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Items: 1 to 50 of 94

1.

Microbiome analysis as a platform R&D tool for parasitic nematode disease management.

Hogan G, Walker S, Turnbull F, Curiao T, Morrison AA, Flores Y, Andrews L, Claesson MJ, Tangney M, Bartley DJ.

ISME J. 2019 Jun 25. doi: 10.1038/s41396-019-0462-4. [Epub ahead of print]

PMID:
31239540
2.

Resident bacteria in breast cancer tissue: pathogenic agents or harmless commensals?

O'Connor H, MacSharry J, Bueso YF, Lindsay S, Kavanagh EL, Tangney M, Clyne M, Saldova R, McCann A.

Discov Med. 2018 Sep;26(142):93-102. Review.

3.

The Who, What, and Why of Drug Discovery and Development.

Hogan G, Tangney M.

Trends Pharmacol Sci. 2018 Oct;39(10):848-852. doi: 10.1016/j.tips.2018.08.002. Epub 2018 Sep 6.

PMID:
30196936
4.

Ascending Vaginal Infection Using Bioluminescent Bacteria Evokes Intrauterine Inflammation, Preterm Birth, and Neonatal Brain Injury in Pregnant Mice.

Suff N, Karda R, Diaz JA, Ng J, Baruteau J, Perocheau D, Tangney M, Taylor PW, Peebles D, Buckley SMK, Waddington SN.

Am J Pathol. 2018 Oct;188(10):2164-2176. doi: 10.1016/j.ajpath.2018.06.016. Epub 2018 Jul 21.

5.

In situ biomolecule production by bacteria; a synthetic biology approach to medicine.

Flores Bueso Y, Lehouritis P, Tangney M.

J Control Release. 2018 Apr 10;275:217-228. doi: 10.1016/j.jconrel.2018.02.023. Epub 2018 Feb 22. Review.

PMID:
29477351
6.

Development of a Click Beetle Luciferase Reporter System for Enhanced Bioluminescence Imaging of Listeria monocytogenes: Analysis in Cell Culture and Murine Infection Models.

Ur Rahman S, Stanton M, Casey PG, Spagnuolo A, Bensi G, Hill C, Francis KP, Tangney M, Gahan CGM.

Front Microbiol. 2017 Sep 26;8:1797. doi: 10.3389/fmicb.2017.01797. eCollection 2017.

7.

Designer bacteria as intratumoural enzyme biofactories.

Lehouritis P, Hogan G, Tangney M.

Adv Drug Deliv Rev. 2017 Sep 1;118:8-23. doi: 10.1016/j.addr.2017.09.012. Epub 2017 Sep 12. Review.

PMID:
28916496
8.

Intratumoural production of TNF╬▒ by bacteria mediates cancer therapy.

Murphy C, Rettedal E, Lehouritis P, Devoy C, Tangney M.

PLoS One. 2017 Jun 29;12(6):e0180034. doi: 10.1371/journal.pone.0180034. eCollection 2017.

9.

Synthetic Biology in the Driving Seat of the Bioeconomy.

Flores Bueso Y, Tangney M.

Trends Biotechnol. 2017 May;35(5):373-378. doi: 10.1016/j.tibtech.2017.02.002. Epub 2017 Feb 27.

PMID:
28249675
10.

The Microbiota of Breast Tissue and Its Association with Breast Cancer.

Urbaniak C, Gloor GB, Brackstone M, Scott L, Tangney M, Reid G.

Appl Environ Microbiol. 2016 Jul 29;82(16):5039-48. doi: 10.1128/AEM.01235-16. Print 2016 Aug 15.

11.

In Vivo Bioluminescence Imaging of Intratumoral Bacteria.

Cronin M, Akin AR, Francis KP, Tangney M.

Methods Mol Biol. 2016;1409:69-77. doi: 10.1007/978-1-4939-3515-4_7.

PMID:
26846803
12.

Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria.

Lehouritis P, Stanton M, McCarthy FO, Jeavons M, Tangney M.

