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Items: 1 to 50 of 219

1.

Universal Template-Assisted, Cloning-free Method for the Generation of Small RNA-Expressing Dumbbell-Shaped DNA Vectors.

Cyrill SL, Ghosh A, Loh PS, Tan GSX, Patzel V.

Mol Ther Methods Clin Dev. 2019 Aug 31;15:149-156. doi: 10.1016/j.omtm.2019.08.008. eCollection 2019 Dec 13.

2.

Surgical Approaches for Cell Therapeutics Delivery to the Retinal Pigment Epithelium and Retina.

Stanzel B, Ader M, Liu Z, Amaral J, Aguirre LIR, Rickmann A, Barathi VA, Tan GSW, Degreif A, Al-Nawaiseh S, Szurman P.

Adv Exp Med Biol. 2019;1186:141-170. doi: 10.1007/978-3-030-28471-8_6.

PMID:
31654389
3.

Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides.

Liu Y, Li J, Li D, Li XM, Li D, Zhou G, Xu KP, Kang FH, Zou ZX, Xu PS, Tan GS.

Fitoterapia. 2019 Oct 17;139:104366. doi: 10.1016/j.fitote.2019.104366. [Epub ahead of print]

PMID:
31629868
4.

Severe primary cutaneous Cryptococcus gattii causing ulcerative cellulitis in an immunocompetent patient.

Tan GSE, Singh R, Chong TYR, Su PQ, Lee JSS, Wong KJH, Tan JWL, Vasoo S.

Lancet Infect Dis. 2019 Oct;19(10):1148. doi: 10.1016/S1473-3099(19)30409-8. No abstract available.

PMID:
31559968
5.

Artificial intelligence for diabetic retinopathy screening: a review.

Grzybowski A, Brona P, Lim G, Ruamviboonsuk P, Tan GSW, Abramoff M, Ting DSW.

Eye (Lond). 2019 Sep 5. doi: 10.1038/s41433-019-0566-0. [Epub ahead of print] Review.

PMID:
31488886
6.

Global Assessment of Retinal Arteriolar, Venular and Capillary Microcirculations Using Fundus Photographs and Optical Coherence Tomography Angiography in Diabetic Retinopathy.

Tan TE, Nguyen Q, Chua J, Schmetterer L, Tan GSW, Wong CW, Tsai A, Cheung GCM, Wong TY, Ting DSW.

Sci Rep. 2019 Aug 13;9(1):11751. doi: 10.1038/s41598-019-47770-9.

7.

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.

Ramos I, Smith G, Ruf-Zamojski F, Martínez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, García-Sastre A, Fernandez-Sesma A.

J Virol. 2019 Sep 30;93(20). pii: e00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15.

8.

Artificial Intelligence Screening for Diabetic Retinopathy: the Real-World Emerging Application.

Bellemo V, Lim G, Rim TH, Tan GSW, Cheung CY, Sadda S, He MG, Tufail A, Lee ML, Hsu W, Ting DSW.

Curr Diab Rep. 2019 Jul 31;19(9):72. doi: 10.1007/s11892-019-1189-3. Review.

PMID:
31367962
9.

Deep learning in estimating prevalence and systemic risk factors for diabetic retinopathy: a multi-ethnic study.

Ting DSW, Cheung CY, Nguyen Q, Sabanayagam C, Lim G, Lim ZW, Tan GSW, Soh YQ, Schmetterer L, Wang YX, Jonas JB, Varma R, Lee ML, Hsu W, Lamoureux E, Cheng CY, Wong TY.

NPJ Digit Med. 2019 Apr 10;2:24. doi: 10.1038/s41746-019-0097-x. eCollection 2019.

10.

The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers.

Musharrafieh R, Lagarias PI, Ma C, Tan GS, Kolocouris A, Wang J.

Mol Pharmacol. 2019 Aug;96(2):148-157. doi: 10.1124/mol.119.116640. Epub 2019 Jun 7.

PMID:
31175183
11.

New cytotoxic biflavones from Selaginella doederleinii.

Liu LF, Sun HH, Tan JB, Huang Q, Cheng F, Xu KP, Zou ZX, Tan GS.

Nat Prod Res. 2019 May 21:1-7. doi: 10.1080/14786419.2019.1611813. [Epub ahead of print]

PMID:
31109181
12.

Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein.

Bailey MJ, Broecker F, Freyn AW, Choi A, Brown JA, Fedorova N, Simon V, Lim JK, Evans MJ, García-Sastre A, Palese P, Tan GS.

J Virol. 2019 Jun 28;93(14). pii: e00405-19. doi: 10.1128/JVI.00405-19. Print 2019 Jul 15.

PMID:
31043537
13.

