Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 350

1.

Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol.

Kobayashi M, Nishi K, Mizutani A, Hokama T, Matsue M, Tsujikawa T, Nakanishi T, Nishii R, Tamai I, Kawai K.

Sci Rep. 2019 Sep 16;9(1):13413. doi: 10.1038/s41598-019-50049-8.

2.

Identification of the Catechin Uptake Transporter Responsible for Intestinal Absorption of Epigallocatechin Gallate in Mice.

Ishii S, Kitazawa H, Mori T, Kirino A, Nakamura S, Osaki N, Shimotoyodome A, Tamai I.

Sci Rep. 2019 Jul 29;9(1):11014. doi: 10.1038/s41598-019-47214-4.

3.

Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells.

Arakawa H, Kubo H, Washio I, Staub AY, Nedachi S, Ishiguro N, Nakanishi T, Tamai I.

J Pharm Sci. 2019 Aug;108(8):2798-2804. doi: 10.1016/j.xphs.2019.03.031. Epub 2019 Apr 5.

PMID:
30959054
4.

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

Nishizawa K, Yoda N, Morokado F, Komori H, Nakanishi T, Tamai I.

PLoS One. 2019 Apr 5;14(4):e0214862. doi: 10.1371/journal.pone.0214862. eCollection 2019.

5.

Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats.

Arakawa H, Amezawa N, Katsuyama T, Nakanishi T, Tamai I.

Drug Metab Pharmacokinet. 2019 Apr;34(2):155-158. doi: 10.1016/j.dmpk.2018.12.003. Epub 2018 Dec 27.

PMID:
30826184
6.

Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer.

Myint K, Biswas R, Li Y, Jong N, Jamieson S, Liu J, Han C, Squire C, Merien F, Lu J, Nakanishi T, Tamai I, McKeage M.

Sci Rep. 2019 Feb 19;9(1):2245. doi: 10.1038/s41598-019-38667-8.

7.

Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines.

Washio I, Nakanishi T, Ishiguro N, Bister B, Tamai I.

Biopharm Drug Dispos. 2019 Jan;40(1):32-43. doi: 10.1002/bdd.2167. Epub 2019 Jan 4.

PMID:
30556139
8.

Different Efflux Transporter Affinity and Metabolism of 99mTc-2-Methoxyisobutylisonitrile and 99mTc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer.

Kobayashi M, Tsujiuchi T, Okui Y, Mizutani A, Nishi K, Nakanishi T, Nishii R, Fukuchi K, Tamai I, Kawai K.

Pharm Res. 2018 Nov 29;36(1):18. doi: 10.1007/s11095-018-2548-5.

PMID:
30498970
9.

Experimental Evidence for Resecretion of PGE2 across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport.

Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I.

J Pharmacol Exp Ther. 2019 Feb;368(2):317-325. doi: 10.1124/jpet.118.249789. Epub 2018 Nov 12.

PMID:
30420359
10.

Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.

Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.

Mol Pharm. 2018 Dec 3;15(12):5772-5780. doi: 10.1021/acs.molpharmaceut.8b00921. Epub 2018 Nov 5.

PMID:
30359033
11.

Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System.

Nakamura Y, Nakanishi T, Tamai I.

Biol Pharm Bull. 2018;41(9):1337-1347. doi: 10.1248/bpb.b18-00169. Review.

12.

Foreword.

Nakanishi T, Tamai I, Deguchi Y.

Biol Pharm Bull. 2018;41(9):1322-1323. doi: 10.1248/bpb.b18-ctf4109. No abstract available.

13.

In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans.

Koyanagi T, Yano K, Kim S, Murayama N, Yamazaki H, Tamai I.

Xenobiotica. 2019 Aug;49(8):887-894. doi: 10.1080/00498254.2018.1514476. Epub 2018 Sep 21.

PMID:
30124359
14.

Cyclophosphamide-induced hemorrhagic cystitis in young patients with solid tumors: A single institution study.

Saito Y, Kumamoto T, Shiraiwa M, Sonoda T, Arakawa A, Hashimoto H, Tamai I, Ogawa C, Terakado H.

Asia Pac J Clin Oncol. 2018 Oct;14(5):e460-e464. doi: 10.1111/ajco.13048. Epub 2018 Jul 10.

PMID:
29989294
15.

Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1.

Omote S, Matsuoka N, Arakawa H, Nakanishi T, Tamai I.

Sci Rep. 2018 Jun 18;8(1):9237. doi: 10.1038/s41598-018-27672-y.

16.

Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever.

Nakamura Y, Nakanishi T, Shimada H, Shimizu J, Aotani R, Maruyama S, Higuchi K, Okura T, Deguchi Y, Tamai I.

