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Quiet Outer Membrane Protein G (OmpG) Nanopore for Biosensing.

Sanganna Gari RR, Seelheim P, Liang B, Tamm LK.

ACS Sens. 2019 May 24;4(5):1230-1235. doi: 10.1021/acssensors.8b01645. Epub 2019 Apr 25.


A molecular mechanism for calcium-mediated synaptotagmin-triggered exocytosis.

Kiessling V, Kreutzberger AJB, Liang B, Nyenhuis SB, Seelheim P, Castle JD, Cafiso DS, Tamm LK.

Nat Struct Mol Biol. 2018 Oct;25(10):911-917. doi: 10.1038/s41594-018-0130-9. Epub 2018 Oct 5.


Quaternary structure of the small amino acid transporter OprG from Pseudomonas aeruginosa.

Sanganna Gari RR, Seelheim P, Marsh B, Kiessling V, Creutz CE, Tamm LK.

J Biol Chem. 2018 Nov 2;293(44):17267-17277. doi: 10.1074/jbc.RA118.004461. Epub 2018 Sep 20.


Solution NMR of SNAREs, complexin and α-synuclein in association with membrane-mimetics.

Liang B, Tamm LK.

Prog Nucl Magn Reson Spectrosc. 2018 Apr;105:41-53. doi: 10.1016/j.pnmrs.2018.02.001. Epub 2018 Feb 8. Review.


Distinct reaction mechanisms for hyaluronan biosynthesis in different kingdoms of life.

Blackburn MR, Hubbard C, Kiessling V, Bi Y, Kloss B, Tamm LK, Zimmer J.

Glycobiology. 2018 Feb 1;28(2):108-121. doi: 10.1093/glycob/cwx096.


Asymmetric Phosphatidylethanolamine Distribution Controls Fusion Pore Lifetime and Probability.

Kreutzberger AJB, Kiessling V, Liang B, Yang ST, Castle JD, Tamm LK.

Biophys J. 2017 Nov 7;113(9):1912-1915. doi: 10.1016/j.bpj.2017.09.014. Epub 2017 Oct 13.


Special Issue on Liposomes, Exosomes, and Virosomes.

Tamm LK.

Biophys J. 2017 Sep 19;113(6):E1. doi: 10.1016/j.bpj.2017.08.002. No abstract available.


Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.

Lee J, Nyenhuis DA, Nelson EA, Cafiso DS, White JM, Tamm LK.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7987-E7996. doi: 10.1073/pnas.1708052114. Epub 2017 Sep 5.


HIV virions sense plasma membrane heterogeneity for cell entry.

Yang ST, Kreutzberger AJB, Kiessling V, Ganser-Pornillos BK, White JM, Tamm LK.

Sci Adv. 2017 Jun 28;3(6):e1700338. doi: 10.1126/sciadv.1700338. eCollection 2017 Jun.


Reconstitution of calcium-mediated exocytosis of dense-core vesicles.

Kreutzberger AJB, Kiessling V, Liang B, Seelheim P, Jakhanwal S, Jahn R, Castle JD, Tamm LK.

Sci Adv. 2017 Jul 19;3(7):e1603208. doi: 10.1126/sciadv.1603208. eCollection 2017 Jul.


Solution NMR Provides New Insight into Lipid-Protein Interaction.

Kucharska I, Tamm LK.

Biochemistry. 2017 Aug 22;56(33):4291-4292. doi: 10.1021/acs.biochem.7b00336. Epub 2017 Jun 1. No abstract available.


Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.

Zdanowicz R, Kreutzberger A, Liang B, Kiessling V, Tamm LK, Cafiso DS.

Biophys J. 2017 Sep 19;113(6):1235-1250. doi: 10.1016/j.bpj.2017.04.002. Epub 2017 Apr 26.


Planar Supported Membranes with Mobile SNARE Proteins and Quantitative Fluorescence Microscopy Assays to Study Synaptic Vesicle Fusion.

Kiessling V, Liang B, Kreutzberger AJ, Tamm LK.

Front Mol Neurosci. 2017 Mar 16;10:72. doi: 10.3389/fnmol.2017.00072. eCollection 2017. Review.


A quantized mechanism for activation of pannexin channels.

Chiu YH, Jin X, Medina CB, Leonhardt SA, Kiessling V, Bennett BC, Shu S, Tamm LK, Yeager M, Ravichandran KS, Bayliss DA.

Nat Commun. 2017 Jan 30;8:14324. doi: 10.1038/ncomms14324.


Refinement of OprH-LPS Interactions by Molecular Simulations.

Lee J, Patel DS, Kucharska I, Tamm LK, Im W.

Biophys J. 2017 Jan 24;112(2):346-355. doi: 10.1016/j.bpj.2016.12.006.


Site-specific fluorescent labeling to visualize membrane translocation of a myristoyl switch protein.

