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Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer.

Tan TZ, Heong V, Ye J, Lim D, Low J, Choolani M, Scott C, Tan DSP, Huang RY.

J Pathol. 2018 Oct 30. doi: 10.1002/path.5191. [Epub ahead of print]


Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.

Chong PSY, Zhou J, Chooi JY, Chan ZL, Toh SHM, Tan TZ, Wee S, Gunaratne J, Zeng Q, Chng WJ.

Oncogene. 2018 Oct 10. doi: 10.1038/s41388-018-0526-3. [Epub ahead of print]


Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors.

Tan TZ, Rouanne M, Tan KT, Huang RY, Thiery JP.

Eur Urol. 2018 Sep 10. pii: S0302-2838(18)30619-5. doi: 10.1016/j.eururo.2018.08.027. [Epub ahead of print]


DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum-Implications for the Choice of Circulating Tumour DNA Methylation Markers.

Le AV, Szaumkessel M, Tan TZ, Thiery JP, Thompson EW, Dobrovic A.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2553. doi: 10.3390/ijms19092553.


RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair.

Tay LS, Krishnan V, Sankar H, Chong YL, Chuang LSH, Tan TZ, Kolinjivadi AM, Kappei D, Ito Y.

Cell Rep. 2018 Aug 14;24(7):1747-1755. doi: 10.1016/j.celrep.2018.07.038.


BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia.

Zhou Y, Zhou J, Lu X, Tan TZ, Chng WJ.

BMC Cancer. 2018 Jul 11;18(1):731. doi: 10.1186/s12885-018-4661-6.


The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.

Antony J, Zanini E, Kelly Z, Tan TZ, Karali E, Alomary M, Jung Y, Nixon K, Cunnea P, Fotopoulou C, Paterson A, Roy-Nawathe S, Mills GB, Huang RY, Thiery JP, Gabra H, Recchi C.

EMBO Rep. 2018 Aug;19(8). pii: e45670. doi: 10.15252/embr.201745670. Epub 2018 Jun 15.


Integrated use of bioinformatic resources reveals that co-targeting of histone deacetylases, IKBK and SRC inhibits epithelial-mesenchymal transition in cancer.

Barneh F, Mirzaie M, Nickchi P, Tan TZ, Thiery JP, Piran M, Salimi M, Goshadrou F, Aref AR, Jafari M.

Brief Bioinform. 2018 May 2. doi: 10.1093/bib/bby030. [Epub ahead of print]


NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B.

Zhou J, Chooi JY, Ching YQ, Quah JY, Toh SH, Ng Y, Tan TZ, Chng WJ.

World J Stem Cells. 2018 Apr 26;10(4):34-42. doi: 10.4252/wjsc.v10.i4.34.


RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer.

Kulkarni M, Tan TZ, Syed Sulaiman NB, Lamar JM, Bansal P, Cui J, Qiao Y, Ito Y.

Oncotarget. 2018 Feb 6;9(18):14175-14192. doi: 10.18632/oncotarget.24419. eCollection 2018 Mar 6.


MiR-632 promotes laryngeal carcinoma cell proliferation, migration and invasion through negative regulation of GSK3β.

Zhou ZX, Zhang ZP, Tao ZZ, Tan TZ.

Oncol Res. 2018 Mar 21. doi: 10.3727/096504018X15213142076069. [Epub ahead of print]


A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase.

Zhou J, Toh SH, Chan ZL, Quah JY, Chooi JY, Tan TZ, Chong PSY, Zeng Q, Chng WJ.

J Hematol Oncol. 2018 Mar 7;11(1):36. doi: 10.1186/s13045-018-0581-9.


Dual role of autophagy in hallmarks of cancer.

Singh SS, Vats S, Chia AY, Tan TZ, Deng S, Ong MS, Arfuso F, Yap CT, Goh BC, Sethi G, Huang RY, Shen HM, Manjithaya R, Kumar AP.

