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Items: 1 to 50 of 83

1.

Chemical Space Exploration Around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold led to a Novel Class of Highly Active Clostridium difficile Inhibitors.

Shao X, AbdelKhalek A, Abutaleb NS, Velagapudi UK, Yoganathan S, Seleem MN, Talele TT.

J Med Chem. 2019 Oct 4. doi: 10.1021/acs.jmedchem.9b01198. [Epub ahead of print]

PMID:
31584822
2.

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.

Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT.

J Med Chem. 2019 Jun 13;62(11):5330-5357. doi: 10.1021/acs.jmedchem.8b01709. Epub 2019 May 24.

PMID:
31042381
3.

Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.

Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT.

J Med Chem. 2018 Feb 8;61(3):834-864. doi: 10.1021/acs.jmedchem.7b01340. Epub 2018 Jan 23.

4.

Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies.

Li J, Kumar P, Anreddy N, Zhang YK, Wang YJ, Chen Y, Talele TT, Gupta K, Trombetta LD, Chen ZS.

Oncotarget. 2017 Sep 16;8(55):93785-93799. doi: 10.18632/oncotarget.21078. eCollection 2017 Nov 7.

5.

Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.

Talele TT.

J Med Chem. 2018 Mar 22;61(6):2166-2210. doi: 10.1021/acs.jmedchem.7b00315. Epub 2017 Sep 8. Review.

PMID:
28850227
6.

The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions.

Beaury M, Velagapudi UK, Weber S, Soto C, Talele TT, Nichols DB.

Virus Genes. 2017 Aug;53(4):522-531. doi: 10.1007/s11262-017-1456-9. Epub 2017 Apr 20.

PMID:
28425034
7.

Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1.

Wang YJ, Patel BA, Anreddy N, Zhang YK, Zhang GN, Alqahtani S, Singh S, Shukla S, Kaddoumi A, Ambudkar SV, Talele TT, Chen ZS.

Sci Rep. 2017 Feb 9;7:42106. doi: 10.1038/srep42106.

8.

In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates.

AbdelKhalek A, Ashby CR Jr, Patel BA, Talele TT, Seleem MN.

PLoS One. 2016 Oct 6;11(10):e0164227. doi: 10.1371/journal.pone.0164227. eCollection 2016.

9.
10.

Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters.

Zhang YK, Zhang GN, Wang YJ, Patel BA, Talele TT, Yang DH, Chen ZS.

Sci Rep. 2016 May 9;6:25694. doi: 10.1038/srep25694.

11.

Characterization of Solid Dispersion of Itraconazole Prepared by Solubilization in Concentrated Aqueous Solutions of Weak Organic Acids and Drying.

Parikh T, Sandhu HK, Talele TT, Serajuddin AT.

Pharm Res. 2016 Jun;33(6):1456-71. doi: 10.1007/s11095-016-1890-8. Epub 2016 Mar 7.

PMID:
26951566
12.

Discovery of conjugated thiazolidinone-thiadiazole scaffold as anti-dengue virus polymerase inhibitors.

Manvar D, Küçükgüzel İ, Erensoy G, Tatar E, Deryabaşoğulları G, Reddy H, Talele TT, Cevik O, Kaushik-Basu N.

Biochem Biophys Res Commun. 2016 Jan 15;469(3):743-7. doi: 10.1016/j.bbrc.2015.12.042. Epub 2015 Dec 15.

PMID:
26697747
13.

Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines.

Werner MM, Patel BA, Talele TT, Ashby CR, Li Z, Zauhar RJ.

Bioorg Med Chem. 2015 Sep 15;23(18):6125-37. doi: 10.1016/j.bmc.2015.08.004. Epub 2015 Aug 14.

PMID:
26320664
14.

Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles.

Çıkla-Süzgün P, Kaushik-Basu N, Basu A, Arora P, Talele TT, Durmaz I, Çetin-Atalay R, Küçükgüzel ŞG.

