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Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.

Oh HYP, Ellero-Simatos S, Manickam R, Tan NS, Guillou H, Wahli W.

Int J Mol Sci. 2019 Feb 14;20(4). pii: E812. doi: 10.3390/ijms20040812.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley ER, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Dec 18;49(6):1191. doi: 10.1016/j.immuni.2018.12.009. No abstract available.


Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4.

Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W.

Oncogene. 2018 Dec 5. doi: 10.1038/s41388-018-0592-6. [Epub ahead of print]


Mechanoregulation of cancer-associated fibroblasts phenotype in 3D interpenetrating hydrogel networks.

Cao H, Lee MKH, Yang H, Sze SK, Tan NS, Tay CY.

Langmuir. 2018 Nov 27. doi: 10.1021/acs.langmuir.8b02649. [Epub ahead of print]


Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs.

Lim MMK, Wee JWK, Soong JC, Chua D, Tan WR, Lizwan M, Li Y, Teo Z, Goh WWB, Zhu P, Tan NS.

Mol Cancer. 2018 Oct 20;17(1):152. doi: 10.1186/s12943-018-0904-z.


Serum progesterone distribution in normal pregnancies compared to pregnancies complicated by threatened miscarriage from 5 to 13 weeks gestation: a prospective cohort study.

Ku CW, Allen JC Jr, Lek SM, Chia ML, Tan NS, Tan TC.

BMC Pregnancy Childbirth. 2018 Sep 5;18(1):360. doi: 10.1186/s12884-018-2002-z.


Previous and New Onset Atrial Fibrillation and Associated Outcomes in Acute Coronary Syndromes (from the Global Registry of Acute Coronary Events).

Worme MD, Tan MK, Armstrong DWJ, Yan AT, Tan NS, Brieger D, Budaj A, Gore JM, López-Sendón J, Van de Werf F, Steg PG, Fox KAA, Goodman SG, Udell JA.

Am J Cardiol. 2018 Sep 15;122(6):944-951. doi: 10.1016/j.amjcard.2018.06.001. Epub 2018 Jun 21.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley RE, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Aug 21;49(2):326-341.e7. doi: 10.1016/j.immuni.2018.06.008. Epub 2018 Jul 24. Erratum in: Immunity. 2018 Dec 18;49(6):1191.


Metabolic cardiomyopathy from propionic acidemia precipitating cardiac arrest in a 25-year-old man.

Tan NS, Bajaj RR, Morel C, Singh SM.

CMAJ. 2018 Jul 23;190(29):E883-E887. doi: 10.1503/cmaj.180240. No abstract available.


Out-of-Hospital Cardiac Arrest in the Presence of Ischemic Heart Disease: What Is the Long-term Arrhythmic Risk After Revascularization?

Tan NS, Dorian P.

Can J Cardiol. 2018 Aug;34(8):1079-1082. doi: 10.1016/j.cjca.2018.04.001. Epub 2018 Apr 6.


Insights into the Role of PPARβ/δ in NAFLD.

Chen J, Montagner A, Tan NS, Wahli W.

Int J Mol Sci. 2018 Jun 27;19(7). pii: E1893. doi: 10.3390/ijms19071893. Review.


Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo.

Yeo CK, Vikhe YS, Li P, Guo Z, Greenberg P, Duan H, Tan NS, Chan-Park MB.

ACS Appl Mater Interfaces. 2018 Jun 20;10(24):20356-20367. doi: 10.1021/acsami.8b06262. Epub 2018 Jun 7.


An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors.

Phua WWT, Wong MXY, Liao Z, Tan NS.

Int J Mol Sci. 2018 May 10;19(5). pii: E1425. doi: 10.3390/ijms19051425. Review.


Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression.

Sng MK, Chan JSK, Teo Z, Phua T, Tan EHP, Wee JWK, Koh NJN, Tan CK, Chen JP, Pal M, Tong BMK, Tnay YL, Ng XR, Zhu P, Chiba S, Wang X, Wahli W, Tan NS.

Cell Discov. 2018 Apr 3;4:15. doi: 10.1038/s41421-018-0014-5. eCollection 2018.


