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Multiplex Surface-Enhanced Raman Scattering Identification and Quantification of Urine Metabolites in Patient Samples within 30 Minutes.

Kao YC, Han X, Lee YH, Lee HK, Phan-Quang GC, Lay CL, Sim HYF, Phua VJX, Ng LS, Ku CW, Tan TC, Phang IY, Tan NS, Ling XY.

ACS Nano. 2020 Feb 12. doi: 10.1021/acsnano.0c00515. [Epub ahead of print]


Collaborative Regulation of LRG1 by TGF-β1 and PPAR-β/δ Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis.

Liu C, Lim ST, Teo MHY, Tan MSY, Kulkarni MD, Qiu B, Li A, Lal S, Dos Remedios CG, Tan NS, Wahli W, Ferenczi MA, Song W, Hong W, Wang X.

Circ Heart Fail. 2019 Dec;12(12):e005962. doi: 10.1161/CIRCHEARTFAILURE.119.005962. Epub 2019 Dec 13.


A (2-(naphthalen-2-yl)phenyl)rhodium(i) complex formed by a proposed intramolecular 1,4-ortho-to-ortho' Rh metal-atom migration and its efficacy as an initiator in the controlled stereospecific polymerisation of phenylacetylene.

Tan NSL, Nealon GL, Lynam JM, Sobolev AN, Rowles MR, Ogden MI, Massi M, Lowe AB.

Dalton Trans. 2019 Nov 21;48(43):16437-16447. doi: 10.1039/c9dt02953b. Epub 2019 Oct 25.


The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD.

Chen J, Zhuang Y, Sng MK, Tan NS, Wahli W.

Int J Mol Sci. 2019 Oct 15;20(20). pii: E5115. doi: 10.3390/ijms20205115.


Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

Cheng HS, Tan WR, Low ZS, Marvalim C, Lee JYH, Tan NS.

Int J Mol Sci. 2019 Oct 11;20(20). pii: E5055. doi: 10.3390/ijms20205055. Review.


Polymerizations Mediated by Well-Defined Rhodium Complexes.

Tan NSL, Lowe AB.

Angew Chem Int Ed Engl. 2019 Sep 25. doi: 10.1002/anie.201909909. [Epub ahead of print] Review.


Materials Stiffness-Dependent Redox Metabolic Reprogramming of Mesenchymal Stem Cells for Secretome-Based Therapeutic Angiogenesis.

Yang H, Cheam NMJ, Cao H, Lee MKH, Sze SK, Tan NS, Tay CY.

Adv Healthc Mater. 2019 Oct;8(20):e1900929. doi: 10.1002/adhm.201900929. Epub 2019 Sep 18.


A STAT3-based gene signature stratifies glioma patients for targeted therapy.

Tan MSY, Sandanaraj E, Chong YK, Lim SW, Koh LWH, Ng WH, Tan NS, Tan P, Ang BT, Tang C.

Nat Commun. 2019 Aug 9;10(1):3601. doi: 10.1038/s41467-019-11614-x.


Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework.

Pal M, Chen H, Lee BH, Lee JYH, Yip YS, Tan NS, Tan LP.

Sci Rep. 2019 Jun 20;9(1):8997. doi: 10.1038/s41598-019-45384-9.


Psychosocial characteristics of smoking patterns among young adult Samoans and Tongans in California.

Rainer MA, Xie B, Sabado-Liwag M, Kwan PP, Pike JR, Tan NS, Vaivao DES, Tui'one May V, Ka'ala Pang J, Pang VK, Toilolo TB, Tanjasiri SP, Palmer PH.

Addict Behav Rep. 2019 Mar 29;9:100177. doi: 10.1016/j.abrep.2019.100177. eCollection 2019 Jun.


Antibody Treatment against Angiopoietin-Like 4 Reduces Pulmonary Edema and Injury in Secondary Pneumococcal Pneumonia.

Li L, Foo BJW, Kwok KW, Sakamoto N, Mukae H, Izumikawa K, Mandard S, Quenot JP, Lagrost L, Teh WK, Singh Kohli G, Zhu P, Choi H, Buist ML, Seet JE, Yang L, He F, Kwong Chow VT, Tan NS.

mBio. 2019 Jun 4;10(3). pii: e02469-18. doi: 10.1128/mBio.02469-18.


