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Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background.

Falcone S, Wisby L, Nicol T, Blease A, Starbuck B, Parker A, Sanderson J, Brown SDM, Scudamore CL, Pusey CD, Tam FWK, Potter PK.

Sci Rep. 2019 Dec 31;9(1):20398. doi: 10.1038/s41598-019-56837-6.


P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury.

Luz HL, Reichel M, Unwin RJ, Mutig K, Najenson AC, Tonner LM, Eckardt KU, Tam FWK, Knauf F.

Sci Rep. 2019 Dec 27;9(1):20086. doi: 10.1038/s41598-019-56560-2.


Autologous Stem Cell Transplant for the Treatment of Type I Crystal Cryoglobulinemic Glomerulonephritis Caused by Monoclonal Gammopathy of Renal Significance (MGRS).

Kousios A, Duncan N, Charif R, Tam FWK, Levy J, Cook HT, Pusey CD, Roufosse C, Chaidos A.

Kidney Int Rep. 2019 May 22;4(9):1342-1348. doi: 10.1016/j.ekir.2019.05.014. eCollection 2019 Sep. No abstract available.


Dr. Kang, et al, reply.

Kang A, Antonelou M, Wong NL, Tanna A, Arulkumaran N, Tam FWK, Pusey CD.

J Rheumatol. 2019 Sep;46(9):1244. doi: 10.3899/jrheum.181446. Epub 2019 Jul 1. No abstract available.


IgG4-related disease in a multi-ethnic community: clinical characteristics and association with malignancy.

Poo SX, Tham CSW, Smith C, Lee J, Cairns T, Galliford J, Hamdulay S, Jacyna M, Levy JB, McAdoo SP, Roufosse C, Wernig F, Mason JC, Pusey CD, Tam FWK, Tomlinson JAP.

QJM. 2019 Oct 1;112(10):763-769. doi: 10.1093/qjmed/hcz149.


Dr. Kang, et al reply.

Kang A, Antonelou M, Wong NL, Tanna A, Arulkumaran N, Tam FWK, Pusey CD.

J Rheumatol. 2019 Jul;46(7):866-867. doi: 10.3899/jrheum.190500. Epub 2019 Jun 1. No abstract available.


Renal monocyte chemoattractant protein-1: an emerging universal biomarker and therapeutic target for kidney diseases?

Tam FWK, Ong ACM.

Nephrol Dial Transplant. 2020 Feb 1;35(2):198-203. doi: 10.1093/ndt/gfz082. No abstract available.


Plasmacytoma-Like Posttransplant Lymphoproliferative Disease in a Disused Arteriovenous Fistula: The Importance of Histopathology.

Kousios A, Storey R, Troy-Barnes E, Hamady M, Salisbury E, Duncan N, Charif R, Tam FWK, Cook HT, Crane J, Chaidos A, Roufosse C, Flora R.

Kidney Int Rep. 2019 Feb 13;4(5):749-755. doi: 10.1016/j.ekir.2019.02.003. eCollection 2019 May. No abstract available.


Higher serum galactose-deficient immunoglobulin A1 concentration is associated with stronger mesangial cellular inflammatory response and more severe histologic findings in immunoglobulin A nephropathy.

Nguyen C, König K, Tam FWK, Hopfer H, Molyneux K, Binet FI, Kim MJ.

Clin Kidney J. 2018 Aug 3;12(2):232-238. doi: 10.1093/ckj/sfy068. eCollection 2019 Apr.


Proliferative glomerulonephritis with monoclonal Ig deposits (PGNMID): diagnostic and treatment challenges for the nephrologist!

Kousios A, Duncan N, Tam FWK, Chaidos A, Cook HT, Roufosse C, Charif R.

Kidney Int. 2019 Feb;95(2):467-468. doi: 10.1016/j.kint.2018.10.016. No abstract available.


High Incidence of Arterial and Venous Thrombosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.

Kang A, Antonelou M, Wong NL, Tanna A, Arulkumaran N, Tam FWK, Pusey CD.

