186/s12889-019-7590-7.


FOLFOXIRI Plus Panitumumab As First-Line Treatment of RAS Wild-Type Metastatic Colorectal Cancer: The Randomized, Open-Label, Phase II VOLFI Study (AIO KRK0109).

Modest DP, Martens UM, Riera-Knorrenschild J, Greeve J, Florschütz A, Wessendorf S, Ettrich T, Kanzler S, Nörenberg D, Ricke J, Seidensticker M, Held S, Buechner-Steudel P, Atzpodien J, Heinemann V, Seufferlein T, Tannapfel A, Reinacher-Schick AC, Geissler M.

J Clin Oncol. 2019 Dec 10;37(35):3401-3411. doi: 10.1200/JCO.19.01340. Epub 2019 Oct 14.


An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.

Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A.

Cancers (Basel). 2019 Sep 21;11(10). pii: E1410. doi: 10.3390/cancers11101410.


Hypereosinophilic syndrome complicated by severe vascular damage and gangrene.

Gambichler T, Kröger ES, Tannapfel A, Dörler M, Susok L.

J Vasc Surg Cases Innov Tech. 2019 Aug 28;5(3):384-387. doi: 10.1016/j.jvscit.2017.12.001. eCollection 2019 Sep.


TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration.

Lang K, Kahveci S, Bonberg N, Wichert K, Behrens T, Hovanec J, Roghmann F, Noldus J, Tam YC, Tannapfel A, Käfferlein HU, Brüning T.

Int J Mol Sci. 2019 Sep 11;20(18). pii: E4483. doi: 10.3390/ijms20184483.


[Use of monoclonal antibodies in pathological diagnostics].

Förster S, Tannapfel A.

Internist (Berl). 2019 Oct;60(10):1021-1031. doi: 10.1007/s00108-019-00667-1. Review. German.


[Autopsy reveals rare cause of death].

Thum S, Tannapfel A, Hilje T, Sen Gupta R.

Pathologe. 2019 Aug 23. doi: 10.1007/s00292-019-00650-5. [Epub ahead of print] German.


Immunotherapy: New Options in Gastrointestinal Cancers?

Tannapfel A, Reinacher-Schick A, Hacker U, Lorenzen S, Möhler M, Vogel A.

Visc Med. 2019 Mar;35(1):47-51. doi: 10.1159/000497293. Epub 2019 Feb 14. No abstract available.


Immunotherapy in Gastrointestinal Cancer: Where Do We Stand?

Tannapfel A, Reinacher-Schick A.

Visc Med. 2019 Mar;35(1):1-2. doi: 10.1159/000497294. Epub 2019 Feb 8. No abstract available.


Phenotype of histologically suspected drug-induced colitis; results of a comparative, retrospective cohort study.

Brechmann T, Günther K, Neid M, Tannapfel A, Schmiegel W.

Scand J Gastroenterol. 2019 Jul;54(7):855-862. doi: 10.1080/00365521.2019.1630674. Epub 2019 Jun 19.


N-Methyl-D-Aspartate Receptor Encephalitis with Psychiatric Symptoms and an Ovarian Teratoma Detected by MRI in a 17-Year-Old Girl.

Barth A, Nassenstein I, Tröbs RB, Tannapfel A, Dercks H, Rostásy K, Wegener-Panzer A.

Neuropediatrics. 2019 Aug;50(4):253-256. doi: 10.1055/s-0039-1692417. Epub 2019 Jun 4.


Noninvasive diagnosis of urothelial cancer in urine using DNA hypermethylation signatures-Gender matters.

Köhler CU, Bonberg N, Ahrens M, Behrens T, Hovanec J, Eisenacher M, Noldus J, Deix T, Braun K, Gohlke H, Walter M, Tannapfel A, Tam Y, Sommerer F, Marcus K, Jöckel KH, Erbel R, Cantor CR, Käfferlein HU, Brüning T.

Int J Cancer. 2019 Nov 15;145(10):2861-2872. doi: 10.1002/ijc.32356. Epub 2019 May 16.


[Persistent Diarrhea of an Elderly Lady - How to Combine Blood Pressure and Diarrhea].

Israel H, Hartig A, Siebolts U, Wickenhauser C, Tannapfel A, Ernst F, Wahl U.

Dtsch Med Wochenschr. 2019 Mar;144(6):394-397. doi: 10.1055/a-0830-6521. Epub 2019 Mar 14. German.


A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer.

