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Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).

Fong PY, Tan SH, Lim DWT, Tan EH, Ng QS, Sommat K, Tan DSW, Ang MK.

PLoS One. 2019 Nov 20;14(11):e0224665. doi: 10.1371/journal.pone.0224665. eCollection 2019.


Asian Thoracic Oncology Research Group expert consensus statement on optimal management of stage III non-small cell lung cancer.

Tan WL, Chua KLM, Lin CC, Lee VHF, Tho LM, Chan AW, Ho GF, Reungwetwattana T, Yang JC, Kim DW, Soo RA, Chan Ahn Y, Onishi H, Ahn MJ, Mok TSK, Tan DSW, Yang F.

J Thorac Oncol. 2019 Nov 13. pii: S1556-0864(19)33640-8. doi: 10.1016/j.jtho.2019.10.022. [Epub ahead of print] Review.


CYP2C19 phenotype in South-East Asian Acute Coronary Syndrome patients and impact on major adverse cardiovascular events.

Tan DS, Aw JWX, Winther M, Goh LL, Ong HY, Wee E, Liu J, Ho HK.

J Clin Pharm Ther. 2019 Oct 31. doi: 10.1111/jcpt.13062. [Epub ahead of print]


Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768.

Xu Y, Tan DS.

Org Lett. 2019 Nov 1;21(21):8731-8735. doi: 10.1021/acs.orglett.9b03348. Epub 2019 Oct 21.


Cancer-associated missense mutations enhance the pluripotency reprogramming activity of OCT4 and SOX17.

Srivastava Y, Tan DS, Malik V, Weng M, Javed A, Cojocaru V, Wu G, Veerapandian V, Cheung LWT, Jauch R.

FEBS J. 2019 Sep 30. doi: 10.1111/febs.15076. [Epub ahead of print]


Circulating extracellular vesicle-associated TGFβ3 modulates response to cytotoxic therapy in head and neck squamous cell carcinoma.

Rodrigues-Junior DM, Tan SS, Lim SK, Leong HS, Melendez ME, Ramos CRN, Viana LS, Tan DSW, Carvalho AL, Iyer NG, Vettore AL.

Carcinogenesis. 2019 Aug 22. pii: bgz148. doi: 10.1093/carcin/bgz148. [Epub ahead of print]


SOX17 in cellular reprogramming and cancer.

Tan DS, Holzner M, Weng M, Srivastava Y, Jauch R.

Semin Cancer Biol. 2019 Aug 13. pii: S1044-579X(19)30030-6. doi: 10.1016/j.semcancer.2019.08.008. [Epub ahead of print] Review.


Addressing cellular heterogeneity in tumor and circulation for refined prognostication.

Lim SB, Yeo T, Lee WD, Bhagat AAS, Tan SJ, Tan DSW, Lim WT, Lim CT.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17957-17962. doi: 10.1073/pnas.1907904116. Epub 2019 Aug 15.


Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3-Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations.

Bardia A, Gounder M, Rodon J, Janku F, Lolkema MP, Stephenson JJ, Bedard PL, Schuler M, Sessa C, LoRusso P, Thomas M, Maacke H, Evans H, Sun Y, Tan DSW.

Oncologist. 2019 Aug 8. pii: theoncologist.2019-0297. doi: 10.1634/theoncologist.2019-0297. [Epub ahead of print]


Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.

McElreavey K, Jorgensen A, Eozenou C, Merel T, Bignon-Topalovic J, Tan DS, Houzelstein D, Buonocore F, Warr N, Kay RGG, Peycelon M, Siffroi JP, Mazen I, Achermann JC, Shcherbak Y, Leger J, Sallai A, Carel JC, Martinerie L, Le Ru R, Conway GS, Mignot B, Van Maldergem L, Bertalan R, Globa E, Brauner R, Jauch R, Nef S, Greenfield A, Bashamboo A.

Genet Med. 2019 Jul 24. doi: 10.1038/s41436-019-0606-y. [Epub ahead of print]


Challenges and insights of early phase oncology drug development in the Asia-Pacific region.

Loong HH, Tan DSW, Shimizu T.

Chin Clin Oncol. 2019 Jun;8(3):26. doi: 10.21037/cco.2019.06.02.


Structural basis for adenylation and thioester bond formation in the ubiquitin E1.

Hann ZS, Ji C, Olsen SK, Lu X, Lux MC, Tan DS, Lima CD.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15475-15484. doi: 10.1073/pnas.1905488116. Epub 2019 Jun 24.


Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.

Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG.

Nat Commun. 2019 Jun 19;10(1):2691. doi: 10.1038/s41467-019-10523-3.


Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction.

Lux MC, Boby ML, Brooks JL, Tan DS.

Chem Commun (Camb). 2019 Jun 21;55(49):7013-7016. doi: 10.1039/c9cc03775f. Epub 2019 May 31.


Publisher Correction: Methionine is a metabolic dependency of tumor-initiating cells.

Wang Z, Yip LY, Lee JHJ, Wu Z, Chew HY, Chong PKW, Teo CC, Ang HY, Peh KLE, Yuan J, Ma S, Choo LSK, Basri N, Jiang X, Yu Q, Hillmer AM, Lim WT, Lim TKH, Takano A, Tan EH, Tan DSW, Ho YS, Lim B, Tam WL.

Nat Med. 2019 Jun;25(6):1022. doi: 10.1038/s41591-019-0486-3.


Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa.

Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS.

ACS Chem Biol. 2019 Jun 21;14(6):1380. doi: 10.1021/acschembio.9b00298. Epub 2019 May 14. No abstract available.


Methionine is a metabolic dependency of tumor-initiating cells.

Wang Z, Yip LY, Lee JHJ, Wu Z, Chew HY, Chong PKW, Teo CC, Ang HY, Peh KLE, Yuan J, Ma S, Choo LSK, Basri N, Jiang X, Yu Q, Hillmer AM, Lim WT, Lim TKH, Takano A, Tan EH, Tan DSW, Ho YS, Lim B, Tam WL.

Nat Med. 2019 May;25(5):825-837. doi: 10.1038/s41591-019-0423-5. Epub 2019 May 6. Erratum in: Nat Med. 2019 Jun;25(6):1022.


Depth Map Upsampling via Multi-Modal Generative Adversarial Network.

Tan DS, Lin JM, Lai YC, Ilao J, Hua KL.

Sensors (Basel). 2019 Apr 2;19(7). pii: E1587. doi: 10.3390/s19071587.


Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.

Lux MC, Standke LC, Tan DS.

J Antibiot (Tokyo). 2019 Jun;72(6):325-349. doi: 10.1038/s41429-019-0171-2. Epub 2019 Apr 15. Review.


Sex Differences in 1-Year Rehospitalization for Heart Failure and Myocardial Infarction After Primary Percutaneous Coronary Intervention.

Zheng H, Foo LL, Tan HC, Richards AM, Chan SP, Lee CH, Low AFH, Hausenloy DJ, Tan JWC, Sahlen AO, Ho HH, Chai SC, Tong KL, Tan DSY, Yeo KK, Chua TSJ, Lam CSP, Chan MY.

Am J Cardiol. 2019 Jun 15;123(12):1935-1940. doi: 10.1016/j.amjcard.2019.03.021. Epub 2019 Mar 19.


Single-Image Depth Inference Using Generative Adversarial Networks.

Tan DS, Yao CY, Ruiz C Jr, Hua KL.

Sensors (Basel). 2019 Apr 10;19(7). pii: E1708. doi: 10.3390/s19071708.


Third generation EGFR TKI landscape for metastatic EGFR mutant non-small cell lung cancer (NSCLC).

Tan AC, Teh YL, Lai GGY, Tan DSW.

Expert Rev Anticancer Ther. 2019 Jun;19(6):431-435. doi: 10.1080/14737140.2019.1604228. Epub 2019 Apr 14. No abstract available.


Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.

Evans CE, Si Y, Matarlo JS, Yin Y, French JB, Tonge PJ, Tan DS.

Biochemistry. 2019 Apr 9;58(14):1918-1930. doi: 10.1021/acs.biochem.9b00003. Epub 2019 Mar 26.


25OUse of CTTA to predict treatment response in patients with EGFR T790M+ NSCLC treated with osimertinib.

Tan WL, Tran Nguyen TA, Koh TS, Priyanthi Hennedige T, Yip CSP, Tan SH, Tan DSW, Thng CH, Lim DW, Ng QS.

Ann Oncol. 2019 Feb 1;30(Supplement_1). pii: mdz030. doi: 10.1093/annonc/mdz030. No abstract available.


The 4th European Society for Medical Oncology Asia Congress: bridging ultimate cancer care with real-world practice for the Asian practitioner in gynecological cancers.

Ngoi NY, Tan DS.

J Gynecol Oncol. 2019 Mar;30(2):e48. doi: 10.3802/jgo.2019.30.e48. Epub 2019 Jan 11. No abstract available.


Asian Society of Gynecologic Oncology International Workshop 2018.

