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Items: 1 to 50 of 356

1.

MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer.

Nishiuchi A, Hisamori S, Sakaguchi M, Fukuyama K, Hoshino N, Itatani Y, Honma S, Maekawa H, Nishigori T, Tsunoda S, Obama K, Miyoshi H, Shimono Y, Taketo MM, Sakai Y.

Cancers (Basel). 2019 Nov 27;11(12). pii: E1891. doi: 10.3390/cancers11121891.

2.

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.

Xuan F, Yano F, Mori D, Chijimatsu R, Maenohara Y, Nakamoto H, Mori Y, Makii Y, Oichi T, Taketo MM, Hojo H, Ohba S, Chung UI, Tanaka S, Saito T.

Arthritis Res Ther. 2019 Nov 27;21(1):247. doi: 10.1186/s13075-019-2041-5.

3.

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.

Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D, Nishimura EK, Ito M.

Nat Commun. 2019 Nov 4;10(1):5023. doi: 10.1038/s41467-019-12733-1.

4.

β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells.

Aono S, Hatanaka A, Hatanaka A, Gao Y, Hippo Y, Taketo MM, Waku T, Kobayashi A.

Int J Mol Sci. 2019 Jul 8;20(13). pii: E3344. doi: 10.3390/ijms20133344.

5.

Stromal iodothyronine deiodinase 2 (DIO2) promotes the growth of intestinal tumors in ApcΔ716 mutant mice.

Kojima Y, Kondo Y, Fujishita T, Mishiro-Sato E, Kajino-Sakamoto R, Taketo MM, Aoki M.

Cancer Sci. 2019 Aug;110(8):2520-2528. doi: 10.1111/cas.14100. Epub 2019 Jul 7.

6.

Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells.

Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12996-13005. doi: 10.1073/pnas.1900251116. Epub 2019 Jun 10.

PMID:
31182574
7.

Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice.

Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M, Longhi MP.

Diabetes. 2019 Jul;68(7):1473-1484. doi: 10.2337/db18-1243. Epub 2019 May 2.

PMID:
31048369
8.

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L.

Cell Stem Cell. 2019 May 2;24(5):753-768.e6. doi: 10.1016/j.stem.2019.03.010. Epub 2019 Apr 11.

PMID:
30982770
9.

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice.

Benz F, Wichitnaowarat V, Lehmann M, Germano RF, Mihova D, Macas J, Adams RH, Taketo MM, Plate KH, Guérit S, Vanhollebeke B, Liebner S.

Elife. 2019 Apr 1;8. pii: e43818. doi: 10.7554/eLife.43818.

10.

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Terakawa J, Serna VA, Taketo MM, Daikoku T, Suarez AA, Kurita T.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4528-4537. doi: 10.1073/pnas.1814506116. Epub 2019 Feb 19.

11.

Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate.

Wegner KA, Mehta V, Johansson JA, Mueller BR, Keil KP, Abler LL, Marker PC, Taketo MM, Headon DJ, Vezina CM.

Biol Open. 2019 Mar 18;8(3). pii: bio037945. doi: 10.1242/bio.037945.

12.

Mesothelial mobilization in the developing lung and heart differs in timing, quantity, and pathway dependency.

Lüdtke TH, Rudat C, Kurz J, Häfner R, Greulich F, Wojahn I, Aydoğdu N, Mamo TM, Kleppa MJ, Trowe MO, Bohnenpoll T, Taketo MM, Kispert A.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L767-L783. doi: 10.1152/ajplung.00212.2018. Epub 2019 Jan 31.

PMID:
30702346
13.

Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.

Yamaura T, Miyoshi H, Maekawa H, Morimoto T, Yamamoto T, Kakizaki F, Higasa K, Kawada K, Matsuda F, Sakai Y, Taketo MM.

Oncotarget. 2018 Dec 25;9(101):37534-37548. doi: 10.18632/oncotarget.26495. eCollection 2018 Dec 25.

14.

Arid1a is essential for intestinal stem cells through Sox9 regulation.

Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713. doi: 10.1073/pnas.1804858116. Epub 2019 Jan 11.

15.

Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis.

Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P.

Dev Cell. 2019 Jan 7;48(1):17-31.e6. doi: 10.1016/j.devcel.2018.11.032. Epub 2018 Dec 27.

