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High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells.

Takihara Y, Nakamura-Ishizu A, Tan DQ, Fukuda M, Matsumura T, Endoh M, Arima Y, Chin DWL, Umemoto T, Hashimoto M, Mizuno H, Suda T.

Blood Adv. 2019 Aug 13;3(15):2323-2327. doi: 10.1182/bloodadvances.2019032169. No abstract available.


A novel c.1664G > T(p.Gly555Val) mutation in the KEL gene encoding the Kmod phenotype.

Horikawa T, Kusumi T, Kamada I, Okuda K, Tateyama H, Kimura T, Takihara Y, Tani Y, Tanaka M.

Transfusion. 2019 May 11. doi: 10.1111/trf.15340. [Epub ahead of print] No abstract available.


Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.

Nakamura-Ishizu A, Matsumura T, Stumpf PS, Umemoto T, Takizawa H, Takihara Y, O'Neil A, Majeed ABBA, MacArthur BD, Suda T.

Cell Rep. 2018 Nov 13;25(7):1772-1785.e6. doi: 10.1016/j.celrep.2018.10.059.


Prospective cohort study of corneal endothelial cell loss after Baerveldt glaucoma implantation.

Iwasaki K, Arimura S, Takihara Y, Takamura Y, Inatani M.

PLoS One. 2018 Jul 26;13(7):e0201342. doi: 10.1371/journal.pone.0201342. eCollection 2018.


A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.

Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y, Sonoda Y.

Nat Commun. 2018 Jun 6;9(1):2202. doi: 10.1038/s41467-018-04441-z.


Pcgf5 Contributes to PRC1 (Polycomb Repressive Complex 1) in Developing Cardiac Cells.

Shirai M, Takihara Y, Morisaki T.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 43.
2016 Jun 25.


Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning.

Kobayashi W, Onishi A, Tu HY, Takihara Y, Matsumura M, Tsujimoto K, Inatani M, Nakazawa T, Takahashi M.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):776-787. doi: 10.1167/iovs.17-22406.


Effect of Microtubule Disruption on Dynamics of Acidic Organelles in the Axons of Primary Cultured Retinal Ganglion Cells.

Miyake S, Takihara Y, Yokota S, Takamura Y, Inatani M.

Curr Eye Res. 2018 Jan;43(1):77-83. doi: 10.1080/02713683.2017.1370117. Epub 2017 Sep 22.


Evaluation of Bleb Fluid After Baerveldt Glaucoma Implantation Using Magnetic Resonance Imaging.

Iwasaki K, Kanamoto M, Takihara Y, Arimura S, Takamura Y, Kimura H, Inatani M.

Sci Rep. 2017 Sep 12;7(1):11345. doi: 10.1038/s41598-017-11054-x.


Comparison of subconjunctival scarring after microincision vitrectomy surgery using 20-, 23-, 25- and 27-gauge systems in rabbits.

Gozawa M, Takamura Y, Miyake S, Iwasaki K, Arimura S, Takihara Y, Inatani M.

Acta Ophthalmol. 2017 Nov;95(7):e602-e609. doi: 10.1111/aos.13459. Epub 2017 Jun 19.


T cells bearing anti-CD19 and/or anti-CD38 chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells.

Mihara K, Yoshida T, Takei Y, Sasaki N, Takihara Y, Kuroda J, Ichinohe T.

J Hematol Oncol. 2017 Jun 8;10(1):116. doi: 10.1186/s13045-017-0488-x.


Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration.

Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK.

Sci Rep. 2017 Jan 19;7:40460. doi: 10.1038/srep40460. No abstract available.


All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38 chimeric antigen receptor in acute myeloid leukemia.

Yoshida T, Mihara K, Takei Y, Yanagihara K, Kubo T, Bhattacharyya J, Imai C, Mino T, Takihara Y, Ichinohe T.

Clin Transl Immunology. 2016 Dec 9;5(12):e116. doi: 10.1038/cti.2016.73. eCollection 2016 Dec.


