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Stepped-wedge trials should be classified as research for the purpose of ethical review.

Hemming K, Taljaard M, Marshall T, Goldstein CE, Weijer C.

Clin Trials. 2019 Dec;16(6):580-588. doi: 10.1177/1740774519873322.


Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis.

Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ.

BMJ. 2019 Dec 4;367:l6373. doi: 10.1136/bmj.l6373.


Effectiveness of upgraded maternity waiting homes and local leader training in improving institutional births among women in the Jimma zone, Ethiopia: study protocol for a cluster-randomized controlled trial.

Kurji J, Kulkarni MA, Gebretsadik LA, Wordofa MA, Morankar S, Bedru KH, Bulcha G, Thavorn K, Labonte R, Taljaard M.

Trials. 2019 Dec 4;20(1):671. doi: 10.1186/s13063-019-3755-z.


Ottawa Statement does not impede randomised evaluation of government health programmes.

Weijer C, Taljaard M.

J Med Ethics. 2019 Nov 26. pii: medethics-2019-105938. doi: 10.1136/medethics-2019-105938. [Epub ahead of print]


SURE Test Accuracy for Decisional Conflict Screening among Parents Making Decisions for Their Child.

Boland L, Légaré F, McIsaac DI, Graham ID, Taljaard M, Dècary S, Stacey D.

Med Decis Making. 2019 Nov;39(8):1010-1018. doi: 10.1177/0272989X19884541. Epub 2019 Nov 15.


The Effect of Transplant Volume and Patient Case Mix on Center Variation in Kidney Transplantation Outcomes.

Tsampalieros A, Fergusson D, Dixon S, English SW, Manuel D, Van Walraven C, Taljaard M, Knoll GA.

Can J Kidney Health Dis. 2019 Sep 20;6:2054358119875462. doi: 10.1177/2054358119875462. eCollection 2019.


Response by Thiruganasambandamoorthy et al to Letters Regarding Article, "Duration of Electrocardiographic Monitoring of Emergency Department Patients With Syncope".

Thiruganasambandamoorthy V, Rowe BH, Sivilotti MLA, McRae AD, Arcot K, Nemnom MJ, Huang L, Mukarram M, Krahn AD, Wells GA, Taljaard M.

Circulation. 2019 Sep 17;140(12):e655-e656. doi: 10.1161/CIRCULATIONAHA.119.041639. Epub 2019 Sep 16. No abstract available.


Management Strategies and Patient Selection After a Hospital Funding Reform for Prostate Cancer Surgery in Canada.

Wettstein MS, Palmer KS, Kulkarni GS, Paterson JM, Ling V, Lapointe-Shaw L, Li AH, Brown A, Taljaard M, Ivers N.

JAMA Netw Open. 2019 Aug 2;2(8):e1910505. doi: 10.1001/jamanetworkopen.2019.10505.


Factors associated with maternity waiting home use among women in Jimma Zone, Ethiopia: a multilevel cross-sectional analysis.

Kurji J, Gebretsadik LA, Wordofa MA, Sudhakar M, Asefa Y, Kiros G, Mamo A, Bergen N, Asfaw S, Bedru KH, Bulcha G, Labonte R, Taljaard M, Kulkarni M.

BMJ Open. 2019 Aug 28;9(8):e028210. doi: 10.1136/bmjopen-2018-028210.


The ethics of cluster randomized trials: response to a proposal for revision of the Ottawa Statement.

Weijer C, Taljaard M.

J Clin Epidemiol. 2019 Dec;116:140-145. doi: 10.1016/j.jclinepi.2019.08.006. Epub 2019 Aug 23.


Development and field testing of a tool to elicit women's preferences among cervical cancer screening modalities.

Wood B, Taljaard M, El-Khatib Z, McFaul S, Graham ID, Little J.

J Eval Clin Pract. 2019 Dec;25(6):1169-1181. doi: 10.1111/jep.13258. Epub 2019 Aug 18.


Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis.

Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ.

BMJ. 2019 Jul 24;366:l4225. doi: 10.1136/bmj.l4225.


Information content of stepped-wedge designs when treatment effect heterogeneity and/or implementation periods are present.

Kasza J, Taljaard M, Forbes AB.

Stat Med. 2019 Oct 15;38(23):4686-4701. doi: 10.1002/sim.8327. Epub 2019 Jul 18.


A mixed-methods evaluation of the MOREOB program in Ontario hospitals: participant knowledge, organizational culture, and experiences.

Reszel J, Weiss D, Sprague AE, Fell DB, Dunn S, Walker MC, Sidney D, Taljaard M, Peterson WE.

BMC Health Serv Res. 2019 Jul 8;19(1):460. doi: 10.1186/s12913-019-4224-9.


