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Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

Deng M, Guo H, Tam JW, Johnson BM, Brickey WJ, New JS, Lenox A, Shi H, Golenbock DT, Koller BH, McKinnon KP, Beutler B, Ting JP.

J Exp Med. 2019 Sep 26. pii: jem.20190111. doi: 10.1084/jem.20190111. [Epub ahead of print]


Inflammatory monocytes provide a niche for Salmonella expansion in the lumen of the inflamed intestine.

McLaughlin PA, Bettke JA, Tam JW, Leeds J, Bliska JB, Butler BP, van der Velden AWM.

PLoS Pathog. 2019 Jul 15;15(7):e1007847. doi: 10.1371/journal.ppat.1007847. eCollection 2019 Jul.


NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.

Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP.

Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. Epub 2019 Mar 19.


Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon.

Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP.

Immunity. 2019 Mar 19;50(3):591-599.e6. doi: 10.1016/j.immuni.2019.02.009.


Verbal fluency in a national sample: Telephone administration methods.

Marceaux JC, Prosje MA, McClure LA, Kana B, Crowe M, Kissela B, Manly J, Howard G, Tam JW, Unverzagt FW, Wadley VG.

Int J Geriatr Psychiatry. 2019 Apr;34(4):578-587. doi: 10.1002/gps.5054. Epub 2019 Jan 18.


The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.

Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, Chou WC, Wilson JE, Brickey WJ, Petrucelli A, Liu R, Cooper DE, Koenigsknecht MJ, Young VB, Netea MG, Stienstra R, Sartor RB, Montgomery SA, Coleman RA, Ting JP.

Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6. doi: 10.1016/j.chom.2018.08.009.


A caregiver educational program: A video program to promote aging services technologies awareness.

Tam JW, Schmitter-Edgecombe M.

Geriatr Nurs. 2019 Jan - Feb;40(1):78-83. doi: 10.1016/j.gerinurse.2018.06.015. Epub 2018 Aug 7.


The Use of Intranasal Fentanyl for the Palliation of Incident Dyspnea in Advanced Congestive Heart Failure: A Pilot Study.

Pilkey J, Pedersen A, Tam JW, Malik A, Wong J.

J Palliat Care. 2019 Apr;34(2):96-102. doi: 10.1177/0825859718777343. Epub 2018 May 31.


Cor Triatriatum Sinister: An Unusual Cause of Atrial Fibrillation in Adults.

Hayes C, Liu S, Tam JW, Kass M.

Case Rep Cardiol. 2018 Mar 31;2018:9242519. doi: 10.1155/2018/9242519. eCollection 2018.


Relationship of Extreme Cold Weather and Implantable Cardioverter Defibrillator Shocks.

Cloutier JM, Liu S, Hiebert B, Tam JW, Seifer CM.

Am J Cardiol. 2017 Sep 15;120(6):1002-1007. doi: 10.1016/j.amjcard.2017.06.031. Epub 2017 Jun 28.


Venous Diversion Surgery Revisited: A Baffling Situation.

Klassen JR, Jassal DS, Memauri B, Kass M, Tam JW, Windram J, Ross D, Shaikh N.

Cureus. 2017 Jun 6;9(6):e1320. doi: 10.7759/cureus.1320.


It's not just the snow; it's also the cold.

Liu S, Ducas RA, Hiebert B, Koley L, Philipp RK, Tam JW.

CMAJ. 2017 Apr 10;189(14):E546. doi: 10.1503/cmaj.732931. No abstract available.


An educational video program to increase aging services technology awareness among older adults.

Tam JW, Van Son C, Dyck D, Schmitter-Edgecombe M.

Patient Educ Couns. 2017 Aug;100(8):1564-1571. doi: 10.1016/j.pec.2017.03.020. Epub 2017 Mar 15.


Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial.

Capoulade R, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S.

Atherosclerosis. 2017 May;260:1-7. doi: 10.1016/j.atherosclerosis.2017.03.013. Epub 2017 Mar 9.


Effectiveness of a video-based aging services technology education program for health care professionals.

Weakley A, Tam JW, Van Son C, Schmitter-Edgecombe M.

Gerontol Geriatr Educ. 2019 Jul-Sep;40(3):339-356. doi: 10.1080/02701960.2017.1281805. Epub 2017 Feb 17.


