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Items: 1 to 50 of 109

1.

Hydrogelation with a water-insoluble organogelator - surfactant mediated gelation (SMG).

Aramaki K, Koitani S, Takimoto E, Kondo M, Stubenrauch C.

Soft Matter. 2019 Nov 21;15(43):8896-8904. doi: 10.1039/c9sm01700c. Epub 2019 Oct 16.

PMID:
31617557
2.

Analysis of Oxygenation in Chronic Thromboembolic Pulmonary Hypertension Using Dead Space Ratio and Intrapulmonary Shunt Ratio.

Minatsuki S, Hatano M, Maki H, Takimoto E, Morita H, Komuro I.

Int Heart J. 2019 Sep 27;60(5):1137-1141. doi: 10.1536/ihj.19-079. Epub 2019 Sep 4.

3.

Effectiveness of balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension despite having lesion types suitable for surgical treatment.

Minatsuki S, Kiyosue A, Kodera S, Hara T, Saito A, Maki H, Hatano M, Takimoto E, Ando M, Komuro I.

J Cardiol. 2020 Feb;75(2):182-188. doi: 10.1016/j.jjcc.2019.07.006. Epub 2019 Aug 17.

PMID:
31427133
4.

Overview of the 83rd Annual Scientific Meeting of the Japanese Circulation Society - Renaissance of Cardiology for the Creation of Future Medicine.

Akazawa H, Toko H, Harada M, Ueda K, Kodera S, Kiyosue A, Fujiu K, Hatano M, Daimon M, Ando J, Takimoto E, Morita H, Komuro I.

Circ J. 2019 Aug 23;83(9):1829-1835. doi: 10.1253/circj.CJ-19-0587. Epub 2019 Aug 3.

5.

Emergency percutaneous coronary intervention for left main trunk thrombus following orthotopic heart transplantation.

Tsuji M, Nitta D, Minatsuki S, Maki H, Hosoya Y, Amiya E, Hatano M, Takimoto E, Kinoshita O, Nawata K, Ono M, Komuro I.

ESC Heart Fail. 2019 Jun;6(3):575-578. doi: 10.1002/ehf2.12422. Epub 2019 Mar 10.

6.

Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung.

Minatsuki S, Takeda N, Soma K, Katoh M, Maki H, Hatano M, Takimoto E, Manabe I, Komuro I.

Int Heart J. 2019 Mar 20;60(2):451-456. doi: 10.1536/ihj.18-281. Epub 2019 Feb 22.

7.

High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.

Satoh M, Nomura S, Harada M, Yamaguchi T, Ko T, Sumida T, Toko H, Naito AT, Takeda N, Tobita T, Fujita T, Ito M, Fujita K, Ishizuka M, Kariya T, Akazawa H, Kobayashi Y, Morita H, Takimoto E, Aburatani H, Komuro I.

J Mol Cell Cardiol. 2019 Mar;128:77-89. doi: 10.1016/j.yjmcc.2018.12.018. Epub 2019 Jan 3.

8.

Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.

Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.

JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. doi: 10.1016/j.jacbts.2018.07.005. eCollection 2018 Oct.

9.

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure.

Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.

Nat Commun. 2018 Oct 30;9(1):4435. doi: 10.1038/s41467-018-06639-7.

10.

Clinically Worsening Chronic Thromboembolic Pulmonary Hypertension by Riociguat After Balloon Pulmonary Angioplasty.

Minatsuki S, Hatano M, Kiyosue A, Saito A, Maki H, Takimoto E, Komuro I.

Int Heart J. 2018 Sep 26;59(5):1186-1188. doi: 10.1536/ihj.17-660. Epub 2018 Aug 29.

11.

Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A.

Ueda K, Takimoto E, Lu Q, Liu P, Fukuma N, Adachi Y, Suzuki R, Chou S, Baur W, Aronovitz MJ, Greenberg AS, Komuro I, Karas RH.

Diabetes. 2018 Aug;67(8):1524-1537. doi: 10.2337/db17-1342. Epub 2018 May 15.

12.

Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys-Dietz syndrome or multiple self-healing squamous epithelioma.

Fujiwara T, Takeda N, Hara H, Morita H, Kishihara J, Inuzuka R, Yagi H, Maemura S, Toko H, Harada M, Ikeda Y, Kumagai H, Nomura S, Takimoto E, Akazawa H, Ako J, Komuro I.

Eur J Hum Genet. 2018 Aug;26(8):1151-1158. doi: 10.1038/s41431-018-0127-1. Epub 2018 Apr 30.

13.

Sildenafil ameliorates right ventricular early molecular derangement during left ventricular pressure overload.

Imai Y, Kariya T, Iwakiri M, Yamada Y, Takimoto E.

PLoS One. 2018 Apr 5;13(4):e0195528. doi: 10.1371/journal.pone.0195528. eCollection 2018.

14.

Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling.

Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.

Sci Rep. 2018 Jan 31;8(1):1998. doi: 10.1038/s41598-018-20114-9.

15.

Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report.

Numata G, Kodera S, Kiriyama H, Nakayama A, Amiya E, Kiyosue A, Hatano M, Takimoto E, Watanabe M, Komuro I.