J Control Release. 2016 Jan 28;222:9-17. doi: 10.1016/j.jconrel.2015.11.030. Epub 2015 Dec 2.

PMID:
26655063
13.

Local bacteria affect the efficacy of chemotherapeutic drugs.

Lehouritis P, Cummins J, Stanton M, Murphy CT, McCarthy FO, Reid G, Urbaniak C, Byrne WL, Tangney M.

Sci Rep. 2015 Sep 29;5:14554. doi: 10.1038/srep14554.

14.

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.

Vorobyeva AG, Stanton M, Godinat A, Lund KB, Karateev GG, Francis KP, Allen E, Gelovani JG, McCormack E, Tangney M, Dubikovskaya EA.

PLoS One. 2015 Jun 25;10(6):e0131037. doi: 10.1371/journal.pone.0131037. eCollection 2015.

15.

In vivo bacterial imaging without engineering; A novel probe-based strategy facilitated by endogenous nitroreductase enzymes.

Stanton M, Cronin M, Lehouritis P, Tangney M.

Curr Gene Ther. 2015;15(3):277-88.

PMID:
25619884
16.

Bacterial-mediated DNA delivery to tumour associated phagocytic cells.

Byrne WL, Murphy CT, Cronin M, Wirth T, Tangney M.

J Control Release. 2014 Dec 28;196:384-93. doi: 10.1016/j.jconrel.2014.10.030. Epub 2014 Nov 17.

PMID:
25466954
17.

Oral tolerance to cancer can be abrogated by T regulatory cell inhibition.

Whelan MC, Casey G, Larkin JO, Guinn BA, O'Sullivan GC, Tangney M.

PLoS One. 2014 May 15;9(5):e97602. doi: 10.1371/journal.pone.0097602. eCollection 2014.

18.

Microbiota of human breast tissue.

Urbaniak C, Cummins J, Brackstone M, Macklaim JM, Gloor GB, Baban CK, Scott L, O'Hanlon DM, Burton JP, Francis KP, Tangney M, Reid G.

Appl Environ Microbiol. 2014 May;80(10):3007-14. doi: 10.1128/AEM.00242-14. Epub 2014 Mar 7.

19.

Bacterial-mediated knockdown of tumor resistance to an oncolytic virus enhances therapy.

Cronin M, Le Boeuf F, Murphy C, Roy DG, Falls T, Bell JC, Tangney M.

Mol Ther. 2014 Jun;22(6):1188-1197. doi: 10.1038/mt.2014.23. Epub 2014 Feb 26.

20.

Bacterial systems for gene delivery to systemic tumors.

Cummins J, Cronin M, van Pijkeren JP, Gahan CG, Tangney M.

Methods Mol Biol. 2014;1141:201-9. doi: 10.1007/978-1-4939-0363-4_13.

PMID:
24567141
21.

Bacterial-directed enzyme prodrug therapy.

Lehouritis P, Springer C, Tangney M.

J Control Release. 2013 Aug 28;170(1):120-31. doi: 10.1016/j.jconrel.2013.05.005. Epub 2013 May 17. Review.

PMID:
23688772
22.

Use of optical imaging to progress novel therapeutics to the clinic.

Byrne WL, DeLille A, Kuo C, de Jong JS, van Dam GM, Francis KP, Tangney M.

J Control Release. 2013 Dec 10;172(2):523-34. doi: 10.1016/j.jconrel.2013.05.004. Epub 2013 May 13. Review.

PMID:
23680286
23.

Bacteria and tumours: causative agents or opportunistic inhabitants?

Cummins J, Tangney M.

Infect Agent Cancer. 2013 Mar 28;8(1):11. doi: 10.1186/1750-9378-8-11.

24.

New targets for the immunotherapy of colon cancer-does reactive disease hold the answer?

Boncheva V, Bonney SA, Brooks SE, Tangney M, O'Sullivan G, Mirnezami A, Guinn BA.