Biospecimen Education Among Pacific Islanders in Southern California.

Tan NS, Custodio H, LaBreche M, Fex CC, Tui'one May V, Pang JK, Pang VK, Sablan-Santos L, Toilolo T, Tulua A, Vaivao DS, Sabado-Liwag M, Pike JR, Xie B, Kwan PP, Palmer PH, Tanjasiri SP.

J Cancer Educ. 2018 Apr 3. doi: 10.1007/s13187-018-1352-6. [Epub ahead of print]


Cancer-associated fibroblasts in tumor microenvironment - Accomplices in tumor malignancy.

Liao Z, Tan ZW, Zhu P, Tan NS.

Cell Immunol. 2018 Jan 31. pii: S0008-8749(17)30222-8. doi: 10.1016/j.cellimm.2017.12.003. [Epub ahead of print] Review.


ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response.

Tan EHP, Sng MK, How ISB, Chan JSK, Chen J, Tan CK, Wahli W, Tan NS.

Oncogene. 2018 Apr;37(15):2067-2078. doi: 10.1038/s41388-017-0109-8. Epub 2018 Jan 25.


Electrocardiographic Findings in Patients With Acute Coronary Syndrome Presenting With Out-of-Hospital Cardiac Arrest.

Sarak B, Goodman SG, Brieger D, Gale CP, Tan NS, Budaj A, Wong GC, Huynh T, Tan MK, Udell JA, Bagai A, Fox KAA, Yan AT; Global Registry of Acute Coronary Events (GRACE) Investigators and the Canadian Acute Coronary Syndromes I Investigators.

Am J Cardiol. 2018 Feb 1;121(3):294-300. doi: 10.1016/j.amjcard.2017.10.030. Epub 2017 Nov 3.


Recellularization of decellularized adipose tissue-derived stem cells: role of the cell-secreted extracellular matrix in cellular differentiation.

Guneta V, Zhou Z, Tan NS, Sugii S, Wong MTC, Choong C.

Biomater Sci. 2017 Dec 19;6(1):168-178. doi: 10.1039/c7bm00695k.


Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids.

Baek JS, Choo CC, Tan NS, Loo SCJ.

Oncotarget. 2017 Aug 24;8(46):80841-80852. doi: 10.18632/oncotarget.20591. eCollection 2017 Oct 6.


Nanoparticles of Short Cationic Peptidopolysaccharide Self-Assembled by Hydrogen Bonding with Antibacterial Effect against Multidrug-Resistant Bacteria.

Hou Z, Shankar YV, Liu Y, Ding F, Subramanion JL, Ravikumar V, Zamudio-Vázquez R, Keogh D, Lim H, Tay MYF, Bhattacharjya S, Rice SA, Shi J, Duan H, Liu XW, Mu Y, Tan NS, Tam KC, Pethe K, Chan-Park MB.

ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38288-38303. doi: 10.1021/acsami.7b12120. Epub 2017 Oct 26.


Temporal Trends in Use of Composite End Points in Major Cardiovascular Randomized Clinical Trials in Prominent Medical Journals.

Tan NS, Ali SH, Lebovic G, Mamdani M, Laupacis A, Yan AT.

Circ Cardiovasc Qual Outcomes. 2017 Oct;10(10). pii: e003753. doi: 10.1161/CIRCOUTCOMES.117.003753. Review.


Cardiovascular disease in the Eastern Mediterranean region: epidemiology and risk factor burden.

Turk-Adawi K, Sarrafzadegan N, Fadhil I, Taubert K, Sadeghi M, Wenger NK, Tan NS, Grace SL.

Nat Rev Cardiol. 2018 Feb;15(2):106-119. doi: 10.1038/nrcardio.2017.138. Epub 2017 Sep 21. Review.


Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors.

Chan JSK, Sng MK, Teo ZQ, Chong HC, Twang JS, Tan NS.

Oncogene. 2018 Jan 11;37(2):160-173. doi: 10.1038/onc.2017.319. Epub 2017 Sep 11.


Fish scale-derived collagen patch promotes growth of blood and lymphatic vessels in vivo.