PMID:
30595533
16.

TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme.

Aydoğdu N, Rudat C, Trowe MO, Kaiser M, Lüdtke TH, Taketo MM, Christoffels VM, Moon A, Kispert A.

Development. 2018 Nov 26;145(23). pii: dev171827. doi: 10.1242/dev.171827.

17.

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing.

Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M.

Nat Commun. 2018 Nov 21;9(1):4903. doi: 10.1038/s41467-018-07142-9.

18.

Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.

Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S.

Dev Biol. 2018 Oct 15;442(2):236-248. doi: 10.1016/j.ydbio.2018.07.021. Epub 2018 Jul 29.

19.

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.

Perekatt AO, Shah PP, Cheung S, Jariwala N, Wu A, Gandhi V, Kumar N, Feng Q, Patel N, Chen L, Joshi S, Zhou A, Taketo MM, Xing J, White E, Gao N, Gatza ML, Verzi MP.

Cancer Res. 2018 Sep 1;78(17):4878-4890. doi: 10.1158/0008-5472.CAN-18-0043. Epub 2018 Jul 9.

20.

A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells.

Maekawa H, Miyoshi H, Yamaura T, Itatani Y, Kawada K, Sakai Y, Taketo MM.

Mol Cancer Ther. 2018 Oct;17(10):2187-2196. doi: 10.1158/1535-7163.MCT-18-0128. Epub 2018 Jul 3.

21.

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.

Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.

22.

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.

Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M.

Nat Commun. 2018 Jun 5;9(1):2174. doi: 10.1038/s41467-018-04527-8.

23.

An improved method for culturing patient-derived colorectal cancer spheroids.

Miyoshi H, Maekawa H, Kakizaki F, Yamaura T, Kawada K, Sakai Y, Taketo MM.

Oncotarget. 2018 Apr 24;9(31):21950-21964. doi: 10.18632/oncotarget.25134. eCollection 2018 Apr 24.

24.

Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.

Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM.

Genes Cells. 2018 Jul;23(7):580-589. doi: 10.1111/gtc.12592. Epub 2018 May 11.

25.

Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.

Vidal R, Garro-Martínez E, Díaz Á, Castro E, Florensa-Zanuy E, Taketo MM, Pazos Á, Pilar-Cuéllar F.

Mol Neurobiol. 2019 Jan;56(1):553-566. doi: 10.1007/s12035-018-1100-2. Epub 2018 May 8.

PMID:
29737454
26.

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria.

Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW.

Kidney Int. 2018 Jun;93(6):1367-1383. doi: 10.1016/j.kint.2017.12.017. Epub 2018 Mar 28.

27.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice.

Lemberger UJ, Fuchs CD, Schöfer C, Bileck A, Gerner C, Stojakovic T, Taketo MM, Trauner M, Egger G, Österreicher CH.

Oncotarget. 2018 Jan 30;9(13):11243-11257. doi: 10.18632/oncotarget.24346. eCollection 2018 Feb 16.

28.

Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing.

Sun Q, Rabbani P, Takeo M, Lee SH, Lim CH, Noel ES, Taketo MM, Myung P, Millar S, Ito M.

J Invest Dermatol. 2018 Jul;138(7):1591-1600. doi: 10.1016/j.jid.2018.01.030. Epub 2018 Feb 8.

29.

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.

Reichman DE, Park L, Man L, Redmond D, Chao K, Harvey RP, Taketo MM, Rosenwaks Z, James D.

Development. 2018 Jan 8;145(1). pii: dev159905. doi: 10.1242/dev.159905.

30.

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.

Wu CC, Hou S, Orr BA, Kuo BR, Youn YH, Ong T, Roth F, Eberhart CG, Robinson GW, Solecki DJ, Taketo MM, Gilbertson RJ, Roussel MF, Han YG.

Dev Cell. 2017 Dec 18;43(6):673-688.e5. doi: 10.1016/j.devcel.2017.10.011. Epub 2017 Nov 2.

31.

Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation.

Osmundsen AM, Keisler JL, Taketo MM, Davis SW.

Endocrinology. 2017 Oct 1;158(10):3339-3353. doi: 10.1210/en.2017-00581.

PMID:
28938441
32.

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.