Renal Insufficiency and Early Bystander CPR Predict In-Hospital Outcomes in Cardiac Arrest Patients Undergoing Mild Therapeutic Hypothermia and Cardiac Catheterization: Return of Spontaneous Circulation, Cooling, and Catheterization Registry (ROSCCC Registry).

Chelvanathan A, Allen D, Bews H, Ducas J, Minhas K, Vo M, Kass M, Ravandi A, Tam JW, Jassal DS, Hussain F.

Cardiol Res Pract. 2016;2016:8798261. doi: 10.1155/2016/8798261. Epub 2016 Jan 18.


Pilot Test of a Culturally Sensitive Hypertension Management Intervention Protocol for Older Chinese Immigrants: Chinese Medicine as Longevity Modality.

Li WW, Gomez CA, Tam JW.

Comput Inform Nurs. 2015 Nov;33(11):495-501. doi: 10.1097/CIN.0000000000000195.


CCR2+ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8+ T Cell Response to the Protective YopE69-77 Epitope during Yersinia Infection.

Zhang Y, Tam JW, Mena P, van der Velden AW, Bliska JB.

PLoS Pathog. 2015 Oct 15;11(10):e1005167. doi: 10.1371/journal.ppat.1005167. eCollection 2015 Oct.


Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S.

J Am Coll Cardiol. 2015 Sep 15;66(11):1236-1246. doi: 10.1016/j.jacc.2015.07.020.


Novel high-sensitivity troponin assay requires higher cut-off value to separate acute myocardial infarction from non-acute myocardial infarction in a high-risk population.

Wassef AW, Hiebert B, Saeed MF, Tam JW.

Can J Physiol Pharmacol. 2015 Oct;93(10):873-7. doi: 10.1139/cjpp-2014-0473. Epub 2015 Mar 20.


Partial PFO Closure for Persistent Hypoxemia in a Patient with Ebstein Anomaly.

Zuberi SA, Liu S, Tam JW, Hussain F, Maguire D, Kass M.

Case Rep Cardiol. 2015;2015:531382. doi: 10.1155/2015/531382. Epub 2015 Apr 7.


Early diagnosis and management of myocardial rupture.

Liu S, Glavinovic T, Tam JW.

Can J Cardiol. 2015 Jan;31(1):88-90. doi: 10.1016/j.cjca.2014.09.026. Epub 2014 Sep 28.


Embolus from probable Takotsubo cardiomyopathy: a bedside diagnosis.

Hrymak C, Liu S, Koulack J, Funk DJ, Schaffer SA, Tam JW.

Can J Cardiol. 2014 Dec;30(12):1732.e9-11. doi: 10.1016/j.cjca.2014.08.008. Epub 2014 Aug 19.


Circulating levels of matrix gla protein and progression of aortic stenosis: a substudy of the Aortic Stenosis Progression Observation: Measuring Effects of rosuvastatin (ASTRONOMER) trial.

Capoulade R, Côté N, Mathieu P, Chan KL, Clavel MA, Dumesnil JG, Teo KK, Tam JW, Fournier D, Després JP, Pibarot P; ASTRONOMER Investigators.

Can J Cardiol. 2014 Sep;30(9):1088-95. doi: 10.1016/j.cjca.2014.03.025. Epub 2014 Mar 24.


Persistent salmonellosis causes pancreatitis in a murine model of infection.

DelGiorno KE, Tam JW, Hall JC, Thotakura G, Crawford HC, van der Velden AW.

PLoS One. 2014 Apr 9;9(4):e92807. doi: 10.1371/journal.pone.0092807. eCollection 2014.


CD11b+ Ly6Chi Ly6G- immature myeloid cells recruited in response to Salmonella enterica serovar Typhimurium infection exhibit protective and immunosuppressive properties.

Tam JW, Kullas AL, Mena P, Bliska JB, van der Velden AW.

Infect Immun. 2014 Jun;82(6):2606-14. doi: 10.1128/IAI.01590-13. Epub 2014 Apr 7.


Functional mitral regurgitation: current understanding and approach to management.

Ducas RA, White CW, Wassef AW, Farag A, Bhagirath KM, Freed DH, Tam JW.

Can J Cardiol. 2014 Feb;30(2):173-80. doi: 10.1016/j.cjca.2013.11.022. Epub 2013 Nov 23. Review.