Cancer Gene Ther. 2013 Mar;20(3):157-68. doi: 10.1038/cgt.2013.5. Epub 2013 Mar 15. Review.

PMID:
23492821
25.

Adenovirus-mediated transcriptional targeting of colorectal cancer and effects on treatment-resistant hypoxic cells.

Rajendran S, O'Sullivan GC, O'Hanlon D, Tangney M.

Clin Colorectal Cancer. 2013 Sep;12(3):152-162.e1. doi: 10.1016/j.clcc.2012.11.005. Epub 2013 Jan 10.

PMID:
23313233
26.

Bioluminescent bacterial imaging in vivo.

Baban CK, Cronin M, Akin AR, O'Brien A, Gao X, Tabirca S, Francis KP, Tangney M.

J Vis Exp. 2012 Nov 4;(69):e4318. doi: 10.3791/4318.

27.

DNA vaccination for prostate cancer, from preclinical to clinical trials - where we stand?

Ahmad S, Sweeney P, Sullivan GC, Tangney M.

Genet Vaccines Ther. 2012 Oct 9;10(1):9. doi: 10.1186/1479-0556-10-9.

28.

Bacterial vectors for imaging and cancer gene therapy: a review.

Cronin M, Stanton RM, Francis KP, Tangney M.

Cancer Gene Ther. 2012 Nov;19(11):731-40. doi: 10.1038/cgt.2012.59. Epub 2012 Sep 21. Review.

PMID:
22996740
29.

Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity.

Collins JW, Akin AR, Kosta A, Zhang N, Tangney M, Francis KP, Frankel G.

Microbiology. 2012 Nov;158(Pt 11):2826-34. doi: 10.1099/mic.0.060830-0. Epub 2012 Aug 17.

30.

Control and augmentation of long-term plasmid transgene expression in vivo in murine muscle tissue and ex vivo in patient mesenchymal tissue.

Morrissey D, van Pijkeren JP, Rajendran S, Collins SA, Casey G, O'Sullivan GC, Tangney M.

J Biomed Biotechnol. 2012;2012:379845. doi: 10.1155/2012/379845. Epub 2012 Jul 1.

31.

Polymer coatings for delivery of nucleic acid therapeutics.

Laga R, Carlisle R, Tangney M, Ulbrich K, Seymour LW.

J Control Release. 2012 Jul 20;161(2):537-53. doi: 10.1016/j.jconrel.2012.02.013. Epub 2012 Feb 18. Review.

PMID:
22366547
32.

Editorial: in vivo imaging & gene therapy.

Tangney M.

Curr Gene Ther. 2012 Feb 1;12(1):1. No abstract available.

PMID:
22348524
33.

High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting.

Cronin M, Akin AR, Collins SA, Meganck J, Kim JB, Baban CK, Joyce SA, van Dam GM, Zhang N, van Sinderen D, O'Sullivan GC, Kasahara N, Gahan CG, Francis KP, Tangney M.

PLoS One. 2012;7(1):e30940. doi: 10.1371/journal.pone.0030940. Epub 2012 Jan 25.

34.

PET imaging for gene & cell therapy.

Collins SA, Hiraoka K, Inagaki A, Kasahara N, Tangney M.

Curr Gene Ther. 2012 Feb 1;12(1):20-32. Review.

PMID:
22263921
35.

In vivo optical imaging in gene & cell therapy.

Tangney M, Francis KP.

Curr Gene Ther. 2012 Feb 1;12(1):2-11. Review.

PMID:
22263919
36.

Induction of effective antitumor response after mucosal bacterial vector mediated DNA vaccination with endogenous prostate cancer specific antigen.

Ahmad S, Casey G, Cronin M, Rajendran S, Sweeney P, Tangney M, O'Sullivan GC.

J Urol. 2011 Aug;186(2):687-93. doi: 10.1016/j.juro.2011.03.139. Epub 2011 Jun 17.

PMID:
21683415
37.

Targeting of breast metastases using a viral gene vector with tumour-selective transcription.