Artificial Intelligence in Diabetic Eye Disease Screening.

Cheung CY, Tang F, Ting DSW, Tan GSW, Wong TY.

Asia Pac J Ophthalmol (Phila). 2019 Apr 24. doi: 10.22608/APO.201976. [Epub ahead of print]

PMID:
31016915
14.

Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus.

Bailey MJ, Broecker F, Duehr J, Arumemi F, Krammer F, Palese P, Tan GS.

MBio. 2019 Apr 2;10(2). pii: e02861-18. doi: 10.1128/mBio.02861-18.

15.

Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention.

Nusinovici S, Sabanayagam C, Teo BW, Tan GSW, Wong TY.

Am J Kidney Dis. 2019 Jun;73(6):846-857. doi: 10.1053/j.ajkd.2018.12.047. Epub 2019 Mar 28. Review.

PMID:
30929852
16.

In vivo development of amoxicillin and ceftriaxone resistance in Salmonella enterica serovar Typhi.

Tan GSE, Octavia S, Teo JWP, Ang MLT, La MV, Lin RTP, Choudhury S, Ang BSP.

Clin Microbiol Infect. 2019 Aug;25(8):1045-1047. doi: 10.1016/j.cmi.2019.03.015. Epub 2019 Mar 23. No abstract available.

PMID:
30914348
17.

Sinensiols B-G, six novel neolignans from Selaginella sinensis.

Chen X, Xu PS, Zou ZX, Liu Y, Zhou WH, Ren Q, Li D, Li XM, Xu KP, Tan GS.

Fitoterapia. 2019 Apr;134:256-263. doi: 10.1016/j.fitote.2019.02.034. Epub 2019 Feb 28.

PMID:
30826368
18.

Optimization of qRT-PCR assay for zika virus detection in human serum and urine.

Del Pilar Martinez Viedma M, Puri V, Oldfield LM, Shabman RS, Tan GS, Pickett BE.

Virus Res. 2019 Apr 2;263:173-178. doi: 10.1016/j.virusres.2019.01.013. Epub 2019 Feb 10.

19.

Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW.

J Clin Oncol. 2019 Apr 10;37(11):876-884. doi: 10.1200/JCO.18.00177. Epub 2019 Jan 24.

PMID:
30676858
20.

Pictalignans D-F, three new neolignan derivatives from Selaginella picta.

Cheng F, Zou ZX, Xu PS, Zhang SH, Zhang Y, Yao CP, Xu KP, Tan GS.

Nat Prod Res. 2019 Jan 19:1-6. doi: 10.1080/14786419.2018.1560284. [Epub ahead of print]

PMID:
30663380
21.

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Pollack S, Igo RP Jr, Jensen RA, Christiansen M, Li X, Cheng CY, Ng MCY, Smith AV, Rossin EJ, Segrè AV, Davoudi S, Tan GS, Chen YI, Kuo JZ, Dimitrov LM, Stanwyck LK, Meng W, Hosseini SM, Imamura M, Nousome D, Kim J, Hai Y, Jia Y, Ahn J, Leong A, Shah K, Park KH, Guo X, Ipp E, Taylor KD, Adler SG, Sedor JR, Freedman BI; Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group, Lee IT, Sheu WH, Kubo M, Takahashi A, Hadjadj S, Marre M, Tregouet DA, Mckean-Cowdin R, Varma R, McCarthy MI, Groop L, Ahlqvist E, Lyssenko V, Agardh E, Morris A, Doney ASF, Colhoun HM, Toppila I, Sandholm N, Groop PH, Maeda S, Hanis CL, Penman A, Chen CJ, Hancock H, Mitchell P, Craig JE, Chew EY, Paterson AD, Grassi MA, Palmer C, Bowden DW, Yaspan BL, Siscovick D, Cotch MF, Wang JJ, Burdon KP, Wong TY, Klein BEK, Klein R, Rotter JI, Iyengar SK, Price AL, Sobrin L.

Diabetes. 2019 Feb;68(2):441-456. doi: 10.2337/db18-0567. Epub 2018 Nov 28.

22.

Advances in Retinal Imaging and Applications in Diabetic Retinopathy Screening: A Review.

Fenner BJ, Wong RLM, Lam WC, Tan GSW, Cheung GCM.

Ophthalmol Ther. 2018 Dec;7(2):333-346. doi: 10.1007/s40123-018-0153-7. Epub 2018 Nov 10. Review.

23.

The Relationship between Generalized and Abdominal Obesity with Diabetic Kidney Disease in Type 2 Diabetes: A Multiethnic Asian Study and Meta-Analysis.

Man REK, Gan ATL, Fenwick EK, Gupta P, Wong MYZ, Wong TY, Tan GSW, Teo BW, Sabanayagam C, Lamoureux EL.

