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Infection, Antibiotics, and Patient Outcomes in the Intensive Care Unit.

Yin M, Tambyah PA, Perencevich EN.

JAMA. 2020 Mar 24. doi: 10.1001/jama.2020.2241. [Epub ahead of print] No abstract available.


Clofazimine in Mycobacterium abscessus peritonitis: A pediatric case report.

Pinapala A, Koh LJ, Ng KH, Tambyah PA, Yap HK.

Perit Dial Int. 2020 Mar 9:896860820909702. doi: 10.1177/0896860820909702. [Epub ahead of print]


Covert COVID-19 and false-positive dengue serology in Singapore.

Yan G, Lee CK, Lam LTM, Yan B, Chua YX, Lim AYN, Phang KF, Kew GS, Teng H, Ngai CH, Lin L, Foo RM, Pada S, Ng LC, Tambyah PA.

Lancet Infect Dis. 2020 Mar 4. pii: S1473-3099(20)30158-4. doi: 10.1016/S1473-3099(20)30158-4. [Epub ahead of print] No abstract available.


Outbreak of COVID-19 - an urgent need for good science to silence our fears?

Lum LHW, Tambyah PA.

Singapore Med J. 2020 Feb;61(2):55-57. doi: 10.11622/smedj.2020018. Epub 2020 Feb 13. No abstract available.


Histoplasmosis presenting with Sweet's syndrome.

Yan G, Tan KB, Chandran NS, Chai L, Chew KL, Somani J, Tambyah PA.

Clin Microbiol Infect. 2020 Feb 6. pii: S1198-743X(20)30057-4. doi: 10.1016/j.cmi.2020.01.031. [Epub ahead of print] No abstract available.


Gut microbiota changes in children with autism spectrum disorder: a systematic review.

Ho LKH, Tong VJW, Syn N, Nagarajan N, Tham EH, Tay SK, Shorey S, Tambyah PA, Law ECN.

Gut Pathog. 2020 Feb 3;12:6. doi: 10.1186/s13099-020-0346-1. eCollection 2020. Review.


Emergence of a novel coronavirus causing respiratory illness from Wuhan, China.

Tang JW, Tambyah PA, Hui DSC.

J Infect. 2020 Mar;80(3):350-371. doi: 10.1016/j.jinf.2020.01.014. Epub 2020 Jan 28. No abstract available.


Outcomes of treating AmpC-producing Enterobacterales bacteraemia with carbapenems vs. non-carbapenems.

Tan SH, Ng TM, Chew KL, Yong J, Wu JE, Yap MY, Heng ST, Ng WHW, Wan S, Cheok SJH, Tambyah PA, Lye DC.

Int J Antimicrob Agents. 2020 Feb;55(2):105860. doi: 10.1016/j.ijantimicag.2019.105860. Epub 2019 Dec 11.


Effectiveness of a Ward level target accountability strategy for hand hygiene.

Pada SMSK, Chee PL, Rathenam S, Ng KS, Alenton LS, Poh L, Tambyah PA.

Antimicrob Resist Infect Control. 2019 Nov 15;8:177. doi: 10.1186/s13756-019-0641-0. eCollection 2019.


Persistent Dengue Infection in an Immunosuppressed Patient Reveals the Roles of Humoral and Cellular Immune Responses in Virus Clearance.

Ng KH, Zhang SL, Tan HC, Kwek SS, Sessions OM, Chan CY, Liu ID, Lee CK, Tambyah PA, Ooi EE, Yap HK.

Cell Host Microbe. 2019 Nov 13;26(5):601-605.e3. doi: 10.1016/j.chom.2019.10.005. Epub 2019 Oct 29.


Predictors and Clinical Outcomes of Poor Platelet Recovery in Adult Dengue With Thrombocytopenia: A Multicenter, Prospective Study.

Archuleta S, Chia PY, Wei Y, Syed-Omar SF, Low JG, Oh HM, Fisher D, Ponnampalavanar SSL, Wijaya L, Kamarulzaman A, Lum LCS, Tambyah PA, Leo YS, Lye DC.

Clin Infect Dis. 2019 Oct 18. pii: ciz850. doi: 10.1093/cid/ciz850. [Epub ahead of print]


Impact of vaccines on antimicrobial resistance.

Buchy P, Ascioglu S, Buisson Y, Datta S, Nissen M, Tambyah PA, Vong S.

Int J Infect Dis. 2020 Jan;90:188-196. doi: 10.1016/j.ijid.2019.10.005. Epub 2019 Oct 14. Review.


Group B streptococcus bacteraemia and purulent pericarditis in an immunocompetent adult.