Kong TW, Ryu HS, Kim SC, Enomoto T, Li J, Kim KH, Shim SH, Wang PH, Therasakvichya S, Kobayashi Y, Lee M, Shi T, Lee SW, Mikami M, Nagase S, Lim MC, Wang J, Wilailak S, Kim SW, Hong SH, Tan DS, Mandai M, Chang SJ, Huang RYJ, Ushijima K, Lee JY, Chen X, Ochiai K, Lee TS, Yang B, Kalam F, Lv Q, Ahmad MF, Yaznil MR, Modi KB, Manopunya M, Jeong DH, Lertkhachonsuk AA, Chung HH, Watari H, Jeon S.

J Gynecol Oncol. 2019 Mar;30(2):e39. doi: 10.3802/jgo.2019.30.e39. Epub 2019 Jan 14.


Validation of the Chinese Manchester foot pain and disability index (C-MFPDI) among patients with inflammatory arthritis.

Erh BXY, He HG, Carter KF, Cheung PP, Tan DS, Wang W, Rome K.

J Foot Ankle Res. 2019 Jan 23;12:6. doi: 10.1186/s13047-019-0316-3. eCollection 2019.


Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW.

J Clin Oncol. 2019 Apr 10;37(11):876-884. doi: 10.1200/JCO.18.00177. Epub 2019 Jan 24.


Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.


Pan-Asian adapted Clinical Practice Guidelines for the management of patients with metastatic non-small-cell lung cancer: a CSCO-ESMO initiative endorsed by JSMO, KSMO, MOS, SSO and TOS.

Wu YL, Planchard D, Lu S, Sun H, Yamamoto N, Kim DW, Tan DSW, Yang JC, Azrif M, Mitsudomi T, Park K, Soo RA, Chang JWC, Alip A, Peters S, Douillard JY.

Ann Oncol. 2019 Feb 1;30(2):171-210. doi: 10.1093/annonc/mdy554.


Efficacy and safety of reduced-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a meta-analysis of randomized controlled trials.

Wang KL, Lopes RD, Patel MR, Büller HR, Tan DS, Chiang CE, Giugliano RP.

Eur Heart J. 2019 May 14;40(19):1492-1500. doi: 10.1093/eurheartj/ehy802.


Correction to: Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases.

Tan WL, Ng QS, Lim C, Tan EH, Toh CK, Ang MK, Kanesvaran R, Jain A, Tan DSW, Lim DW.

BMC Cancer. 2018 Dec 24;18(1):1288. doi: 10.1186/s12885-018-5215-7.


Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents.

Bythrow GV, Mohandas P, Guney T, Standke LC, Germain GA, Lu X, Ji C, Levendosky K, Chavadi SS, Tan DS, Quadri LEN.

Biochemistry. 2019 Feb 12;58(6):833-847. doi: 10.1021/acs.biochem.8b01153. Epub 2019 Jan 10.


Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures.

Kong SL, Li H, Tai JA, Courtois ET, Poh HM, Lau DP, Haw YX, Iyer NG, Tan DSW, Prabhakar S, Ruff D, Hillmer AM.

Clin Chem. 2019 Feb;65(2):272-281. doi: 10.1373/clinchem.2018.295717. Epub 2018 Dec 6.


Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases.

Tan WL, Ng QS, Lim C, Tan EH, Toh CK, Ang MK, Kanesvaran R, Jain A, Tan DSW, Lim DW.

BMC Cancer. 2018 Dec 3;18(1):1198. doi: 10.1186/s12885-018-5110-2. Erratum in: BMC Cancer. 2018 Dec 24;18(1):1288.


Effects of Single Nucleotide Polymorphisms on the Binding of Afatinib to EGFR: A Potential Patient Stratification Factor Revealed by Modeling Studies.

Kannan S, Tan DS, Verma CS.

J Chem Inf Model. 2019 Jan 28;59(1):309-315. doi: 10.1021/acs.jcim.8b00491. Epub 2018 Dec 10.


Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction.

Karimov RR, Tan DS, Gin DY.

Tetrahedron. 2018 Jun 28;74(26):3370-3383. doi: 10.1016/j.tet.2018.04.051. Epub 2018 Apr 19.


Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer.

Tan TZ, Heong V, Ye J, Lim D, Low J, Choolani M, Scott C, Tan DSP, Huang RY.

J Pathol. 2019 Mar;247(3):305-319. doi: 10.1002/path.5191. Epub 2018 Dec 18.


Phase Ib/II Study of Capmatinib (INC280) Plus Gefitinib After Failure of Epidermal Growth Factor Receptor (EGFR) Inhibitor Therapy in Patients With EGFR-Mutated, MET Factor-Dysregulated Non-Small-Cell Lung Cancer.

