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Items: 1 to 50 of 60

1.

Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains.

Hussack G, Ryan S, van Faassen H, Rossotti M, MacKenzie CR, Tanha J.

PLoS One. 2018 Dec 12;13(12):e0208978. doi: 10.1371/journal.pone.0208978. eCollection 2018.

2.

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.

Rossotti MA, Henry KA, van Faassen H, Tanha J, Callaghan D, Hussack G, Arbabi-Ghahroudi M, MacKenzie CR.

Biochem J. 2019 Jan 7;476(1):39-50. doi: 10.1042/BCJ20180795.

PMID:
30455372
3.

Performance evaluation of phage-displayed synthetic human single-domain antibody libraries: A retrospective analysis.

Henry KA, Tanha J.

J Immunol Methods. 2018 May;456:81-86. doi: 10.1016/j.jim.2018.02.009. Epub 2018 Feb 17.

PMID:
29462605
4.

Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody.

Sulea T, Hussack G, Ryan S, Tanha J, Purisima EO.

Sci Rep. 2018 Feb 2;8(1):2260. doi: 10.1038/s41598-018-20599-4.

5.

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries.

Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J.

Front Immunol. 2017 Dec 12;8:1759. doi: 10.3389/fimmu.2017.01759. eCollection 2017.

6.

A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders.

Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J.

Mol Immunol. 2017 Oct;90:190-196. doi: 10.1016/j.molimm.2017.07.006. Epub 2017 Aug 15.

PMID:
28820969
7.

Attitudes Toward Cancer and Cancer Patients in an Urban Iranian Population.

Badihian S, Choi EK, Kim IR, Parnia A, Manouchehri N, Badihian N, Tanha JM, Guallar E, Cho J.

Oncologist. 2017 Aug;22(8):944-950. doi: 10.1634/theoncologist.2017-0073. Epub 2017 May 30.

8.

Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing.

Henry KA, Hussack G, Collins C, Zwaagstra JC, Tanha J, MacKenzie CR.

Protein Eng Des Sel. 2016 Oct;29(10):439-443. doi: 10.1093/protein/gzw043. Epub 2016 Sep 8.

PMID:
27613412
9.

An update on antibody-based immunotherapies for Clostridium difficile infection.

Hussack G, Tanha J.

Clin Exp Gastroenterol. 2016 Aug 1;9:209-24. doi: 10.2147/CEG.S84017. eCollection 2016. Review.

10.

Fighting cancer together: Development and implementation of shared medical appointments to standardize and improve chemotherapy education.

Prescott LS, Dickens AS, Guerra SL, Tanha JM, Phillips DG, Patel KT, Umberson KM, Lozano MA, Lowe KB, Brown AJ, Taylor JS, Soliman PT, Garcia EA, Levenback CF, Bodurka DC.

Gynecol Oncol. 2016 Jan;140(1):114-9. doi: 10.1016/j.ygyno.2015.11.006. Epub 2015 Nov 5.

11.

Identification of cross-reactive single-domain antibodies against serum albumin using next-generation DNA sequencing.

Henry KA, Tanha J, Hussack G.

Protein Eng Des Sel. 2015 Oct;28(10):379-83. doi: 10.1093/protein/gzv039. Epub 2015 Aug 27.

PMID:
26319004
12.

Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease.

Kandalaft H, Hussack G, Aubry A, van Faassen H, Guan Y, Arbabi-Ghahroudi M, MacKenzie R, Logan SM, Tanha J.

Appl Microbiol Biotechnol. 2015 Oct;99(20):8549-62. doi: 10.1007/s00253-015-6594-1. Epub 2015 May 5.

13.

Mutational approaches to improve the biophysical properties of human single-domain antibodies.

Kim DY, Hussack G, Kandalaft H, Tanha J.

Biochim Biophys Acta. 2014 Nov;1844(11):1983-2001. doi: 10.1016/j.bbapap.2014.07.008. Epub 2014 Jul 24. Review.

PMID:
25065345
14.

Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.

Hussack G, Riazi A, Ryan S, van Faassen H, MacKenzie R, Tanha J, Arbabi-Ghahroudi M.

Protein Eng Des Sel. 2014 Jun;27(6):191-8. doi: 10.1093/protein/gzu011. Epub 2014 Apr 16.

PMID:
24742504
15.

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.

Kim DY, To R, Kandalaft H, Ding W, van Faassen H, Luo Y, Schrag JD, St-Amant N, Hefford M, Hirama T, Kelly JF, MacKenzie R, Tanha J.

MAbs. 2014 Jan-Feb;6(1):219-35. doi: 10.4161/mabs.26844.

16.

Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile.

Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK.

J Biol Chem. 2014 Jan 24;289(4):2331-43. doi: 10.1074/jbc.M113.505917. Epub 2013 Dec 5.

17.

Disulfide linkage engineering for improving biophysical properties of human VH domains.

Kim DY, Kandalaft H, Ding W, Ryan S, van Faassen H, Hirama T, Foote SJ, MacKenzie R, Tanha J.

Protein Eng Des Sel. 2012 Oct;25(10):581-9. Epub 2012 Aug 30.

