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Technical and imaging factors influencing performance of deep learning systems for diabetic retinopathy.

Yip MYT, Lim G, Lim ZW, Nguyen QD, Chong CCY, Yu M, Bellemo V, Xie Y, Lee XQ, Hamzah H, Ho J, Tan TE, Sabanayagam C, Grzybowski A, Tan GSW, Hsu W, Lee ML, Wong TY, Ting DSW.

NPJ Digit Med. 2020 Mar 23;3:40. doi: 10.1038/s41746-020-0247-1. eCollection 2020.


25-years Trends and Risk factors related to Surgical Outcomes of Giant Retinal Tear-Rhegmatogenous Retinal Detachments.

Ting DSW, Foo VHX, Tan TE, Sie NM, Wong CW, Tsai ASH, Tan GSW, Lim LS, Yeo IYS, Wong DWK, Ong SG, Wong EYM, Ang CL, Lee SY.

Sci Rep. 2020 Mar 25;10(1):5474. doi: 10.1038/s41598-020-61592-0.


Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model.

Duehr J, McMahon M, Williamson B, Amanat F, Durbin A, Hawman DW, Noack D, Uhl S, Tan GS, Feldmann H, Krammer F.

mBio. 2020 Mar 24;11(2). pii: e00028-20. doi: 10.1128/mBio.00028-20.


Palhinosides A-H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from Palhinhaea cernua.

Li J, Tan LH, Zou H, Zou ZX, Long HP, Wang WX, Xu PS, Liu LF, Xu KP, Tan GS.

J Nat Prod. 2020 Feb 28;83(2):216-222. doi: 10.1021/acs.jnatprod.9b00470. Epub 2020 Jan 29.


Quantitative Microvascular Analysis With Wide-Field Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy.

Tan B, Chua J, Lin E, Cheng J, Gan A, Yao X, Wong DWK, Sabanayagam C, Wong D, Chan CM, Wong TY, Schmetterer L, Tan GS.

JAMA Netw Open. 2020 Jan 3;3(1):e1919469. doi: 10.1001/jamanetworkopen.2019.19469.


DIABETIC MACULAR ISCHEMIA: Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit.

Tsai ASH, Gan ATL, Ting DSW, Wong CW, Teo KYC, Tan ACS, Lee SY, Wong TY, Tan GSW, Gemmy Cheung CM.

Retina. 2019 Dec 13. doi: 10.1097/IAE.0000000000002721. [Epub ahead of print]


Two new biflavanoids from Selaginella trichoclada Alsto.

Xie Y, Xu PS, Xu KP, Zou ZX, Zhou G, Li D, Li D, Li XM, Li J, Tan GS.

Nat Prod Res. 2019 Dec 14:1-7. doi: 10.1080/14786419.2019.1700506. [Epub ahead of print]


Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis.

Tan AC, Lai GGY, Tan GS, Poon SY, Doble B, Lim TH, Aung ZW, Takano A, Tan WL, Ang MK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Lim AST, Lim WT, Toh CK, Tan EH, Lim TKH, Tan DSW.

Lung Cancer. 2020 Jan;139:207-215. doi: 10.1016/j.lungcan.2019.11.022. Epub 2019 Nov 26.


Correction to: Artificial intelligence for diabetic retinopathy screening: a review.

Grzybowski A, Brona P, Lim G, Ruamviboonsuk P, Tan GSW, Abramoff M, Ting DSW.

Eye (Lond). 2020 Mar;34(3):604. doi: 10.1038/s41433-019-0728-0.


Large solitary lytic skull vault lesions in adults: radiological review with pathological correlation.

Kee TP, Liauw L, Sathiyamoorthy S, Lee HY, Tan GSL, Yu WY.

Clin Imaging. 2020 Feb;59(2):129-143. doi: 10.1016/j.clinimag.2019.10.011. Epub 2019 Nov 27. Review.


Monoclonal Antibodies with Neutralizing Activity and Fc-Effector Functions against the Machupo Virus Glycoprotein.

Amanat F, Duehr J, Huang C, Paessler S, Tan GS, Krammer F.

J Virol. 2020 Feb 14;94(5). pii: e01741-19. doi: 10.1128/JVI.01741-19. Print 2020 Feb 14.


Universal Template-Assisted, Cloning-free Method for the Generation of Small RNA-Expressing Dumbbell-Shaped DNA Vectors.

Cyrill SL, Ghosh A, Loh PS, Tan GSX, Patzel V.

Mol Ther Methods Clin Dev. 2019 Aug 31;15:149-156. doi: 10.1016/j.omtm.2019.08.008. eCollection 2019 Dec 13.