J Neurosci. 2018 Jun 13;38(24):5584-5595. doi: 10.1523/JNEUROSCI.3276-17.2018. Epub 2018 May 21.

17.

Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells.

Hioki M, Shimada T, Yuan T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto KI, Ohta T, Tamai I, Shimada T, Sai Y.

Biopharm Drug Dispos. 2018 May;39(5):256-264. doi: 10.1002/bdd.2131.

PMID:
29682747
18.

Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter-Enzyme Interplay.

Matsunaga N, Fukuchi Y, Imawaka H, Tamai I.

Drug Metab Dispos. 2018 May;46(5):680-691. doi: 10.1124/dmd.117.079236. Epub 2018 Jan 19.

PMID:
29352067
19.

Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells.

Komori H, Yamada K, Tamai I.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):973-980. doi: 10.1016/j.bbamem.2018.01.006. Epub 2018 Jan 6.

20.

Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines.

Washio I, Nakanishi T, Ishiguro N, Yamamura N, Tamai I.

Drug Metab Dispos. 2018 Mar;46(3):214-222. doi: 10.1124/dmd.117.078402. Epub 2017 Dec 15.

PMID:
29246888
21.

Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins.

Nakanishi T, Tamai I.

AAPS J. 2017 Dec 4;20(1):13. doi: 10.1208/s12248-017-0163-8. Review.

PMID:
29204966
22.

A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.

Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I.

Sci Rep. 2017 Nov 29;7(1):16567. doi: 10.1038/s41598-017-16738-y.

23.

Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transports of anticancer trifluridine.

Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I.

Biopharm Drug Dispos. 2018 Jan;39(1):38-46. doi: 10.1002/bdd.2110. Epub 2017 Dec 15.

PMID:
29055025
24.

Usefulness of kidney slices for functional analysis of apical reabsorptive transporters.

Arakawa H, Washio I, Matsuoka N, Kubo H, Staub AY, Nakamichi N, Ishiguro N, Kato Y, Nakanishi T, Tamai I.

Sci Rep. 2017 Oct 9;7(1):12814. doi: 10.1038/s41598-017-12828-z.

25.

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts.

Inagaki M, Nishimura T, Akanuma SI, Nakanishi T, Tachikawa M, Tamai I, Hosoya KI, Nakashima E, Tomi M.

Placenta. 2017 May;53:76-82. doi: 10.1016/j.placenta.2017.04.002. Epub 2017 Apr 6.

PMID:
28487024
26.

Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1.

Kamo S, Nakanishi T, Aotani R, Nakamura Y, Gose T, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2483-2490. doi: 10.1016/j.xphs.2017.04.046. Epub 2017 May 4.

PMID:
28479361
27.

Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban.

Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2524-2534. doi: 10.1016/j.xphs.2017.04.044. Epub 2017 Apr 26.

PMID:
28456731
28.

Association of miR-145 With Statin-Induced Skeletal Muscle Toxicity in Human Rhabdomyosarcoma RD Cells.

Saito S, Nakanishi T, Shirasaki Y, Nakajima M, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2873-2880. doi: 10.1016/j.xphs.2017.04.005. Epub 2017 Apr 21.

PMID:
28438533
29.

JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation.

Kurimoto T, Tamai I, Miyai A, Kosugi Y, Nakagawa T, Yamamoto Y, Deai K, Misaki S, Bessho Y, Negoro T, Yamaguchi T, Hata T, Matsushita M.

Eur J Pharmacol. 2017 May 15;803:179-186. doi: 10.1016/j.ejphar.2017.03.057. Epub 2017 Mar 31.

PMID:
28366807
30.

Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2.

Arakawa H, Omote S, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2899-2903. doi: 10.1016/j.xphs.2017.03.013. Epub 2017 Mar 21.

PMID:
28336299
31.

Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect?

Rostami-Hodjegan A, Tamai I, Pang KS.

Biopharm Drug Dispos. 2017 Mar;38(2):87-93. doi: 10.1002/bdd.2071. No abstract available.

PMID:
28317174
32.

Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions.

Nishizawa K, Nakanishi T, Tamai I.

Drug Metab Dispos. 2017 Feb;45(2):224-227. doi: 10.1124/dmd.116.072355. Epub 2016 Dec 1.

PMID:
27934638
33.

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.

Visentin M, van Rosmalen BV, Hiller C, Bieze M, Hofstetter L, Verheij J, Kullak-Ublick GA, Koepsell H, Phoa SS, Tamai I, Bennink RJ, van Gulik TM, Stieger B.

Drug Metab Dispos. 2017 Feb;45(2):166-173. doi: 10.1124/dmd.116.072371. Epub 2016 Nov 30.

PMID:
27903597
34.

