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Items: 1 to 50 of 52

1.

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads.

Kulkarni JA, Witzigmann D, Leung J, van der Meel R, Zaifman J, Darjuan MM, Grisch-Chan HM, Thöny B, Tam YYC, Cullis PR.

Nanoscale. 2019 May 9;11(18):9023-9031. doi: 10.1039/c9nr02004g.

PMID:
31021343
2.

Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids.

Chen S, Zaifman J, Kulkarni JA, Zhigaltsev IV, Tam YK, Ciufolini MA, Tam YYC, Cullis PR.

J Control Release. 2018 Sep 28;286:46-54. doi: 10.1016/j.jconrel.2018.07.026. Epub 2018 Jul 17.

PMID:
30026080
3.

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA.

Kulkarni JA, Darjuan MM, Mercer JE, Chen S, van der Meel R, Thewalt JL, Tam YYC, Cullis PR.

ACS Nano. 2018 May 22;12(5):4787-4795. doi: 10.1021/acsnano.8b01516. Epub 2018 Apr 6.

PMID:
29614232
4.

Pneumocephalus Following Self-Inflicted Penetrating Brain Injury.

Ho CF, Tam YY, Wu CC.

Case Rep Otolaryngol. 2017;2017:7878646. doi: 10.1155/2017/7878646. Epub 2017 Sep 26.

5.

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes.

Neumann UH, Ho JSS, Chen S, Tam YYC, Cullis PR, Kieffer TJ.

Mol Metab. 2017 Oct;6(10):1161-1172. doi: 10.1016/j.molmet.2017.06.012. Epub 2017 Jun 22.

6.

Rapid synthesis of lipid nanoparticles containing hydrophobic inorganic nanoparticles.

Kulkarni JA, Tam YYC, Chen S, Tam YK, Zaifman J, Cullis PR, Biswas S.

Nanoscale. 2017 Sep 21;9(36):13600-13609. doi: 10.1039/c7nr03272b.

PMID:
28876010
7.

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.

Lee JB, Zhang K, Tam YY, Quick J, Tam YK, Lin PJ, Chen S, Liu Y, Nair JK, Zlatev I, Rajeev KG, Manoharan M, Rennie PS, Cullis PR.

Mol Ther Nucleic Acids. 2016;5:e348. doi: 10.1038/mtna.2016.43.

8.

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA.

Kulkarni JA, Myhre JL, Chen S, Tam YYC, Danescu A, Richman JM, Cullis PR.

Nanomedicine. 2017 May;13(4):1377-1387. doi: 10.1016/j.nano.2016.12.014. Epub 2016 Dec 28.

PMID:
28038954
9.

The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA.

Wang H, Tam YY, Chen S, Zaifman J, van der Meel R, Ciufolini MA, Cullis PR.

Mol Ther. 2016 Dec;24(12):2100-2108. doi: 10.1038/mt.2016.179. Epub 2016 Sep 16.

10.

Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study.

Shao IH, Wu CC, Tseng HJ, Lee TJ, Lin YH, Tam YY.

Drug Des Devel Ther. 2016 Jul 19;10:2333-9. doi: 10.2147/DDDT.S108819. eCollection 2016.

11.

The effect of nocturia on sleep quality and daytime function in patients with lower urinary tract symptoms: a cross-sectional study.

Shao IH, Wu CC, Hsu HS, Chang SC, Wang HH, Chuang HC, Tam YY.

Clin Interv Aging. 2016 Jun 29;11:879-85. doi: 10.2147/CIA.S104634. eCollection 2016.

12.

The clinicopathological features of sinonasal angiomatous polyps.

Tam YY, Wu CC, Lee TJ, Lin YY, Chen TD, Huang CC.

Int J Gen Med. 2016 Jun 17;9:207-12. doi: 10.2147/IJGM.S104628. eCollection 2016.

13.

Front blind spot crashes in Hong Kong.

Cheng YK, Wong KH, Tao CH, Tam CN, Tam YY, Tsang CN.

Forensic Sci Int. 2016 Sep;266:102-108. doi: 10.1016/j.forsciint.2016.05.013. Epub 2016 May 21.

PMID:
27239752
14.

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA.

Chen S, Tam YYC, Lin PJC, Sung MMH, Tam YK, Cullis PR.

J Control Release. 2016 Aug 10;235:236-244. doi: 10.1016/j.jconrel.2016.05.059. Epub 2016 May 26.

PMID:
27238441
15.

Importance of clothing removal in scalds.

Lau EY, Tam YY, Chiu TW.

Hong Kong Med J. 2016 Apr;22(2):152-7. doi: 10.12809/hkmj144476. Epub 2016 Feb 26.

