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Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles.

Yuen TY, Brown CJ, Xue Y, Tan YS, Ferrer Gago FJ, Lee XE, Neo JY, Thean D, Kaan HYK, Partridge AW, Verma CS, Lane DP, Johannes CW.

Chem Sci. 2019 May 30;10(26):6457-6466. doi: 10.1039/c9sc01456j. eCollection 2019 Jul 14.


Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.

Partridge AW, Kaan HYK, Juang YC, Sadruddin A, Lim S, Brown CJ, Ng S, Thean D, Ferrer F, Johannes C, Yuen TY, Kannan S, Aronica P, Tan YS, Pradhan MR, Verma CS, Hochman J, Chen S, Wan H, Ha S, Sherborne B, Lane DP, Sawyer TK.

Molecules. 2019 Jun 20;24(12). pii: E2292. doi: 10.3390/molecules24122292.


Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR.

Chem Commun (Camb). 2019 Jul 14;55(55):7914-7917. doi: 10.1039/c9cc04022f. Epub 2019 Jun 21.


Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR.

Chem Sci. 2019 Apr 12;10(19):5056-5063. doi: 10.1039/c9sc00798a. eCollection 2019 May 21.


CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation.

Ly PT, Tan YS, Koe CT, Zhang Y, Xie G, Endow S, Deng WM, Yu F, Wang H.

PLoS Biol. 2019 Jun 6;17(6):e3000276. doi: 10.1371/journal.pbio.3000276. eCollection 2019 Jun.


The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells.

Zhang Y, Koe CT, Tan YS, Ho J, Tan P, Yu F, Sung WK, Wang H.

Cell Rep. 2019 Apr 23;27(4):987-996.e3. doi: 10.1016/j.celrep.2019.03.089.


Surface Decoration of Selenium Nanoparticles by Proteins from the Culinary-Medicinal Shiitake Mushroom, Lentinus edodes (Agaricomycetes), for Enhanced Fibrinolytic Activity.

Ali SM, Raman J, Lakshmanan H, Ling TC, Phan CW, Tan YS, Sabaratnam V.

Int J Med Mushrooms. 2018;20(11):1021-1030. doi: 10.1615/IntJMedMushrooms.2018028307.


Isolation of Tumor-Infiltrating Lymphocytes by Ficoll-Paque Density Gradient Centrifugation.

Tan YS, Lei YL.

Methods Mol Biol. 2019;1960:93-99. doi: 10.1007/978-1-4939-9167-9_8.


Generation and Culture of Mouse Embryonic Fibroblasts.

Tan YS, Lei YL.

Methods Mol Biol. 2019;1960:85-91. doi: 10.1007/978-1-4939-9167-9_7.


Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting.

Tan YS, Mhoumadi Y, Verma CS.

J Mol Cell Biol. 2019 Apr 1;11(4):306-316. doi: 10.1093/jmcb/mjz009.


Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2.

Yadahalli S, Neira JL, Johnson CM, Tan YS, Rowling PJE, Chattopadhyay A, Verma CS, Itzhaki LS.

Sci Rep. 2019 Jan 24;9(1):693. doi: 10.1038/s41598-018-36589-5.


In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR')}2.

Tan YJ, Tan YS, Yeo CI, Chew J, Tiekink ERT.

J Inorg Biochem. 2019 Mar;192:107-118. doi: 10.1016/j.jinorgbio.2018.12.017. Epub 2019 Jan 6.


Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-κB pathways.

Xiong D, Hu W, Ye ST, Tan YS.

Biochem Biophys Res Commun. 2018 Nov 17;506(1):161-168. doi: 10.1016/j.bbrc.2018.09.013. Epub 2018 Oct 16.


Expression and DNA methylation of SERK, BBM, LEC2 and WUS genes in in vitro cultures of Boesenbergia rotunda (L.) Mansf.

Karim R, Tan YS, Singh P, Khalid N, Harikrishna JA.