Yang ST, Lim SI, Kiessling V, Kwon I, Tamm LK.

Sci Rep. 2016 Sep 8;6:32866. doi: 10.1038/srep32866.


Molecular Interactions of Lipopolysaccharide with an Outer Membrane Protein from Pseudomonas aeruginosa Probed by Solution NMR.

Kucharska I, Liang B, Ursini N, Tamm LK.

Biochemistry. 2016 Sep 13;55(36):5061-72. doi: 10.1021/acs.biochem.6b00630. Epub 2016 Aug 31.


NMR as a tool to investigate the structure, dynamics and function of membrane proteins.

Liang B, Tamm LK.

Nat Struct Mol Biol. 2016 Jun 7;23(6):468-74. doi: 10.1038/nsmb.3226.


The role of cholesterol in membrane fusion.

Yang ST, Kreutzberger AJB, Lee J, Kiessling V, Tamm LK.

Chem Phys Lipids. 2016 Sep;199:136-143. doi: 10.1016/j.chemphyslip.2016.05.003. Epub 2016 May 11. Review.


Assembly and Comparison of Plasma Membrane SNARE Acceptor Complexes.

Kreutzberger AJ, Liang B, Kiessling V, Tamm LK.

Biophys J. 2016 May 24;110(10):2147-50. doi: 10.1016/j.bpj.2016.04.011. Epub 2016 May 10.


Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion.

Yang ST, Kiessling V, Tamm LK.

Nat Commun. 2016 Apr 26;7:11401. doi: 10.1038/ncomms11401.


The Roles of Histidines and Charged Residues as Potential Triggers of a Conformational Change in the Fusion Loop of Ebola Virus Glycoprotein.

Lee J, Gregory SM, Nelson EA, White JM, Tamm LK.

PLoS One. 2016 Mar 29;11(3):e0152527. doi: 10.1371/journal.pone.0152527. eCollection 2016.


OprG Harnesses the Dynamics of its Extracellular Loops to Transport Small Amino Acids across the Outer Membrane of Pseudomonas aeruginosa.

Kucharska I, Seelheim P, Edrington T, Liang B, Tamm LK.

Structure. 2015 Dec 1;23(12):2234-2245. doi: 10.1016/j.str.2015.10.009. Epub 2015 Nov 19.


High cholesterol obviates a prolonged hemifusion intermediate in fast SNARE-mediated membrane fusion.

Kreutzberger AJ, Kiessling V, Tamm LK.

Biophys J. 2015 Jul 21;109(2):319-29. doi: 10.1016/j.bpj.2015.06.022.


Supported lipid bilayers as models for studying membrane domains.

Kiessling V, Yang ST, Tamm LK.

Curr Top Membr. 2015;75:1-23. doi: 10.1016/bs.ctm.2015.03.001. Epub 2015 Apr 11. Review.


Reconstituting SNARE-mediated membrane fusion at the single liposome level.

Kiessling V, Liang B, Tamm LK.

Methods Cell Biol. 2015;128:339-63. doi: 10.1016/bs.mcb.2015.02.005. Epub 2015 Apr 8.


HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains.

Yang ST, Kiessling V, Simmons JA, White JM, Tamm LK.

Nat Chem Biol. 2015 Jun;11(6):424-31. doi: 10.1038/nchembio.1800. Epub 2015 Apr 27.


Optimizing nanodiscs and bicelles for solution NMR studies of two β-barrel membrane proteins.

Kucharska I, Edrington TC, Liang B, Tamm LK.

J Biomol NMR. 2015 Apr;61(3-4):261-74. doi: 10.1007/s10858-015-9905-z. Epub 2015 Feb 10.


Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate.

Tamm LK, Lee J, Liang B.

Structure. 2014 Sep 2;22(9):1225-1226. doi: 10.1016/j.str.2014.08.010.


Variable cooperativity in SNARE-mediated membrane fusion.

Hernandez JM, Kreutzberger AJ, Kiessling V, Tamm LK, Jahn R.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12037-42. doi: 10.1073/pnas.1407435111. Epub 2014 Aug 4.


The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.

Lu B, Kiessling V, Tamm LK, Cafiso DS.

J Biol Chem. 2014 Aug 8;289(32):22161-71. doi: 10.1074/jbc.M114.569327. Epub 2014 Jun 27.


Control of the conductance of engineered protein nanopores through concerted loop motions.

Zhuang T, Tamm LK.

Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5897-902. doi: 10.1002/anie.201400400. Epub 2014 Apr 28.


Mass spectrometry defines the C-terminal dimerization domain and enables modeling of the structure of full-length OmpA.

Marcoux J, Politis A, Rinehart D, Marshall DP, Wallace MI, Tamm LK, Robinson CV.