Testing e-mail content to encourage physicians to access an audit and feedback tool: a factorial randomized experiment.

Vaisson G, Witteman HO, Chipenda-Dansokho S, Saragosa M, Bouck Z, Bravo CA, Desveaux L, Llovet D, Presseau J, Taljaard M, Umar S, Grimshaw JM, Tinmouth J, Ivers NM.

Curr Oncol. 2019 Jun;26(3):205-216. doi: 10.3747/co.26.4829. Epub 2019 Jun 1.


Ethical Issues in Pragmatic Cluster-Randomized Trials in Dialysis Facilities.

Goldstein CE, Weijer C, Taljaard M, Al-Jaishi AA, Basile E, Brehaut J, Cook CL, Grimshaw JM, Lacson E Jr, Lindsay C, Jardine M, Dember LM, Garg AX.

Am J Kidney Dis. 2019 Nov;74(5):659-666. doi: 10.1053/j.ajkd.2019.04.019. Epub 2019 Jun 19.


Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study.

Murthy SK, Begum J, Benchimol EI, Bernstein CN, Kaplan GG, McCurdy JD, Singh H, Targownik L, Taljaard M.

Gut. 2019 Jun 12. pii: gutjnl-2019-318440. doi: 10.1136/gutjnl-2019-318440. [Epub ahead of print]


Ethical issues raised by cluster randomised trials conducted in low-resource settings: identifying gaps in the Ottawa Statement through an analysis of the PURE Malawi trial.

Mtande TK, Weijer C, Hosseinipour MC, Taljaard M, Matoga M, Goldstein CE, Nyambalo B, Rosenberg NE.

J Med Ethics. 2019 Jun;45(6):388-393. doi: 10.1136/medethics-2019-105374. Epub 2019 Jun 12.


Government policy interventions to reduce human antimicrobial use: A systematic review and evidence map.

Rogers Van Katwyk S, Grimshaw JM, Nkangu M, Nagi R, Mendelson M, Taljaard M, Hoffman SJ.

PLoS Med. 2019 Jun 11;16(6):e1002819. doi: 10.1371/journal.pmed.1002819. eCollection 2019 Jun.


Understanding the impact of a multispecialty electronic consultation service on family physician referral rates to specialists: a randomized controlled trial using health administrative data.

Liddy C, Moroz I, Keely E, Taljaard M, Deri Armstrong C, Afkham A, Kendall CE.

Trials. 2019 Jun 10;20(1):348. doi: 10.1186/s13063-019-3393-5.


Mucilage powder from cactus pears as functional ingredient: influence of cultivar and harvest month on the physicochemical and technological properties.

Du Toit A, De Wit M, Fouché HJ, Taljaard M, Venter SL, Hugo A.

J Food Sci Technol. 2019 May;56(5):2404-2416. doi: 10.1007/s13197-019-03706-9. Epub 2019 Mar 25.


Effect of implementation of the MOREOB program on adverse maternal and neonatal birth outcomes in Ontario, Canada: a retrospective cohort study.

Weiss D, Fell DB, Sprague AE, Walker MC, Dunn S, Reszel J, Peterson WE, Coyle D, Taljaard M.

BMC Pregnancy Childbirth. 2019 May 3;19(1):151. doi: 10.1186/s12884-019-2296-5.


Sample size calculation for stepped-wedge cluster-randomized trials with more than two levels of clustering.

Teerenstra S, Taljaard M, Haenen A, Huis A, Atsma F, Rodwell L, Hulscher M.

Clin Trials. 2019 Jun;16(3):225-236. doi: 10.1177/1740774519829053. Epub 2019 Apr 24.


Diagnostic Accuracy and Financial Implications of Age-Adjusted D-Dimer Strategies for the Diagnosis of Deep Venous Thrombosis in the Emergency Department.

Reardon PM, Patrick S, Taljaard M, Thavorn K, Nemnom MJ, Mukarram M, Kim SM, Le Gal G, Huang L, Thiruganasambandamoorthy V.

J Emerg Med. 2019 May;56(5):469-477. doi: 10.1016/j.jemermed.2019.01.027. Epub 2019 Mar 16.


Stress reactivity in healthy child offspring of parents with anxiety disorders.

Koszycki D, Taljaard M, Bielajew C, Gow RM, Bradwejn J.

Psychiatry Res. 2019 Feb;272:756-764. doi: 10.1016/j.psychres.2018.12.171. Epub 2019 Jan 3.


In Reply.

Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Thiruganasambandamoorthy V, Kyeremanteng K, Perry JJ.

Acad Emerg Med. 2019 Jun;26(6):704-706. doi: 10.1111/acem.13716. Epub 2019 Mar 12. No abstract available.