Surgical Approaches for Cell Therapeutics Delivery to the Retinal Pigment Epithelium and Retina.

Stanzel B, Ader M, Liu Z, Amaral J, Aguirre LIR, Rickmann A, Barathi VA, Tan GSW, Degreif A, Al-Nawaiseh S, Szurman P.

Adv Exp Med Biol. 2019;1186:141-170. doi: 10.1007/978-3-030-28471-8_6.


Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides.

Liu Y, Li J, Li D, Li XM, Li D, Zhou G, Xu KP, Kang FH, Zou ZX, Xu PS, Tan GS.

Fitoterapia. 2019 Nov;139:104366. doi: 10.1016/j.fitote.2019.104366. Epub 2019 Oct 17.


Severe primary cutaneous Cryptococcus gattii causing ulcerative cellulitis in an immunocompetent patient.

Tan GSE, Singh R, Chong TYR, Su PQ, Lee JSS, Wong KJH, Tan JWL, Vasoo S.

Lancet Infect Dis. 2019 Oct;19(10):1148. doi: 10.1016/S1473-3099(19)30409-8. No abstract available.


Artificial intelligence for diabetic retinopathy screening: a review.

Grzybowski A, Brona P, Lim G, Ruamviboonsuk P, Tan GSW, Abramoff M, Ting DSW.

Eye (Lond). 2020 Mar;34(3):451-460. doi: 10.1038/s41433-019-0566-0. Epub 2019 Sep 5. Review. Erratum in: Eye (Lond). 2019 Dec 10;:.


Global Assessment of Retinal Arteriolar, Venular and Capillary Microcirculations Using Fundus Photographs and Optical Coherence Tomography Angiography in Diabetic Retinopathy.

Tan TE, Nguyen Q, Chua J, Schmetterer L, Tan GSW, Wong CW, Tsai A, Cheung GCM, Wong TY, Ting DSW.

Sci Rep. 2019 Aug 13;9(1):11751. doi: 10.1038/s41598-019-47770-9.


Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.

Ramos I, Smith G, Ruf-Zamojski F, Martínez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, García-Sastre A, Fernandez-Sesma A.

J Virol. 2019 Sep 30;93(20). pii: e00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15.


Artificial Intelligence Screening for Diabetic Retinopathy: the Real-World Emerging Application.

Bellemo V, Lim G, Rim TH, Tan GSW, Cheung CY, Sadda S, He MG, Tufail A, Lee ML, Hsu W, Ting DSW.

Curr Diab Rep. 2019 Jul 31;19(9):72. doi: 10.1007/s11892-019-1189-3.


Deep learning in estimating prevalence and systemic risk factors for diabetic retinopathy: a multi-ethnic study.

Ting DSW, Cheung CY, Nguyen Q, Sabanayagam C, Lim G, Lim ZW, Tan GSW, Soh YQ, Schmetterer L, Wang YX, Jonas JB, Varma R, Lee ML, Hsu W, Lamoureux E, Cheng CY, Wong TY.

NPJ Digit Med. 2019 Apr 10;2:24. doi: 10.1038/s41746-019-0097-x. eCollection 2019.


The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers.

Musharrafieh R, Lagarias PI, Ma C, Tan GS, Kolocouris A, Wang J.

Mol Pharmacol. 2019 Aug;96(2):148-157. doi: 10.1124/mol.119.116640. Epub 2019 Jun 7.


New cytotoxic biflavones from Selaginella doederleinii.

Liu LF, Sun HH, Tan JB, Huang Q, Cheng F, Xu KP, Zou ZX, Tan GS.

Nat Prod Res. 2019 May 21:1-7. doi: 10.1080/14786419.2019.1611813. [Epub ahead of print]


Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein.

Bailey MJ, Broecker F, Freyn AW, Choi A, Brown JA, Fedorova N, Simon V, Lim JK, Evans MJ, García-Sastre A, Palese P, Tan GS.

J Virol. 2019 Jun 28;93(14). pii: e00405-19. doi: 10.1128/JVI.00405-19. Print 2019 Jul 15.


Artificial Intelligence in Diabetic Eye Disease Screening.

Cheung CY, Tang F, Ting DSW, Tan GSW, Wong TY.

Asia Pac J Ophthalmol (Phila). 2019 Apr 24. doi: 10.22608/APO.201976. [Epub ahead of print]


Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus.

Bailey MJ, Broecker F, Duehr J, Arumemi F, Krammer F, Palese P, Tan GS.

mBio. 2019 Apr 2;10(2). pii: e02861-18. doi: 10.1128/mBio.02861-18.


Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention.

Nusinovici S, Sabanayagam C, Teo BW, Tan GSW, Wong TY.