J Intensive Care. 2017 Nov 6;5:61. doi: 10.1186/s40560-017-0255-7. eCollection 2017.

16.

Successful bridge to recovery in fulminant myocarditis using a biventricular assist device: a case report.

Adachi Y, Kinoshita O, Hatano M, Shintani Y, Naito N, Kimura M, Nawata K, Nitta D, Maki H, Ueda K, Amiya E, Takimoto E, Komuro I, Ono M.

J Med Case Rep. 2017 Oct 24;11(1):295. doi: 10.1186/s13256-017-1466-1.

17.

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice.

Rouf R, MacFarlane EG, Takimoto E, Chaudhary R, Nagpal V, Rainer PP, Bindman JG, Gerber EE, Bedja D, Schiefer C, Miller KL, Zhu G, Myers L, Amat-Alarcon N, Lee DI, Koitabashi N, Judge DP, Kass DA, Dietz HC.

JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588. eCollection 2017 Aug 3.

18.

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure.

Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.

PLoS One. 2017 Mar 22;12(3):e0174099. doi: 10.1371/journal.pone.0174099. eCollection 2017.

19.

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.

Tanaka M, Ishizuka K, Nekooki-Machida Y, Endo R, Takashima N, Sasaki H, Komi Y, Gathercole A, Huston E, Ishii K, Hui KK, Kurosawa M, Kim SH, Nukina N, Takimoto E, Houslay MD, Sawa A.

J Clin Invest. 2017 Apr 3;127(4):1438-1450. doi: 10.1172/JCI85594. Epub 2017 Mar 6.

20.

Hydrogen Sulfide, a Potential Cardioprotective Gas Activating a Life Span Regulator.

Ueda K, Fukuma N, Takimoto E.

Int Heart J. 2016 Jul 27;57(4):393-4. doi: 10.1536/ihj.16-252. Epub 2016 Jul 11. No abstract available.

21.

Sentinel lymph node mapping with staging lymphadenectomy for patients with endometrial cancer increases the detection of metastasis.

Holloway RW, Gupta S, Stavitzski NM, Zhu X, Takimoto EL, Gubbi A, Bigsby GE, Brudie LA, Kendrick JE, Ahmad S.

Gynecol Oncol. 2016 May;141(2):206-210. doi: 10.1016/j.ygyno.2016.02.018. Epub 2016 Mar 2.

PMID:
26905211
22.

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension.

Johns RA, Takimoto E, Meuchel LW, Elsaigh E, Zhang A, Heller NM, Semenza GL, Yamaji-Kegan K.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):134-44. doi: 10.1161/ATVBAHA.115.306710. Epub 2015 Nov 19.

23.

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate.

Thoonen R, Giovanni S, Govindan S, Lee DI, Wang GR, Calamaras TD, Takimoto E, Kass DA, Sadayappan S, Blanton RM.

Circ Heart Fail. 2015 Nov;8(6):1115-22. doi: 10.1161/CIRCHEARTFAILURE.115.002308. Epub 2015 Oct 18.

24.

Comparison of the results from simple radiography, from before to after Salter osteotomy, in patients with Legg-Calvé-Perthes disease.

Toma HF, de Almeida Oliveira Felippe Viana T, Meireles RM, Borelli IM, Blumetti FC, Takimoto ES, Dobashi ET.

Rev Bras Ortop. 2014 Sep 16;49(5):488-93. doi: 10.1016/j.rboe.2014.09.003. eCollection 2014 Sep-Oct.

25.

SH2B1: a new player in the regulation of cardiac hypertrophic response in failing hearts.

Ikeda Y, Takimoto E, Komuro I.

Cardiovasc Res. 2015 Jul 15;107(2):197-9. doi: 10.1093/cvr/cvv172. Epub 2015 Jun 15. No abstract available.

PMID:
26077625
26.

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.

Ikeda Y, Kumagai H, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M.

PLoS One. 2015 Jun 1;10(6):e0127445. doi: 10.1371/journal.pone.0127445. eCollection 2015.

27.

Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling.

Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M.

PLoS One. 2015 May 28;10(5):e0129394. doi: 10.1371/journal.pone.0129394. eCollection 2015.

28.

Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes.

Sawaki D, Hou L, Tomida S, Sun J, Zhan H, Aizawa K, Son BK, Kariya T, Takimoto E, Otsu K, Conway SJ, Manabe I, Komuro I, Friedman SL, Nagai R, Suzuki T.

Cardiovasc Res. 2015 Sep 1;107(4):420-30. doi: 10.1093/cvr/cvv155. Epub 2015 May 17.

29.

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA.

Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18.

30.

Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome.

Sumida M, Doi K, Ogasawara E, Yamashita T, Hamasaki Y, Kariya T, Takimoto E, Yahagi N, Nangaku M, Noiri E.

J Am Soc Nephrol. 2015 Oct;26(10):2378-87. doi: 10.1681/ASN.2014080750. Epub 2015 Feb 2.

31.

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.

Zhu G, Groneberg D, Sikka G, Hori D, Ranek MJ, Nakamura T, Takimoto E, Paolocci N, Berkowitz DE, Friebe A, Kass DA.