16.

Evaluation of depression and anxiety in empty nose syndrome after surgical treatment.

Lee TJ, Fu CH, Wu CL, Tam YY, Huang CC, Chang PH, Chen YW, Wu MH.

Laryngoscope. 2016 Jun;126(6):1284-9. doi: 10.1002/lary.25814. Epub 2015 Dec 15.

PMID:
26667794
17.

Validation of pedestrian throw equations by video footage of real life pedestrian/vehicle collisions.

Cheng YK, Wong KH, Tam CN, Tam YY, Wong TW, Tao CH.

Forensic Sci Int. 2015 Dec;257:409-412. doi: 10.1016/j.forsciint.2015.10.008. Epub 2015 Oct 19.

PMID:
26562788
18.

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems.

Leung AK, Tam YY, Chen S, Hafez IM, Cullis PR.

J Phys Chem B. 2015 Jul 16;119(28):8698-706. doi: 10.1021/acs.jpcb.5b02891. Epub 2015 Jul 7.

PMID:
26087393
19.

Lipid nanoparticles for short interfering RNA delivery.

Leung AK, Tam YY, Cullis PR.

Adv Genet. 2014;88:71-110. doi: 10.1016/B978-0-12-800148-6.00004-3. Review.

PMID:
25409604
20.

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration.

Chen S, Tam YY, Lin PJ, Leung AK, Tam YK, Cullis PR.

J Control Release. 2014 Dec 28;196:106-12. doi: 10.1016/j.jconrel.2014.09.025. Epub 2014 Oct 5.

PMID:
25285610
21.

Clinical analysis of submucosal Medpor implantation for empty nose syndrome.

Tam YY, Lee TJ, Wu CC, Chang PH, Chen YW, Fu CH, Huang CC.

Rhinology. 2014 Mar;52(1):35-40. doi: 10.4193/Rhin13.086.

PMID:
24618626
22.

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice.

Neumann UH, Chen S, Tam YY, Baker RK, Covey SD, Cullis PR, Kieffer TJ.

Endocrinology. 2014 Mar;155(3):716-25. doi: 10.1210/en.2013-1622. Epub 2014 Jan 1.

PMID:
24424049
23.

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles.

Mui BL, Tam YK, Jayaraman M, Ansell SM, Du X, Tam YY, Lin PJ, Chen S, Narayanannair JK, Rajeev KG, Manoharan M, Akinc A, Maier MA, Cullis P, Madden TD, Hope MJ.

Mol Ther Nucleic Acids. 2013 Dec 17;2:e139. doi: 10.1038/mtna.2013.66.

24.

Advances in Lipid Nanoparticles for siRNA Delivery.

Tam YY, Chen S, Cullis PR.

Pharmaceutics. 2013 Sep 18;5(3):498-507. doi: 10.3390/pharmaceutics5030498.

25.

Sphenoethmoidal inverted papilloma causing ipsilateral abducens nerve palsy.

Tam YY, Chen CK, Chang KP.

Otolaryngol Head Neck Surg. 2013 Apr;148(4):703-4. doi: 10.1177/0194599812473236. Epub 2013 Jan 11. No abstract available.

PMID:
23314158
26.

Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA.

Tam YY, Chen S, Zaifman J, Tam YK, Lin PJ, Ansell S, Roberge M, Ciufolini MA, Cullis PR.

Nanomedicine. 2013 Jul;9(5):665-74. doi: 10.1016/j.nano.2012.11.006. Epub 2012 Dec 6.

PMID:
23219877
27.

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae.

Babu M, Vlasblom J, Pu S, Guo X, Graham C, Bean BD, Burston HE, Vizeacoumar FJ, Snider J, Phanse S, Fong V, Tam YY, Davey M, Hnatshak O, Bajaj N, Chandran S, Punna T, Christopolous C, Wong V, Yu A, Zhong G, Li J, Stagljar I, Conibear E, Wodak SJ, Emili A, Greenblatt JF.

Nature. 2012 Sep 27;489(7417):585-9. doi: 10.1038/nature11354. Epub 2012 Sep 2.

PMID:
22940862
28.

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA.

Lin PJ, Tam YY, Hafez I, Sandhu A, Chen S, Ciufolini MA, Nabi IR, Cullis PR.

Nanomedicine. 2013 Feb;9(2):233-46. doi: 10.1016/j.nano.2012.05.019. Epub 2012 Jun 12.

PMID:
22698807
29.

Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo.

Lee JB, Zhang K, Tam YY, Tam YK, Belliveau NM, Sung VY, Lin PJ, LeBlanc E, Ciufolini MA, Rennie PS, Cullis PR.

