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Items: 22

1.

Transient CHO expression platform for robust antibody production and its enhanced N-glycan sialylation on therapeutic glycoproteins.

Zhong X, Ma W, Meade CL, Tam AS, Llewellyn E, Cornell R, Cote K, Scarcelli JJ, Marshall JK, Tzvetkova B, Figueroa B, DiNino D, Sievers A, Lee C, Guo J, Mahan E, Francis C, Lam K, D'Antona AM, Zollner R, Zhu HL, Kriz R, Somers W, Lin L.

Biotechnol Prog. 2018 Oct 9. doi: 10.1002/btpr.2724. [Epub ahead of print]

PMID:
30299005
2.

RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.

Chang EY, Novoa CA, Aristizabal MJ, Coulombe Y, Segovia R, Chaturvedi R, Shen Y, Keong C, Tam AS, Jones SJM, Masson JY, Kobor MS, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):3991-4005. doi: 10.1083/jcb.201703168. Epub 2017 Oct 17.

3.

Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.

Mathew V, Tam AS, Milbury KL, Hofmann AK, Hughes CS, Morin GB, Loewen CJR, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):4027-4040. doi: 10.1083/jcb.201612018. Epub 2017 Oct 4.

4.

Genome-wide bisulfite sensitivity profiling of yeast suggests bisulfite inhibits transcription.

Segovia R, Mathew V, Tam AS, Stirling PC.

Mutat Res. 2017 Sep;821:13-19. doi: 10.1016/j.mrgentox.2017.06.004. Epub 2017 Jul 3.

PMID:
28735739
5.

Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells.

Zhong X, He T, Prashad AS, Wang W, Cohen J, Ferguson D, Tam AS, Sousa E, Lin L, Tchistiakova L, Gatto S, D'Antona A, Luan YT, Ma W, Zollner R, Zhou J, Arve B, Somers W, Kriz R.

J Biotechnol. 2017 Apr 20;248:48-58. doi: 10.1016/j.jbiotec.2017.03.006. Epub 2017 Mar 11.

PMID:
28300660
6.

Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans.

Tam AS, Chu JS, Rose AM.

G3 (Bethesda). 2015 Nov 12;6(1):133-40. doi: 10.1534/g3.115.021915.

7.

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).

Tu C, Terraube V, Tam AS, Stochaj W, Fennell BJ, Lin L, Stahl M, LaVallie ER, Somers W, Finlay WJ, Mosyak L, Bard J, Cunningham O.

J Biol Chem. 2016 Jan 15;291(3):1267-76. doi: 10.1074/jbc.M115.688010. Epub 2015 Oct 29.

8.

Dissecting genetic and environmental mutation signatures with model organisms.

Segovia R, Tam AS, Stirling PC.

Trends Genet. 2015 Aug;31(8):465-74. doi: 10.1016/j.tig.2015.04.001. Epub 2015 May 1. Review.

PMID:
25940384
9.

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

Fennell BJ, McDonnell B, Tam AS, Chang L, Steven J, Broadbent ID, Gao H, Kieras E, Alley J, Luxenberg D, Edmonds J, Fitz LJ, Miao W, Whitters MJ, Medley QG, Guo YJ, Darmanin-Sheehan A, Autin B, Shúilleabháin DN, Cummins E, King A, Krebs MR, Grace C, Hickling TP, Boisvert A, Zhong X, McKenna M, Francis C, Olland S, Bloom L, Paulsen J, Somers W, Jensen A, Lin L, Finlay WJ, Cunningham O.

MAbs. 2013 Nov-Dec;5(6):882-95. doi: 10.4161/mabs.26201. Epub 2013 Aug 21.

10.

Exploring the self-concepts of persons with intellectual disabilities.

Li EP, Tam AS, Man DW.

J Intellect Disabil. 2006 Mar;10(1):19-34.

PMID:
16495322
11.

Exploring self-concepts of persons with brain injury.

Man DW, Tam AS, Li EP.

Brain Inj. 2003 Sep;17(9):775-88.

PMID:
12850943
12.

Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors.

Tam AS, Devereux TR, Patel AC, Foley JF, Maronpot RR, Massey TE.

Carcinogenesis. 2003 Jan;24(1):121-32.

PMID:
12538357
13.

Mechanisms of aflatoxin B1 lung tumorigenesis.

Massey TE, Smith GB, Tam AS.

Exp Lung Res. 2000 Dec;26(8):673-83. Review.

PMID:
11195464
14.

High frequency and heterogeneous distribution of p53 mutations in aflatoxin B1-induced mouse lung tumors.

Tam AS, Foley JF, Devereux TR, Maronpot RR, Massey TE.

Cancer Res. 1999 Aug 1;59(15):3634-40.

15.
16.

Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production.

Card JW, Lalonde BR, Rafeiro E, Tam AS, Racz WJ, Brien JF, Bray TM, Massey TE.

Toxicol Lett. 1998 Sep 1;98(1-2):41-50.

PMID:
9776560
18.

The effects of dermatan sulfate at submicrogram/ml concentrations on in vitro thrombin generation.

Delorme MA, Tam AS, Xu L.

Thromb Haemost. 1996 May;75(5):747-51.

PMID:
8725717
19.

Modulation of clonal progression in B16F1 melanoma cells.

Harris JF, Chambers AF, Tam AS.

Clin Exp Metastasis. 1991 Mar-Apr;9(2):151-62.

PMID:
2032420
20.

Some ras-transformed cells have increased radiosensitivity and decreased repair of sublethal radiation damage.

Harris JF, Chambers AF, Tam AS.

Somat Cell Mol Genet. 1990 Jan;16(1):39-48.

PMID:
2408158
21.

Coarctation of the aorta in infancy and childhood.

Shinebourne EA, Tam AS, Elseed AM, Paneth M, Lennox SC, Cleland WP.

Br Heart J. 1976 Apr;38(4):375-80.

22.

Gastric aspirate findings in neonatal pneumonia.

Yeung CY, Tam AS.

Arch Dis Child. 1972 Oct;47(255):735-40. No abstract available.

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