Oncogene. 2018 Mar;37(9):1142-1158. doi: 10.1038/s41388-017-0046-6. Epub 2017 Dec 19. Review.


Measurement of fetal fraction in cell-free DNA from maternal plasma using a panel of insertion/deletion polymorphisms.

Barrett AN, Xiong L, Tan TZ, Advani HV, Hua R, Laureano-Asibal C, Soong R, Biswas A, Nagarajan N, Choolani M.

PLoS One. 2017 Oct 30;12(10):e0186771. doi: 10.1371/journal.pone.0186771. eCollection 2017.


TGFβ Promotes Genomic Instability after Loss of RUNX3.

Krishnan V, Chong YL, Tan TZ, Kulkarni M, Bin Rahmat MB, Tay LS, Sankar H, Jokhun DS, Ganesan A, Chuang LSH, Voon DC, Shivashankar GV, Thiery JP, Ito Y.

Cancer Res. 2018 Jan 1;78(1):88-102. doi: 10.1158/0008-5472.CAN-17-1178. Epub 2017 Oct 26.


PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers.

Chen L, Yuan Y, Kar S, Kanchi MM, Arora S, Kim JE, Koh PF, Yousef E, Samy RP, Shanmugam MK, Tan TZ, Shin SW, Arfuso F, Shen HM, Yang H, Goh BC, Park JI, Gaboury L, Lobie PE, Sethi G, Lim LHK, Kumar AP.

Mol Cancer Ther. 2017 Nov;16(11):2528-2542. doi: 10.1158/1535-7163.MCT-16-0739. Epub 2017 Aug 15.


Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer.

Chung VY, Tan TZ, Huang RL, Lai HC, Huang RY.

Gene. 2017 Nov 30;635:9-15. doi: 10.1016/j.gene.2017.09.001. Epub 2017 Sep 5.


Molecular characterization of breast cancer CTCs associated with brain metastasis.

Boral D, Vishnoi M, Liu HN, Yin W, Sprouse ML, Scamardo A, Hong DS, Tan TZ, Thiery JP, Chang JC, Marchetti D.

Nat Commun. 2017 Aug 4;8(1):196. doi: 10.1038/s41467-017-00196-1.


Aerosol pollution and its potential impacts on outdoor human thermal sensation: East Asian perspectives.

Wai KM, Ng EYY, Wong CMS, Tan TZ, Lin TH, Lien WH, Tanner PA, Wang CSH, Lau KKL, He NMH, Kim J.

Environ Res. 2017 Oct;158:753-758. doi: 10.1016/j.envres.2017.07.036. Epub 2017 Jul 25.


'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.

Ong MS, Cai W, Yuan Y, Leong HC, Tan TZ, Mohammad A, You ML, Arfuso F, Goh BC, Warrier S, Sethi G, Tolwinski NS, Lobie PE, Yap CT, Hooi SC, Huang RY, Kumar AP.

Br J Pharmacol. 2017 Dec;174(24):4684-4700. doi: 10.1111/bph.13958. Epub 2017 Aug 23. Review.


Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia.

Zhou J, Bi C, Ching YQ, Chooi JY, Lu X, Quah JY, Toh SH, Chan ZL, Tan TZ, Chong PS, Chng WJ.

J Hematol Oncol. 2017 Jul 11;10(1):138. doi: 10.1186/s13045-017-0507-y.


Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis.

Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP.

Physiol Rep. 2017 Jun;5(11). pii: e13305. doi: 10.14814/phy2.13305. Erratum in: Physiol Rep. 2018 Apr;6(8):e13671.


Targeting the AXL signaling pathway in ovarian cancer.

Huang RY, Antony J, Tan TZ, Tan DS.

Mol Cell Oncol. 2016 Nov 28;4(2):e1263716. doi: 10.1080/23723556.2016.1263716. eCollection 2017.


Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma.

Kong LR, Tan TZ, Ong WR, Bi C, Huynh H, Lee SC, Chng WJ, Eichhorn PJA, Goh BC.