Temporal Trends of Women Enrollment in Major Cardiovascular Randomized Clinical Trials.

Gong IY, Tan NS, Ali SH, Lebovic G, Mamdani M, Goodman SG, Ko DT, Laupacis A, Yan AT.

Can J Cardiol. 2019 May;35(5):653-660. doi: 10.1016/j.cjca.2019.01.010. Epub 2019 Jan 30.


Coronary vasospasm-induced polymorphic ventricular tachycardia: a case report and literature review.

Tan NS, Almehmadi F, Tang ASL.

Eur Heart J Case Rep. 2018 Mar 5;2(1):yty021. doi: 10.1093/ehjcr/yty021. eCollection 2018 Mar.


Reactive oxygen species: a volatile driver of field cancerization and metastasis.

Liao Z, Chua D, Tan NS.

Mol Cancer. 2019 Mar 30;18(1):65. doi: 10.1186/s12943-019-0961-y. Review.


Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment.

Cheng HS, Lee JXT, Wahli W, Tan NS.

Mol Cancer. 2019 Mar 30;18(1):51. doi: 10.1186/s12943-019-0971-9. Review.


Migration and Phenotype Control of Human Dermal Fibroblasts by Electrospun Fibrous Substrates.

Chen H, Lui YS, Tan ZW, Lee JYH, Tan NS, Tan LP.

Adv Healthc Mater. 2019 May;8(9):e1801378. doi: 10.1002/adhm.201801378. Epub 2019 Mar 22.


Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.

Oh HYP, Ellero-Simatos S, Manickam R, Tan NS, Guillou H, Wahli W.

Int J Mol Sci. 2019 Feb 14;20(4). pii: E812. doi: 10.3390/ijms20040812.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley ER, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Dec 18;49(6):1191. doi: 10.1016/j.immuni.2018.12.009. No abstract available.


Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4.

Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W.

Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5.


Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel Networks.

Cao H, Lee MKH, Yang H, Sze SK, Tan NS, Tay CY.

Langmuir. 2019 Jun 11;35(23):7487-7495. doi: 10.1021/acs.langmuir.8b02649. Epub 2018 Dec 7.


Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs.

Lim MMK, Wee JWK, Soong JC, Chua D, Tan WR, Lizwan M, Li Y, Teo Z, Goh WWB, Zhu P, Tan NS.

Mol Cancer. 2018 Oct 20;17(1):152. doi: 10.1186/s12943-018-0904-z.


Serum progesterone distribution in normal pregnancies compared to pregnancies complicated by threatened miscarriage from 5 to 13 weeks gestation: a prospective cohort study.

Ku CW, Allen JC Jr, Lek SM, Chia ML, Tan NS, Tan TC.

BMC Pregnancy Childbirth. 2018 Sep 5;18(1):360. doi: 10.1186/s12884-018-2002-z.


Previous and New Onset Atrial Fibrillation and Associated Outcomes in Acute Coronary Syndromes (from the Global Registry of Acute Coronary Events).

Worme MD, Tan MK, Armstrong DWJ, Yan AT, Tan NS, Brieger D, Budaj A, Gore JM, López-Sendón J, Van de Werf F, Steg PG, Fox KAA, Goodman SG, Udell JA.

Am J Cardiol. 2018 Sep 15;122(6):944-951. doi: 10.1016/j.amjcard.2018.06.001. Epub 2018 Jun 21.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley RE, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Aug 21;49(2):326-341.e7. doi: 10.1016/j.immuni.2018.06.008. Epub 2018 Jul 24. Erratum in: Immunity. 2018 Dec 18;49(6):1191.


Metabolic cardiomyopathy from propionic acidemia precipitating cardiac arrest in a 25-year-old man.

Tan NS, Bajaj RR, Morel C, Singh SM.

CMAJ. 2018 Jul 23;190(29):E883-E887. doi: 10.1503/cmaj.180240. No abstract available.


Out-of-Hospital Cardiac Arrest in the Presence of Ischemic Heart Disease: What Is the Long-term Arrhythmic Risk After Revascularization?

Tan NS, Dorian P.

