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Exploring early human embryo development.

Rossant J, Tam PPL.

Science. 2018 Jun 8;360(6393):1075-1076. doi: 10.1126/science.aas9302. No abstract available.


Mutations in Hnrnpa1 cause congenital heart defects.

Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ.

JCI Insight. 2018 Jan 25;3(2). pii: 98555. doi: 10.1172/jci.insight.98555. [Epub ahead of print]


Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation.

McDonald MM, Morse A, Schindeler A, Mikulec K, Peacock L, Cheng T, Bobyn J, Lee L, Baldock PA, Croucher PI, Tam PPL, Little DG.

Calcif Tissue Int. 2018 Jan;102(1):105-116. doi: 10.1007/s00223-017-0338-4. Epub 2017 Nov 6.


Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development doi: 10.1242/dev.146241.

Chiang IK, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, Overman J, D'Angelo D, Omini A, Hermkens D, Lesieur E, Fossat N, Radziewic T, Liu K, Ratnayaka I, Corada M, Bou-Gharios G, Tam PPL, Carroll J, Dejana E, Schulte-Merker S, Hogan BM, Beltrame M, De Val S, Francois M.

Development. 2017 Oct 15;144(20):3847-3848. doi: 10.1242/dev.159715. No abstract available.


Establishment of mouse expanded potential stem cells.

Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P.

Nature. 2017 Oct 19;550(7676):393-397. doi: 10.1038/nature24052. Epub 2017 Oct 11.


Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Logan GJ, Dane AP, Hallwirth CV, Smyth CM, Wilkie EE, Amaya AK, Zhu E, Khandekar N, Ginn SL, Liao SHY, Cunningham SC, Sasaki N, Cabanes-Creus M, Tam PPL, Russell DW, Lisowski L, Alexander IE.

Nat Genet. 2017 Aug;49(8):1267-1273. doi: 10.1038/ng.3893. Epub 2017 Jun 19.


Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.

Zamir L, Singh R, Nathan E, Patrick R, Yifa O, Yahalom-Ronen Y, Arraf AA, Schultheiss TM, Suo S, Han JJ, Peng G, Jing N, Wang Y, Palpant N, Tam PP, Harvey RP, Tzahor E.

Elife. 2017 Mar 8;6. pii: e20994. doi: 10.7554/eLife.20994.


Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq.

Chen J, Suo S, Tam PP, Han JJ, Peng G, Jing N.

Nat Protoc. 2017 Mar;12(3):566-580. doi: 10.1038/nprot.2017.003. Epub 2017 Feb 16.


Prolonged Activation of Invariant Natural Killer T Cells and TH2-Skewed Immunity in Stroke Patients.

Wong CH, Jenne CN, Tam PP, Léger C, Venegas A, Ryckborst K, Hill MD, Kubes P.

Front Neurol. 2017 Jan 19;8:6. doi: 10.3389/fneur.2017.00006. eCollection 2017.


Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff.

Savatier P, Osteil P, Tam PP.

Stem Cell Res. 2017 Mar;19:104-112. doi: 10.1016/j.scr.2017.01.008. Epub 2017 Jan 17. Review.


New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation.

Rossant J, Tam PPL.

Cell Stem Cell. 2017 Jan 5;20(1):18-28. doi: 10.1016/j.stem.2016.12.004. Review.


Interactome of the inhibitory isoform of the nuclear transporter Importin 13.

Fatima S, Wagstaff KM, Lieu KG, Davies RG, Tanaka SS, Yamaguchi YL, Loveland KL, Tam PP, Jans DA.

Biochim Biophys Acta. 2017 Mar;1864(3):546-561. doi: 10.1016/j.bbamcr.2016.12.017. Epub 2016 Dec 16.


Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest.

Bildsoe H, Fan X, Wilkie EE, Ashoti A, Jones VJ, Power M, Qin J, Wang J, Tam PP, Loebel DA.

Data Brief. 2016 Sep 12;9:372-375. eCollection 2016 Dec.


Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance.

Bildsoe H, Fan X, Wilkie EE, Ashoti A, Jones VJ, Power M, Qin J, Wang J, Tam PPL, Loebel DAF.

Dev Biol. 2016 Oct 1;418(1):189-203. doi: 10.1016/j.ydbio.2016.08.016. Epub 2016 Aug 18.


α3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice.

Zheng G, Zhang J, Zhao H, Wang H, Pang M, Qiao X, Lee SR, Hsu TT, Tan TK, Lyons JG, Zhao Y, Tian X, Loebel DAF, Rubera I, Tauc M, Wang Y, Wang Y, Wang YM, Cao Q, Wang C, Lee VWS, Alexander SI, Tam PPL, Harris DCH.

Am J Pathol. 2016 Jul;186(7):1847-1860. doi: 10.1016/j.ajpath.2016.03.015. Epub 2016 May 13.


Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo.

Peng G, Suo S, Chen J, Chen W, Liu C, Yu F, Wang R, Chen S, Sun N, Cui G, Song L, Tam PP, Han JD, Jing N.

Dev Cell. 2016 Mar 21;36(6):681-97. doi: 10.1016/j.devcel.2016.02.020.


Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network.

Tam PP, Fossat N, Wilkie E, Loebel DA, Ip CK, Ramialison M.

Curr Top Dev Biol. 2016;117:497-521. doi: 10.1016/bs.ctdb.2015.11.019. Epub 2016 Feb 15. Review.


Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth.

Fossat N, Radziewic T, Jones V, Tourle K, Tam PP.

Genesis. 2016 Mar;54(3):115-22. doi: 10.1002/dvg.22920. Epub 2016 Feb 5.


Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction.

Loebel DA, Plageman TF Jr, Tang TL, Jones VJ, Muccioli M, Tam PP.

Biol Open. 2016 Jan 15;5(2):130-9. doi: 10.1242/bio.014415.


Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos.

Tam PP.

Cell Stem Cell. 2016 Jan 7;18(1):3-4. doi: 10.1016/j.stem.2015.12.010.


Generation of genome-edited mouse epiblast stem cells via a detour through ES cell-chimeras.

Osteil P, Studdert J, Wilkie E, Fossat N, Tam PP.

Differentiation. 2016 Apr-Jun;91(4-5):119-25. doi: 10.1016/j.diff.2015.10.004. Epub 2015 Nov 21.


What if stem cells turn into embryos in a dish?

Pera MF, de Wert G, Dondorp W, Lovell-Badge R, Mummery CL, Munsie M, Tam PP.

Nat Methods. 2015 Oct;12(10):917-9. doi: 10.1038/nmeth.3586.


Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization.

Greenlees R, Mihelec M, Yousoof S, Speidel D, Wu SK, Rinkwitz S, Prokudin I, Perveen R, Cheng A, Ma A, Nash B, Gillespie R, Loebel DA, Clayton-Smith J, Lloyd IC, Grigg JR, Tam PP, Yap AS, Becker TS, Black GC, Semina E, Jamieson RV.

Hum Mol Genet. 2015 Oct 15;24(20):5789-804. doi: 10.1093/hmg/ddv298. Epub 2015 Jul 30.


Cellular basis of neuroepithelial bending during mouse spinal neural tube closure.

McShane SG, Molè MA, Savery D, Greene ND, Tam PP, Copp AJ.

Dev Biol. 2015 Aug 15;404(2):113-24. doi: 10.1016/j.ydbio.2015.06.003. Epub 2015 Jun 12.


Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity.

Kondo MA, Gray LJ, Pelka GJ, Leang SK, Christodoulou J, Tam PP, Hannan AJ.

Dev Neurobiol. 2016 Feb;76(2):209-24. doi: 10.1002/dneu.22308. Epub 2015 Jun 23.


Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.

Fossat N, Ip CK, Jones VJ, Studdert JB, Khoo PL, Lewis SL, Power M, Tourle K, Loebel DA, Kwan KM, Behringer RR, Tam PP.

Development. 2015 Jun 1;142(11):2069-79. doi: 10.1242/dev.120907. Epub 2015 May 14.


Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing.

Fossat N, Tam PP.

RNA Biol. 2014;11(10):1233-7. doi: 10.1080/15476286.2014.996054.


Mechanisms of left-right asymmetry and patterning: driver, mediator and responder.

Hamada H, Tam PP.

F1000Prime Rep. 2014 Dec 1;6:110. doi: 10.12703/P6-110. eCollection 2014. Review.


Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype.

Williamson SL, Ellaway CJ, Peters GB, Pelka GJ, Tam PP, Christodoulou J.

Eur J Hum Genet. 2015 Sep;23(9):1171-5. doi: 10.1038/ejhg.2014.249. Epub 2014 Nov 26.


Differential response of epiblast stem cells to Nodal and Activin signalling: a paradigm of early endoderm development in the embryo.

Kaufman-Francis K, Goh HN, Kojima Y, Studdert JB, Jones V, Power MD, Wilkie E, Teber E, Loebel DA, Tam PP.

Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130550. doi: 10.1098/rstb.2013.0550. Review.


Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm.

Ip CK, Fossat N, Jones V, Lamonerie T, Tam PP.

Development. 2014 Oct;141(20):3859-67. doi: 10.1242/dev.114900. Epub 2014 Sep 17.


Timing of developmental events in the early mouse embryo.

Kojima Y, Tam OH, Tam PP.

Semin Cell Dev Biol. 2014 Oct;34:65-75. doi: 10.1016/j.semcdb.2014.06.010. Epub 2014 Jun 17. Review.


