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Items: 35


Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA.

Fujimoto M, Takii R, Katiyar A, Srivastava P, Nakai A.

Mol Cell Biol. 2018 Jun 14;38(13). pii: e00051-18. doi: 10.1128/MCB.00051-18. Print 2018 Jul 1.


Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice.

Takii R, Kadowaki T, Tsukuba T, Yamamoto K.

Eur J Pharmacol. 2018 Apr 5;824:48-56. doi: 10.1016/j.ejphar.2018.01.028. Epub 2018 Feb 6.


The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis.

Fujimoto M, Takii R, Takaki E, Katiyar A, Nakato R, Shirahige K, Nakai A.

Nat Commun. 2017 Nov 21;8(1):1638. doi: 10.1038/s41467-017-01807-7.


HSF1 and HSF3 cooperatively regulate the heat shock response in lizards.

Takii R, Fujimoto M, Matsuura Y, Wu F, Oshibe N, Takaki E, Katiyar A, Akashi H, Makino T, Kawata M, Nakai A.

PLoS One. 2017 Jul 7;12(7):e0180776. doi: 10.1371/journal.pone.0180776. eCollection 2017.


Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein.

Oka S, Shiraishi K, Fujimoto M, Katiyar A, Takii R, Nakai A, Matsuyama H.

Endocrinology. 2017 Aug 1;158(8):2648-2658. doi: 10.1210/en.2017-00132.


Anti-TNF-α Agent Infliximab and Splenectomy Are Protective Against Renal Ischemia-Reperfusion Injury.

Nagata Y, Fujimoto M, Nakamura K, Isoyama N, Matsumura M, Fujikawa K, Uchiyama K, Takaki E, Takii R, Nakai A, Matsuyama H.

Transplantation. 2016 Aug;100(8):1675-82. doi: 10.1097/TP.0000000000001222.


Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8, between rice and yeast.

Maegawa K, Takii R, Ushimaru T, Kozaki A.

Mol Genet Genomics. 2015 Oct;290(5):2019-30. doi: 10.1007/s00438-015-1056-0. Epub 2015 May 9.


Erratum: mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity.

Tan K, Fujimoto M, Takii R, Takaki E, Hayashida N, Nakai A.

Nat Commun. 2015 Apr 17;6:6964. doi: 10.1038/ncomms7964. No abstract available.


Analysis of the heat shock factor complex in mammalian HSP70 promoter.

Fujimoto M, Takii R, Hayashida N, Nakai A.

Methods Mol Biol. 2015;1292:53-65. doi: 10.1007/978-1-4939-2522-3_4.


Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity.

Tan K, Fujimoto M, Takii R, Takaki E, Hayashida N, Nakai A.

Nat Commun. 2015 Mar 12;6:6580. doi: 10.1038/ncomms7580. Erratum in: Nat Commun. 2015;6:6964.


ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex.

Takii R, Fujimoto M, Tan K, Takaki E, Hayashida N, Nakato R, Shirahige K, Nakai A.

Mol Cell Biol. 2015 Jan;35(1):11-25. doi: 10.1128/MCB.00754-14. Epub 2014 Oct 13.


Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo.

Nakamura Y, Fujimoto M, Fukushima S, Nakamura A, Hayashida N, Takii R, Takaki E, Nakai A, Muto M.

Cancer Lett. 2014 Nov 28;354(2):329-35. doi: 10.1016/j.canlet.2014.08.029. Epub 2014 Sep 3.


A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy.

Kataoka S, Baba A, Suda Y, Takii R, Hashimoto M, Kawakubo T, Asao T, Kadowaki T, Yamamoto K.

FASEB J. 2014 Aug;28(8):3564-78. doi: 10.1096/fj.14-252130. Epub 2014 Apr 28.


Cathepsin E deficiency impairs autophagic proteolysis in macrophages.

Tsukuba T, Yanagawa M, Kadowaki T, Takii R, Okamoto Y, Sakai E, Okamoto K, Yamamoto K.

PLoS One. 2013 Dec 5;8(12):e82415. doi: 10.1371/journal.pone.0082415. eCollection 2013. Erratum in: PLoS One. 2014;9(5):e99278.


Chicken IL-6 is a heat-shock gene.

Prakasam R, Fujimoto M, Takii R, Hayashida N, Takaki E, Tan K, Wu F, Inouye S, Nakai A.

FEBS Lett. 2013 Nov 1;587(21):3541-7. doi: 10.1016/j.febslet.2013.09.012. Epub 2013 Sep 18.


RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.

Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.