Am J Kidney Dis. 2019 Jun;73(6):846-857. doi: 10.1053/j.ajkd.2018.12.047. Epub 2019 Mar 28. Review.


In vivo development of amoxicillin and ceftriaxone resistance in Salmonella enterica serovar Typhi.

Tan GSE, Octavia S, Teo JWP, Ang MLT, La MV, Lin RTP, Choudhury S, Ang BSP.

Clin Microbiol Infect. 2019 Aug;25(8):1045-1047. doi: 10.1016/j.cmi.2019.03.015. Epub 2019 Mar 23. No abstract available.


Sinensiols B-G, six novel neolignans from Selaginella sinensis.

Chen X, Xu PS, Zou ZX, Liu Y, Zhou WH, Ren Q, Li D, Li XM, Xu KP, Tan GS.

Fitoterapia. 2019 Apr;134:256-263. doi: 10.1016/j.fitote.2019.02.034. Epub 2019 Feb 28.


Optimization of qRT-PCR assay for zika virus detection in human serum and urine.

Del Pilar Martinez Viedma M, Puri V, Oldfield LM, Shabman RS, Tan GS, Pickett BE.

Virus Res. 2019 Apr 2;263:173-178. doi: 10.1016/j.virusres.2019.01.013. Epub 2019 Feb 10.


Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW.

J Clin Oncol. 2019 Apr 10;37(11):876-884. doi: 10.1200/JCO.18.00177. Epub 2019 Jan 24.


Pictalignans D-F, three new neolignan derivatives from Selaginella picta.

Cheng F, Zou ZX, Xu PS, Zhang SH, Zhang Y, Yao CP, Xu KP, Tan GS.

Nat Prod Res. 2019 Jan 19:1-6. doi: 10.1080/14786419.2018.1560284. [Epub ahead of print]


Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Pollack S, Igo RP Jr, Jensen RA, Christiansen M, Li X, Cheng CY, Ng MCY, Smith AV, Rossin EJ, Segrè AV, Davoudi S, Tan GS, Chen YI, Kuo JZ, Dimitrov LM, Stanwyck LK, Meng W, Hosseini SM, Imamura M, Nousome D, Kim J, Hai Y, Jia Y, Ahn J, Leong A, Shah K, Park KH, Guo X, Ipp E, Taylor KD, Adler SG, Sedor JR, Freedman BI; Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group, Lee IT, Sheu WH, Kubo M, Takahashi A, Hadjadj S, Marre M, Tregouet DA, Mckean-Cowdin R, Varma R, McCarthy MI, Groop L, Ahlqvist E, Lyssenko V, Agardh E, Morris A, Doney ASF, Colhoun HM, Toppila I, Sandholm N, Groop PH, Maeda S, Hanis CL, Penman A, Chen CJ, Hancock H, Mitchell P, Craig JE, Chew EY, Paterson AD, Grassi MA, Palmer C, Bowden DW, Yaspan BL, Siscovick D, Cotch MF, Wang JJ, Burdon KP, Wong TY, Klein BEK, Klein R, Rotter JI, Iyengar SK, Price AL, Sobrin L.

Diabetes. 2019 Feb;68(2):441-456. doi: 10.2337/db18-0567. Epub 2018 Nov 28.


Advances in Retinal Imaging and Applications in Diabetic Retinopathy Screening: A Review.

Fenner BJ, Wong RLM, Lam WC, Tan GSW, Cheung GCM.

Ophthalmol Ther. 2018 Dec;7(2):333-346. doi: 10.1007/s40123-018-0153-7. Epub 2018 Nov 10. Review.


The Relationship between Generalized and Abdominal Obesity with Diabetic Kidney Disease in Type 2 Diabetes: A Multiethnic Asian Study and Meta-Analysis.

Man REK, Gan ATL, Fenwick EK, Gupta P, Wong MYZ, Wong TY, Tan GSW, Teo BW, Sabanayagam C, Lamoureux EL.

Nutrients. 2018 Nov 5;10(11). pii: E1685. doi: 10.3390/nu10111685.


Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model.

Bailey MJ, Duehr J, Dulin H, Broecker F, Brown JA, Arumemi FO, Bermúdez González MC, Leyva-Grado VH, Evans MJ, Simon V, Lim JK, Krammer F, Hai R, Palese P, Tan GS.

Nat Commun. 2018 Nov 1;9(1):4560. doi: 10.1038/s41467-018-07008-0.


Artificial intelligence and deep learning in ophthalmology.

Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, Tan GSW, Schmetterer L, Keane PA, Wong TY.

Br J Ophthalmol. 2019 Feb;103(2):167-175. doi: 10.1136/bjophthalmol-2018-313173. Epub 2018 Oct 25. Review.