Neumann JE, Wefers AK, Lambo S, Bianchi E, Bockstaller M, Dorostkar MM, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider MR, Renner-Müller I, Merk DJ, Shakarami M, Sharma T, Chavez L, Glass R, Chan JA, Taketo MM, Neumann P, Kool M, Schüller U.

Nat Med. 2017 Oct;23(10):1191-1202. doi: 10.1038/nm.4402. Epub 2017 Sep 11.

PMID:
28892064
33.

Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.

Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7697-E7706. doi: 10.1073/pnas.1710366114. Epub 2017 Aug 28.

34.

Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.

Fujishita T, Kojima Y, Kajino-Sakamoto R, Taketo MM, Aoki M.

Oncogene. 2017 Nov 16;36(46):6480-6489. doi: 10.1038/onc.2017.242. Epub 2017 Jul 31.

PMID:
28759045
35.

Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD.

Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS.

J Am Soc Nephrol. 2017 Dec;28(12):3490-3503. doi: 10.1681/ASN.2016121351. Epub 2017 Jul 12.

36.

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C.

Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26.

PMID:
28650479
37.

A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.

Li MY, Miao WY, Wu QZ, He SJ, Yan G, Yang Y, Liu JJ, Taketo MM, Yu X.

Neuron. 2017 Jun 21;94(6):1155-1172.e8. doi: 10.1016/j.neuron.2017.05.022.

38.

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.

Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M.

Oncogene. 2017 Oct 19;36(42):5885-5896. doi: 10.1038/onc.2017.194. Epub 2017 Jun 19.

39.

Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.

Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H.

Cancer Res. 2017 Jul 1;77(13):3442-3454. doi: 10.1158/0008-5472.CAN-16-3192. Epub 2017 May 23.

40.

Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.

Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM.

J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629. Epub 2017 May 2.

41.

Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion.

Chassot AA, Le Rolle M, Jourden M, Taketo MM, Ghyselinck NB, Chaboissier MC.

Dev Biol. 2017 Jun 1;426(1):17-27. doi: 10.1016/j.ydbio.2017.04.010. Epub 2017 Apr 26.

42.

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.

Cancer Discov. 2017 May;7(5):522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15.

43.

SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.

Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.

Stem Cell Reports. 2017 Mar 14;8(3):561-575. doi: 10.1016/j.stemcr.2017.01.006. Epub 2017 Feb 9.

44.

Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.

Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo MM.

Cancer Sci. 2017 Apr;108(4):744-752. doi: 10.1111/cas.13187. Epub 2017 Apr 12.

45.

Beta-catenin and estrogen signaling collaborate to drive cyclin D1 expression in developing mouse prostate.

Mulligan WA, Wegner KA, Keil KP, Mehta V, Taketo MM, Vezina CM.

Differentiation. 2017 Jan - Feb;93:66-71. doi: 10.1016/j.diff.2016.11.002. Epub 2016 Dec 2.

46.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.

Lemberger UJ, Fuchs CD, Karer M, Haas S, Stojakovic T, Schöfer C, Marschall HU, Wrba F, Taketo MM, Egger G, Trauner M, Österreicher CH.

Oncotarget. 2016 Dec 27;7(52):86985-86998. doi: 10.18632/oncotarget.13521.

47.

Manipulating Wnt signaling at different subcellular levels affects the fate of neonatal neural stem/progenitor cells.

Kriska J, Honsa P, Dzamba D, Butenko O, Kolenicova D, Janeckova L, Nahacka Z, Andera L, Kozmik Z, Taketo MM, Korinek V, Anderova M.

Brain Res. 2016 Nov 15;1651:73-87. doi: 10.1016/j.brainres.2016.09.026. Epub 2016 Sep 19.

PMID:
27659965
48.

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.

Muñoz-Bravo JL, Flores-Martínez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA.

PLoS One. 2016 Oct 13;11(10):e0164714. doi: 10.1371/journal.pone.0164714. eCollection 2016.

49.

Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis.

Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo MM, Nagayama S, Sakai Y, Matsuda M.

PLoS One. 2016 Sep 2;11(9):e0162300. doi: 10.1371/journal.pone.0162300. eCollection 2016.

50.

Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.

Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM.

Cancer Sci. 2016 Nov;107(11):1622-1631. doi: 10.1111/cas.13063.

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