Sim MY, Sia CH, Chew KL, Lum LH, Loh PH, Tambyah PA.

QJM. 2019 Oct 1;112(10):801-802. doi: 10.1093/qjmed/hcz201. No abstract available.


Tuberculosis care: enhancing directly observed therapy in a peri-urban, low socioeconomic status neighbourhood.

Cai EZ, Chua SM, Tan M, Tambyah PA.

Singapore Med J. 2019 Jul;60(7):334-336. doi: 10.11622/smedj.2019072.


Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.

Kandilya D, Maskomani S, Shyamasundar S, Tambyah PA, Shiao Yng C, Lee RCH, Hande MP, Mallilankaraman K, Chu JJH, Dheen ST.

Epigenomics. 2019 Aug;11(10):1143-1161. doi: 10.2217/epi-2018-0180. Epub 2019 Jun 25.


An inactivated enterovirus 71 vaccine is safe and immunogenic in healthy adults: A phase I, double blind, randomized, placebo-controlled, study of two dosages.

Tambyah PA, Oon J, Asli R, Kristanto W, Hwa SH, Vang F, Karwal L, Fuchs J, Santangelo JD, Gordon GS, Thomson C, Rao R, Dean H, Das SC, Stinchcomb DT.

Vaccine. 2019 Jul 18;37(31):4344-4353. doi: 10.1016/j.vaccine.2019.06.023. Epub 2019 Jun 20.


The global challenge of carbapenemases and the critical need for more data.

Marimuthu K, Ng OT, Bagdasarian N, Tambyah PA.

Int J Infect Dis. 2019 Jul;84:141-142. doi: 10.1016/j.ijid.2019.05.018. Epub 2019 May 14. No abstract available.


Mucocutaneous Features of Zika-a Review.

Koh XQ, Chandran NS, Tambyah PA.

Curr Infect Dis Rep. 2019 Apr 30;21(5):18. doi: 10.1007/s11908-019-0671-z. Review.


Relating knowledge, attitude and practice of antibiotic use to extended-spectrum beta-lactamase-producing Enterobacteriaceae carriage: results of a cross-sectional community survey.

Mo Y, Seah I, Lye PSP, Kee XLJ, Wong KYM, Ko KKK, Ong RT, Tambyah PA, Cook AR.

BMJ Open. 2019 Mar 5;9(3):e023859. doi: 10.1136/bmjopen-2018-023859.


Postmortem evidence of disseminated Zika virus infection in an adult patient.

Rajahram GS, Hale G, Bhatnagar J, Hiu J, Thayan R, William T, Wong KT, Tambyah PA, Yeo TW.

Int J Infect Dis. 2019 Jun;83:163-166. doi: 10.1016/j.ijid.2019.01.047. Epub 2019 Feb 11. No abstract available.


Hallmarks of improved immunological responses in the vaccination of more physically active elderly females.

Wong GCL, Narang V, Lu Y, Camous X, Nyunt MSZ, Carre C, Tan C, Xian CH, Chong J, Chua M, How W, Mok E, Tambyah P, Poidinger M, Abel B, Burdin N, Quemeneur L, Bosco N, Ng TP, Larbi A.

Exerc Immunol Rev. 2019;25:20-33.


Antibiotics for Ceftriaxone Resistant Gram-Negative Bacterial Bloodstream Infections-Reply.

Harris PNA, Tambyah P, Paterson DL.

JAMA. 2019 Feb 12;321(6):613. doi: 10.1001/jama.2018.19353. No abstract available.


Evidence for Cross-Protection Against Subsequent Febrile Respiratory Illness Episodes From Prior Infections by Different Viruses Among Singapore Military Recruits 2009-2014.

Chen IM, Loh JP, Chuah CXP, Gao QHC, Sun Y, Ng SH, Koh WV, Goh EH, Zhao X, Tambyah PA, Cook AR, Chng J, Pang J, Tan BH, Lee VJ.

J Infect Dis. 2019 May 24;219(12):1913-1923. doi: 10.1093/infdis/jiz046.


Winds of change in medical education in Singapore: what does the future hold?

Lum LHW, Poh KK, Tambyah PA.

Singapore Med J. 2018 Dec;59(12):614-615. doi: 10.11622/smedj.2018142. No abstract available.


Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine.

Camous X, Visan L, Ying CTT, Abel B, Nyunt MSZ, Narang V, Poidinger M, Carre C, Sesay S, Bosco N, Burdin N, Tambyah PA, Pin NT, Larbi A.

Immun Ageing. 2018 Nov 12;15:28. doi: 10.1186/s12979-018-0137-4. eCollection 2018.