Recent advances in the applications of metabolomics in eye research.

Chen L, Gao Y, Wang LZ, Cheung N, Tan GSW, Cheung GCM, Beuerman RW, Wong TY, Chan ECY, Zhou L.

Anal Chim Acta. 2018 Dec 11;1037:28-40. doi: 10.1016/j.aca.2018.01.060. Epub 2018 Feb 7. Review.


Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their cholinesterase inhibitory activities.

Liu Y, Xu PS, Ren Q, Chen X, Zhou G, Li D, Li XM, Xu KP, Yu X, Tan GS.

Fitoterapia. 2018 Oct;130:203-209. doi: 10.1016/j.fitote.2018.09.005. Epub 2018 Sep 11.


Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum.

Zou ZX, Tan GS, Huang Q, Sun HH, Huo LQ, Zhong WQ, Zhao LY, Liu HX, Tan HB.

Fitoterapia. 2018 Oct;130:184-189. doi: 10.1016/j.fitote.2018.08.026. Epub 2018 Aug 30.


Parallel Behind Your Head.

Kappers AML, Çetinkaya AÖR, Tan GS.

Iperception. 2018 Jun 13;9(3):2041669518781141. doi: 10.1177/2041669518781141. eCollection 2018 May-Jun.


New adenine analogues and a pyrrole alkaloid from Selaginella delicatula.

Yao CP, Zou ZX, Zhang Y, Li J, Cheng F, Xu PS, Zhou G, Li XM, Xu KP, Tan GS.

Nat Prod Res. 2019 Jul;33(14):1985-1991. doi: 10.1080/14786419.2018.1482892. Epub 2018 Jul 4.


Yellow Fever - What It Means for Singapore.

Tan GS, Chan M, Lim PL.

Ann Acad Med Singapore. 2018 May;47(5):185-187. No abstract available.


Sequences of Zika Virus Genomes from a Pediatric Cohort in Nicaragua.

Oldfield LM, Fedorova N, Puri V, Shrivastava S, Amedeo P, Durbin A, Rocchi I, Williams T, Shabman RS, Tan GS, Balmaseda A, Kuan G, Saborio S, Gordon A, Harris E, Pickett BE.

Genome Announc. 2018 Jun 14;6(24). pii: e00498-18. doi: 10.1128/genomeA.00498-18.


A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies.

Li Y, Busoy JM, Zaman BAA, Tan QSW, Tan GSW, Barathi VA, Cheung N, Wei JJ, Hunziker W, Hong W, Wong TY, Cheung CMG.

Exp Eye Res. 2018 Sep;174:98-106. doi: 10.1016/j.exer.2018.05.027. Epub 2018 May 28.


Two new anthraquinone derivatives and one new triarylbenzophenone analog from Selaginella tamariscina.

Liu R, Zou H, Zou ZX, Cheng F, Yu X, Xu PS, Li XM, Li D, Xu KP, Tan GS.

Nat Prod Res. 2018 Apr 15:1-6. doi: 10.1080/14786419.2018.1452008. [Epub ahead of print]


A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies.

Bailey MJ, Broecker F, Leon PE, Tan GS.

J Vis Exp. 2018 Feb 23;(132). doi: 10.3791/56256.


Whole-Genome Sequences of Zika Virus FLR Strains after Passage in Vero or C6/36 Cells.

Moser LA, Oldfield LM, Fedorova N, Puri V, Shrivastava S, Amedeo P, Isom R, Hu L, Durbin A, Rocchi I, Williams T, Tan GS, Shabman RS, Bernard KA, Pickett BE.

Genome Announc. 2018 Jan 25;6(4). pii: e01528-17. doi: 10.1128/genomeA.01528-17.


The End of Acquired Immunodeficiency Syndrome (AIDS) in Singapore - Are We There Yet?

Tan GS, Tambyah PA.

Ann Acad Med Singapore. 2017 Dec;46(12):452-454. No abstract available.


The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes.

Chua J, Chia AR, Chee ML, Man REK, Tan GSW, Lamoureux EL, Wong TY, Chong MF, Schmetterer L.

Sci Rep. 2018 Jan 15;8(1):730. doi: 10.1038/s41598-017-18930-6.


Is Emergency Transcatheter Hepatic Arterial Embolization Suitable for Spontaneously Ruptured Hepatocellular Carcinoma in Child-Pugh C Cirrhosis?

Fan WZ, Zhang YQ, Yao W, Wang Y, Tan GS, Huang YH, Yang JY, Li JP.

J Vasc Interv Radiol. 2018 Mar;29(3):404-412.e3. doi: 10.1016/j.jvir.2017.09.022. Epub 2017 Dec 14.


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