PMID:
22942392
18.

Characterization of single-domain antibodies with an engineered disulfide bond.

Hussack G, Mackenzie CR, Tanha J.

Methods Mol Biol. 2012;911:417-29. doi: 10.1007/978-1-61779-968-6_25.

PMID:
22886266
19.

Solubility and stability engineering of human VH domains.

Kim DY, Ding W, Tanha J.

Methods Mol Biol. 2012;911:355-72. doi: 10.1007/978-1-61779-968-6_21.

PMID:
22886262
20.

Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies.

Hussack G, Arbabi-Ghahroudi M, Mackenzie CR, Tanha J.

Methods Mol Biol. 2012;911:211-39. doi: 10.1007/978-1-61779-968-6_14.

PMID:
22886255
21.

Modulation of toxin production by the flagellar regulon in Clostridium difficile.

Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM.

Infect Immun. 2012 Oct;80(10):3521-32. doi: 10.1128/IAI.00224-12. Epub 2012 Jul 30.

22.

Surface-immobilization of chromatographically purified bacteriophages for the optimized capture of bacteria.

Naidoo R, Singh A, Arya SK, Beadle B, Glass N, Tanha J, Szymanski CM, Evoy S.

Bacteriophage. 2012 Jan 1;2(1):15-24.

23.

A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders.

Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J.

Protein Eng Des Sel. 2012 Jun;25(6):313-8. doi: 10.1093/protein/gzs014. Epub 2012 Apr 6.

PMID:
22490957
24.

Crystal structure of a human single domain antibody dimer formed through V(H)-V(H) non-covalent interactions.

Baral TN, Chao SY, Li S, Tanha J, Arbabi-Ghahroudi M, Zhang J, Wang S.

PLoS One. 2012;7(1):e30149. doi: 10.1371/journal.pone.0030149. Epub 2012 Jan 12.

25.

Silica encapsulated SERS nanoprobe conjugated to the bacteriophage tailspike protein for targeted detection of Salmonella.

Tay LL, Huang PJ, Tanha J, Ryan S, Wu X, Hulse J, Chau LK.

Chem Commun (Camb). 2012 Jan 25;48(7):1024-6. doi: 10.1039/c1cc16325f. Epub 2011 Dec 8.

PMID:
22158658
26.

Engineered single-domain antibodies with high protease resistance and thermal stability.

Hussack G, Hirama T, Ding W, Mackenzie R, Tanha J.

PLoS One. 2011;6(11):e28218. doi: 10.1371/journal.pone.0028218. Epub 2011 Nov 30.

27.

Multifunctional nanoprobes for pathogen-selective capture and detection.

Paquet C, Ryan S, Zou S, Kell A, Tanha J, Hulse J, Tay LL, Simard B.

Chem Commun (Camb). 2012 Jan 14;48(4):561-3. doi: 10.1039/c1cc16245d. Epub 2011 Nov 8.

PMID:
22068209
28.

Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain.

Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, Tanha J.

J Biol Chem. 2011 Mar 18;286(11):8961-76. doi: 10.1074/jbc.M110.198754. Epub 2011 Jan 7.

29.

Orally administered P22 phage tailspike protein reduces salmonella colonization in chickens: prospects of a novel therapy against bacterial infections.

Waseh S, Hanifi-Moghaddam P, Coleman R, Masotti M, Ryan S, Foss M, MacKenzie R, Henry M, Szymanski CM, Tanha J.

PLoS One. 2010 Nov 22;5(11):e13904. doi: 10.1371/journal.pone.0013904.

30.

Site-directed mutagenesis for improving biophysical properties of VH domains.

Arbabi-Ghahroudi M, Mackenzie R, Tanha J.

Methods Mol Biol. 2010;634:309-30. doi: 10.1007/978-1-60761-652-8_22.

PMID:
20676993
31.

Bacteriophage tailspike proteins as molecular probes for sensitive and selective bacterial detection.

Singh A, Arya SK, Glass N, Hanifi-Moghaddam P, Naidoo R, Szymanski CM, Tanha J, Evoy S.

Biosens Bioelectron. 2010 Sep 15;26(1):131-8. doi: 10.1016/j.bios.2010.05.024. Epub 2010 May 24.

PMID:
20541928
32.

Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives.

Hussack G, Tanha J.

Toxins (Basel). 2010 May;2(5):998-1018. doi: 10.3390/toxins2050998. Epub 2010 May 7. Review.

33.

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis for screening nonaggregating human antibody heavy chain variable domains.

Kim DY, Tanha J.

Anal Biochem. 2010 Aug;403(1-2):117-9. doi: 10.1016/j.ab.2010.04.017. Epub 2010 Apr 18.

PMID:
20406618
34.

Single-domain antibody-nanoparticles: promising architectures for increased staphylococcus aureus detection specificity and sensitivity.

Ryan S, Kell AJ, van Faassen H, Tay LL, Simard B, MacKenzie R, Gilbert M, Tanha J.

Bioconjug Chem. 2009 Oct 21;20(10):1966-74. doi: 10.1021/bc900332r. Epub 2009 Sep 14.

