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Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.

Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM.

Sci Rep. 2020 Mar 26;10(1):5495. doi: 10.1038/s41598-020-62271-w.


Obesity and ageing: Two sides of the same coin.

Tam BT, Morais JA, Santosa S.

Obes Rev. 2020 Apr;21(4):e12991. doi: 10.1111/obr.12991. Epub 2020 Feb 5. Review.


Organ Donation at the End of Life: Experiences From the 3 Wishes Project.

Takaoka A, Honarmand K, Vanstone M, Tam B, Smith OM, Baker A, LeBlanc A, Swinton M, Neville TH, Clarke FJ, Hancock J, McMullen S, Meade MO, Rose T, Arora S, Cook DJ.

J Intensive Care Med. 2020 Jan 21:885066619900125. doi: 10.1177/0885066619900125. [Epub ahead of print]


Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis.

Tam B, Sherf D, Cohen S, Eisdorfer SA, Perez M, Soffer A, Vilenchik D, Akabayov SR, Wagner G, Akabayov B.

Chem Sci. 2019 Aug 6;10(38):8764-8767. doi: 10.1039/c9sc02520k. eCollection 2019 Oct 14.


Compassionate End-of-Life Care: Mixed-Methods Multisite Evaluation of the 3 Wishes Project.

Vanstone M, Neville TH, Clarke FJ, Swinton M, Sadik M, Takaoka A, Smith O, Baker AJ, LeBlanc A, Foster D, Dhingra V, Phung P, Xu XS, Kao Y, Heels-Ansdell D, Tam B, Toledo F, Boyle A, Cook DJ.

Ann Intern Med. 2019 Nov 12. doi: 10.7326/M19-2438. [Epub ahead of print]


Fostering humanism: a mixed methods evaluation of the Footprints Project in critical care.

Hoad N, Swinton M, Takaoka A, Tam B, Shears M, Waugh L, Toledo F, Clarke FJ, Duan EH, Soth M, Cook DJ.

BMJ Open. 2019 Nov 2;9(11):e029810. doi: 10.1136/bmjopen-2019-029810.


The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models.

Tam BY, Chiu K, Chung H, Bossard C, Nguyen JD, Creger E, Eastman BW, Mak CC, Ibanez M, Ghias A, Cahiwat J, Do L, Cho S, Nguyen J, Deshmukh V, Stewart J, Chen CW, Barroga C, Dellamary L, Kc SK, Phalen TJ, Hood J, Cha S, Yazici Y.

Cancer Lett. 2020 Mar 31;473:186-197. doi: 10.1016/j.canlet.2019.09.009. Epub 2019 Sep 24.


Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease.

Liu H, He J, Koh SP, Zhong Y, Liu Z, Wang Z, Zhang Y, Li Z, Tam BT, Lin P, Xiao M, Young KH, Amini B, Starbuck MW, Lee HC, Navone NM, Davis RE, Tong Q, Bergsagel PL, Hou J, Yi Q, Orlowski RZ, Gagel RF, Yang J.

Sci Transl Med. 2019 May 29;11(494). pii: eaau9087. doi: 10.1126/scitranslmed.aau9087.


Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment.

Deshmukh V, O'Green AL, Bossard C, Seo T, Lamangan L, Ibanez M, Ghias A, Lai C, Do L, Cho S, Cahiwat J, Chiu K, Pedraza M, Anderson S, Harris R, Dellamary L, Kc S, Barroga C, Melchior B, Tam B, Kennedy S, Tambiah J, Hood J, Yazici Y.

Osteoarthritis Cartilage. 2019 Sep;27(9):1347-1360. doi: 10.1016/j.joca.2019.05.006. Epub 2019 May 25.


Autophagy in Xenopus laevis rod photoreceptors is independently regulated by phototransduction and misfolded RHOP23H.

Wen RH, Stanar P, Tam B, Moritz OL.

Autophagy. 2019 Nov;15(11):1970-1989. doi: 10.1080/15548627.2019.1596487. Epub 2019 Apr 12.


Electrophysiological Changes During Early Steps of Retinitis Pigmentosa.

Bocchero U, Tam BM, Chiu CN, Torre V, Moritz OL.

Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):933-943. doi: 10.1167/iovs.18-25347.