Development and evaluation of methodologies for teaching focused cardiac ultrasound skills to medical students.

Cawthorn TR, Nickel C, O'Reilly M, Kafka H, Tam JW, Jackson LC, Sanfilippo AJ, Johri AM.

J Am Soc Echocardiogr. 2014 Mar;27(3):302-9. doi: 10.1016/j.echo.2013.12.006. Epub 2014 Jan 13.


The role of processing speed in the Brief Visuospatial Memory Test - revised.

Tam JW, Schmitter-Edgecombe M.

Clin Neuropsychol. 2013;27(6):962-72. doi: 10.1080/13854046.2013.797500. Epub 2013 May 20.


Insulin resistance and LVH progression in patients with calcific aortic stenosis: a substudy of the ASTRONOMER trial.

Capoulade R, Clavel MA, Dumesnil JG, Chan KL, Teo KK, Tam JW, Côté N, Mathieu P, Després JP, Pibarot P; ASTRONOMER Investigators.

JACC Cardiovasc Imaging. 2013 Feb;6(2):165-74. doi: 10.1016/j.jcmg.2012.11.004.


The impact of telemetry on survival of in-hospital cardiac arrests in non-critical care patients.

Cleverley K, Mousavi N, Stronger L, Ann-Bordun K, Hall L, Tam JW, Tischenko A, Jassal DS, Philipp RK.

Resuscitation. 2013 Jul;84(7):878-82. doi: 10.1016/j.resuscitation.2013.01.038. Epub 2013 Feb 18.


Event-based prospective memory and everyday forgetting in healthy older adults and individuals with mild cognitive impairment.

Tam JW, Schmitter-Edgecombe M.

J Clin Exp Neuropsychol. 2013;35(3):279-90. doi: 10.1080/13803395.2013.770823. Epub 2013 Feb 18.


L-asparaginase II produced by Salmonella typhimurium inhibits T cell responses and mediates virulence.

Kullas AL, McClelland M, Yang HJ, Tam JW, Torres A, Porwollik S, Mena P, McPhee JB, Bogomolnaya L, Andrews-Polymenis H, van der Velden AW.

Cell Host Microbe. 2012 Dec 13;12(6):791-8. doi: 10.1016/j.chom.2012.10.018.


A "no-option" left main PCI registry: outcomes and predictors of in hospital mortality-utility of the logistic EuroSCORE.

Elmayergi N, Nguyen T, Hiebert B, Philipp RK, Jassal DS, Tam JW, Hussain F.

Catheter Cardiovasc Interv. 2013 Sep 1;82(3):361-9. doi: 10.1002/ccd.24769. Epub 2013 Apr 8.


Management of adults with congenital heart disease using videoconferencing across Western Canada: a 3-year experience.

Dehghani P, Atallah J, Rebeyka I, Ross D, Quinonez L, Kantoch M, Heggie P, Taylor D, Alvarez N, Human D, Pausjenssen E, Tam JW, Vonder Muhll I.

Can J Cardiol. 2013 Jul;29(7):873-8. doi: 10.1016/j.cjca.2012.06.016. Epub 2012 Aug 24.


The acutely occluded left main coronary artery culprit in cardiogenic shock and initial percutaneous coronary intervention: a substudy of the Manitoba "no option" left main PCI registry.

Hussain F, Nguyen T, Elmayergi N, Ducas J, Minhas K, Vo M, Kass M, Ravandi A, Parmar G, Jassal DS, Tam JW, Freed D, Menkis AH, Philipp RK.

Can J Physiol Pharmacol. 2012 Sep;90(9):1325-31. doi: 10.1139/y2012-111. Epub 2012 Aug 22.


Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy.

Capoulade R, Clavel MA, Dumesnil JG, Chan KL, Teo KK, Tam JW, Côté N, Mathieu P, Després JP, Pibarot P; ASTRONOMER Investigators.

J Am Coll Cardiol. 2012 Jul 17;60(3):216-23. doi: 10.1016/j.jacc.2012.03.052.


On the time course of accessing meaning in a second language: an electrophysiological and behavioral investigation of translation recognition.

Guo T, Misra M, Tam JW, Kroll JF.