Physiol Mol Biol Plants. 2018 Sep;24(5):741-751. doi: 10.1007/s12298-018-0566-8. Epub 2018 Jun 28.


Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.


Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.

Iegre J, Ahmed NS, Gaynord JS, Wu Y, Herlihy KM, Tan YS, Lopes-Pires ME, Jha R, Lau YH, Sore HF, Verma C, O' Donovan DH, Pugh N, Spring DR.

Chem Sci. 2018 Apr 25;9(20):4638-4643. doi: 10.1039/c8sc00284c. eCollection 2018 May 28.


Antimelanogenesis and Anti-Inflammatory Activity of Selected Culinary-Medicinal Mushrooms.

Saad HM, Sim KS, Tan YS.

Int J Med Mushrooms. 2018;20(2):141-153. doi: 10.1615/IntJMedMushrooms.2018025463.


Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine.

Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile E, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nör JE, Ferris RL, Wolf GT, Sun D, Lei YL.

Clin Cancer Res. 2018 Sep 1;24(17):4242-4255. doi: 10.1158/1078-0432.CCR-17-2807. Epub 2018 May 16.


[Explore mechanism of Compound Uncaria Hypotensive Tablet for hypertension based on network pharmacology].

Long HP, Lin XY, Wang YH, Ren WQ, Shao L, Zhang W, Tan YS.

Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1360-1365. doi: 10.19540/j.cnki.cjcmm.20180115.010. Chinese.


Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, Surdi L, Peier A, Sauvagnat B, Dandliker PJ, Brown CJ, Ng S, Ferrer F, Lane DP.

Bioorg Med Chem. 2018 Jun 1;26(10):2807-2815. doi: 10.1016/j.bmc.2018.03.008. Epub 2018 Mar 16.


A framework for mentoring of medical students: thematic analysis of mentoring programmes between 2000 and 2015.

Tan YS, Teo SWA, Pei Y, Sng JH, Yap HW, Toh YP, Krishna LKR.

Adv Health Sci Educ Theory Pract. 2018 Oct;23(4):671-697. doi: 10.1007/s10459-018-9821-6. Epub 2018 Mar 17. Review.


Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer.

Tan YS, Sansanaphongpricha K, Prince MEP, Sun D, Wolf GT, Lei YL.

J Dent Res. 2018 Jun;97(6):627-634. doi: 10.1177/0022034518764416. Epub 2018 Mar 13. Review.


A bilayer photoreceptor-retinal tissue model with gradient cell density design: A study of microvalve-based bioprinting.

Shi P, Tan YSE, Yeong WY, Li HY, Laude A.

J Tissue Eng Regen Med. 2018 May;12(5):1297-1306. doi: 10.1002/term.2661. Epub 2018 Mar 24.


Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.

Koe CT, Tan YS, Lönnfors M, Hur SK, Low CSL, Zhang Y, Kanchanawong P, Bankaitis VA, Wang H.

Elife. 2018 Feb 27;7. pii: e33555. doi: 10.7554/eLife.33555.


Tissue engineering of retina and Bruch's membrane: a review of cells, materials and processes.

Tan YSE, Shi PJ, Choo CJ, Laude A, Yeong WY.

Br J Ophthalmol. 2018 Sep;102(9):1182-1187. doi: 10.1136/bjophthalmol-2017-311390. Epub 2018 Feb 16. Review.


Acute Toxicity Study and the In Vitro Cytotoxicity of a Black Lingzhi Medicinal Mushroom, Amauroderma rugosum (Agaricomycetes), from Malaysia.

Fung SY, Tan NH, Kong BH, Lee SS, Tan YS, Sabaratnam V.

Int J Med Mushrooms. 2017;19(12):1093-1099. doi: 10.1615/IntJMedMushrooms.2017024550.


Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53.

Chan JV, Ping Koh DX, Liu Y, Joseph TL, Lane DP, Verma CS, Tan YS.

