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Items: 41


The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.

Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA.

Sci Signal. 2020 Jan 7;13(613). pii: eaax4569. doi: 10.1126/scisignal.aax4569.


Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.

Zeng B, Mou TC, Doukov TI, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F, Sprang SR.

Structure. 2019 Jul 2;27(7):1137-1147.e5. doi: 10.1016/j.str.2019.04.013. Epub 2019 May 30.


Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma.

Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL.

Mol Cancer Res. 2019 Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.


Production of Phosphorylated Ric-8A proteins using protein kinase CK2.

Yu W, Yu M, Papasergi-Scott MM, Tall GG.

Protein Expr Purif. 2019 Feb;154:98-103. doi: 10.1016/j.pep.2018.10.002. Epub 2018 Oct 2.


A simple supported tubulated bilayer system for evaluating protein-mediated membrane remodeling.

Schenk NA, Dahl PJ, Hanna MG 4th, Audhya A, Tall GG, Knight JD, Anantharam A.

Chem Phys Lipids. 2018 Sep;215:18-28. doi: 10.1016/j.chemphyslip.2018.06.002. Epub 2018 Jul 22.


Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.

Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG.

Sci Signal. 2018 May 29;11(532). pii: eaap8113. doi: 10.1126/scisignal.aap8113.


Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells.

Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X.

Elife. 2018 May 29;7. pii: e33385. doi: 10.7554/eLife.33385.


Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.

Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1632-1643. doi: 10.1161/ATVBAHA.118.311112. Epub 2018 May 10.


Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5.

Stoveken HM, Larsen SD, Smrcka AV, Tall GG.

Mol Pharmacol. 2018 May;93(5):477-488. doi: 10.1124/mol.117.111476. Epub 2018 Feb 23.


Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.

Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D.

Neuron. 2016 Sep 21;91(6):1292-1304. doi: 10.1016/j.neuron.2016.08.022.


Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.

Patel BR, Tall GG.

Oncogenesis. 2016 Jun 27;5(6):e236. doi: 10.1038/oncsis.2016.45.


Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.

Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG.

Mol Pharmacol. 2016 Sep;90(3):214-24. doi: 10.1124/mol.116.104828. Epub 2016 Jun 23.


Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.

Sánchez-Fernández G, Cabezudo S, Caballero Á, García-Hoz C, Tall GG, Klett J, Michnick SW, Mayor F Jr, Ribas C.

J Biol Chem. 2016 Apr 29;291(18):9513-25. doi: 10.1074/jbc.M115.684308. Epub 2016 Feb 17.


Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.

Carr R 3rd, Koziol-White C, Zhang J, Lam H, An SS, Tall GG, Panettieri RA Jr, Benovic JL.

Mol Pharmacol. 2016 Jan;89(1):94-104. doi: 10.1124/mol.115.100339. Epub 2015 Oct 13.


Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist.

Stoveken HM, Hajduczok AG, Xu L, Tall GG.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6194-9. doi: 10.1073/pnas.1421785112. Epub 2015 Apr 27. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3452.


New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X.

Ann N Y Acad Sci. 2014 Dec;1333:43-64. doi: 10.1111/nyas.12580. Epub 2014 Nov 25.


The G protein α chaperone Ric-8 as a potential therapeutic target.

Papasergi MM, Patel BR, Tall GG.

Mol Pharmacol. 2015 Jan;87(1):52-63. doi: 10.1124/mol.114.094664. Epub 2014 Oct 15. Review.


M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.

Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV.

J Biol Chem. 2014 Apr 18;289(16):11206-18. doi: 10.1074/jbc.M113.538546. Epub 2014 Mar 4.


Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI.

J Biol Chem. 2013 Oct 11;288(41):29772-84. doi: 10.1074/jbc.M113.502203. Epub 2013 Aug 16.


Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling.

Tall GG, Patel BR, Chan P.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3148. doi: 10.1073/pnas.1307476110. Epub 2013 Jul 12. No abstract available.


Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits.

Chan P, Thomas CJ, Sprang SR, Tall GG.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3794-9. doi: 10.1073/pnas.1220943110. Epub 2013 Feb 19.


Ric-8 regulation of heterotrimeric G proteins.

Tall GG.

J Recept Signal Transduct Res. 2013 Jun;33(3):139-43. doi: 10.3109/10799893.2013.763828. Epub 2013 Feb 6. Review.


Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM.

J Biol Chem. 2013 Feb 1;288(5):3003-15. doi: 10.1074/jbc.M112.418467. Epub 2012 Dec 4.


Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association.

Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG.

Sci Signal. 2011 Nov 22;4(200):ra79. doi: 10.1126/scisignal.2002223.


The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.

Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR.

PLoS One. 2011;6(8):e23197. doi: 10.1371/journal.pone.0023197. Epub 2011 Aug 11.


Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.

Chan P, Gabay M, Wright FA, Tall GG.

J Biol Chem. 2011 Jun 3;286(22):19932-42. doi: 10.1074/jbc.M110.163675. Epub 2011 Apr 5.


Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner.

Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM.

J Biol Chem. 2011 Apr 29;286(17):15116-25. doi: 10.1074/jbc.M110.216234. Epub 2011 Feb 27.


Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.

Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR.

Biochemistry. 2011 Feb 8;50(5):752-62. doi: 10.1021/bi101910n. Epub 2011 Jan 11.


Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf).

Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG.

J Biol Chem. 2011 Jan 28;286(4):2625-35. doi: 10.1074/jbc.M110.178897. Epub 2010 Nov 29.


Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.

Woodard GE, Huang NN, Cho H, Miki T, Tall GG, Kehrl JH.

Mol Cell Biol. 2010 Jul;30(14):3519-30. doi: 10.1128/MCB.00394-10. Epub 2010 May 17.


Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.

Thomas CJ, Tall GG, Adhikari A, Sprang SR.

J Biol Chem. 2008 Aug 22;283(34):23150-60. doi: 10.1074/jbc.M802422200. Epub 2008 Jun 9.


Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.

Johnston CA, Afshar K, Snyder JT, Tall GG, Gönczy P, Siderovski DP, Willard FS.

J Biol Chem. 2008 Aug 1;283(31):21550-8. doi: 10.1074/jbc.M803023200. Epub 2008 Jun 2.


Direct interactions with G α i and G βγ mediate nongenomic signaling by estrogen receptor α .

Kumar P, Wu Q, Chambliss KL, Yuhanna IS, Mumby SM, Mineo C, Tall GG, Shaul PW.

Mol Endocrinol. 2007 Jun;21(6):1370-80. Epub 2007 Apr 3.


Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells.

Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV.

Mol Pharmacol. 2005 Jul;68(1):129-36. Epub 2005 Mar 31.


Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic.

Davies BA, Topp JD, Sfeir AJ, Katzmann DJ, Carney DS, Tall GG, Friedberg AS, Deng L, Chen Z, Horazdovsky BF.

J Biol Chem. 2003 May 30;278(22):19826-33. Epub 2003 Mar 24.


Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.

Tall GG, Krumins AM, Gilman AG.

J Biol Chem. 2003 Mar 7;278(10):8356-62. Epub 2002 Dec 30.


Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF.

Dev Cell. 2001 Jul;1(1):73-82.


Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport.

Hama H, Tall GG, Horazdovsky BF.

J Biol Chem. 1999 May 21;274(21):15284-91.

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