Hypertension. 2015 Feb;65(2):385-92. doi: 10.1161/HYPERTENSIONAHA.114.04285. Epub 2014 Dec 1.

32.

Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity.

Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM.

J Appl Physiol (1985). 2015 Jan 15;118(2):212-23. doi: 10.1152/japplphysiol.00463.2014. Epub 2014 Oct 16.

33.

PDE5 inhibitor efficacy is estrogen dependent in female heart disease.

Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.

J Clin Invest. 2014 Jun;124(6):2464-71. doi: 10.1172/JCI70731. Epub 2014 May 16.

34.

Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension.

Yamaji-Kegan K, Takimoto E, Zhang A, Weiner NC, Meuchel LW, Berger AE, Cheadle C, Johns RA.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1090-103. doi: 10.1152/ajplung.00279.2013. Epub 2014 May 2.

35.

Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.

Liu T, Takimoto E, Dimaano VL, DeMazumder D, Kettlewell S, Smith G, Sidor A, Abraham TP, O'Rourke B.

Circ Res. 2014 Jun 20;115(1):44-54. doi: 10.1161/CIRCRESAHA.115.303062. Epub 2014 Apr 29.

36.

Nitroxyl (HNO): A novel approach for the acute treatment of heart failure.

Sabbah HN, Tocchetti CG, Wang M, Daya S, Gupta RC, Tunin RS, Mazhari R, Takimoto E, Paolocci N, Cowart D, Colucci WS, Kass DA.

Circ Heart Fail. 2013 Nov;6(6):1250-8. doi: 10.1161/CIRCHEARTFAILURE.113.000632. Epub 2013 Oct 9.

37.

Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.

Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME.

J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8.

38.

Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.

Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N.

Antioxid Redox Signal. 2014 Jan 10;20(2):267-80. doi: 10.1089/ars.2012.4616. Epub 2013 May 22.

39.

Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.

Blanton RM, Takimoto E, Lane AM, Aronovitz M, Piotrowski R, Karas RH, Kass DA, Mendelsohn ME.

J Am Heart Assoc. 2012 Oct;1(5):e003731. doi: 10.1161/JAHA.112.003731. Epub 2012 Oct 25.

40.

Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling.

Zhang M, Takimoto E, Lee DI, Santos CX, Nakamura T, Hsu S, Jiang A, Nagayama T, Bedja D, Yuan Y, Eaton P, Shah AM, Kass DA.

Circulation. 2012 Aug 21;126(8):942-51. doi: 10.1161/CIRCULATIONAHA.112.090977. Epub 2012 Jul 24.

41.

Cyclic GMP-dependent signaling in cardiac myocytes.

Takimoto E.

Circ J. 2012;76(8):1819-25. Epub 2012 Jul 29. Review.

42.

Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation.

Tsai EJ, Liu Y, Koitabashi N, Bedja D, Danner T, Jasmin JF, Lisanti MP, Friebe A, Takimoto E, Kass DA.

Circ Res. 2012 Jan 20;110(2):295-303. doi: 10.1161/CIRCRESAHA.111.259242. Epub 2011 Nov 17.

43.

Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.

Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA.

Sci Transl Med. 2011 Sep 14;3(100):100ra88. doi: 10.1126/scitranslmed.3001909.

44.

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.

Moens AL, Ketner EA, Takimoto E, Schmidt TS, O'Neill CA, Wolin MS, Alp NJ, Channon KM, Kass DA.

J Mol Cell Cardiol. 2011 Oct;51(4):564-9. doi: 10.1016/j.yjmcc.2011.05.017. Epub 2011 May 30.

45.

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload.

Koitabashi N, Danner T, Zaiman AL, Pinto YM, Rowell J, Mankowski J, Zhang D, Nakamura T, Takimoto E, Kass DA.

J Clin Invest. 2011 Jun;121(6):2301-12. doi: 10.1172/JCI44824. Epub 2011 May 2.

46.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP.

J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.

47.

Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.

Zhang M, Takimoto E, Hsu S, Lee DI, Nagayama T, Danner T, Koitabashi N, Barth AS, Bedja D, Gabrielson KL, Wang Y, Kass DA.

J Am Coll Cardiol. 2010 Dec 7;56(24):2021-30. doi: 10.1016/j.jacc.2010.08.612. Epub 2010 Oct 21.

48.

Regulation and role of myocyte cyclic GMP-dependent protein kinase-1.

Kass DA, Takimoto E.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):E98; author reply E99. doi: 10.1073/pnas.1003889107. Epub 2010 May 24. No abstract available.

49.

PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation.

Lee DI, Vahebi S, Tocchetti CG, Barouch LA, Solaro RJ, Takimoto E, Kass DA.

Basic Res Cardiol. 2010 May;105(3):337-47. doi: 10.1007/s00395-010-0084-5. Epub 2010 Jan 27.

50.

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.

Koitabashi N, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli GF, Kass DA.

J Mol Cell Cardiol. 2010 Apr;48(4):713-24. doi: 10.1016/j.yjmcc.2009.11.015. Epub 2009 Dec 1.

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