Nutrients. 2018 Nov 5;10(11). pii: E1685. doi: 10.3390/nu10111685.

24.

Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model.

Bailey MJ, Duehr J, Dulin H, Broecker F, Brown JA, Arumemi FO, Bermúdez González MC, Leyva-Grado VH, Evans MJ, Simon V, Lim JK, Krammer F, Hai R, Palese P, Tan GS.

Nat Commun. 2018 Nov 1;9(1):4560. doi: 10.1038/s41467-018-07008-0.

25.

Artificial intelligence and deep learning in ophthalmology.

Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, Tan GSW, Schmetterer L, Keane PA, Wong TY.

Br J Ophthalmol. 2019 Feb;103(2):167-175. doi: 10.1136/bjophthalmol-2018-313173. Epub 2018 Oct 25. Review.

26.

Recent advances in the applications of metabolomics in eye research.

Chen L, Gao Y, Wang LZ, Cheung N, Tan GSW, Cheung GCM, Beuerman RW, Wong TY, Chan ECY, Zhou L.

Anal Chim Acta. 2018 Dec 11;1037:28-40. doi: 10.1016/j.aca.2018.01.060. Epub 2018 Feb 7. Review.

PMID:
30292303
27.

Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their cholinesterase inhibitory activities.

Liu Y, Xu PS, Ren Q, Chen X, Zhou G, Li D, Li XM, Xu KP, Yu X, Tan GS.

Fitoterapia. 2018 Oct;130:203-209. doi: 10.1016/j.fitote.2018.09.005. Epub 2018 Sep 11.

PMID:
30213757
28.

Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum.

Zou ZX, Tan GS, Huang Q, Sun HH, Huo LQ, Zhong WQ, Zhao LY, Liu HX, Tan HB.

Fitoterapia. 2018 Oct;130:184-189. doi: 10.1016/j.fitote.2018.08.026. Epub 2018 Aug 30.

PMID:
30172824
29.

Parallel Behind Your Head.

Kappers AML, Çetinkaya AÖR, Tan GS.

Iperception. 2018 Jun 13;9(3):2041669518781141. doi: 10.1177/2041669518781141. eCollection 2018 May-Jun.

30.

New adenine analogues and a pyrrole alkaloid from Selaginella delicatula.

Yao CP, Zou ZX, Zhang Y, Li J, Cheng F, Xu PS, Zhou G, Li XM, Xu KP, Tan GS.

Nat Prod Res. 2019 Jul;33(14):1985-1991. doi: 10.1080/14786419.2018.1482892. Epub 2018 Jul 4.

PMID:
29972034
31.

Yellow Fever - What It Means for Singapore.

Tan GS, Chan M, Lim PL.

Ann Acad Med Singapore. 2018 May;47(5):185-187. No abstract available.

32.

Sequences of Zika Virus Genomes from a Pediatric Cohort in Nicaragua.

Oldfield LM, Fedorova N, Puri V, Shrivastava S, Amedeo P, Durbin A, Rocchi I, Williams T, Shabman RS, Tan GS, Balmaseda A, Kuan G, Saborio S, Gordon A, Harris E, Pickett BE.

Genome Announc. 2018 Jun 14;6(24). pii: e00498-18. doi: 10.1128/genomeA.00498-18.

33.

A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies.

Li Y, Busoy JM, Zaman BAA, Tan QSW, Tan GSW, Barathi VA, Cheung N, Wei JJ, Hunziker W, Hong W, Wong TY, Cheung CMG.

Exp Eye Res. 2018 Sep;174:98-106. doi: 10.1016/j.exer.2018.05.027. Epub 2018 May 28.

PMID:
29852133
34.

Two new anthraquinone derivatives and one new triarylbenzophenone analog from Selaginella tamariscina.

Liu R, Zou H, Zou ZX, Cheng F, Yu X, Xu PS, Li XM, Li D, Xu KP, Tan GS.

Nat Prod Res. 2018 Apr 15:1-6. doi: 10.1080/14786419.2018.1452008. [Epub ahead of print]

PMID:
29658323
35.

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies.

Bailey MJ, Broecker F, Leon PE, Tan GS.

J Vis Exp. 2018 Feb 23;(132). doi: 10.3791/56256.

36.

Whole-Genome Sequences of Zika Virus FLR Strains after Passage in Vero or C6/36 Cells.

Moser LA, Oldfield LM, Fedorova N, Puri V, Shrivastava S, Amedeo P, Isom R, Hu L, Durbin A, Rocchi I, Williams T, Tan GS, Shabman RS, Bernard KA, Pickett BE.

Genome Announc. 2018 Jan 25;6(4). pii: e01528-17. doi: 10.1128/genomeA.01528-17.