Wang JK, Yeo KP, Chun YY, Tan TTY, Tan NS, Angeli V, Choong C.

Acta Biomater. 2017 Nov;63:246-260. doi: 10.1016/j.actbio.2017.09.001. Epub 2017 Sep 6.


Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile.

Ku CW, Tan ZW, Lim MK, Tam ZY, Lin CH, Ng SP, Allen JC, Lek SM, Tan TC, Tan NS.

BBA Clin. 2017 Aug 19;8:48-55. doi: 10.1016/j.bbacli.2017.07.003. eCollection 2017 Dec.


Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.

Kalailingam P, Tan HB, Jain N, Sng MK, Chan JSK, Tan NS, Thanabalu T.

Sci Rep. 2017 Aug 4;7(1):7311. doi: 10.1038/s41598-017-07125-8.


Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial-mesenchymal transition by inducing 14-3-3γ expression.

Teo Z, Sng MK, Chan JSK, Lim MMK, Li Y, Li L, Phua T, Lee JYH, Tan ZW, Zhu P, Tan NS.

Oncogene. 2017 Nov 16;36(46):6408-6419. doi: 10.1038/onc.2017.244. Epub 2017 Jul 24.


Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression.

Teo Z, Chan JSK, Chong HC, Sng MK, Choo CC, Phua GZM, Teo DJR, Zhu P, Choong C, Wong MTC, Tan NS.

Sci Rep. 2017 Jul 24;7(1):6303. doi: 10.1038/s41598-017-05869-x.


Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases.

Baek JS, Yeo EW, Lee YH, Tan NS, Loo SCJ.

Drug Des Devel Ther. 2017 Jun 8;11:1707-1717. doi: 10.2147/DDDT.S133344. eCollection 2017.


ANGPTL4 T266M variant is associated with reduced cancer invasiveness.

Tan ZW, Teo Z, Tan C, Choo CC, Loo WS, Song Y, Tam ZY, Ng SP, Koh HZ, Ng YS, Shochat SG, Yau YH, Zhu P, Tan NS.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1525-1536. doi: 10.1016/j.bbamcr.2017.06.010. Epub 2017 Jun 19.


Nanomechanically Visualizing Drug-Cell Interaction at the Early Stage of Chemotherapy.

Wu YL, Engl W, Hu B, Cai P, Leow WR, Tan NS, Lim CT, Chen X.

ACS Nano. 2017 Jul 25;11(7):6996-7005. doi: 10.1021/acsnano.7b02376. Epub 2017 May 30.


Supercritical carbon dioxide extracted extracellular matrix material from adipose tissue.

Wang JK, Luo B, Guneta V, Li L, Foo SEM, Dai Y, Tan TTY, Tan NS, Choong C, Wong MTC.

Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:349-358. doi: 10.1016/j.msec.2017.02.002. Epub 2017 Feb 5.


Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites.

Oteng AB, Bhattacharya A, Brodesser S, Qi L, Tan NS, Kersten S.

J Lipid Res. 2017 Jun;58(6):1100-1113. doi: 10.1194/jlr.M074278. Epub 2017 Apr 15.


Pulse pressure in acute coronary syndromes: Comparative prognostic significance with systolic blood pressure.

Tan NS, Sarak B, Fox KA, Brieger D, Steg PG, Gale CP, Bhatt DL, Spencer FA, Grondin FR, Goodman SG, Yan AT; Canadian GRACE/GRACE-2 and CANRACE Investigators.

Eur Heart J Acute Cardiovasc Care. 2017 Mar 1:2048872617700871. doi: 10.1177/2048872617700871. [Epub ahead of print]


Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model.

Azam MA, Zamiri N, Massé S, Kusha M, Lai PF, Nair GK, Tan NS, Labos C, Nanthakumar K.

Circ Arrhythm Electrophysiol. 2017 Mar;10(3). pii: e004331. doi: 10.1161/CIRCEP.116.004331.


Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin.

Phua T, Sng MK, Tan EH, Chee DS, Li Y, Wee JW, Teo Z, Chan JS, Lim MM, Tan CK, Zhu P, Arulampalam V, Tan NS.