Int J Cancer. 2012 Sep 1;131(5):E781-90. doi: 10.1002/ijc.27361. Epub 2012 Jan 3.

30.

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.

Basha G, Novobrantseva TI, Rosin N, Tam YY, Hafez IM, Wong MK, Sugo T, Ruda VM, Qin J, Klebanov B, Ciufolini M, Akinc A, Tam YK, Hope MJ, Cullis PR.

Mol Ther. 2011 Dec;19(12):2186-200. doi: 10.1038/mt.2011.190. Epub 2011 Oct 4.

31.

Unilateral high vagal paralysis: relationship of the severity of swallowing disturbance and types of injuries.

Fang TJ, Tam YY, Courey MS, Li HY, Chiang HC.

Laryngoscope. 2011 Feb;121(2):245-9. doi: 10.1002/lary.21342. Epub 2011 Jan 13.

PMID:
21271569
32.

A high-throughput method for the quantitative analysis of auxins.

Barkawi LS, Tam YY, Tillman JA, Normanly J, Cohen JD.

Nat Protoc. 2010 Sep;5(10):1609-18. doi: 10.1038/nprot.2010.118. Epub 2010 Sep 9.

PMID:
20885372
33.

Lymphoepithelial carcinoma of the nasolacrimal duct.

Tam YY, Lee LY, Chang KP.

Otolaryngol Head Neck Surg. 2010 Jan;142(1):144-5. doi: 10.1016/j.otohns.2009.05.035. Epub 2009 Sep 2. No abstract available.

PMID:
20096243
34.

Synthesis of a labeled RGD-lipid, its incorporation into liposomal nanoparticles, and their trafficking in cultured endothelial cells.

Cressman S, Dobson I, Lee JB, Tam YY, Cullis PR.

Bioconjug Chem. 2009 Jul;20(7):1404-11. doi: 10.1021/bc900041f.

PMID:
19534457
35.

A high-throughput method for the quantitative analysis of indole-3-acetic acid and other auxins from plant tissue.

Barkawi LS, Tam YY, Tillman JA, Pederson B, Calio J, Al-Amier H, Emerick M, Normanly J, Cohen JD.

Anal Biochem. 2008 Jan 15;372(2):177-88. Epub 2007 Aug 11.

PMID:
17889819
36.

Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer.

Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH.

Cell. 2007 May 4;129(3):485-98. Epub 2007 Apr 19.

37.

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.

Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17384-9. Epub 2006 Nov 7.

38.

Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.

Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY.

Arthritis Rheum. 2006 Mar;54(3):742-53. Erratum in: Arthritis Rheum. 2006 May;54(5):1704. Saba, Julie D [added]; Tam, Yuen Yee [added].

39.

The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.

Bandhuvula P, Tam YY, Oskouian B, Saba JD.

J Biol Chem. 2005 Oct 7;280(40):33697-700. Epub 2005 Aug 23.

40.

Pex3p initiates the formation of a preperoxisomal compartment from a subdomain of the endoplasmic reticulum in Saccharomyces cerevisiae.

Tam YY, Fagarasanu A, Fagarasanu M, Rachubinski RA.

J Biol Chem. 2005 Oct 14;280(41):34933-9. Epub 2005 Aug 8.

41.

Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae.

Fagarasanu M, Fagarasanu A, Tam YY, Aitchison JD, Rachubinski RA.

J Cell Biol. 2005 Jun 6;169(5):765-75. Epub 2005 May 31.

42.

Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane.

Marelli M, Smith JJ, Jung S, Yi E, Nesvizhskii AI, Christmas RH, Saleem RA, Tam YY, Fagarasanu A, Goodlett DR, Aebersold R, Rachubinski RA, Aitchison JD.

J Cell Biol. 2004 Dec 20;167(6):1099-112. Epub 2004 Dec 13.

43.

Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae.

Tam YY, Torres-Guzman JC, Vizeacoumar FJ, Smith JJ, Marelli M, Aitchison JD, Rachubinski RA.

Mol Biol Cell. 2003 Oct;14(10):4089-102. Epub 2003 May 18.

44.

YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae.

Vizeacoumar FJ, Torres-Guzman JC, Tam YY, Aitchison JD, Rachubinski RA.

J Cell Biol. 2003 Apr 28;161(2):321-32. Epub 2003 Apr 21.

46.
47.

Indole-3-acetic acid metabolism in Lemna gibba undergoes dynamic changes in response to growth temperature.

Rapparini F, Tam YY, Cohen JD, Slovin JP.

Plant Physiol. 2002 Apr;128(4):1410-6.

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