J Enzyme Inhib Med Chem. 2015;30(5):778-85. doi: 10.3109/14756366.2014.971780.

PMID:
25676325
15.

Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.

Çakir G, Küçükgüzel İ, Guhamazumder R, Tatar E, Manvar D, Basu A, Patel BA, Zia J, Talele TT, Kaushik-Basu N.

Arch Pharm (Weinheim). 2015 Jan;348(1):10-22. doi: 10.1002/ardp.201400247. Epub 2014 Dec 2.

PMID:
25449674
16.

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.

Tang SJ, Chen LK, Wang F, Zhang YK, Huang ZC, To KK, Wang XK, Talele TT, Chen ZS, Chen WQ, Fu LW.

Biochem Pharmacol. 2014 Sep 15;91(2):144-56. doi: 10.1016/j.bcp.2014.07.008. Epub 2014 Jul 21.

PMID:
25058526
17.

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.

Wang DS, Patel A, Shukla S, Zhang YK, Wang YJ, Kathawala RJ, Robey RW, Zhang L, Yang DH, Talele TT, Bates SE, Ambudkar SV, Xu RH, Chen ZS.

Oncotarget. 2014 Jun 30;5(12):4529-42.

18.

Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells.

Huang XC, Xiao X, Zhang YK, Talele TT, Salim AA, Chen ZS, Capon RJ.

Mar Drugs. 2014 Jun 27;12(7):3818-37. doi: 10.3390/md12073818.

19.

ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.

Wang DS, Patel A, Sim HM, Zhang YK, Wang YJ, Kathawala RJ, Zhang H, Talele TT, Ambudkar SV, Xu RH, Chen ZS.

J Cell Biochem. 2014 Aug;115(8):1381-91. doi: 10.1002/jcb.24787.

20.

Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.

Wang YJ, Kathawala RJ, Zhang YK, Patel A, Kumar P, Shukla S, Fung KL, Ambudkar SV, Talele TT, Chen ZS.

Biochem Pharmacol. 2014 Aug 15;90(4):367-78. doi: 10.1016/j.bcp.2014.06.006. Epub 2014 Jun 14.

21.

Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.

Patel MR, Bhatt A, Steffen JD, Chergui A, Murai J, Pommier Y, Pascal JM, Trombetta LD, Fronczek FR, Talele TT.

J Med Chem. 2014 Jul 10;57(13):5579-601. doi: 10.1021/jm5002502. Epub 2014 Jun 25.

22.

WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells.

Zhang H, Zhang YK, Wang YJ, Kathawala RJ, Patel A, Zhu H, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Fu LW.

Cancer Sci. 2014 Aug;105(8):1071-8. doi: 10.1111/cas.12462. Epub 2014 Aug 21.

23.

Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approach.

Shukla S, Kouanda A, Silverton L, Talele TT, Ambudkar SV.

Mol Pharm. 2014 Jul 7;11(7):2313-22. doi: 10.1021/mp400762h. Epub 2014 Jun 5.

24.

Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.

Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, Ambudkar SV, Talele TT.

J Med Chem. 2014 May 22;57(10):4058-72. doi: 10.1021/jm401966m. Epub 2014 May 7.

25.

AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.

Zhang H, Wang YJ, Zhang YK, Wang DS, Kathawala RJ, Patel A, Talele TT, Chen ZS, Fu LW.

Cancer Lett. 2014 Aug 1;350(1-2):61-8. doi: 10.1016/j.canlet.2014.04.008. Epub 2014 Apr 18.

PMID:
24747122
26.

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.

Zhang H, Kathawala RJ, Wang YJ, Zhang YK, Patel A, Shukla S, Robey RW, Talele TT, Ashby CR Jr, Ambudkar SV, Bates SE, Fu LW, Chen ZS.

Int J Biochem Cell Biol. 2014 Jun;51:111-9. doi: 10.1016/j.biocel.2014.03.026. Epub 2014 Apr 12.

PMID:
24726739
27.

Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.

Kathawala RJ, Chen JJ, Zhang YK, Wang YJ, Patel A, Wang DS, Talele TT, Ashby CR Jr, Chen ZS.

Int J Oncol. 2014 May;44(5):1634-42. doi: 10.3892/ijo.2014.2341. Epub 2014 Mar 13.

28.

Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo.

Sodani K, Patel A, Anreddy N, Singh S, Yang DH, Kathawala RJ, Kumar P, Talele TT, Chen ZS.

Biochem Pharmacol. 2014 May 1;89(1):52-61. doi: 10.1016/j.bcp.2014.02.012. Epub 2014 Feb 22.

29.

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.

Shukla S, Chufan EE, Singh S, Skoumbourdis AP, Kapoor K, Boxer MB, Duveau DY, Thomas CJ, Talele TT, Ambudkar SV.

Leukemia. 2014 Apr;28(4):961-4. doi: 10.1038/leu.2014.21. Epub 2014 Jan 14. No abstract available.

30.

Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).

Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV.

PLoS One. 2013 Dec 5;8(12):e82463. doi: 10.1371/journal.pone.0082463. eCollection 2013.

31.

Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).

Singh S, Prasad NR, Kapoor K, Chufan EE, Patel BA, Ambudkar SV, Talele TT.

Chembiochem. 2014 Jan 3;15(1):157-69. doi: 10.1002/cbic.201300565. Epub 2013 Nov 29.

32.

β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter.

Guo HQ, Zhang GN, Wang YJ, Zhang YK, Sodani K, Talele TT, Ashby CR Jr, Chen ZS.

Oncol Rep. 2014 Feb;31(2):858-66. doi: 10.3892/or.2013.2870. Epub 2013 Nov 27.

PMID:
24284783
33.

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G.

Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14.

34.

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

Küçükgüzel I, Satılmış G, Gurukumar KR, Basu A, Tatar E, Nichols DB, Talele TT, Kaushik-Basu N.

Eur J Med Chem. 2013 Nov;69:931-41. doi: 10.1016/j.ejmech.2013.08.043. Epub 2013 Sep 12.

35.

Identification of novel PARP-1 inhibitors by structure-based virtual screening.

Hannigan K, Kulkarni SS, Bdzhola VG, Golub AG, Yarmoluk SM, Talele TT.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5790-4. doi: 10.1016/j.bmcl.2013.09.007. Epub 2013 Sep 10.

PMID:
24074844
36.

Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis.

Das TK, Dana D, Paroly SS, Perumal SK, Singh S, Jhun H, Pendse J, Cagan RL, Talele TT, Kumar S.

Oncogenesis. 2013 Sep 9;2:e69. doi: 10.1038/oncsis.2013.34.

37.

The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.

Patel BA, Ashby CR Jr, Hardej D, Talele TT.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5523-7. doi: 10.1016/j.bmcl.2013.08.059. Epub 2013 Aug 20.

PMID:
24012180
38.

Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.

Patel BA, Krishnan R, Khadtare N, Gurukumar KR, Basu A, Arora P, Bhatt A, Patel MR, Dana D, Kumar S, Kaushik-Basu N, Talele TT.

Bioorg Med Chem. 2013 Jun 1;21(11):3262-71. doi: 10.1016/j.bmc.2013.03.041. Epub 2013 Mar 31.

39.

Synthesis and characterization of celecoxib derivatives as possible anti-inflammatory, analgesic, antioxidant, anticancer and anti-HCV agents.

Küçükgüzel ŞG, Coşkun İ, Aydın S, Aktay G, Gürsoy Ş, Çevik Ö, Özakpınar ÖB, Özsavcı D, Şener A, Kaushik-Basu N, Basu A, Talele TT.

Molecules. 2013 Mar 21;18(3):3595-614. doi: 10.3390/molecules18033595.

40.

BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells.