Structure. 2014 May 6;22(5):781-90. doi: 10.1016/j.str.2014.03.004. Epub 2014 Apr 17.


Ebolavirus entry requires a compact hydrophobic fist at the tip of the fusion loop.

Gregory SM, Larsson P, Nelson EA, Kasson PM, White JM, Tamm LK.

J Virol. 2014 Jun;88(12):6636-49. doi: 10.1128/JVI.00396-14. Epub 2014 Apr 2.


Regulation of Rac1 translocation and activation by membrane domains and their boundaries.

Moissoglu K, Kiessling V, Wan C, Hoffman BD, Norambuena A, Tamm LK, Schwartz MA.

J Cell Sci. 2014 Jun 1;127(Pt 11):2565-76. doi: 10.1242/jcs.149088. Epub 2014 Apr 2.


The SNARE motif of synaptobrevin exhibits an aqueous-interfacial partitioning that is modulated by membrane curvature.

Liang B, Dawidowski D, Ellena JF, Tamm LK, Cafiso DS.

Biochemistry. 2014 Mar 11;53(9):1485-94. doi: 10.1021/bi401638u. Epub 2014 Feb 28.


Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate.

Liang B, Kiessling V, Tamm LK.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19384-9. doi: 10.1073/pnas.1314699110. Epub 2013 Nov 11.


NMR-based conformational ensembles explain pH-gated opening and closing of OmpG channel.

Zhuang T, Chisholm C, Chen M, Tamm LK.

J Am Chem Soc. 2013 Oct 9;135(40):15101-13. doi: 10.1021/ja408206e. Epub 2013 Oct 1.


Membrane depth-dependent energetic contribution of the tryptophan side chain to the stability of integral membrane proteins.

Hong H, Rinehart D, Tamm LK.

Biochemistry. 2013 Jun 25;52(25):4413-21. doi: 10.1021/bi400344b. Epub 2013 Jun 13.


Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes.

Kiessling V, Ahmed S, Domanska MK, Holt MG, Jahn R, Tamm LK.

Biophys J. 2013 May 7;104(9):1950-8. doi: 10.1016/j.bpj.2013.03.038.


Lateral membrane diffusion corralled.

Tamm LK.

Biophys J. 2013 Apr 2;104(7):1399-400. doi: 10.1016/j.bpj.2013.02.046. No abstract available.


Benjamin Franklin, Philadelphia's favorite son, was a membrane biophysicist.

Wang DN, Stieglitz H, Marden J, Tamm LK.

Biophys J. 2013 Jan 22;104(2):287-91. doi: 10.1016/j.bpj.2012.12.028.


Role of sequence and structure of the Hendra fusion protein fusion peptide in membrane fusion.

Smith EC, Gregory SM, Tamm LK, Creamer TP, Dutch RE.

J Biol Chem. 2012 Aug 24;287(35):30035-48. doi: 10.1074/jbc.M112.367862. Epub 2012 Jul 3.


Fusion activity of HIV gp41 fusion domain is related to its secondary structure and depth of membrane insertion in a cholesterol-dependent fashion.

Lai AL, Moorthy AE, Li Y, Tamm LK.

J Mol Biol. 2012 Apr 20;418(1-2):3-15. doi: 10.1016/j.jmb.2012.02.010. Epub 2012 Feb 17.


Molecular mechanism of cholesterol- and polyphosphoinositide-mediated syntaxin clustering.

Murray DH, Tamm LK.

Biochemistry. 2011 Oct 25;50(42):9014-22. doi: 10.1021/bi201307u. Epub 2011 Sep 27.


Structural basis for the interaction of lipopolysaccharide with outer membrane protein H (OprH) from Pseudomonas aeruginosa.

Edrington TC, Kintz E, Goldberg JB, Tamm LK.

J Biol Chem. 2011 Nov 11;286(45):39211-23. doi: 10.1074/jbc.M111.280933. Epub 2011 Aug 24.


Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2.

Gregory SM, Harada E, Liang B, Delos SE, White JM, Tamm LK.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11211-6. doi: 10.1073/pnas.1104760108. Epub 2011 Jun 20.


Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine.

Lai AL, Tamm LK, Ellena JF, Cafiso DS.

J Biol Chem. 2011 Jul 15;286(28):25291-300. doi: 10.1074/jbc.M111.258848. Epub 2011 May 24.


Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases.

Wan C, Kiessling V, Cafiso DS, Tamm LK.

Biochemistry. 2011 Apr 5;50(13):2478-85. doi: 10.1021/bi101864k. Epub 2011 Mar 7.


Single SNARE-mediated vesicle fusion observed in vitro by polarized TIRFM.

Kiessling V, Domanska MK, Tamm LK.

Biophys J. 2010 Dec 15;99(12):4047-55. doi: 10.1016/j.bpj.2010.10.022.

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