C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.

Fossat N, Tourle K, Radziewic T, Barratt K, Liebhold D, Studdert JB, Power M, Jones V, Loebel DA, Tam PP.

EMBO Rep. 2014 Aug;15(8):903-10. doi: 10.15252/embr.201438450. Epub 2014 Jun 10.


Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning.

Loebel DA, Hor AC, Bildsoe HK, Tam PP.

PLoS One. 2014 Jun 3;9(6):e98945. doi: 10.1371/journal.pone.0098945. eCollection 2014.


Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): implications for the disease phenotype.

Gold WA, Williamson SL, Kaur S, Hargreaves IP, Land JM, Pelka GJ, Tam PP, Christodoulou J.

Mitochondrion. 2014 Mar;15:10-7. doi: 10.1016/j.mito.2014.02.012. Epub 2014 Mar 6.


Analyzing gene function in whole mouse embryo and fetal organ in vitro.

Tanaka SS, Yamaguchi YL, Jones VJ, Tam PP.

Methods Mol Biol. 2014;1092:367-93. doi: 10.1007/978-1-60327-292-6_22.


Generation of mouse embryos with small hairpin RNA-mediated knockdown of gene expression.

Loebel DA, Radziewic T, Power M, Studdert JB, Tam PP.

Methods Mol Biol. 2014;1092:119-42. doi: 10.1007/978-1-60327-292-6_8.


Chromatin context and ncRNA highlight targets of MeCP2 in brain.

Maxwell SS, Pelka GJ, Tam PP, El-Osta A.

RNA Biol. 2013 Nov;10(11):1741-57. doi: 10.4161/rna.26921. Epub 2013 Oct 30.


The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

Kojima Y, Kaufman-Francis K, Studdert JB, Steiner KA, Power MD, Loebel DA, Jones V, Hor A, de Alencastro G, Logan GJ, Teber ET, Tam OH, Stutz MD, Alexander IE, Pickett HA, Tam PP.

Cell Stem Cell. 2014 Jan 2;14(1):107-20. doi: 10.1016/j.stem.2013.09.014. Epub 2013 Oct 17.


The mystique of cellular reprogramming.

Ng HH, Tam PP.

Curr Opin Genet Dev. 2013 Oct;23(5):501-3. doi: 10.1016/j.gde.2013.08.001. Epub 2013 Sep 1. No abstract available.


Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.

Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T, Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam PP, Pearson RC, Crossley M.

Mol Cell Biol. 2013 Aug;33(15):2976-87. doi: 10.1128/MCB.00074-13. Epub 2013 May 28.


Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output.

Arkell RM, Fossat N, Tam PP.

Curr Opin Genet Dev. 2013 Aug;23(4):454-60. doi: 10.1016/j.gde.2013.03.001. Epub 2013 Apr 19. Review.


Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.

Tanaka SS, Nakane A, Yamaguchi YL, Terabayashi T, Abe T, Nakao K, Asashima M, Steiner KA, Tam PP, Nishinakamura R.

PLoS One. 2013;8(3):e57428. doi: 10.1371/journal.pone.0057428. Epub 2013 Mar 4.


Stem cell science and regenerative medicine.

Tam PP, Pera MF.

Bioessays. 2013 Mar;35(3):147-8. doi: 10.1002/bies.201300003. No abstract available.


Alternative lengthening of telomeres in normal mammalian somatic cells.

Neumann AA, Watson CM, Noble JR, Pickett HA, Tam PP, Reddel RR.

Genes Dev. 2013 Jan 1;27(1):18-23. doi: 10.1101/gad.205062.112.


The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function.

Bildsoe H, Loebel DA, Jones VJ, Hor AC, Braithwaite AW, Chen YT, Behringer RR, Tam PP.

Dev Biol. 2013 Feb 15;374(2):295-307. doi: 10.1016/j.ydbio.2012.12.004. Epub 2012 Dec 19.


Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes.

Stephenson RO, Rossant J, Tam PP.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a008235. doi: 10.1101/cshperspect.a008235. Review.


Initiating head development in mouse embryos: integrating signalling and transcriptional activity.

Arkell RM, Tam PP.

Open Biol. 2012 Mar;2(3):120030. doi: 10.1098/rsob.120030.


Rho GTPases in endoderm development and differentiation.

Loebel DA, Tam PP.

Small GTPases. 2012 Jan-Mar;3(1):40-4. doi: 10.4161/sgtp.18820.


Gram-negative and Gram-positive bacterial infections give rise to a different metabolic response in a mouse model.

Hoerr V, Zbytnuik L, Leger C, Tam PP, Kubes P, Vogel HJ.

J Proteome Res. 2012 Jun 1;11(6):3231-45. doi: 10.1021/pr201274r. Epub 2012 May 3.

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