Influenza Vaccine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly With Natural Influenza Exposure.

Narang V, Lu Y, Tan C, Camous XFN, Nyunt SZ, Carre C, Mok EWH, Wong G, Maurer-Stroh S, Abel B, Burdin N, Poidinger M, Tambyah PA, Bosco N, Visan L, Ng TP, Larbi A.

Front Immunol. 2018 Oct 24;9:2465. doi: 10.3389/fimmu.2018.02465. eCollection 2018.


Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial.

Harris PNA, Tambyah PA, Lye DC, Mo Y, Lee TH, Yilmaz M, Alenazi TH, Arabi Y, Falcone M, Bassetti M, Righi E, Rogers BA, Kanj S, Bhally H, Iredell J, Mendelson M, Boyles TH, Looke D, Miyakis S, Walls G, Al Khamis M, Zikri A, Crowe A, Ingram P, Daneman N, Griffin P, Athan E, Lorenc P, Baker P, Roberts L, Beatson SA, Peleg AY, Harris-Brown T, Paterson DL; MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN).

JAMA. 2018 Sep 11;320(10):984-994. doi: 10.1001/jama.2018.12163. Erratum in: JAMA. 2019 Jun 18;321(23):2370.


The socio-economic impact of multidrug-resistant nosocomial infections: a qualitative study.

Mo Y, Low I, Tambyah SK, Tambyah PA.

J Hosp Infect. 2019 Aug;102(4):454-460. doi: 10.1016/j.jhin.2018.08.013. Epub 2018 Aug 29.


The Threat of Multiresistant Nosocomial Fungi.

Chai LY, Tambyah PA.

Ann Acad Med Singapore. 2018 Jul;47(7):241-242. No abstract available.


Disseminated Volvariella volvacea infections in patients with haematological malignancies: a case series.

Chew KL, Ng DHL, Teo JWP, Tan KB, Poon LM, Tambyah PA, Ong CWM.

Clin Microbiol Infect. 2019 Jan;25(1):117-119. doi: 10.1016/j.cmi.2018.07.032. Epub 2018 Aug 9. No abstract available.


Restriction of in vivo infection by antifouling coating on urinary catheter with controllable and sustained silver release: a proof of concept study.

Mandakhalikar KD, Wang R, Rahmat JN, Chiong E, Neoh KG, Tambyah PA.

BMC Infect Dis. 2018 Aug 6;18(1):370. doi: 10.1186/s12879-018-3296-1.


Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore.

Yan G, Pang L, Cook AR, Ho HJ, Win MS, Khoo AL, Wong JGX, Lee CK, Yan B, Jureen R, Ho SS, Lye DC, Tambyah PA, Leo YS, Fisher D, Oon J, Bagdasarian N, Chow A, Smitasin N, Chai LYA.

Emerg Infect Dis. 2018 Aug;24(8):1565-1568. doi: 10.3201/eid2408.171883.


Case 255: Foot Binding.

Mei-Yen Yong A, Tambyah PA.

Radiology. 2018 Jul;288(1):312-315. doi: 10.1148/radiol.2018160344.


Impact of financial background and student debt on postgraduate residency choices of medical students in Singapore.

Fong JMN, Tan YTW, Sayampanathan AA, Mohan N, Koh YQ, Jang JHJ, Low JRI, Vasudevan A, Ng CL, Tambyah PA.

Singapore Med J. 2018 Dec;59(12):647-651. doi: 10.11622/smedj.2018068. Epub 2018 Jun 7.


Extraction and quantification of biofilm bacteria: Method optimized for urinary catheters.

Mandakhalikar KD, Rahmat JN, Chiong E, Neoh KG, Shen L, Tambyah PA.

Sci Rep. 2018 May 23;8(1):8069. doi: 10.1038/s41598-018-26342-3.


Premenopausal women with recurrent urinary tract infections have lower quality of life.

Ennis SS, Guo H, Raman L, Tambyah PA, Chen SL, Tiong HY.

Int J Urol. 2018 Jul;25(7):684-689. doi: 10.1111/iju.13698. Epub 2018 May 22.


Dengue virus not detected in human semen.

Molton JS, Low I, Choy MMJ, Aw PPK, Hibberd ML, Tambyah PA, Wilder-Smith A.

J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay023.


Anhydrous polymer-based coating with sustainable controlled release functionality for facile, efficacious impregnation, and delivery of antimicrobial peptides.

Lim K, Saravanan R, Chong KKL, Goh SHM, Chua RRY, Tambyah PA, Chang MW, Kline KA, Leong SSJ.