J Exp Psychol Learn Mem Cogn. 2012 Sep;38(5):1165-86. doi: 10.1037/a0028076. Epub 2012 Jun 11.


To transmit or not to transmit: how good are emergency medical personnel in detecting STEMI in patients with chest pain?

Ducas RA, Wassef AW, Jassal DS, Weldon E, Schmidt C, Grierson R, Tam JW.

Can J Cardiol. 2012 Jul-Aug;28(4):432-7. doi: 10.1016/j.cjca.2012.04.008. Epub 2012 Jun 7.


Phenotypic, morphological, and functional heterogeneity of splenic immature myeloid cells in the host response to tularemia.

Rasmussen JW, Tam JW, Okan NA, Mena P, Furie MB, Thanassi DG, Benach JL, van der Velden AW.

Infect Immun. 2012 Jul;80(7):2371-81. doi: 10.1128/IAI.00365-12. Epub 2012 Apr 23.


Cardiac Outcomes Through Digital Evaluation (CODE) STEMI project: prehospital digitally-assisted reperfusion strategies.

Ducas RA, Philipp RK, Jassal DS, Wassef AW, Weldon E, Hussain F, Schmidt C, Khadem A, Ducas J, Grierson R, Tam JW.

Can J Cardiol. 2012 Jul-Aug;28(4):423-31. doi: 10.1016/j.cjca.2012.02.005. Epub 2012 Apr 10.


Multimodality imaging of aortic dimensions: comparison of transthoracic echocardiography with multidetector row computed tomography.

Tsang JF, Lytwyn M, Farag A, Zeglinski M, Wallace K, daSilva M, Bohonis S, Walker JR, Tam JW, Strzelczyk J, Jassal DS.

Echocardiography. 2012 Jul;29(6):735-41. doi: 10.1111/j.1540-8175.2012.01666.x. Epub 2012 Mar 9.


2010 Canadian Cardiovascular Society/Canadian Society of Echocardiography Guidelines for Training and Maintenance of Competency in Adult Echocardiography.

Burwash IG, Basmadjian A, Bewick D, Choy JB, Cujec B, Jassal DS, MacKenzie S, Nair P, Rudski LG, Yu E, Tam JW.

Can J Cardiol. 2011 Nov-Dec;27(6):862-4. doi: 10.1016/j.cjca.2011.03.003. Epub 2011 Jul 27.


Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients.

Teo KK, Corsi DJ, Tam JW, Dumesnil JG, Chan KL.

Can J Cardiol. 2011 Nov-Dec;27(6):800-8. doi: 10.1016/j.cjca.2011.03.012. Epub 2011 Jul 13. Review.


The ability to achieve complete revascularization is associated with improved in-hospital survival in cardiogenic shock due to myocardial infarction: Manitoba cardiogenic SHOCK Registry investigators.

Hussain F, Philipp RK, Ducas RA, Elliott J, Džavík V, Jassal DS, Tam JW, Roberts D, Garber PJ, Ducas J.

Catheter Cardiovasc Interv. 2011 Oct 1;78(4):540-8. doi: 10.1002/ccd.23006. Epub 2011 May 5.


Ventricular septal defect as a result of direct trauma from mechanical mitral valve prosthesis.

Kotrec M, Jassal DS, Zieroth S, Freed DH, Tam JW.

Can J Cardiol. 2011 Mar-Apr;27(2):263.e21-3. doi: 10.1016/j.cjca.2010.12.022.


Structure and process measures of quality of care in adult congenital heart disease patients: a pan-Canadian study.

Beauchesne LM, Therrien J, Alvarez N, Bergin L, Burggraf G, Chetaille P, Gordon E, Kells CM, Kiess M, Mercier LA, Oechslin EN, Stein J, Tam JW, Taylor D, Williams A, Khairy P, Mackie AS, Silversides CK, Marelli AJ.

Int J Cardiol. 2012 May 17;157(1):70-4. doi: 10.1016/j.ijcard.2010.12.024. Epub 2010 Dec 28.


Case of the month #166: carcinoid heart disease. Carcinoid syndrome.

Wardell S, Mousavi N, Tam JW, Kirkpatrick ID, Maycher B, Jassal DS.

Can Assoc Radiol J. 2010 Dec;61(5):297-8. doi: 10.1016/j.carj.2009.11.012. No abstract available.

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