Mol Oncol. 2017 Aug;11(8):965-980. doi: 10.1002/1878-0261.12064. Epub 2017 May 30.


USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7.

Kit Leng Lui S, Iyengar PV, Jaynes P, Isa ZFBA, Pang B, Tan TZ, Eichhorn PJA.

EMBO Rep. 2017 May;18(5):797-808. doi: 10.15252/embr.201643270. Epub 2017 Apr 5.


Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity.

Terry S, Buart S, Tan TZ, Gros G, Noman MZ, Lorens JB, Mami-Chouaib F, Thiery JP, Chouaib S.

Oncoimmunology. 2017 Jan 17;6(2):e1271858. doi: 10.1080/2162402X.2016.1271858. eCollection 2017.


Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells.

Yadavalli S, Jayaram S, Manda SS, Madugundu AK, Nayakanti DS, Tan TZ, Bhat R, Rangarajan A, Chatterjee A, Gowda H, Thiery JP, Kumar P.

Sci Rep. 2017 Mar 6;7:43710. doi: 10.1038/srep43710.


Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.

Chen L, Jenjaroenpun P, Pillai AM, Ivshina AV, Ow GS, Efthimios M, Zhiqun T, Tan TZ, Lee SC, Rogers K, Ward JM, Mori S, Adams DJ, Jenkins NA, Copeland NG, Ban KH, Kuznetsov VA, Thiery JP.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2215-E2224. doi: 10.1073/pnas.1701512114. Epub 2017 Mar 1.


The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200.

Noman MZ, Janji B, Abdou A, Hasmim M, Terry S, Tan TZ, Mami-Chouaib F, Thiery JP, Chouaib S.

Oncoimmunology. 2017 Jan 23;6(1):e1263412. doi: 10.1080/2162402X.2016.1263412. eCollection 2017.


LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.

Zhou J, Chan ZL, Bi C, Lu X, Chong PS, Chooi JY, Cheong LL, Liu SC, Ching YQ, Zhou Y, Osato M, Tan TZ, Ng CH, Ng SB, Wang S, Zeng Q, Chng WJ.

Mol Cancer Res. 2017 Mar;15(3):294-303. doi: 10.1158/1541-7786.MCR-16-0275-T. Epub 2016 Dec 23.


'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin.

Abu-Tayeh H, Weidenfeld K, Zhilin-Roth A, Schif-Zuck S, Thaler S, Cotarelo C, Tan TZ, Thiery JP, Green JE, Klorin G, Sabo E, Sleeman JP, Tzukerman M, Barkan D.

Cell Death Dis. 2016 Dec 1;7(12):e2491. doi: 10.1038/cddis.2016.387.


A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets.

Jia D, Liu Z, Deng N, Tan TZ, Huang RY, Taylor-Harding B, Cheon DJ, Lawrenson K, Wiedemeyer WR, Walts AE, Karlan BY, Orsulic S.

Cancer Lett. 2016 Nov 28;382(2):203-214. doi: 10.1016/j.canlet.2016.09.001. Epub 2016 Sep 5.


The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.

Antony J, Tan TZ, Kelly Z, Low J, Choolani M, Recchi C, Gabra H, Thiery JP, Huang RY.

Sci Signal. 2016 Oct 4;9(448):ra97.


TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.

Zhang Y, Subbaiah VK, Rajagopalan D, Tham CY, Abdullah LN, Toh TB, Gong M, Tan TZ, Jadhav SP, Pandey AK, Karnani N, Chow EK, Thiery JP, Jha S.

J Mol Cell Biol. 2016 Sep 20. pii: mjw038. [Epub ahead of print]


An epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers.

Tang HM, Kuay KT, Koh PF, Asad M, Tan TZ, Chung VY, Lee SC, Thiery JP, Huang RJ.

Cell Death Discov. 2016 Jun 13;2:16041. doi: 10.1038/cddiscovery.2016.41. eCollection 2016.


Correction: RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration.