Mol Cell. 2012 Oct 26;48(2):182-94. doi: 10.1016/j.molcel.2012.07.026. Epub 2012 Aug 30.


Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation.

Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A.

Mol Biol Cell. 2011 Oct;22(19):3571-83. doi: 10.1091/mbc.E11-04-0330. Epub 2011 Aug 3.


Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea.

Nakamoto T, Mikuriya T, Sugahara K, Hirose Y, Hashimoto T, Shimogori H, Takii R, Nakai A, Yamashita H.

Auris Nasus Larynx. 2012 Jun;39(3):270-4. doi: 10.1016/j.anl.2011.06.001. Epub 2011 Jul 26.


Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell lines.

Nakamura Y, Fujimoto M, Hayashida N, Takii R, Nakai A, Muto M.

J Dermatol Sci. 2010 Dec;60(3):187-92. doi: 10.1016/j.jdermsci.2010.09.009. Epub 2010 Oct 8.


Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.

Hayashida N, Fujimoto M, Tan K, Prakasam R, Shinkawa T, Li L, Ichikawa H, Takii R, Nakai A.

EMBO J. 2010 Oct 20;29(20):3459-69. doi: 10.1038/emboj.2010.225. Epub 2010 Sep 10.


DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.

Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Côté JF, Nagasawa T, Fukui Y.

Circ Res. 2010 Oct 29;107(9):1102-5. doi: 10.1161/CIRCRESAHA.110.223388. Epub 2010 Sep 9.


Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3.

Takii R, Inouye S, Fujimoto M, Nakamura T, Shinkawa T, Prakasam R, Tan K, Hayashida N, Ichikawa H, Hai T, Nakai A.

J Immunol. 2010 Jan 15;184(2):1041-8. doi: 10.4049/jimmunol.0902579. Epub 2009 Dec 16.


A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock.

Fujimoto M, Hayashida N, Katoh T, Oshima K, Shinkawa T, Prakasam R, Tan K, Inouye S, Takii R, Nakai A.

Mol Biol Cell. 2010 Jan 1;21(1):106-16. doi: 10.1091/mbc.E09-07-0639. Epub 2009 Oct 28.


Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses.

Fujimoto M, Oshima K, Shinkawa T, Wang BB, Inouye S, Hayashida N, Takii R, Nakai A.

J Biol Chem. 2008 Oct 31;283(44):29961-70. doi: 10.1074/jbc.M804629200. Epub 2008 Aug 27.


Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses.

Shin M, Kadowaki T, Iwata J, Kawakubo T, Yamaguchi N, Takii R, Tsukuba T, Yamamoto K.

Biol Chem. 2007 Nov;388(11):1173-81.


T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.

Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R, Kawaguchi M, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y.

Nat Immunol. 2007 Oct;8(10):1067-75. Epub 2007 Sep 2.


A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells.

Kadowaki T, Takii R, Yamatake K, Kawakubo T, Tsukuba T, Yamamoto K.

Front Biosci. 2007 Sep 1;12:4800-9. Review.


Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells.

Yamatake K, Maeda M, Kadowaki T, Takii R, Tsukuba T, Ueno T, Kominami E, Yokota S, Yamamoto K.

Infect Immun. 2007 May;75(5):2090-100. Epub 2007 Feb 12.


Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.

Yanagawa M, Tsukuba T, Nishioku T, Okamoto Y, Okamoto K, Takii R, Terada Y, Nakayama KI, Kadowaki T, Yamamoto K.

J Biol Chem. 2007 Jan 19;282(3):1851-62. Epub 2006 Nov 9.


DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.

Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, Watanabe K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y.

J Cell Biol. 2006 Aug 28;174(5):647-52.


Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes.

Abe N, Baba A, Takii R, Nakayama K, Kamaguchi A, Shibata Y, Abiko Y, Okamoto K, Kadowaki T, Yamamoto K.

Biol Chem. 2004 Nov;385(11):1041-7.


Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors.

Kadowaki T, Baba A, Abe N, Takii R, Hashimoto M, Tsukuba T, Okazaki S, Suda Y, Asao T, Yamamoto K.

Mol Pharmacol. 2004 Dec;66(6):1599-606. Epub 2004 Sep 10.


Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70.

Kadowaki T, Kitano S, Baba A, Takii R, Hashimoto M, Katunuma N, Yamamoto K.

Biol Chem. 2003 Jun;384(6):911-20.


[Gingipains as the determinants of periodontopathogenicity].

Kadowaki T, Takii R, Baba A, Yamamoto K.

Nihon Yakurigaku Zasshi. 2003 Jul;122(1):37-44. Review. Japanese.


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