Sci Rep. 2017 Mar 13;7:44351. doi: 10.1038/srep44351.


Validation of serum progesterone <35nmol/L as a predictor of miscarriage among women with threatened miscarriage.

Lek SM, Ku CW, Allen JC Jr, Malhotra R, Tan NS, Østbye T, Tan TC.

BMC Pregnancy Childbirth. 2017 Mar 6;17(1):78. doi: 10.1186/s12884-017-1261-4.


Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress.

Chan JS, Tan MJ, Sng MK, Teo Z, Phua T, Choo CC, Li L, Zhu P, Tan NS.

Cell Death Dis. 2017 Jan 19;8(1):e2562. doi: 10.1038/cddis.2016.492.


Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure.

Jain N, Kalailingam P, Tan KW, Tan HB, Sng MK, Chan JS, Tan NS, Thanabalu T.

Sci Rep. 2016 Dec 2;6:38109. doi: 10.1038/srep38109.


Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex.

Goh YY, Yan YK, Tan NS, Goh SA, Li S, Teoh YC, Lee PP.

Sci Rep. 2016 Nov 14;6:36868. doi: 10.1038/srep36868.


Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ.

Tan NS, Vázquez-Carrera M, Montagner A, Sng MK, Guillou H, Wahli W.

Prog Lipid Res. 2016 Oct;64:98-122. doi: 10.1016/j.plipres.2016.09.001. Epub 2016 Sep 22. Review. No abstract available.


Comparative study of adipose-derived stem cells and bone marrow-derived stem cells in similar microenvironmental conditions.

Guneta V, Tan NS, Chan SK, Tanavde V, Lim TC, Wong TC, Choong C.

Exp Cell Res. 2016 Nov 1;348(2):155-164. doi: 10.1016/j.yexcr.2016.09.012. Epub 2016 Sep 19.


Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists.

Ang Z, Er JZ, Tan NS, Lu J, Liou YC, Grosse J, Ding JL.

Sci Rep. 2016 Sep 26;6:34145. doi: 10.1038/srep34145.


Soft Material Approach to Induce Oxidative Stress in Mesenchymal Stem Cells for Functional Tissue Repair.

Yang H, Nguyen KT, Leong DT, Tan NS, Tay CY.

ACS Appl Mater Interfaces. 2016 Oct 12;8(40):26591-26599. Epub 2016 Sep 28.


Multi-Drug-Loaded Microcapsules with Controlled Release for Management of Parkinson's Disease.

Baek JS, Choo CC, Qian C, Tan NS, Shen Z, Loo SC.

Small. 2016 Jul;12(27):3712-22. doi: 10.1002/smll.201600067. Epub 2016 Jun 2.


Prognostic value of dynamic electrocardiographic T wave changes in non-ST elevation acute coronary syndrome.

Sarak B, Goodman SG, Yan RT, Tan MK, Steg PG, Tan NS, Fox KA, Udell JA, Brieger D, Welsh RC, Gale CP, Yan AT; Canadian Acute Coronary Syndromes I, and Global Registry of Acute Coronary Events (GRACE) Investigators.

Heart. 2016 Sep 1;102(17):1396-402. doi: 10.1136/heartjnl-2015-309161. Epub 2016 Apr 25.


Fabrication and characterization of a novel crosslinked human keratin-alginate sponge.

Hartrianti P, Nguyen LTH, Johanes J, Chou SM, Zhu P, Tan NS, Tang MBY, Ng KW.

J Tissue Eng Regen Med. 2017 Sep;11(9):2590-2602. doi: 10.1002/term.2159. Epub 2016 Apr 25.


Comparative Study of Adipose-Derived Stem Cells From Abdomen and Breast.

Guneta V, Tan NS, Sugii S, Lim TC, Wong TC, Choong C.

Ann Plast Surg. 2016 May;76(5):569-75. doi: 10.1097/SAP.0000000000000797.


From Mars to Venus: Gender Differences in the Management and Outcomes of Acute Coronary Syndromes.

Tan NS, Yan AT.

Curr Pharm Des. 2016;22(25):3790-801. Review.


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