Berger AW, Schwerdel D, Reinacher-Schick A, Uhl W, Algül H, Friess H, Janssen KP, König A, Ghadimi M, Gallmeier E, Bartsch DK, Geissler M, Staib L, Tannapfel A, Kleger A, Beutel A, Schulte LA, Kornmann M, Ettrich TJ, Seufferlein T.

Theranostics. 2019 Feb 12;9(5):1280-1287. doi: 10.7150/thno.29247. eCollection 2019.


Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.

Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Maghnouj A, Müller MP, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler JG, Hahn SA, Siveke JT, Rauh D.

Cancer Res. 2019 May 1;79(9):2367-2378. doi: 10.1158/0008-5472.CAN-18-2861. Epub 2019 Mar 11.


ROBO1 Expression in Metastasizing Breast and Ovarian Cancer: SLIT2-induced Chemotaxis Requires Heparan Sulfates (Heparin).

Rezniczek GA, Grunwald C, Hilal Z, Scheich J, Reifenberger G, Tannapfel A, Tempfer CB.

Anticancer Res. 2019 Mar;39(3):1267-1273. doi: 10.21873/anticanres.13237.


Proposal of a new classification system for complete mesocolic excison in right-sided colon cancer.

Benz S, Tannapfel A, Tam Y, Grünenwald A, Vollmer S, Stricker I.

Tech Coloproctol. 2019 Mar;23(3):251-257. doi: 10.1007/s10151-019-01949-4. Epub 2019 Mar 5.


Triggers of histologically suspected drug-induced colitis.

Brechmann T, Günther K, Neid M, Schmiegel W, Tannapfel A.

World J Gastroenterol. 2019 Feb 28;25(8):967-979. doi: 10.3748/wjg.v25.i8.967.


Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer.

Witzke KE, Großerueschkamp F, Jütte H, Horn M, Roghmann F, von Landenberg N, Bracht T, Kallenbach-Thieltges A, Käfferlein H, Brüning T, Schork K, Eisenacher M, Marcus K, Noldus J, Tannapfel A, Sitek B, Gerwert K.

Am J Pathol. 2019 Mar;189(3):619-631. doi: 10.1016/j.ajpath.2018.11.018. Epub 2019 Feb 12.


Outcome Determining Factors of Intraductal Papillary Neoplasm of the Biliary Tract (IPNB)-a Single Center Survey and Analysis of Current Literature.

Höhn P, Braumann C, Munding J, Tannapfel A, Uhl W, Künzli BM.

J Gastrointest Cancer. 2019 Mar;50(1):160-169. doi: 10.1007/s12029-018-00199-1.


Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group.

Ettrich TJ, Berger AW, Perkhofer L, Daum S, König A, Dickhut A, Wittel U, Wille K, Geissler M, Algül H, Gallmeier E, Atzpodien J, Kornmann M, Muche R, Prasnikar N, Tannapfel A, Reinacher-Schick A, Uhl W, Seufferlein T.

BMC Cancer. 2018 Dec 29;18(1):1298. doi: 10.1186/s12885-018-5183-y.


Authors' response (April 30, 2018) to the letter to the editor concerning the paper "Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany".

Feder IS, Theile A, Tannapfel A.

Int J Occup Med Environ Health. 2018 Dec 20;31(6):849-851. doi: 10.13075/ijomeh.1896.01358. Epub 2018 Nov 28. No abstract available.


Amphiregulin (AREG) and Epiregulin (EREG) Gene Expression as Predictor for Overall Survival (OS) in Oxaliplatin/Fluoropyrimidine Plus Bevacizumab Treated mCRC Patients-Analysis of the Phase III AIO KRK-0207 Trial.

Stintzing S, Ivanova B, Ricard I, Jung A, Kirchner T, Tannapfel A, Juette H, Hegewisch-Becker S, Arnold D, Reinacher-Schick A.

Front Oncol. 2018 Nov 8;8:474. doi: 10.3389/fonc.2018.00474. eCollection 2018.


[The German Mesothelioma Register : Current pathological diagnostics and services].

Feder IS, Jülich M, Tannapfel A, Tischoff I.

Pathologe. 2018 Dec;39(Suppl 2):241-246. doi: 10.1007/s00292-018-0509-8. Review. German.


Authors' response (March 14, 2018) to the letter to the Editor concerning the paper "Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany".

Feder IS, Theile A, Tannapfel A.

Int J Occup Med Environ Health. 2018 Dec 20;31(6):841-843. doi: 10.13075/ijomeh.1896.01338. Epub 2018 Nov 13. No abstract available.