Datar I, Qiu X, Ma HZ, Yeung M, Aras S, de la Serna I, Al-Mulla F, Tan TZ, Thiery JP, Trumbly R, Xuan F, Cui H, Yeung KC.

Oncotarget. 2016 May 3;7(18):26925. doi: 10.18632/oncotarget.9139.


Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma.

Loo SY, Hirpara JL, Pandey V, Tan TZ, Yap CT, Lobie PE, Thiery JP, Goh BC, Pervaiz S, Clément MV, Kumar AP.

Antioxid Redox Signal. 2016 Aug 20;25(6):283-99. doi: 10.1089/ars.2015.6524.


Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion.

Tochhawng L, Deng S, Pugalenthi G, Kumar AP, Lim KH, Tan TZ, Yang H, Hooi SC, Goh YC, Maciver SK, Pervaiz S, Yap CT.

Oncotarget. 2016 Aug 16;7(33):52832-52848. doi: 10.18632/oncotarget.10451.


Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.

Kothapalli R, Sivaraman Siveen K, Tan TZ, Paul Thiery J, Kumar AP, Sethi G, Swaminathan K.

Biosci Biotechnol Biochem. 2016 Jun 29:1-10. [Epub ahead of print]


TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex.

Lee WH, Choong LY, Mon NN, Lu S, Lin Q, Pang B, Yan B, Krishna VS, Singh H, Tan TZ, Thiery JP, Lim CT, Tan PB, Johansson M, Harteneck C, Lim YP.

Sci Rep. 2016 Jun 13;6:27903. doi: 10.1038/srep27903.


Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse.

Al-Temaimi RA, Tan TZ, Marafie MJ, Thiery JP, Quirke P, Al-Mulla F.

Int J Mol Sci. 2016 Apr 28;17(5). pii: E598. doi: 10.3390/ijms17050598.


GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Chung VY, Tan TZ, Tan M, Wong MK, Kuay KT, Yang Z, Ye J, Muller J, Koh CM, Guccione E, Thiery JP, Huang RY.

Sci Rep. 2016 Feb 18;6:19943. doi: 10.1038/srep19943.


Identification of AIM2 as a downstream target of JAK2V617F.

Liew EL, Araki M, Hironaka Y, Mori S, Tan TZ, Morishita S, Edahiro Y, Ohsaka A, Komatsu N.

Exp Hematol Oncol. 2016 Jan 28;5:2. doi: 10.1186/s40164-016-0032-7. eCollection 2015.


CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype.

Tan TZ, Yang H, Ye J, Low J, Choolani M, Tan DS, Thiery JP, Huang RY.

Oncotarget. 2015 Dec 22;6(41):43843-52. doi: 10.18632/oncotarget.5983.


Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy.

Khoo BL, Lee SC, Kumar P, Tan TZ, Warkiani ME, Ow SG, Nandi S, Lim CT, Thiery JP.

Oncotarget. 2015 Jun 20;6(17):15578-93.


Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma.

Kumar P, Nandi S, Tan TZ, Ler SG, Chia KS, Lim WY, Bütow Z, Vordos D, De la Taille A, Al-Haddawi M, Raida M, Beyer B, Ricci E, Colombel M, Chong TW, Chiong E, Soo R, Park MK, Ha HK, Gunaratne J, Thiery JP.

Oncotarget. 2015 May 30;6(15):13539-49.


The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.

Davidson B, Holth A, Hellesylt E, Tan TZ, Huang RY, Tropé C, Nesland JM, Thiery JP.

Hum Pathol. 2015 Jan;46(1):1-8. doi: 10.1016/j.humpath.2014.10.004. Epub 2014 Oct 16.


Non-invasive prenatal diagnostic testing for β-thalassaemia using cell-free fetal DNA and next generation sequencing.

Xiong L, Barrett AN, Hua R, Tan TZ, Ho SS, Chan JK, Zhong M, Choolani M.

Prenat Diagn. 2015 Mar;35(3):258-65. doi: 10.1002/pd.4536. Epub 2014 Dec 29.


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