J Rheumatol. 2019 Mar;46(3):285-293. doi: 10.3899/jrheum.170896. Epub 2018 Nov 1.


Role of the Spleen Tyrosine Kinase Pathway in Driving Inflammation in IgA Nephropathy.

McAdoo S, Tam FWK.

Semin Nephrol. 2018 Sep;38(5):496-503. doi: 10.1016/j.semnephrol.2018.05.019. Review.


Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis.

Dooley D, van Timmeren MM, O'Reilly VP, Brady G, O'Brien EC, Fazekas B, Hickey FB, Leacy E, Pusey CD, Tam FWK, Mehrling T, Heeringa P, Little MA.

Kidney Int. 2018 Nov;94(5):926-936. doi: 10.1016/j.kint.2018.05.028. Epub 2018 Aug 26.


Primary IgA nephropathy: current challenges and future prospects.

Penfold RS, Prendecki M, McAdoo S, Tam FW.

Int J Nephrol Renovasc Dis. 2018 Apr 12;11:137-148. doi: 10.2147/IJNRD.S129227. eCollection 2018. Review.


P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis.

Arulkumaran N, Sixma ML, Pollen S, Ceravola E, Jentho E, Prendecki M, Bass PS, Tam FWK, Unwin RJ, Singer M.

Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13622.


Defining Phenotypes in Diabetic Nephropathy: a novel approach using a cross-sectional analysis of a single centre cohort.

Montero RM, Herath A, Qureshi A, Esfandiari E, Pusey CD, Frankel AH, Tam FWK.

Sci Rep. 2018 Jan 8;8(1):53. doi: 10.1038/s41598-017-18595-1.


Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.

Arulkumaran N, Pollen S, Greco E, Courtneidge H, Hall AM, Duchen MR, Tam FWK, Unwin RJ, Singer M.

Crit Care Med. 2018 Apr;46(4):e318-e325. doi: 10.1097/CCM.0000000000002937.


Pharmacokinetics, disease-modifying activity, and safety of an experimental therapeutic targeting an immunological isoform of macrophage migration inhibitory factor, in rat glomerulonephritis.

Höllriegl W, Bauer A, Baumgartner B, Dietrich B, Douillard P, Kerschbaumer RJ, Höbarth G, McKee JS, Schinagl A, Tam FWK, Thiele M, Weber A, Wolfsegger M, Turecek M, Muchitsch EM, Scheiflinger F, Glantschnig H.

Eur J Pharmacol. 2018 Feb 5;820:206-216. doi: 10.1016/j.ejphar.2017.12.040. Epub 2017 Dec 20.


TESTING Corticosteroids in IgA Nephropathy: A Continuing Challenge.

Tam FWK, Pusey CD.

Clin J Am Soc Nephrol. 2018 Jan 6;13(1):158-160. doi: 10.2215/CJN.10560917. Epub 2017 Dec 13. No abstract available.


Label Free Detection of Sensitive Mid-Infrared Biomarkers of Glomerulonephritis in Urine Using Fourier Transform Infrared Spectroscopy.

Yu MC, Rich P, Foreman L, Smith J, Yu MS, Tanna A, Dibbur V, Unwin R, Tam FWK.

Sci Rep. 2017 Jul 4;7(1):4601. doi: 10.1038/s41598-017-04774-7.


Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.

Menzies RI, Booth JWR, Mullins JJ, Bailey MA, Tam FWK, Norman JT, Unwin RJ.

EBioMedicine. 2017 May;19:73-83. doi: 10.1016/j.ebiom.2017.04.011. Epub 2017 Apr 20.


Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery.

Arulkumaran N, Sixma ML, Jentho E, Ceravola E, Bass PS, Kellum JA, Unwin RJ, Tam FWK, Singer M.

Crit Care Med. 2017 Aug;45(8):e821-e830. doi: 10.1097/CCM.0000000000002381.


Long-term outcome in biopsy-proven acute interstitial nephritis treated with steroids.

Prendecki M, Tanna A, Salama AD, Tam FW, Cairns T, Taube D, Cook HT, Ashby D, Duncan ND, Pusey CD.