Prognostic accuracy of the Hamilton Early Warning Score (HEWS) and the National Early Warning Score 2 (NEWS2) among hospitalized patients assessed by a rapid response team.

Fernando SM, Fox-Robichaud AE, Rochwerg B, Cardinal P, Seely AJE, Perry JJ, McIsaac DI, Tran A, Skitch S, Tam B, Hickey M, Reardon PM, Tanuseputro P, Kyeremanteng K.

Crit Care. 2019 Feb 21;23(1):60. doi: 10.1186/s13054-019-2355-3.


Solution-Deposited Solid-State Electrochromic Windows.

Cheng W, Moreno-Gonzalez M, Hu K, Krzyszkowski C, Dvorak DJ, Weekes DM, Tam B, Berlinguette CP.

iScience. 2018 Dec 21;10:80-86. doi: 10.1016/j.isci.2018.11.014. Epub 2018 Nov 10.


An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex.

Kandachar V, Tam BM, Moritz OL, Deretic D.

J Cell Sci. 2018 Dec 10;131(24). pii: jcs222034. doi: 10.1242/jcs.222034.


Generation and Analysis of Xenopus laevis Models of Retinal Degeneration Using CRISPR/Cas9.

Feehan JM, Stanar P, Tam BM, Chiu C, Moritz OL.

Methods Mol Biol. 2019;1834:193-207. doi: 10.1007/978-1-4939-8669-9_14.


One Year of Yoga Training Alters Ghrelin Axis in Centrally Obese Adults With Metabolic Syndrome.

Yu AP, Ugwu FN, Tam BT, Lee PH, Lai CW, Wong CSC, Lam WW, Sheridan S, Siu PM.

Front Physiol. 2018 Sep 20;9:1321. doi: 10.3389/fphys.2018.01321. eCollection 2018.


Live Cell Imaging of Bioorthogonally Labelled Proteins Generated With a Single Pyrrolysine tRNA Gene.

Aloush N, Schvartz T, König AI, Cohen S, Brozgol E, Tam B, Nachmias D, Ben-David O, Garini Y, Elia N, Arbely E.

Sci Rep. 2018 Sep 28;8(1):14527. doi: 10.1038/s41598-018-32824-1.


Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension.

Yu AP, Ugwu FN, Tam BT, Lee PH, Lai CW, Wong CSC, Siu PM.

Front Endocrinol (Lausanne). 2018 Sep 12;9:534. doi: 10.3389/fendo.2018.00534. eCollection 2018.


Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults.

Supriya R, Tam BT, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, Chan LW, Yung BY, Sheridan S, Siu PM.

PLoS One. 2018 Aug 16;13(8):e0201585. doi: 10.1371/journal.pone.0201585. eCollection 2018.


DnaG Primase-A Target for the Development of Novel Antibacterial Agents.

Ilic S, Cohen S, Singh M, Tam B, Dayan A, Akabayov B.

Antibiotics (Basel). 2018 Aug 13;7(3). pii: E72. doi: 10.3390/antibiotics7030072. Review.


An examination of critical parameters in hybridization-based epigenotyping using magnetic microparticles.

Tam BE, Hao Y, Sikes HD.

Biotechnol Prog. 2018 Nov;34(6):1589-1595. doi: 10.1002/btpr.2644. Epub 2018 Jul 27.


Revealing the Neural Mechanisms Underlying the Beneficial Effects of Tai Chi: A Neuroimaging Perspective.

Yu AP, Tam BT, Lai CW, Yu DS, Woo J, Chung KF, Hui SS, Liu JY, Wei GX, Siu PM.

Am J Chin Med. 2018;46(2):231-259. doi: 10.1142/S0192415X18500131. Review.


Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury.

Tam BT, Yu AP, Tam EW, Monks DA, Wang XP, Pei XM, Koh SP, Sin TK, Law HKW, Ugwu FN, Supriya R, Yung BY, Yip SP, Wong SC, Chan LW, Lai CW, Ouyang P, Siu PM.

Sci Rep. 2018 Feb 27;8(1):3689. doi: 10.1038/s41598-018-21853-5.


NMR-Fragment Based Virtual Screening: A Brief Overview.

Singh M, Tam B, Akabayov B.