Prospective observational study of conjunctival scarring after phacoemulsification.

Gozawa M, Takamura Y, Miyake S, Yokota S, Sakashita M, Arimura S, Takihara Y, Inatani M.

Acta Ophthalmol. 2016 Nov;94(7):e541-e549. doi: 10.1111/aos.13071. Epub 2016 May 11.


Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration.

Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK.

Sci Rep. 2016 Sep 22;6:33830. doi: 10.1038/srep33830. Erratum in: Sci Rep. 2017 Jan 19;7:40460.


Immunological Analyses of Leukemia Stem Cells.

Naka K, Takihara Y.

Methods Mol Biol. 2016;1465:37-45. doi: 10.1007/978-1-4939-4011-0_4.


The relationship between self-reported habitual exercise and visual field defect progression: a retrospective cohort study.

Yokota S, Takihara Y, Kimura K, Takamura Y, Inatani M.

BMC Ophthalmol. 2016 Aug 23;16(1):147. doi: 10.1186/s12886-016-0326-x.


Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs).

Yasunaga S, Ohno Y, Shirasu N, Zhang B, Suzuki-Takedachi K, Ohtsubo M, Takihara Y.

Int J Hematol. 2016 Sep;104(3):324-9. doi: 10.1007/s12185-016-2060-9. Epub 2016 Jul 15. Review.


Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin.

Ohno Y, Suzuki-Takedachi K, Yasunaga S, Kurogi T, Santo M, Masuhiro Y, Hanazawa S, Ohtsubo M, Naka K, Takihara Y.

PLoS One. 2016 May 19;11(5):e0155558. doi: 10.1371/journal.pone.0155558. eCollection 2016.


Randomized Clinical Trial for Early Postoperative Complications of Ex-PRESS Implantation versus Trabeculectomy: Complications Postoperatively of Ex-PRESS versus Trabeculectomy Study (CPETS).

Arimura S, Takihara Y, Miyake S, Iwasaki K, Gozawa M, Matsumura T, Tomomatsu T, Takamura Y, Inatani M.

Sci Rep. 2016 May 17;6:26080. doi: 10.1038/srep26080.


All-trans retinoic acid and interferon-α increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors.

Mihara K, Yoshida T, Ishida S, Takei Y, Kitanaka A, Shimoda K, Morishita K, Takihara Y, Ichinohe T.

Blood Cancer J. 2016 May 13;6:e421. doi: 10.1038/bcj.2016.30. No abstract available.


Significance of ACADM mutations identified through newborn screening of MCAD deficiency in Japan.

Hara K, Tajima G, Okada S, Tsumura M, Kagawa R, Shirao K, Ohno Y, Yasunaga S, Ohtsubo M, Hata I, Sakura N, Shigematsu Y, Takihara Y, Kobayashi M.

Mol Genet Metab. 2016 May;118(1):9-14. doi: 10.1016/j.ymgme.2015.12.011. Epub 2015 Dec 29.


Altered Transport Velocity of Axonal Mitochondria in Retinal Ganglion Cells After Laser-Induced Axonal Injury In Vitro.

Yokota S, Takihara Y, Arimura S, Miyake S, Takamura Y, Yoshimura N, Inatani M.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8019-25. doi: 10.1167/iovs.15-17876.


Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.

Naka K, Ishihara K, Jomen Y, Jin CH, Kim DH, Gu YK, Jeong ES, Li S, Krause DS, Kim DW, Bae E, Takihara Y, Hirao A, Oshima H, Oshima M, Ooshima A, Sheen YY, Kim SJ, Kim DK.

Cancer Sci. 2016 Feb;107(2):140-8. doi: 10.1111/cas.12849. Epub 2016 Jan 26.


Correlation between central retinal thickness after successful macular hole surgery and visual outcome.

Takamura Y, Tomomatsu T, Matsumura T, Arimura S, Gozawa M, Takihara Y, Inatani M.