The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort.

Chaudhry SH, Taljaard M, MacFarlane AJ, Gaudet LM, Smith GN, Rodger M, Rennicks White R, Walker MC, Wen SW.

BMC Pregnancy Childbirth. 2019 Feb 19;19(1):75. doi: 10.1186/s12884-019-2219-5.


Cost Benefit of High-Dose vs Standard-Dose Influenza Vaccine in a Long-Term Care Population During an A/H1N1-Predominant Influenza Season.

Shireman TI, Ogarek J, Gozalo P, Zhang T, Mor V, Davidson HE, Han L, Taljaard M, Gravenstein S.

J Am Med Dir Assoc. 2019 Jul;20(7):874-878. doi: 10.1016/j.jamda.2018.12.003. Epub 2019 Feb 15.


Use of a maternal newborn audit and feedback system in Ontario: a collective case study.

Reszel J, Dunn SI, Sprague AE, Graham ID, Grimshaw JM, Peterson WE, Ockenden H, Wilding J, Quosdorf A, Darling EK, Fell DB, Harrold J, Lanes A, Smith GN, Taljaard M, Weiss D, Walker MC.

BMJ Qual Saf. 2019 Aug;28(8):635-644. doi: 10.1136/bmjqs-2018-008354. Epub 2019 Feb 16.


The stepped wedge cluster randomised trial: what it is and when it should be used.

Campbell MJ, Hemming K, Taljaard M.

Med J Aust. 2019 Apr;210(6):253-254.e1. doi: 10.5694/mja2.50018. Epub 2019 Feb 13. No abstract available.


Design characteristics and statistical methods used in interrupted time series studies evaluating public health interventions: protocol for a review.

Turner SL, Karahalios A, Forbes AB, Taljaard M, Grimshaw JM, Cheng AC, Bero L, McKenzie JE.

BMJ Open. 2019 Jan 28;9(1):e024096. doi: 10.1136/bmjopen-2018-024096.


A Parent-Targeted and Mediated Video Intervention to Improve Uptake of Pain Treatment for Infants During Newborn Screening: A Pilot Randomized Controlled Trial.

Lavin Venegas C, Taljaard M, Reszel J, Dunn S, Graham ID, Harrold J, Larocque C, Nicholls B, Nicholls S, OʼFlaherty P, Squires J, Stevens B, Trépanier MJ, Harrison D.

J Perinat Neonatal Nurs. 2019 Jan/Mar;33(1):74-81. doi: 10.1097/JPN.0000000000000386.


Duration of Electrocardiographic Monitoring of Emergency Department Patients With Syncope.

Thiruganasambandamoorthy V, Rowe BH, Sivilotti MLA, McRae AD, Arcot K, Nemnom MJ, Huang L, Mukarram M, Krahn AD, Wells GA, Taljaard M.

Circulation. 2019 Mar 12;139(11):1396-1406. doi: 10.1161/CIRCULATIONAHA.118.036088.


Introducing the new CONSORT extension for stepped-wedge cluster randomised trials.

Hemming K, Taljaard M, Grimshaw J.

Trials. 2019 Jan 18;20(1):68. doi: 10.1186/s13063-018-3116-3.


The Impact of a Maternal Education Program Through Text Messaging in Rural China: Cluster Randomized Controlled Trial.

Xie RH, Tan H, Taljaard M, Liao Y, Krewski D, Du Q, Wen SW.

JMIR Mhealth Uhealth. 2018 Dec 19;6(12):e11213. doi: 10.2196/11213.


Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Rodrigues Botton M, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y, Mushiroda T, Gong IY, Kim RB, Hirai K, Itoh K, Isaza C, Beltrán L, Jiménez-Varo E, Cañadas-Garre M, Giontella A, Kringen MK, Haug KBF, Gwak HS, Lee KE, Minuz P, Lee MTM, Lubitz SA, Scott S, Mazzaccara C, Sacchetti L, Genç E, Özer M, Pathare A, Krishnamoorthy R, Paldi A, Siguret V, Loriot MA, Kutala VK, Suarez-Kurtz G, Perini J, Denny JC, Ramirez AH, Mittal B, Rathore SS, Sagreiya H, Altman R, Shahin MHA, Khalifa SI, Limdi NA, Rivers C, Shendre A, Dillon C, Suriapranata IM, Zhou HH, Tan SL, Tatarunas V, Lesauskaite V, Zhang Y, Maitland-van der Zee AH, Verhoef TI, de Boer A, Taljaard M, Zambon CF, Pengo V, Zhang JE, Pirmohamed M, Johnson JA, Fava C.

Clin Pharmacol Ther. 2019 Jun;105(6):1477-1491. doi: 10.1002/cpt.1323. Epub 2019 Feb 17.