Can J Cardiol. 2018 Aug;34(8):1079-1082. doi: 10.1016/j.cjca.2018.04.001. Epub 2018 Apr 6. Review.


Insights into the Role of PPARβ/δ in NAFLD.

Chen J, Montagner A, Tan NS, Wahli W.

Int J Mol Sci. 2018 Jun 27;19(7). pii: E1893. doi: 10.3390/ijms19071893. Review.


Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo.

Yeo CK, Vikhe YS, Li P, Guo Z, Greenberg P, Duan H, Tan NS, Chan-Park MB.

ACS Appl Mater Interfaces. 2018 Jun 20;10(24):20356-20367. doi: 10.1021/acsami.8b06262. Epub 2018 Jun 7.


An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors.

Phua WWT, Wong MXY, Liao Z, Tan NS.

Int J Mol Sci. 2018 May 10;19(5). pii: E1425. doi: 10.3390/ijms19051425. Review.


Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression.

Sng MK, Chan JSK, Teo Z, Phua T, Tan EHP, Wee JWK, Koh NJN, Tan CK, Chen JP, Pal M, Tong BMK, Tnay YL, Ng XR, Zhu P, Chiba S, Wang X, Wahli W, Tan NS.

Cell Discov. 2018 Apr 3;4:15. doi: 10.1038/s41421-018-0014-5. eCollection 2018.


Biospecimen Education Among Pacific Islanders in Southern California.

Tan NS, Custodio H, LaBreche M, Fex CC, Tui'one May V, Pang JK, Pang VK, Sablan-Santos L, Toilolo T, Tulua A, Vaivao DS, Sabado-Liwag M, Pike JR, Xie B, Kwan PP, Palmer PH, Tanjasiri SP.

J Cancer Educ. 2019 Aug;34(4):658-665. doi: 10.1007/s13187-018-1352-6.


Cancer-associated fibroblasts in tumor microenvironment - Accomplices in tumor malignancy.

Liao Z, Tan ZW, Zhu P, Tan NS.

Cell Immunol. 2019 Sep;343:103729. doi: 10.1016/j.cellimm.2017.12.003. Epub 2018 Feb 13. Review.


ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response.

Tan EHP, Sng MK, How ISB, Chan JSK, Chen J, Tan CK, Wahli W, Tan NS.

Oncogene. 2018 Apr;37(15):2067-2078. doi: 10.1038/s41388-017-0109-8. Epub 2018 Jan 25.


Electrocardiographic Findings in Patients With Acute Coronary Syndrome Presenting With Out-of-Hospital Cardiac Arrest.

Sarak B, Goodman SG, Brieger D, Gale CP, Tan NS, Budaj A, Wong GC, Huynh T, Tan MK, Udell JA, Bagai A, Fox KAA, Yan AT; Global Registry of Acute Coronary Events (GRACE) Investigators and the Canadian Acute Coronary Syndromes I Investigators.

Am J Cardiol. 2018 Feb 1;121(3):294-300. doi: 10.1016/j.amjcard.2017.10.030. Epub 2017 Nov 3.


Recellularization of decellularized adipose tissue-derived stem cells: role of the cell-secreted extracellular matrix in cellular differentiation.

Guneta V, Zhou Z, Tan NS, Sugii S, Wong MTC, Choong C.

Biomater Sci. 2017 Dec 19;6(1):168-178. doi: 10.1039/c7bm00695k.


Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids.

Baek JS, Choo CC, Tan NS, Loo SCJ.

Oncotarget. 2017 Aug 24;8(46):80841-80852. doi: 10.18632/oncotarget.20591. eCollection 2017 Oct 6.


Nanoparticles of Short Cationic Peptidopolysaccharide Self-Assembled by Hydrogen Bonding with Antibacterial Effect against Multidrug-Resistant Bacteria.

Hou Z, Shankar YV, Liu Y, Ding F, Subramanion JL, Ravikumar V, Zamudio-Vázquez R, Keogh D, Lim H, Tay MYF, Bhattacharjya S, Rice SA, Shi J, Duan H, Liu XW, Mu Y, Tan NS, Tam KC, Pethe K, Chan-Park MB.

ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38288-38303. doi: 10.1021/acsami.7b12120. Epub 2017 Oct 26.