Oncotarget. 2017 Dec 1;8(68):112825-112840. doi: 10.18632/oncotarget.22829. eCollection 2017 Dec 22.


An intramolecular tryptophan-condensation approach for peptide stapling.

Hui EY, Rout B, Tan YS, Verma CS, Chan KP, Johannes CW.

Org Biomol Chem. 2018 Jan 17;16(3):389-392. doi: 10.1039/c7ob02667f.


Crystal structure of (4,4'-bipyridyl-κN)bis-[N-(2-hydroxy-ethyl)-N-iso-propyl-dithio-carbamato-κ2S,S']zinc(II)-4,4'-bipyridyl (2/1) and its isostructural cadmium(II) analogue.

Tan YS, Tiekink ERT.

Acta Crystallogr E Crystallogr Commun. 2017 Oct 13;73(Pt 11):1642-1646. doi: 10.1107/S2056989017014396. eCollection 2017 Nov 1.


Potential Medication Treatment According to Pathological Mechanisms in Abdominal Aortic Aneurysm.

Zhang SL, Du X, Chen YQ, Tan YS, Liu L.

J Cardiovasc Pharmacol. 2018 Jan;71(1):46-57. doi: 10.1097/FJC.0000000000000540. Review.


Escaping introns in COI through cDNA barcoding of mushrooms: Pleurotus as a test case.

Avin FA, Subha B, Tan YS, Braukmann TWA, Vikineswary S, Hebert PDN.

Ecol Evol. 2017 Jul 29;7(17):6972-6980. doi: 10.1002/ece3.3049. eCollection 2017 Sep.


[Desmoplastic fibroblastoma: a clinicopathologic analysis of 7 cases].

Yao JM, Zeng HY, Tan YS, Hou YY.

Zhonghua Bing Li Xue Za Zhi. 2017 Apr 8;46(4):223-227. doi: 10.3760/cma.j.issn.0529-5807.2017.04.002. Review. Chinese.


Recovery of lignin peroxidase from submerged liquid fermentation of Amauroderma rugosum (Blume & T. Nees) Torrend using polyethylene glycol/salt aqueous two-phase system.

Jong WYL, Show PL, Ling TC, Tan YS.

J Biosci Bioeng. 2017 Jul;124(1):91-98. doi: 10.1016/j.jbiosc.2017.02.008. Epub 2017 Mar 17.


Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS.

J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7.


Anatomy of Mdm2 and Mdm4 in evolution.

Tan BX, Liew HP, Chua JS, Ghadessy FJ, Tan YS, Lane DP, Coffill CR.

J Mol Cell Biol. 2017 Feb 1;9(1):3-15. doi: 10.1093/jmcb/mjx002. Review.


Outcome after neoadjuvant chemotherapy in Asian breast cancer patients.

Lim LY, Miao H, Lim JS, Lee SC, Bhoo-Pathy N, Yip CH, Taib NA, Chan P, Tan EY, Lim SH, Lim GH, Woo E, Tan YS, Lee JA, Wong M, Tan PH, Ong KW, Wong FY, Yap YS, Hartman M.

Cancer Med. 2017 Jan;6(1):173-185. doi: 10.1002/cam4.985. Epub 2016 Dec 20.


Protocol for Acupuncture Treatment of Lateral Elbow Pain: A Multisite Randomised Controlled Trial in China, Hong Kong, Australia, and Italy.

Zaslawski C, Berle C, Gadau M, Li WH, Li T, Wang FC, Bangrazi S, Li L, Liguori S, Liu YS, Tan YS, Zhang SP.

Evid Based Complement Alternat Med. 2016;2016:1868659. Epub 2016 Nov 23.


Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

Wiedmann MM, Tan YS, Wu Y, Aibara S, Xu W, Sore HF, Verma CS, Itzhaki L, Stewart M, Brenton JD, Spring DR.