Molecules. 2018 Jan 25;23(2). pii: E233. doi: 10.3390/molecules23020233. Review.


Protective Effect of Unacylated Ghrelin on Compression-Induced Skeletal Muscle Injury Mediated by SIRT1-Signaling.

Ugwu FN, Yu AP, Sin TK, Tam BT, Lai CW, Wong SC, Siu PM.

Front Physiol. 2017 Nov 24;8:962. doi: 10.3389/fphys.2017.00962. eCollection 2017.


The effect of pre-cure bracket movement on shear bond strength during placement of orthodontic brackets, an in vitro study.

Tam B, Bollu P, Chaudhry K, Subramani K.

J Clin Exp Dent. 2017 Oct 1;9(10):e1212-e1217. doi: 10.4317/jced.54208. eCollection 2017 Oct.


A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.

Deshmukh V, Hu H, Barroga C, Bossard C, Kc S, Dellamary L, Stewart J, Chiu K, Ibanez M, Pedraza M, Seo T, Do L, Cho S, Cahiwat J, Tam B, Tambiah JRS, Hood J, Lane NE, Yazici Y.

Osteoarthritis Cartilage. 2018 Jan;26(1):18-27. doi: 10.1016/j.joca.2017.08.015. Epub 2017 Sep 6.


Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9.

Feehan JM, Chiu CN, Stanar P, Tam BM, Ahmed SN, Moritz OL.

Sci Rep. 2017 Jul 31;7(1):6920. doi: 10.1038/s41598-017-07153-4.


Addressing Chirality in the Structure and Synthesis of [18 F]5-Fluoroaminosuberic Acid ([18 F]FASu).

Yang H, Tam B, Čolović M, Southcott L, Merkens H, Bénard F, Schaffer P.

Chemistry. 2017 Aug 16;23(46):11100-11107. doi: 10.1002/chem.201702007. Epub 2017 Jul 26.


Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic X. laevis Models of Retinitis Pigmentosa.

Vent-Schmidt RYJ, Wen RH, Zong Z, Chiu CN, Tam BM, May CG, Moritz OL.

J Neurosci. 2017 Jan 25;37(4):1039-1054. doi: 10.1523/JNEUROSCI.1647-16.2016.


Examining the utility of the Hamilton early warning scores (HEWS) at triage: Retrospective pilot study in a Canadian emergency department.

Skitch S, Tam B, Xu M, McInnis L, Vu A, Fox-Robichaud A.

CJEM. 2018 Mar;20(2):266-274. doi: 10.1017/cem.2017.21. Epub 2017 May 10.


From 2-methylimidazole to 1,2,3-triazole: a topological transformation of ZIF-8 and ZIF-67 by post-synthetic modification.

Erkartal M, Erkilic U, Tam B, Usta H, Yazaydin O, Hupp JT, Farha OK, Sen U.

Chem Commun (Camb). 2017 Feb 7;53(12):2028-2031. doi: 10.1039/c6cc08746a.


Developing and validating a localised, self-training mindfulness programme for older Singaporean adults: effects on cognitive functioning and implications for healthcare.

Tam BW, Lo DR, Seah DW, Lee JX, Foo ZF, Poh ZY, Thong FX, Sim SK, Chee CS.

Singapore Med J. 2017 Mar;58(3):126-128. doi: 10.11622/smedj.2016172. Epub 2016 Nov 21.


S100A8 and S100A9 Are Associated with Doxorubicin-Induced Cardiotoxicity in the Heart of Diabetic Mice.

Pei XM, Tam BT, Sin TK, Wang FF, Yung BY, Chan LW, Wong CS, Ying M, Lai CW, Siu PM.

Front Physiol. 2016 Aug 5;7:334. doi: 10.3389/fphys.2016.00334. eCollection 2016.


Doxorubicin Induces Inflammatory Modulation and Metabolic Dysregulation in Diabetic Skeletal Muscle.

Supriya R, Tam BT, Pei XM, Lai CW, Chan LW, Yung BY, Siu PM.

Front Physiol. 2016 Jul 27;7:323. doi: 10.3389/fphys.2016.00323. eCollection 2016.


Using nanobiotechnology to increase the prevalence of epigenotyping assays in precision medicine.