Temporal Trends in Use of Composite End Points in Major Cardiovascular Randomized Clinical Trials in Prominent Medical Journals.

Tan NS, Ali SH, Lebovic G, Mamdani M, Laupacis A, Yan AT.

Circ Cardiovasc Qual Outcomes. 2017 Oct;10(10). pii: e003753. doi: 10.1161/CIRCOUTCOMES.117.003753. Review.


Cardiovascular disease in the Eastern Mediterranean region: epidemiology and risk factor burden.

Turk-Adawi K, Sarrafzadegan N, Fadhil I, Taubert K, Sadeghi M, Wenger NK, Tan NS, Grace SL.

Nat Rev Cardiol. 2018 Feb;15(2):106-119. doi: 10.1038/nrcardio.2017.138. Epub 2017 Sep 21. Review.


Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors.

Chan JSK, Sng MK, Teo ZQ, Chong HC, Twang JS, Tan NS.

Oncogene. 2018 Jan 11;37(2):160-173. doi: 10.1038/onc.2017.319. Epub 2017 Sep 11.


Fish scale-derived collagen patch promotes growth of blood and lymphatic vessels in vivo.

Wang JK, Yeo KP, Chun YY, Tan TTY, Tan NS, Angeli V, Choong C.

Acta Biomater. 2017 Nov;63:246-260. doi: 10.1016/j.actbio.2017.09.001. Epub 2017 Sep 6.


Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile.

Ku CW, Tan ZW, Lim MK, Tam ZY, Lin CH, Ng SP, Allen JC, Lek SM, Tan TC, Tan NS.

BBA Clin. 2017 Aug 19;8:48-55. doi: 10.1016/j.bbacli.2017.07.003. eCollection 2017 Dec.


Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.

Kalailingam P, Tan HB, Jain N, Sng MK, Chan JSK, Tan NS, Thanabalu T.

Sci Rep. 2017 Aug 4;7(1):7311. doi: 10.1038/s41598-017-07125-8.


Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial-mesenchymal transition by inducing 14-3-3γ expression.

Teo Z, Sng MK, Chan JSK, Lim MMK, Li Y, Li L, Phua T, Lee JYH, Tan ZW, Zhu P, Tan NS.

Oncogene. 2017 Nov 16;36(46):6408-6419. doi: 10.1038/onc.2017.244. Epub 2017 Jul 24.


Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression.

Teo Z, Chan JSK, Chong HC, Sng MK, Choo CC, Phua GZM, Teo DJR, Zhu P, Choong C, Wong MTC, Tan NS.

Sci Rep. 2017 Jul 24;7(1):6303. doi: 10.1038/s41598-017-05869-x.


Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases.

Baek JS, Yeo EW, Lee YH, Tan NS, Loo SCJ.

Drug Des Devel Ther. 2017 Jun 8;11:1707-1717. doi: 10.2147/DDDT.S133344. eCollection 2017.


ANGPTL4 T266M variant is associated with reduced cancer invasiveness.

Tan ZW, Teo Z, Tan C, Choo CC, Loo WS, Song Y, Tam ZY, Ng SP, Koh HZ, Ng YS, Shochat SG, Yau YH, Zhu P, Tan NS.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1525-1536. doi: 10.1016/j.bbamcr.2017.06.010. Epub 2017 Jun 19.


Nanomechanically Visualizing Drug-Cell Interaction at the Early Stage of Chemotherapy.

Wu YL, Engl W, Hu B, Cai P, Leow WR, Tan NS, Lim CT, Chen X.

ACS Nano. 2017 Jul 25;11(7):6996-7005. doi: 10.1021/acsnano.7b02376. Epub 2017 May 30.


Supercritical carbon dioxide extracted extracellular matrix material from adipose tissue.

Wang JK, Luo B, Guneta V, Li L, Foo SEM, Dai Y, Tan TTY, Tan NS, Choong C, Wong MTC.

Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:349-358. doi: 10.1016/j.msec.2017.02.002. Epub 2017 Feb 5.


Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites.

Oteng AB, Bhattacharya A, Brodesser S, Qi L, Tan NS, Kersten S.

J Lipid Res. 2017 Jun;58(6):1100-1113. doi: 10.1194/jlr.M074278. Epub 2017 Apr 15.

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