Molecular characterization of Salmonella enterica serotype Enteritidis isolates from food and human samples by serotyping, antimicrobial resistance, plasmid profiling, (GTG)5-PCR and ERIC-PCR.

Fardsanei F, Nikkhahi F, Bakhshi B, Salehi TZ, Tamai IA, Soltan Dallal MM.

New Microbes New Infect. 2016 Aug 4;14:24-30. doi: 10.1016/j.nmni.2016.07.016. eCollection 2016 Nov.

35.

A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors.

Saito Y, Kumamoto T, Makino Y, Tamai I, Ogawa C, Terakado H.

Jpn J Clin Oncol. 2016 Sep;46(9):856-61. doi: 10.1093/jjco/hyw093. Epub 2016 Jul 5.

PMID:
27380806
36.

Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue.

Incecayir T, Sun J, Tsume Y, Xu H, Gose T, Nakanishi T, Tamai I, Hilfinger J, Lipka E, Amidon GL.

J Pharm Sci. 2016 Feb;105(2):925-934. doi: 10.1016/j.xphs.2015.11.036.

37.

Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.

Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I.

Exp Cell Res. 2016 Feb 15;341(2):123-31. doi: 10.1016/j.yexcr.2016.02.002. Epub 2016 Feb 2.

PMID:
26850138
38.

Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.

Gose T, Nakanishi T, Kamo S, Shimada H, Otake K, Tamai I.

Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. doi: 10.1016/j.prostaglandins.2015.12.003. Epub 2015 Dec 10.

PMID:
26692285
39.

Interaction of Drug or Food with Drug Transporters in Intestine and Liver.

Nakanishi T, Tamai I.

Curr Drug Metab. 2015;16(9):753-64. Review.

PMID:
26630906
40.

Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride.

Fujita D, Saito Y, Nakanishi T, Tamai I.

Drug Metab Dispos. 2016 Jan;44(1):1-7. doi: 10.1124/dmd.115.066712. Epub 2015 Nov 2.

PMID:
26526067
41.

Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes.

Matsunaga N, Kaneko N, Staub AY, Nakanishi T, Nunoya K, Imawaka H, Tamai I.

Drug Metab Dispos. 2016 Jan;44(1):16-27. doi: 10.1124/dmd.115.067074. Epub 2015 Oct 26.

PMID:
26502773
42.

OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.

Shimada H, Nakamura Y, Nakanishi T, Tamai I.

Biochem Pharmacol. 2015 Dec 15;98(4):629-38. doi: 10.1016/j.bcp.2015.10.009. Epub 2015 Oct 22.

PMID:
26474801
43.

Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart.

Takeuchi R, Shinozaki K, Nakanishi T, Tamai I.

Drug Metab Dispos. 2016 Jan;44(1):68-74. doi: 10.1124/dmd.115.066654. Epub 2015 Oct 14.

PMID:
26467765
44.

The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.

Akamine Y, Miura M, Komori H, Tamai I, Ieiri I, Yasui-Furukori N, Uno T.

Drug Metab Pharmacokinet. 2015 Oct;30(5):352-7. doi: 10.1016/j.dmpk.2015.06.005. Epub 2015 Jun 26.

PMID:
26213156
45.

Gordon L. Amidon: Very Sustained Drug Absorption.

Donovan MD, Polli JE, Langguth P, Tamai I, Vig B, Yu LX.

J Pharm Sci. 2015 Sep;104(9):2650-63. doi: 10.1002/jps.24523. Epub 2015 Jun 5. No abstract available.

PMID:
26053319
46.

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.

Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto K, Kitagawa H, Ohta T, Tamai I, Sai Y.

J Pharm Sci. 2015 Sep;104(9):3162-9. doi: 10.1002/jps.24498. Epub 2015 Jun 2.

PMID:
26037416
47.

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

Watanabe M, Watanabe T, Yabuki M, Tamai I.

Drug Metab Pharmacokinet. 2015 Apr;30(2):198-204. doi: 10.1016/j.dmpk.2014.12.009. Epub 2015 Jan 6.

PMID:
25989893
48.

Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide.

Matsunaga N, Suzuki K, Nakanishi T, Ogawa M, Imawaka H, Tamai I.

Drug Metab Pharmacokinet. 2015 Apr;30(2):142-8. doi: 10.1016/j.dmpk.2014.10.006. Epub 2014 Nov 14.

PMID:
25989889
49.

Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.

Nakanishi T, Ogawa T, Yanagihara C, Tamai I.

J Pharm Sci. 2015 Sep;104(9):3092-100. doi: 10.1002/jps.24462. Epub 2015 May 8.

PMID:
25959076
50.

Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.

Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I.

PLoS One. 2015 Apr 29;10(4):e0123895. doi: 10.1371/journal.pone.0123895. eCollection 2015.

Supplemental Content

Support Center