Wu YL, Zhang L, Kim DW, Liu X, Lee DH, Yang JC, Ahn MJ, Vansteenkiste JF, Su WC, Felip E, Chia V, Glaser S, Pultar P, Zhao S, Peng B, Akimov M, Tan DSW.

J Clin Oncol. 2018 Nov 1;36(31):3101-3109. doi: 10.1200/JCO.2018.77.7326. Epub 2018 Aug 29. Erratum in: J Clin Oncol. 2019 Jan 20;37(3):261.


Comparison of rivaroxaban concentrations between Asians and Caucasians and their correlation with PT/INR.

Ng Tsai HO, Goh JJN, Aw JWX, Lin Y, Fong AYY, Tiong LL, Tan DS.

J Thromb Thrombolysis. 2018 Nov;46(4):541-548. doi: 10.1007/s11239-018-1726-y.


Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor.

Subhash VV, Yeo MS, Wang L, Tan SH, Wong FY, Thuya WL, Tan WL, Peethala PC, Soe MY, Tan DSP, Padmanabhan N, Baloglu E, Shacham S, Tan P, Koeffler HP, Yong WP.

Sci Rep. 2018 Aug 16;8(1):12248. doi: 10.1038/s41598-018-30686-1.


A Clinical and Molecular Phase II Trial of Oral ENMD-2076 in Ovarian Clear Cell Carcinoma (OCCC): A Study of the Princess Margaret Phase II Consortium.

Lheureux S, Tinker A, Clarke B, Ghatage P, Welch S, Weberpals JI, Dhani NC, Butler MO, Tonkin K, Tan Q, Tan DSP, Brooks K, Ramsahai J, Wang L, Pham NA, Shaw PA, Tsao MS, Garg S, Stockley T, Oza AM.

Clin Cancer Res. 2018 Dec 15;24(24):6168-6174. doi: 10.1158/1078-0432.CCR-18-1244. Epub 2018 Aug 14.


Clinical genetic testing outcome with multi-gene panel in Asian patients with multiple primary cancers.

Chan GHJ, Ong PY, Low JJH, Kong HL, Ow SGW, Tan DSP, Lim YW, Lim SE, Lee SC.

Oncotarget. 2018 Jul 17;9(55):30649-30660. doi: 10.18632/oncotarget.25769. eCollection 2018 Jul 17.


Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor.

Harding JJ, Bauer TM, Tan DSW, Bedard PL, Rodon J, Doi T, Schnell C, Iyer V, Baffert F, Radhakrishnan R, Fabre C, Juric D.

Invest New Drugs. 2019 Apr;37(2):271-281. doi: 10.1007/s10637-018-0627-4. Epub 2018 Aug 3.


DeepDemosaicking: Adaptive Image Demosaicking via Multiple Deep Fully Convolutional Networks.

Tan DS, Chen WY, Hua KL.

IEEE Trans Image Process. 2018 Feb 7. doi: 10.1109/TIP.2018.2803341. [Epub ahead of print]


Letter by Aw et al Regarding Article, "Clinical Outcomes and Sustainability of Using CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention".

Aw JWX, Tan DS, Goh LL.

Circ Genom Precis Med. 2018 Jul;11(7):e002253. doi: 10.1161/CIRCGEN.118.002253. No abstract available.


Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction.

Guney T, Wenderski TA, Boudreau MW, Tan DS.

Chemistry. 2018 Sep 6;24(50):13150-13157. doi: 10.1002/chem.201802880. Epub 2018 Aug 2.


Tumor molecular profiling of responders and non-responders following pembrolizumab monotherapy in chemotherapy resistant advanced cervical cancer.

Ngoi NYL, Heong V, Lee XW, Huang YQ, Thian YL, Choo BA, Lim D, Lim YW, Lim SE, Ilancheran A, Soong R, Tan DSP.

Gynecol Oncol Rep. 2018 Jan 31;24:1-5. doi: 10.1016/j.gore.2018.01.009. eCollection 2018 May.


Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC.

Rolfo C, Mack PC, Scagliotti GV, Baas P, Barlesi F, Bivona TG, Herbst RS, Mok TS, Peled N, Pirker R, Raez LE, Reck M, Riess JW, Sequist LV, Shepherd FA, Sholl LM, Tan DSW, Wakelee HA, Wistuba II, Wynes MW, Carbone DP, Hirsch FR, Gandara DR.

J Thorac Oncol. 2018 Sep;13(9):1248-1268. doi: 10.1016/j.jtho.2018.05.030. Epub 2018 Jun 6. Review.

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