Ultrasound Imaging of Hepatocellular Adenoma Using the New Histology Classification.

Dietrich CF, Tannapfel A, Jang HJ, Kim TK, Burns PN, Dong Y.

Ultrasound Med Biol. 2019 Jan;45(1):1-10. doi: 10.1016/j.ultrasmedbio.2018.06.015. Epub 2018 Nov 3. Review.


Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.

Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T.

J Clin Invest. 2018 Nov 1;128(11):5056-5072. doi: 10.1172/JCI97912. Epub 2018 Oct 15.


Impact of the Localization of the Primary Tumor and RAS/BRAF Mutational Status on Maintenance Strategies After First-line Oxaliplatin, Fluoropyrimidine, and Bevacizumab in Metastatic Colorectal Cancer: Results From the AIO 0207 Trial.

Noepel-Duennebacke S, Arnold D, Hertel J, Tannapfel A, Hinke A, Hegewisch-Becker S, Reinacher-Schick A.

Clin Colorectal Cancer. 2018 Dec;17(4):e733-e739. doi: 10.1016/j.clcc.2018.07.007. Epub 2018 Jul 25.


[Meeting of the Gastroenteropathology Working Group on 24 May 2018 : 102nd annual conference of the German Society of Pathology in Berlin].

Tannapfel A.

Pathologe. 2018 Dec;39(Suppl 2):322-323. doi: 10.1007/s00292-018-0484-0. German. No abstract available.


Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis.

Gotzmann M, Grabbe S, Schöne D, von Frieling-Salewsky M, Dos Remedios CG, Strauch J, Bechtel M, Dietrich JW, Tannapfel A, Mügge A, Linke WA.

JACC Basic Transl Sci. 2018 Jun 25;3(3):335-346. doi: 10.1016/j.jacbts.2018.02.002. eCollection 2018 Jun.


Impact of primary tumour location and RAS/BRAF mutational status in metastatic colorectal cancer treated with first-line regimens containing oxaliplatin and bevacizumab: Prognostic factors from the AIO KRK0207 first-line and maintenance therapy trial.

Hegewisch-Becker S, Nöpel-Dünnebacke S, Hinke A, Graeven U, Reinacher-Schick A, Hertel J, Lerchenmüller CA, Killing B, Depenbusch R, Al-Batran SE, Lange T, Dietrich G, Tannapfel A, Arnold D.

Eur J Cancer. 2018 Sep;101:105-113. doi: 10.1016/j.ejca.2018.06.015. Epub 2018 Jul 20.


Risk of Malignancy in Adenomas Detected During Screening Colonoscopy.

Rösch T, Altenhofen L, Kretschmann J, Hagen B, Brenner H, Pox C, Schmiegel W, Theilmeier A, Aschenbeck J, Tannapfel A, von Stillfried D, Zimmermann-Fraedrich K, Wegscheider K.

Clin Gastroenterol Hepatol. 2018 Nov;16(11):1754-1761. doi: 10.1016/j.cgh.2018.05.043. Epub 2018 Jun 11.


Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer.

Weber L, Schulz WA, Philippou S, Eckardt J, Ubrig B, Hoffmann MJ, Tannapfel A, Kalbe B, Gisselmann G, Hatt H.

Front Physiol. 2018 May 16;9:456. doi: 10.3389/fphys.2018.00456. eCollection 2018.


Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections.

Kuepper C, Kallenbach-Thieltges A, Juette H, Tannapfel A, Großerueschkamp F, Gerwert K.

Sci Rep. 2018 May 16;8(1):7717. doi: 10.1038/s41598-018-26098-w.


Tuberculosis Mimicking Disseminated Peritoneal Carcinomatosis of a Sigmoid Carcinoma.

Fahlbusch T, Künzli B, Schlottmann R, Tannapfel A, Uhl W, Braumann C.

J Gastrointest Surg. 2019 Apr;23(4):877-878. doi: 10.1007/s11605-018-3800-3. Epub 2018 May 7.


Ocular Metastasis of Bronchial Typical Carcinoid.

Guo Y, Shao C, Blau T, Tannapfel A, Koch KR, Heindl LM.

J Thorac Oncol. 2018 Sep;13(9):1422-1423. doi: 10.1016/j.jtho.2018.04.001. Epub 2018 Apr 7. No abstract available.


Acinar Cell Cystadenoma - a Rarity in Advanced von Hippel-Lindau Disease: A Case Report.