PMID:
19751063
35.

Single-domain antibody-conjugated nanoaggregate-embedded beads for targeted detection of pathogenic bacteria.

Huang PJ, Tay LL, Tanha J, Ryan S, Chau LK.

Chemistry. 2009 Sep 21;15(37):9330-4. doi: 10.1002/chem.200901397. No abstract available.

PMID:
19655352
36.

Design, selection and binding mechanism of bivalent miniproteins targeting human thrombin.

Ng A, Tanha J, Narang S, Ni F.

Adv Exp Med Biol. 2009;611:417-8. No abstract available.

PMID:
19400247
37.

Selection of non-aggregating VH binders from synthetic VH phage-display libraries.

Arbabi-Ghahroudi M, MacKenzie R, Tanha J.

Methods Mol Biol. 2009;525:187-216, xiii. doi: 10.1007/978-1-59745-554-1_10.

PMID:
19252860
38.

Multivalent anchoring and oriented display of single-domain antibodies on cellulose.

Hussack G, Luo Y, Veldhuis L, Hall JC, Tanha J, Mackenzie R.

Sensors (Basel). 2009;9(7):5351-67. doi: 10.3390/s90705351. Epub 2009 Jul 7.

39.

Isolation of monoclonal antibody fragments from phage display libraries.

Arbabi-Ghahroudi M, Tanha J, MacKenzie R.

Methods Mol Biol. 2009;502:341-64. doi: 10.1007/978-1-60327-565-1_20.

PMID:
19082566
40.

Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points.

Arbabi-Ghahroudi M, To R, Gaudette N, Hirama T, Ding W, MacKenzie R, Tanha J.

Protein Eng Des Sel. 2009 Feb;22(2):59-66. doi: 10.1093/protein/gzn071. Epub 2008 Nov 24.

PMID:
19033278
41.

Isolation and functional characterization of single domain antibody modulators of Caspase-3 and apoptosis.

McGonigal K, Tanha J, Palazov E, Li S, Gueorguieva-Owens D, Pandey S.

Appl Biochem Biotechnol. 2009 May;157(2):226-36. doi: 10.1007/s12010-008-8266-4. Epub 2008 Jun 14.

PMID:
18553063
42.

Prototype single step lateral flow technology for detection of avian influenza virus and chicken antibody to avian influenza virus.

Nielsen K, Yu WL, Lin M, Davis SA, Elmgren C, Mackenzie R, Tanha J, Li S, Dubuc G, Brown EG, Keleta L, Pasick J.

J Immunoassay Immunochem. 2007;28(4):307-18.

PMID:
17885885
43.

Synthesis and characterization of CN-modified protein analogues as potential vibrational contrast agents.

Noestheden M, Hu Q, Tay LL, Tonary AM, Stolow A, MacKenzie R, Tanha J, Pezacki JP.

Bioorg Chem. 2007 Jun;35(3):284-93. Epub 2007 Feb 21.

PMID:
17316745
44.

The assembly of single domain antibodies into bispecific decavalent molecules.

Stone E, Hirama T, Tanha J, Tong-Sevinc H, Li S, MacKenzie CR, Zhang J.

J Immunol Methods. 2007 Jan 10;318(1-2):88-94. Epub 2006 Nov 17.

PMID:
17141798
45.

Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis.

Gueorguieva D, Li S, Walsh N, Mukerji A, Tanha J, Pandey S.

FASEB J. 2006 Dec;20(14):2636-8. Epub 2006 Oct 23.

PMID:
17060401
46.

Improving solubility and refolding efficiency of human V(H)s by a novel mutational approach.

Tanha J, Nguyen TD, Ng A, Ryan S, Ni F, Mackenzie R.

Protein Eng Des Sel. 2006 Nov;19(11):503-9. Epub 2006 Sep 13.

PMID:
16971398
47.

Prokaryotic expression of antibodies.

Arbabi-Ghahroudi M, Tanha J, MacKenzie R.

Cancer Metastasis Rev. 2005 Dec;24(4):501-19. Review.

PMID:
16408159
48.

Isolation of monomeric human V(H)s by a phage selection.

To R, Hirama T, Arbabi-Ghahroudi M, MacKenzie R, Wang P, Xu P, Ni F, Tanha J.

J Biol Chem. 2005 Dec 16;280(50):41395-403. Epub 2005 Oct 12.

49.

Affinity maturation of a V(H)H by mutational hotspot randomization.

Yau KY, Dubuc G, Li S, Hirama T, Mackenzie CR, Jermutus L, Hall JC, Tanha J.

J Immunol Methods. 2005 Feb;297(1-2):213-24. Epub 2005 Jan 20.

PMID:
15777944
50.

Pentamerization of single-domain antibodies from phage libraries: a novel strategy for the rapid generation of high-avidity antibody reagents.

Zhang J, Tanha J, Hirama T, Khieu NH, To R, Tong-Sevinc H, Stone E, Brisson JR, MacKenzie CR.

J Mol Biol. 2004 Jan 2;335(1):49-56.

PMID:
14659739

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