Jpn J Ophthalmol. 2015 Nov;59(6):394-400. doi: 10.1007/s10384-015-0406-0. Epub 2015 Aug 29.


Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.

Naka K, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae EJ, Mohney RP, Stirdivant SM, Oshima H, Oshima M, Kim DW, Nakauchi H, Takihara Y, Kato Y, Ooshima A, Kim SJ.

Nat Commun. 2015 Aug 20;6:8039. doi: 10.1038/ncomms9039.


In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS.

Takihara Y, Inatani M, Eto K, Inoue T, Kreymerman A, Miyake S, Ueno S, Nagaya M, Nakanishi A, Iwao K, Takamura Y, Sakamoto H, Satoh K, Kondo M, Sakamoto T, Goldberg JL, Nabekura J, Tanihara H.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10515-20. doi: 10.1073/pnas.1509879112. Epub 2015 Aug 3.


Changes in Matrix Metalloproteinases in Diabetes Patients' Tears After Vitrectomy and the Relationship With Corneal Epithelial Disorder.

Matsumura T, Takamura Y, Tomomatsu T, Arimura S, Gozawa M, Takihara Y, Inatani M.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3559-64. doi: 10.1167/iovs.15-16489.


Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions.

Tomomatsu Y, Tomomatsu T, Takamura Y, Gozawa M, Arimura S, Takihara Y, Inatani M.

Acta Ophthalmol. 2016 May;94(3):e225-30. doi: 10.1111/aos.12721. Epub 2015 May 19.


[Regulation of leukemic stem cells by manipulating the Geminin activity].

Yasunaga S, Ohno Y, Takihara Y.

Nihon Rinsho. 2015 May;73(5):800-5. Japanese.


Vitreous and aqueous concentrations of brimonidine following topical application of brimonidine tartrate 0.1% ophthalmic solution in humans.

Takamura Y, Tomomatsu T, Matsumura T, Takihara Y, Kozai S, Arimura S, Yokota S, Inatani M.

J Ocul Pharmacol Ther. 2015 Jun;31(5):282-5. doi: 10.1089/jop.2015.0003. Epub 2015 Apr 28.


Mosaicism of an ELANE mutation in an asymptomatic mother in a familial case of cyclic neutropenia.

Hirata O, Okada S, Tsumura M, Karakawa S, Matsumura I, Kimura Y, Maihara T, Yasunaga S, Takihara Y, Ohara O, Kobayashi M.

J Clin Immunol. 2015 Jul;35(5):512-6. doi: 10.1007/s10875-015-0165-1. Epub 2015 Apr 26.


MK3 modulation affects BMI1-dependent and independent cell cycle check-points.

Prickaerts P, Niessen HE, Dahlmans VE, Spaapen F, Salvaing J, Vanhove J, Geijselaers C, Bartels SJ, Partouns I, Neumann D, Speel EJ, Takihara Y, Wouters BG, Voncken JW.

PLoS One. 2015 Apr 8;10(4):e0118840. doi: 10.1371/journal.pone.0118840. eCollection 2015.


Determinants of anterior chamber angle narrowing after mydriasis in the patients with cataract.

Arimura S, Takamura Y, Takihara Y, Matsumura T, Tomomatsu T, Inatani M.

Graefes Arch Clin Exp Ophthalmol. 2015 Feb;253(2):307-12. doi: 10.1007/s00417-014-2817-x. Epub 2014 Oct 14.


Monthly administration of rituximab is useful for patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma.

Mino T, Mihara K, Yoshida T, Takihara Y, Ichinohe T.

Blood Cancer J. 2014 Sep 12;4:e245. doi: 10.1038/bcj.2014.65. No abstract available.


Large capsulorhexis with implantation of a 7.0 mm optic intraocular lens during cataract surgery in patients with diabetes mellitus.

Takamura Y, Tomomatsu T, Yokota S, Matsumura T, Takihara Y, Inatani M.

J Cataract Refract Surg. 2014 Nov;40(11):1850-6. doi: 10.1016/j.jcrs.2014.02.039. Epub 2014 Sep 8.