Heimer BW, Tam BE, Minkovsky A, Sikes HD.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jan;9(1). doi: 10.1002/wnan.1407. Epub 2016 Apr 29. Review.


Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte.

Cahill CM, Zhu W, Oziolor E, Yang YJ, Tam B, Rajanala S, Rogers JT, Walker WA.

PLoS One. 2016 Jan 22;11(1):e0145184. doi: 10.1371/journal.pone.0145184. eCollection 2016.


Association of endothelin-1 and matrix metallopeptidase-9 with metabolic syndrome in middle-aged and older adults.

Yu AP, Tam BT, Yau WY, Chan KS, Yu SS, Chung TL, Siu PM.

Diabetol Metab Syndr. 2015 Dec 10;7:111. doi: 10.1186/s13098-015-0108-2. eCollection 2015.


Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms.

Sin TK, Tam BT, Yu AP, Yip SP, Yung BY, Chan LW, Wong CS, Rudd JA, Siu PM.

J Gerontol A Biol Sci Med Sci. 2016 Jun;71(6):730-9. doi: 10.1093/gerona/glv175. Epub 2015 Oct 8.


Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis.

Heimer BW, Tam BE, Sikes HD.

Protein Eng Des Sel. 2015 Dec;28(12):543-51. doi: 10.1093/protein/gzv046. Epub 2015 Sep 18.


A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees.

Xu M, Tam B, Thabane L, Fox-Robichaud A.

BMJ Open. 2015 Sep 9;5(9):e008699. doi: 10.1136/bmjopen-2015-008699.


Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function.

Jiang L, Tam BM, Ying G, Wu S, Hauswirth WW, Frederick JM, Moritz OL, Baehr W.

FASEB J. 2015 Dec;29(12):4866-80. doi: 10.1096/fj.15-275677. Epub 2015 Jul 30.


Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice.

Tam BT, Pei XM, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM.

Pflugers Arch. 2015 Dec;467(12):2555-69. doi: 10.1007/s00424-015-1721-5. Epub 2015 Jul 31.


Preparation of Xenopus laevis retinal cryosections for electron microscopy.

Tam BM, Yang LL, Bogėa TH, Ross B, Martens G, Moritz OL.

Exp Eye Res. 2015 Jul;136:86-90. doi: 10.1016/j.exer.2015.05.014. Epub 2015 May 22.


Autophagic adaptation is associated with exercise-induced fibre-type shifting in skeletal muscle.

Tam BT, Pei XM, Yu AP, Sin TK, Leung KK, Au KK, Chong JT, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM.

Acta Physiol (Oxf). 2015 Jun;214(2):221-36. doi: 10.1111/apha.12503. Epub 2015 Apr 21.


High connectivity in Rastrelliger kanagurta: influence of historical signatures and migratory behaviour inferred from mtDNA cytochrome b.

Akib NA, Tam BM, Phumee P, Abidin MZ, Tamadoni S, Mather PB, Nor SA.

PLoS One. 2015 Mar 18;10(3):e0119749. doi: 10.1371/journal.pone.0119749. eCollection 2015.


Iodine status of Eeyou Istchee community members of northern Quebec, Canada, and potential sources.

Tam B, Tsuji LJ, Martin ID, Liberda EN, Ayotte P, Coté S, Dewailly É, Nieboer E.

Environ Sci Process Impacts. 2015 Apr;17(4):844-53. doi: 10.1039/c4em00674g.


Autophagic Adaptations to Long-term Habitual Exercise in Cardiac Muscle.

Tam BT, Pei XM, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM.

Int J Sports Med. 2015 Jun;36(7):526-34. doi: 10.1055/s-0034-1398494. Epub 2015 Mar 11.


Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.

Sin TK, Tam BT, Yung BY, Yip SP, Chan LW, Wong CS, Ying M, Rudd JA, Siu PM.

J Physiol. 2015 Apr 15;593(8):1887-99. doi: 10.1113/jphysiol.2014.270101. Epub 2015 Feb 9.


Is the kidney disease quality of life-36 (KDQOL-36) a valid instrument for Chinese dialysis patients?

Chow SK, Tam BM.

BMC Nephrol. 2014 Dec 15;15:199. doi: 10.1186/1471-2369-15-199.

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