He D, Zhao XQ, Chen XG, Fang Y, Singh S, Talele TT, Qiu HJ, Liang YJ, Wang XK, Zhang GQ, Chen ZS, Fu LW.

PLoS One. 2013;8(1):e54181. doi: 10.1371/journal.pone.0054181. Epub 2013 Jan 18.

41.

Evaluation of coumarin and neoflavone derivatives as HCV NS5B polymerase inhibitors.

Nichols DB, Leão RA, Basu A, Chudayeu M, de Moraes Pde F, Talele TT, Costa PR, Kaushik-Basu N.

Chem Biol Drug Des. 2013 May;81(5):607-14. doi: 10.1111/cbdd.12105. Epub 2013 Apr 4.

PMID:
23311976
42.

Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.

Tatar E, Küçükgüzel I, Daelemans D, Talele TT, Kaushik-Basu N, De Clercq E, Pannecouque C.

Arch Pharm (Weinheim). 2013 Feb;346(2):140-53. doi: 10.1002/ardp.201200311. Epub 2012 Dec 20.

PMID:
23280502
43.

Etodolac Thiosemicarbazides: A novel class of hepatitis C virus NS5B polymerase inhibitors.

Çıkla P, Arora P, Basu A, Talele TT, Kaushik-Basu N, Küçükgüzel ŞG.

Marmara Pharm J. 2013;17:138-146.

44.

Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.

Golub AG, Gurukumar KR, Basu A, Bdzhola VG, Bilokin Y, Yarmoluk SM, Lee JC, Talele TT, Nichols DB, Kaushik-Basu N.

Eur J Med Chem. 2012 Dec;58:258-64. doi: 10.1016/j.ejmech.2012.09.010. Epub 2012 Sep 17.

45.

Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models.

Tiwari AK, Sodani K, Dai CL, Abuznait AH, Singh S, Xiao ZJ, Patel A, Talele TT, Fu L, Kaddoumi A, Gallo JM, Chen ZS.

Cancer Lett. 2013 Jan 28;328(2):307-17. doi: 10.1016/j.canlet.2012.10.001. Epub 2012 Oct 9.

46.

Design, synthesis, and evaluation of 2-(arylsulfonyl)oxiranes as cell-permeable covalent inhibitors of protein tyrosine phosphatases.

Dana D, Das TK, Kumar I, Davalos AR, Mark KJ, Ramai D, Chang EJ, Talele TT, Kumar S.

Chem Biol Drug Des. 2012 Oct;80(4):489-99. doi: 10.1111/j.1747-0285.2012.01437.x. Epub 2012 Jul 25.

PMID:
22726577
47.

Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202.

Cheng C, Liu ZG, Zhang H, Xie JD, Chen XG, Zhao XQ, Wang F, Liang YJ, Chen LK, Singh S, Chen JJ, Talele TT, Chen ZS, Zhong FT, Fu LW.

Mol Pharm. 2012 Jul 2;9(7):1971-82. doi: 10.1021/mp2006714. Epub 2012 Jun 13.

PMID:
22632055
48.

Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo.

Liu KJ, He JH, Su XD, Sim HM, Xie JD, Chen XG, Wang F, Liang YJ, Singh S, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Wu HY, Fu LW.

Int J Cancer. 2013 Jan 1;132(1):224-35. doi: 10.1002/ijc.27649. Epub 2012 Jun 13.

49.

Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.

Sun YL, Kathawala RJ, Singh S, Zheng K, Talele TT, Jiang WQ, Chen ZS.

Anticancer Drugs. 2012 Sep;23(8):865-73. doi: 10.1097/CAD.0b013e328354a196.

PMID:
22614107
50.

Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo.

Zhao XQ, Xie JD, Chen XG, Sim HM, Zhang X, Liang YJ, Singh S, Talele TT, Sun Y, Ambudkar SV, Chen ZS, Fu LW.

Mol Pharmacol. 2012 Jul;82(1):47-58. doi: 10.1124/mol.111.076299. Epub 2012 Apr 4.

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