Biotechnol Bioeng. 2018 Aug;115(8):2000-2012. doi: 10.1002/bit.26713. Epub 2018 Apr 27.


Cost-benefit analysis of introducing next-generation sequencing (metagenomic) pathogen testing in the setting of pyrexia of unknown origin.

Chai JH, Lee CK, Lee HK, Wong N, Teo K, Tan CS, Thokala P, Tang JW, Tambyah PA, Oh VMS, Loh TP, Yoong J.

PLoS One. 2018 Apr 17;13(4):e0194648. doi: 10.1371/journal.pone.0194648. eCollection 2018.


Case 255.

Yong AM, Tambyah PA.

Radiology. 2018 Mar;286(3):1084-1087. doi: 10.1148/radiol.2018160563. No abstract available.


The End of Acquired Immunodeficiency Syndrome (AIDS) in Singapore - Are We There Yet?

Tan GS, Tambyah PA.

Ann Acad Med Singapore. 2017 Dec;46(12):452-454. No abstract available.


Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates.

Vente A, Bentley C, L├╝ckermann M, Tambyah P, Dalhoff A.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02325-17. doi: 10.1128/AAC.02325-17. Print 2018 Apr.


Whole genome analysis of cephalosporin-resistant Escherichia coli from bloodstream infections in Australia, New Zealand and Singapore: high prevalence of CMY-2 producers and ST131 carrying blaCTX-M-15 and blaCTX-M-27.

Harris PNA, Ben Zakour NL, Roberts LW, Wailan AM, Zowawi HM, Tambyah PA, Lye DC, Jureen R, Lee TH, Yin M, Izharuddin E, Looke D, Runnegar N, Rogers B, Bhally H, Crowe A, Schembri MA, Beatson SA, Paterson DL; MERINO Trial investigators.

J Antimicrob Chemother. 2018 Mar 1;73(3):634-642. doi: 10.1093/jac/dkx466.


Infective endocarditis - An update for dental surgeons.

Robinson AN, Tambyah PA.

Singapore Dent J. 2017 Dec;38:2-7. doi: 10.1016/j.sdj.2017.09.001. Review.


Extraintestinal Salmonellosis in the Immunocompromised: An Unusual Case of Pyomyositis.

Meyyur Aravamudan V, Kee Fong P, Singh P, Sze Chin J, Sam YS, Tambyah PA.

Case Rep Med. 2017;2017:5030961. doi: 10.1155/2017/5030961. Epub 2017 Sep 11.


The epidemiology and transmission of methicillin-resistant Staphylococcus aureus in the community in Singapore: study protocol for a longitudinal household study.

Shankar N, Chow ALP, Oon J, Hsu LY, Ang B, Pang J, De Sessions PF, Periaswamy B, Tambyah PA, Teo DB, Tam CC.

BMC Infect Dis. 2017 Oct 11;17(1):678. doi: 10.1186/s12879-017-2793-y.



Hey HWD, Ng NLW, Tan CS, Fisher D, Vasudevan A, Liu GKP, Thambiah J, Kumar N, Lau LL, Wong HK, Tambyah PA.

Spine (Phila Pa 1976). 2017 Jun 15;42(12):E755-E756. doi: 10.1097/BRS.0000000000002199. No abstract available.


An in-vitro urinary catheterization model that approximates clinical conditions for evaluation of innovations to prevent catheter-associated urinary tract infections.

Chua RYR, Lim K, Leong SSJ, Tambyah PA, Ho B.

J Hosp Infect. 2017 Sep;97(1):66-73. doi: 10.1016/j.jhin.2017.05.006. Epub 2017 May 17.


Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey.

Cai Y, Venkatachalam I, Tee NW, Tan TY, Kurup A, Wong SY, Low CY, Wang Y, Lee W, Liew YX, Ang B, Lye DC, Chow A, Ling ML, Oh HM, Cuvin CA, Ooi ST, Pada SK, Lim CH, Tan JWC, Chew KL, Nguyen VH, Fisher DA, Goossens H, Kwa AL, Tambyah PA, Hsu LY, Marimuthu K.

Clin Infect Dis. 2017 May 15;64(suppl_2):S61-S67. doi: 10.1093/cid/cix103.


Community-Acquired Pneumonia Case Validation in an Anonymized Electronic Medical Record-Linked Expert System.

Mukhopadhyay A, Maliapen M, Ong V, Jakes RW, Mundy LM, Jialiang L, Tambyah PA.

Clin Infect Dis. 2017 May 15;64(suppl_2):S141-S144. doi: 10.1093/cid/cix020.


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