Quality of stepped-wedge trial reporting can be reliably assessed using an updated CONSORT: crowd-sourcing systematic review.

Hemming K, Carroll K, Thompson J, Forbes A, Taljaard M; SW-CRT Review Group.

J Clin Epidemiol. 2019 Mar;107:77-88. doi: 10.1016/j.jclinepi.2018.11.017. Epub 2018 Nov 28. Review.


Outcomes and emergency medical services resource utilization among patients with syncope arriving to the emergency department by ambulance.

Yau L, Mukarram MA, Kim SM, Arcot K, Thavorn K, Stiell IG, Taljaard M, Rowe BH, Sivilotti MLA, Thiruganasambandamoorthy V.

CJEM. 2019 Jul;21(4):499-504. doi: 10.1017/cem.2018.464. Epub 2018 Nov 21.


Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.

Nicholls SG, Carroll K, Brehaut J, Weijer C, Hey SP, Goldstein CE, Zwarenstein M, Graham ID, McKenzie JE, McIntyre L, Jairath V, Campbell MK, Grimshaw JM, Fergusson DA, Taljaard M.

BMC Med Ethics. 2018 Nov 20;19(1):90. doi: 10.1186/s12910-018-0332-z.


Accuracy of massive transfusion as a surrogate for significant traumatic bleeding in health administrative datasets.

Tran A, Nemnom MJ, Lampron J, Matar M, Vaillancourt C, Taljaard M.

Injury. 2019 Feb;50(2):318-323. doi: 10.1016/j.injury.2018.11.014. Epub 2018 Nov 10.


Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration.

Hemming K, Taljaard M, McKenzie JE, Hooper R, Copas A, Thompson JA, Dixon-Woods M, Aldcroft A, Doussau A, Grayling M, Kristunas C, Goldstein CE, Campbell MK, Girling A, Eldridge S, Campbell MJ, Lilford RJ, Weijer C, Forbes AB, Grimshaw JM.

BMJ. 2018 Nov 9;363:k1614. doi: 10.1136/bmj.k1614. No abstract available.


Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta-analysis.

Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Thiruganasambandamoorthy V, Kyeremanteng K, Perry JJ.

Acad Emerg Med. 2019 Feb;26(2):140-151. doi: 10.1111/acem.13649. Epub 2018 Nov 29. Review.


In reply: When and how should we cluster and cross over: methodological and ethical issues (letters 1 and 2).

Goldstein CE, Giraudeau B, Weijer C, Taljaard M.

Can J Anaesth. 2019 Feb;66(2):239-240. doi: 10.1007/s12630-018-1239-3. Epub 2018 Oct 19. No abstract available.


A Patient Decision Aid for Men With Localized Prostate Cancer: A Comparative Case Study of Natural Implementation Approaches.

Stacey D, Taljaard M, Breau RH, Baba N, Blackmore T, Boland L, Carley M, Wu RC, Smylie J, Légaré F.

Cancer Nurs. 2020 Jan/Feb;43(1):E10-E21. doi: 10.1097/NCC.0000000000000651.


Non-clinical interventions for reducing unnecessary caesarean section.

Chen I, Opiyo N, Tavender E, Mortazhejri S, Rader T, Petkovic J, Yogasingam S, Taljaard M, Agarwal S, Laopaiboon M, Wasiak J, Khunpradit S, Lumbiganon P, Gruen RL, Betran AP.

Cochrane Database Syst Rev. 2018 Sep 28;9:CD005528. doi: 10.1002/14651858.CD005528.pub3. Review.


Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.


Effect of audit and feedback on physicians' intraoperative temperature management and patient outcomes: a three-arm cluster randomized-controlled trial comparing benchmarked and ranked feedback.

Boet S, Bryson GL, Taljaard M, Pigford AA, McIsaac DI, Brehaut J, Forster A, Mohamed K, Clavel N, Pysyk C, Grimshaw JM; Canadian Perioperative Anesthesia Clinical Trials Group.

Can J Anaesth. 2018 Nov;65(11):1196-1209. doi: 10.1007/s12630-018-1205-0. Epub 2018 Aug 29.


Cancer screening inequities in a time of primary care reform: a population-based longitudinal study in Ontario, Canada.

Lofters AK, Mark A, Taljaard M, Green ME, Glazier RH, Dahrouge S.

BMC Fam Pract. 2018 Aug 29;19(1):147. doi: 10.1186/s12875-018-0827-1.


FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.


Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection.

Fernando SM, Tran A, Taljaard M, Cheng W, Perry JJ.

Ann Intern Med. 2018 Aug 21;169(4):264-265. doi: 10.7326/L18-0291. No abstract available.


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