Clin Kidney J. 2017 Apr;10(2):233-239. doi: 10.1093/ckj/sfw116. Epub 2016 Dec 24.


Targeting the tyrosine kinase signalling pathways for treatment of immune-mediated glomerulonephritis: from bench to bedside and beyond.

Ma TK, McAdoo SP, Tam FW.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i129-i138. doi: 10.1093/ndt/gfw336. Review.


Purinergic signaling in kidney disease.

Menzies RI, Tam FW, Unwin RJ, Bailey MA.

Kidney Int. 2017 Feb;91(2):315-323. doi: 10.1016/j.kint.2016.08.029. Epub 2016 Oct 22. Review.


Spleen Tyrosine Kinase: A Crucial Player and Potential Therapeutic Target in Renal Disease.

Ma TK, McAdoo SP, Tam FW.

Nephron. 2016;133(4):261-9. doi: 10.1159/000446879. Epub 2016 Jul 30. Review.


Erratum to: 'Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease'.

Sulemane S, Panoulas VF, Konstantinou K, Bratsas A, Graspa J, Tam FW, Brown EA, Nihoyannopoulos P.

Cardiovasc Ultrasound. 2016 Apr 19;14:15. doi: 10.1186/s12947-016-0059-2. No abstract available.


Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease.

Sulemane S, Panoulas VF, Konstantinou K, Bratsas A, Tam FW, Brown EA, Nihoyannopoulos P.

Cardiovasc Ultrasound. 2016 Mar 9;14:10. doi: 10.1186/s12947-016-0053-8. Erratum in: Cardiovasc Ultrasound. 2016;14:15.


Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions.

Thiele M, Kerschbaumer RJ, Tam FW, Völkel D, Douillard P, Schinagl A, Kühnel H, Smith J, McDaid JP, Bhangal G, Yu MC, Pusey CD, Cook HT, Kovarik J, Magelky E, Bhan A, Rieger M, Mudde GC, Ehrlich H, Jilma B, Tilg H, Moschen A, Terhorst C, Scheiflinger F.

J Immunol. 2015 Sep 1;195(5):2343-52. doi: 10.4049/jimmunol.1500572. Epub 2015 Jul 24.


Inhibition of the purinergic P2X7 receptor improves renal perfusion in angiotensin-II-infused rats.

Menzies RI, Howarth AR, Unwin RJ, Tam FW, Mullins JJ, Bailey MA.

Kidney Int. 2015 Nov;88(5):1079-87. doi: 10.1038/ki.2015.182. Epub 2015 Jun 24.


Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression.

McAdoo SP, Bhangal G, Page T, Cook HT, Pusey CD, Tam FW.

Kidney Int. 2015 Jul;88(1):52-60. doi: 10.1038/ki.2015.29. Epub 2015 Feb 25.


Multiphasic changes in systemic VEGF following intravitreal injections of ranibizumab in a child.

Shao EH, Sivagnanavel V, Dabbagh A, Dave R, Tempest-Roe S, Tam FW, Taylor SR.

Eye (Lond). 2015 Apr;29(4):569-73. doi: 10.1038/eye.2014.343. Epub 2015 Feb 6.


Necrotizing and crescentic glomerulonephritis presenting with preserved renal function in patients with underlying multisystem autoimmune disease: a retrospective case series.

McAdoo SP, Tanna A, Randone O, Tam FW, Tarzi RM, Levy JB, Griffith M, Lightstone L, Cook HT, Cairns T, Pusey CD.

Rheumatology (Oxford). 2015 Jun;54(6):1025-32. doi: 10.1093/rheumatology/keu445. Epub 2014 Nov 26.


Long-term outcome of anti-neutrophil cytoplasm antibody-associated glomerulonephritis: evaluation of the international histological classification and other prognostic factors.

Tanna A, Guarino L, Tam FW, Rodriquez-Cubillo B, Levy JB, Cairns TD, Griffith M, Tarzi RM, Caplin B, Salama AD, Cook T, Pusey CD.

Nephrol Dial Transplant. 2015 Jul;30(7):1185-92. doi: 10.1093/ndt/gfu237. Epub 2014 Jul 12.


Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN.

McAdoo SP, Reynolds J, Bhangal G, Smith J, McDaid JP, Tanna A, Jackson WD, Masuda ES, Cook HT, Pusey CD, Tam FW.

J Am Soc Nephrol. 2014 Oct;25(10):2291-302. doi: 10.1681/ASN.2013090978. Epub 2014 Apr 3.


Dialysate cytokine levels do not predict encapsulating peritoneal sclerosis.

Goodlad C, Tam FW, Ahmad S, Bhangal G, North BV, Brown EA.

Perit Dial Int. 2014 Sep-Oct;34(6):594-604. doi: 10.3747/pdi.2012.00305. Epub 2014 Mar 1.


Exaggerated renal fibrosis in P2X4 receptor-deficient mice following unilateral ureteric obstruction.

Kim MJ, Turner CM, Hewitt R, Smith J, Bhangal G, Pusey CD, Unwin RJ, Tam FW.

Nephrol Dial Transplant. 2014 Jul;29(7):1350-61. doi: 10.1093/ndt/gfu019. Epub 2014 Feb 25.


Is the inflammasome a potential therapeutic target in renal disease?

Turner CM, Arulkumaran N, Singer M, Unwin RJ, Tam FW.

BMC Nephrol. 2014 Jan 23;15:21. doi: 10.1186/1471-2369-15-21.


B-cell-targeted therapy in adult glomerulonephritis.

Tanna A, Tam FW, Pusey CD.

Expert Opin Biol Ther. 2013 Dec;13(12):1691-706. doi: 10.1517/14712598.2013.851191. Epub 2013 Nov 5. Review.


The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation.

Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW.

Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv73-82. doi: 10.1093/ndt/gft262. Epub 2013 Sep 26. Review.


Purinergic signaling in inflammatory renal disease.

Arulkumaran N, Turner CM, Sixma ML, Singer M, Unwin R, Tam FW.

Front Physiol. 2013 Jul 29;4:194. doi: 10.3389/fphys.2013.00194. eCollection 2013.


ATP and arterial calcification.

Fish RS, Klootwijk E, Tam FW, Kleta R, Wheeler DC, Unwin RJ, Norman J.

Eur J Clin Invest. 2013 Apr;43(4):405-12. doi: 10.1111/eci.12055. Epub 2013 Feb 10. Review.


P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis.

Deplano S, Cook HT, Russell R, Franchi L, Schneiter S, Bhangal G, Unwin RJ, Pusey CD, Tam FW, Behmoaras J.

J Leukoc Biol. 2013 Jan;93(1):127-34. doi: 10.1189/jlb.0612284. Epub 2012 Oct 22.


P2 purinoceptors: Renal pathophysiology and therapeutic potential.

Booth JW, Tam FW, Unwin RJ.

Clin Nephrol. 2012 Aug;78(2):154-63. Review.


Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study.

Fenske WK, Dubb S, Bueter M, Seyfried F, Patel K, Tam FW, Frankel AH, le Roux CW.

Surg Obes Relat Dis. 2013 Jul-Aug;9(4):559-68. doi: 10.1016/j.soard.2012.03.009. Epub 2012 Apr 10.


Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

Fragiadaki M, Hill N, Hewitt R, Bou-Gharios G, Cook T, Tam FW, Domin J, Mason RM.

Diabetes. 2012 Sep;61(9):2280-8. doi: 10.2337/db11-1138. Epub 2012 May 14.


Urinary monocyte chemoattractant protein-1 in renal disease.

Kim MJ, Tam FW.

Clin Chim Acta. 2011 Nov 20;412(23-24):2022-30. doi: 10.1016/j.cca.2011.07.023. Epub 2011 Aug 7. Review.


Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin-angiotensin-aldosterone system inhibition.

Kim MJ, Frankel AH, Donaldson M, Darch SJ, Pusey CD, Hill PD, Mayr M, Tam FW.

Kidney Int. 2011 Oct;80(8):851-60. doi: 10.1038/ki.2011.224. Epub 2011 Aug 10.

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