Rajendran S, Collins S, van Pijkeren JP, O'Hanlon D, O'Sullivan GC, Tangney M.

Anticancer Res. 2011 May;31(5):1627-35.

PMID:
21617219
38.

Bacteria as vectors for gene therapy of cancer.

Baban CK, Cronin M, O'Hanlon D, O'Sullivan GC, Tangney M.

Bioeng Bugs. 2010 Nov-Dec;1(6):385-94. doi: 10.4161/bbug.1.6.13146. Review.

39.

Preclinical evaluation of gene delivery methods for the treatment of loco-regional disease in breast cancer.

Rajendran S, O'Hanlon D, Morrissey D, O'Donovan T, O'Sullivan GC, Tangney M.

Exp Biol Med (Maywood). 2011 Apr 1;236(4):423-34. doi: 10.1258/ebm.2011.010234. Epub 2011 Mar 28.

PMID:
21444371
40.

The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy.

Tangney M, van Pijkeren JP, Gahan CG.

Bioeng Bugs. 2010 Jul-Aug;1(4):284-7. doi: 10.4161/bbug.1.4.11725. Epub 2010 Mar 7.

41.

Ex vivo culture of patient tissue & examination of gene delivery.

Rajendran S, Salwa S, Gao X, Tabirca S, O'Hanlon D, O'Sullivan GC, Tangney M.

J Vis Exp. 2010 Dec 20;(46). pii: 2378. doi: 10.3791/2378.

42.

The emerging role of viruses in the treatment of solid tumours.

Bourke MG, Salwa S, Harrington KJ, Kucharczyk MJ, Forde PF, de Kruijf M, Soden D, Tangney M, Collins JK, O'Sullivan GC.

Cancer Treat Rev. 2011 Dec;37(8):618-32. doi: 10.1016/j.ctrv.2010.12.003. Epub 2011 Jan 12. Review.

PMID:
21232872
43.

AAV2-mediated in vivo immune gene therapy of solid tumours.

Collins SA, Buhles A, Scallan MF, Harrison PT, O'Hanlon DM, O'Sullivan GC, Tangney M.

Genet Vaccines Ther. 2010 Dec 20;8:8. doi: 10.1186/1479-0556-8-8.

44.

Gene therapy for cancer: dairy bacteria as delivery vectors.

Tangney M.

Discov Med. 2010 Sep;10(52):195-200. Review.

45.

Murine bioluminescent hepatic tumour model.

Rajendran S, Salwa S, Gao X, Tabirca S, O'Hanlon D, O'Sullivan GC, Tangney M.

J Vis Exp. 2010 Jul 17;(41). pii: 1977. doi: 10.3791/1977.

46.

Gene therapy for prostate cancer.

Tangney M, Ahmad S, Collins SA, O'Sullivan GC.

Postgrad Med. 2010 May;122(3):166-80. doi: 10.3810/pgm.2010.05.2154.

PMID:
20463426
47.

Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors.

Cronin M, Morrissey D, Rajendran S, El Mashad SM, van Sinderen D, O'Sullivan GC, Tangney M.

Mol Ther. 2010 Jul;18(7):1397-407. doi: 10.1038/mt.2010.59. Epub 2010 Apr 13.

48.

Editorial [Hot Topic: Bacterial Vectors for Gene & Cell Therapy].

Tangney M, Gahan CG.

Curr Gene Ther. 2010 Feb;10(1):1-2. No abstract available.

PMID:
20230364
49.

Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.

Whelan MC, Casey G, MacConmara M, Lederer JA, Soden D, Collins JK, Tangney M, O'Sullivan GC.

Cancer Gene Ther. 2010 Jul;17(7):501-11. doi: 10.1038/cgt.2010.8. Epub 2010 Feb 26.

PMID:
20186173
50.

Optimised electroporation mediated DNA vaccination for treatment of prostate cancer.

Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC.

Genet Vaccines Ther. 2010 Feb 5;8(1):1. doi: 10.1186/1479-0556-8-1.

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