Fahlbusch T, Tannapfel A, Uhl W, Braumann C.

Visc Med. 2018 Feb;34(1):73-75. doi: 10.1159/000480372. Epub 2017 Oct 11.


CUP Syndrome-Metastatic Malignancy with Unknown Primary Tumor.

Zaun G, Schuler M, Herrmann K, Tannapfel A.

Dtsch Arztebl Int. 2018 Mar 9;115(10):157-162. doi: 10.3238/arztebl.2018.0157. Review.


Perioperative chemotherapy with or without epidermal growth factor receptor blockade in unselected patients with locally advanced oesophagogastric adenocarcinoma: Randomized phase II study with advanced biomarker program of the German Cancer Society (AIO/CAO STO-0801).

Stahl M, Maderer A, Lordick F, Mihaljevic AL, Kanzler S, Hoehler T, Thuss-Patience P, Mönig S, Kunzmann V, Schroll S, Sandermann A, Tannapfel A, Meyer HJ, Schuhmacher C, Wilke H, Moehler M; Arbeitsgemeinschaft Internistische Onkologie (AIO) Oesophageal and Gastric Cancer Working Group and the Chirurgische Arbeitsgemeinschaft Onkologie (CAOGI/DGAV) of the German Cancer Society.

Eur J Cancer. 2018 Apr;93:119-126. doi: 10.1016/j.ejca.2018.01.079. Epub 2018 Mar 20.


Olfactory Receptors as Biomarkers in Human Breast Carcinoma Tissues.

Weber L, Maßberg D, Becker C, Altmüller J, Ubrig B, Bonatz G, Wölk G, Philippou S, Tannapfel A, Hatt H, Gisselmann G.

Front Oncol. 2018 Feb 15;8:33. doi: 10.3389/fonc.2018.00033. eCollection 2018.


Histopathological changes resulting from selective internal radiotherapy (SIRT).

Justinger C, Gruden J, Kouladouros K, Stravodimos C, Reimer P, Tannapfel A, Binnenhei M, Bentz M, Tatsch K, Rüdiger T, Schön MR.

J Surg Oncol. 2018 Apr;117(5):1084-1091. doi: 10.1002/jso.24967. Epub 2018 Feb 15.


A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity.

Díaz-Carballo D, Saka S, Klein J, Rennkamp T, Acikelli AH, Malak S, Jastrow H, Wennemuth G, Tempfer C, Schmitz I, Tannapfel A, Strumberg D.

Cancer Res. 2018 May 1;78(9):2318-2331. doi: 10.1158/0008-5472.CAN-17-1861. Epub 2018 Feb 12.


Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas.

Lang K, Bonberg N, Robens S, Behrens T, Hovanec J, Deix T, Braun K, Roghmann F, Noldus J, Harth V, Jöckel KH, Erbel R, Tam YC, Tannapfel A, Käfferlein HU, Brüning T.

Oncotarget. 2017 Sep 8;8(62):104946-104959. doi: 10.18632/oncotarget.20737. eCollection 2017 Dec 1.


Correspondence regarding the article "The asbestos fibre burden in human lungs: new insights into the chrysotile debate".

Feder IS, Tischoff I, Theile A, Schmitz I, Merget R, Tannapfel A.

Eur Respir J. 2017 Dec 21;50(6). pii: 1702204. doi: 10.1183/13993003.02204-2017. Print 2017 Dec. No abstract available.


Intraventricular melanocytoma diagnosis confirmed by gene mutation profile.

Knappe UJ, Tischoff I, Tannapfel A, Reinbold WD, Möller I, Sucker A, Schadendorf D, Griewank KG, van de Nes JAP.

Neuropathology. 2018 Jun;38(3):288-292. doi: 10.1111/neup.12443. Epub 2017 Dec 11.


[Precancerous and early stage cancer of the bile duct system].

Tautenhahn HM, Brückner S, Rauchfuß F, Donndorf F, Ardelt M, Fahrner R, Tannapfel A, Settmacher U.

Chirurg. 2018 Apr;89(4):274-280. doi: 10.1007/s00104-017-0553-6. Review. German.


Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany.

Feder IS, Theile A, Tannapfel A.

Int J Occup Med Environ Health. 2018 Jan 15;31(3):293-305. doi: 10.13075/ijomeh.1896.01148. Epub 2017 Nov 2.



Tischoff I, Tannapfel A.

Pathologe. 2017 Nov;38(6):547-560. doi: 10.1007/s00292-017-0364-z. German.


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