37.

The End of Acquired Immunodeficiency Syndrome (AIDS) in Singapore - Are We There Yet?

Tan GS, Tambyah PA.

Ann Acad Med Singapore. 2017 Dec;46(12):452-454. No abstract available.

38.

The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes.

Chua J, Chia AR, Chee ML, Man REK, Tan GSW, Lamoureux EL, Wong TY, Chong MF, Schmetterer L.

Sci Rep. 2018 Jan 15;8(1):730. doi: 10.1038/s41598-017-18930-6.

39.

Is Emergency Transcatheter Hepatic Arterial Embolization Suitable for Spontaneously Ruptured Hepatocellular Carcinoma in Child-Pugh C Cirrhosis?

Fan WZ, Zhang YQ, Yao W, Wang Y, Tan GS, Huang YH, Yang JY, Li JP.

J Vasc Interv Radiol. 2018 Mar;29(3):404-412.e3. doi: 10.1016/j.jvir.2017.09.022. Epub 2017 Dec 14.

PMID:
29249595
40.

Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes.

Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, Wong EYM, Sabanayagam C, Baskaran M, Ibrahim F, Tan NC, Finkelstein EA, Lamoureux EL, Wong IY, Bressler NM, Sivaprasad S, Varma R, Jonas JB, He MG, Cheng CY, Cheung GCM, Aung T, Hsu W, Lee ML, Wong TY.

JAMA. 2017 Dec 12;318(22):2211-2223. doi: 10.1001/jama.2017.18152.

41.

Ethnic Differences in the Prevalence and Risk Factors of Diabetic Retinopathy: The Singapore Epidemiology of Eye Diseases Study.

Tan GS, Gan A, Sabanayagam C, Tham YC, Neelam K, Mitchell P, Wang JJ, Lamoureux EL, Cheng CY, Wong TY.

Ophthalmology. 2018 Apr;125(4):529-536. doi: 10.1016/j.ophtha.2017.10.026. Epub 2017 Dec 6.

PMID:
29217148
42.

Association Between Perceived Barriers to Diabetes Self-management and Diabetic Retinopathy in Asian Patients With Type 2 Diabetes.

Man REK, Fenwick EK, Gan ATL, Sabanayagam C, Gupta P, Aravindhan A, Wong TY, Tan GSW, Lamoureux EL.

JAMA Ophthalmol. 2017 Dec 1;135(12):1387-1393. doi: 10.1001/jamaophthalmol.2017.4888.

43.

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice.

He W, Chen CJ, Mullarkey CE, Hamilton JR, Wong CK, Leon PE, Uccellini MB, Chromikova V, Henry C, Hoffman KW, Lim JK, Wilson PC, Miller MS, Krammer F, Palese P, Tan GS.

Nat Commun. 2017 Oct 10;8(1):846. doi: 10.1038/s41467-017-00928-3.

44.

Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG.

Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401. Epub 2017 Sep 18.

PMID:
28920960
45.

[A new flavonoid with an aryl moiety from Selaginella uncinata].

Zou H, Sheng XF, Tan GS, Xu KP.

Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(15):2830-2832. doi: 10.4268/cjcmm20161514. Chinese.

PMID:
28914024
46.

Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease.

Deng YH, Wang NN, Zou ZX, Zhang L, Xu KP, Chen AF, Cao DS, Tan GS.

Front Pharmacol. 2017 Aug 25;8:539. doi: 10.3389/fphar.2017.00539. eCollection 2017.

47.

An overview of the clinical applications of optical coherence tomography angiography.

Tan ACS, Tan GS, Denniston AK, Keane PA, Ang M, Milea D, Chakravarthy U, Cheung CMG.

Eye (Lond). 2018 Feb;32(2):262-286. doi: 10.1038/eye.2017.181. Epub 2017 Sep 8. Review.

48.

Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas.

Chan SH, Lim WK, Ishak NDB, Li ST, Goh WL, Tan GS, Lim KH, Teo M, Young CNC, Malik S, Tan MH, Teh JYH, Chin FKC, Kesavan S, Selvarajan S, Tan P, Teh BT, Soo KC, Farid M, Quek R, Ngeow J.

Sci Rep. 2017 Sep 6;7(1):10660. doi: 10.1038/s41598-017-10333-x.

49.

Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization.

Maamary J, Wang TT, Tan GS, Palese P, Ravetch JV.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10172-10177. doi: 10.1073/pnas.1707950114. Epub 2017 Sep 5.

50.

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies.

Leon PE, Wohlbold TJ, He W, Bailey MJ, Henry CJ, Wilson PC, Krammer F, Tan GS.

J Vis Exp. 2017 Aug 29;(126). doi: 10.3791/56067.

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