The effect of photocoagulation in ischemic areas to prevent recurrence of diabetic macular edema after intravitreal bevacizumab injection.

Takamura Y, Tomomatsu T, Matsumura T, Arimura S, Gozawa M, Takihara Y, Inatani M.

Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):4741-6. doi: 10.1167/iovs.14-14682.


Transcription of the Geminin gene is regulated by a negative-feedback loop.

Ohno Y, Saeki K, Yasunaga S, Kurogi T, Suzuki-Takedachi K, Shirai M, Mihara K, Yoshida K, Voncken JW, Ohtsubo M, Takihara Y.

Mol Biol Cell. 2014 Apr;25(8):1374-83. doi: 10.1091/mbc.E13-09-0534. Epub 2014 Feb 19.


Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis.

Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M.

J Leukoc Biol. 2014 Apr;95(4):667-76. doi: 10.1189/jlb.0513250. Epub 2013 Dec 16.


Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.

Takamura Y, Matsumoto T, Tomomatsu T, Matsumura T, Takihara Y, Inatani M.

Mol Vis. 2013 Dec 8;19:2477-86. eCollection 2013.


Trabeculectomy for open-angle glaucoma in phakic eyes vs in pseudophakic eyes after phacoemulsification: a prospective clinical cohort study.

Takihara Y, Inatani M, Ogata-Iwao M, Kawai M, Inoue T, Iwao K, Tanihara H.

JAMA Ophthalmol. 2014 Jan;132(1):69-76. doi: 10.1001/jamaophthalmol.2013.5605.


Prognostic factors in trabeculectomy with mitomycin C having history of previous glaucoma surgery.

Awai-Kasaoka N, Inoue T, Inatani M, Takihara Y, Ogata-Iwao M, Tanihara H.

Jpn J Ophthalmol. 2013 Nov;57(6):514-9. doi: 10.1007/s10384-013-0257-5. Epub 2013 Aug 3.


Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.

Tsunematsu T, Takihara Y, Ishimaru N, Pagano M, Takata T, Kudo Y.

Nat Commun. 2013;4:1885. doi: 10.1038/ncomms2859.


A prospective comparison between trabeculectomy with mitomycin C and phacotrabeculectomy with mitomycin C.

Ogata-Iwao M, Inatani M, Takihara Y, Inoue T, Iwao K, Tanihara H.

Acta Ophthalmol. 2013 Sep;91(6):e500-1. doi: 10.1111/aos.12133. Epub 2013 Apr 26. No abstract available.


Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis.

Hirata O, Okada S, Tsumura M, Kagawa R, Miki M, Kawaguchi H, Nakamura K, Boisson-Dupuis S, Casanova JL, Takihara Y, Kobayashi M.

Haematologica. 2013 Oct;98(10):1641-9. doi: 10.3324/haematol.2013.083741. Epub 2013 Apr 12.


Relationship between lenticular power and refractive error in children with hyperopia.

Tomomatsu T, Kono S, Arimura S, Tomomatsu Y, Matsumura T, Takihara Y, Inatani M, Takamura Y.

Clin Ophthalmol. 2013;7:601-6. doi: 10.2147/OPTH.S42051. Epub 2013 Mar 24.


Anterior capsule contraction and flare intensity in the early stages after cataract surgery in eyes with diabetic retinopathy.

Takamura Y, Tomomatsu T, Arimura S, Tomomatsu Y, Matsumura T, Takihara Y, Inatani M.

J Cataract Refract Surg. 2013 May;39(5):716-21. doi: 10.1016/j.jcrs.2012.12.029. Epub 2013 Mar 28.


Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein.

Ohno Y, Yasunaga S, Janmohamed S, Ohtsubo M, Saeki K, Kurogi T, Mihara K, Iscove NN, Takihara Y.

PLoS One. 2013;8(1):e53161. doi: 10.1371/journal.pone.0053161. Epub 2013 Jan 11.

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