Angew Chem Int Ed Engl. 2017 Jan 9;56(2):524-529. doi: 10.1002/anie.201609427. Epub 2016 Dec 5.


Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis.

Zhu Y, Aupperlee MD, Zhao Y, Tan YS, Kirk EL, Sun X, Troester MA, Schwartz RC, Haslam SZ.

Oncotarget. 2016 Dec 13;7(50):83409-83423. doi: 10.18632/oncotarget.13112.


Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens.

Siau JW, Coffill CR, Zhang WV, Tan YS, Hundt J, Lane D, Verma C, Ghadessy F.

Sci Rep. 2016 Sep 28;6:33972. doi: 10.1038/srep33972.


Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors.

Ray P, Tan YS, Somnay V, Mehta R, Sitto M, Ahsan A, Nyati S, Naughton JP, Bridges A, Zhao L, Rehemtulla A, Lawrence TS, Ray D, Nyati MK.

Oncotarget. 2016 Oct 18;7(42):68597-68613. doi: 10.18632/oncotarget.11860.


Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells.

Morkunas B, Gal B, Galloway WR, Hodgkinson JT, Ibbeson BM, Tan YS, Welch M, Spring DR.

Beilstein J Org Chem. 2016 Jul 11;12:1428-33. doi: 10.3762/bjoc.12.137. eCollection 2016.


Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer.

Lei Y, Xie Y, Tan YS, Prince ME, Moyer JS, Nör J, Wolf GT.

Oral Oncol. 2016 Oct;61:159-65. doi: 10.1016/j.oraloncology.2016.08.003. Epub 2016 Aug 21. Review.


Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.

Tan YS, Reeks J, Brown CJ, Thean D, Ferrer Gago FJ, Yuen TY, Goh ET, Lee XE, Jennings CE, Joseph TL, Lakshminarayanan R, Lane DP, Noble ME, Verma CS.

J Phys Chem Lett. 2016 Sep 1;7(17):3452-7. doi: 10.1021/acs.jpclett.6b01525. Epub 2016 Aug 22.


Measuring the Electronic Properties of DNA-Specific Schottky Diodes Towards Detecting and Identifying Basidiomycetes DNA.

Periasamy V, Rizan N, Al-Ta'ii HM, Tan YS, Tajuddin HA, Iwamoto M.

Sci Rep. 2016 Jul 20;6:29879. doi: 10.1038/srep29879.


Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury.

Ozaki M, Kang Y, Tan YS, Pavlov VI, Liu B, Boyle DC, Kushak RI, Skjoedt MO, Grabowski EF, Taira Y, Stahl GL.

Kidney Int. 2016 Oct;90(4):774-82. doi: 10.1016/j.kint.2016.05.011. Epub 2016 Jul 1.


Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR.

Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528.


Stapled peptide design: principles and roles of computation.

Tan YS, Lane DP, Verma CS.

Drug Discov Today. 2016 Oct;21(10):1642-1653. doi: 10.1016/j.drudis.2016.06.012. Epub 2016 Jun 18. Review.


12-(3,4,5-Tri-meth-oxy-phen-yl)-2,3,4,12-tetra-hydro-1H-5-oxa-tetra-phen-1-one: crystal structure and Hirshfeld surface analysis.

Jotani MM, Iniyavan P, Vijayakumar V, Sarveswari S, Tan YS, Tiekink ER.

Acta Crystallogr E Crystallogr Commun. 2016 May 13;72(Pt 6):809-14. doi: 10.1107/S2056989016007775. eCollection 2016 Jun 1.


Amino Acid and Secondary Metabolite Production in Embryogenic and Non-Embryogenic Callus of Fingerroot Ginger (Boesenbergia rotunda).

Ng TL, Karim R, Tan YS, Teh HF, Danial AD, Ho LS, Khalid N, Appleton DR, Harikrishna JA.

PLoS One. 2016 Jun 3;11(6):e0156714. doi: 10.1371/journal.pone.0156714. eCollection 2016.

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