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Items: 1 to 50 of 348

1.

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Terakawa J, Serna VA, Taketo MM, Daikoku T, Suarez AA, Kurita T.

Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201814506. doi: 10.1073/pnas.1814506116. [Epub ahead of print]

2.

Identifying Mesenchymal Pathways That Initiate Emphysema in Order to Develop Targeted Therapies.

Gaskill CF, Kropski JA, Richmond BW, Foronjy RF, Taketo MM, Majka SM.

Ann Am Thorac Soc. 2018 Dec;15(Supplement_4):S291-S292. doi: 10.1513/AnnalsATS.201804-229MG.

PMID:
30759014
3.

Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate.

Wegner KA, Mehta V, Johansson JA, Mueller BR, Keil KP, Abler LL, Marker PC, Taketo MM, Headon DJ, Vezina CM.

Biol Open. 2019 Mar 18;8(3). pii: bio037945. doi: 10.1242/bio.037945.

4.

Mesothelial mobilization in the developing lung and heart differs in timing, quantity and pathway-dependency.

Lüdtke TH, Rudat C, Kurz J, Häfner R, Greulich F, Wojahn I, Aydoğdu N, Mamo TM, Kleppa MJ, Trowe MO, Bohnenpoll TE, Taketo MM, Kispert A.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 31. doi: 10.1152/ajplung.00212.2018. [Epub ahead of print]

PMID:
30702346
5.

Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.

Yamaura T, Miyoshi H, Maekawa H, Morimoto T, Yamamoto T, Kakizaki F, Higasa K, Kawada K, Matsuda F, Sakai Y, Taketo MM.

Oncotarget. 2018 Dec 25;9(101):37534-37548. doi: 10.18632/oncotarget.26495. eCollection 2018 Dec 25.

6.

Arid1a is essential for intestinal stem cells through Sox9 regulation.

Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713. doi: 10.1073/pnas.1804858116. Epub 2019 Jan 11.

PMID:
30635419
7.

Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis.

Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P.

Dev Cell. 2019 Jan 7;48(1):17-31.e6. doi: 10.1016/j.devcel.2018.11.032. Epub 2018 Dec 27.

PMID:
30595533
8.

TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme.

Aydoğdu N, Rudat C, Trowe MO, Kaiser M, Lüdtke TH, Taketo MM, Christoffels VM, Moon A, Kispert A.

Development. 2018 Nov 26;145(23). pii: dev171827. doi: 10.1242/dev.171827.

PMID:
30478225
9.

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing.

Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M.

Nat Commun. 2018 Nov 21;9(1):4903. doi: 10.1038/s41467-018-07142-9.

10.

Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.

Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S.

Dev Biol. 2018 Oct 15;442(2):236-248. doi: 10.1016/j.ydbio.2018.07.021. Epub 2018 Jul 29.

PMID:
30063881
11.

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.

Perekatt AO, Shah PP, Cheung S, Jariwala N, Wu A, Gandhi V, Kumar N, Feng Q, Patel N, Chen L, Joshi S, Zhou A, Taketo MM, Xing J, White E, Gao N, Gatza ML, Verzi MP.

Cancer Res. 2018 Sep 1;78(17):4878-4890. doi: 10.1158/0008-5472.CAN-18-0043. Epub 2018 Jul 9.

PMID:
29986996
12.

A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells.

Maekawa H, Miyoshi H, Yamaura T, Itatani Y, Kawada K, Sakai Y, Taketo MM.

Mol Cancer Ther. 2018 Oct;17(10):2187-2196. doi: 10.1158/1535-7163.MCT-18-0128. Epub 2018 Jul 3.

PMID:
29970483
13.

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.

Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.

PMID:
29909986
14.

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.

Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M.

Nat Commun. 2018 Jun 5;9(1):2174. doi: 10.1038/s41467-018-04527-8.

15.

An improved method for culturing patient-derived colorectal cancer spheroids.

Miyoshi H, Maekawa H, Kakizaki F, Yamaura T, Kawada K, Sakai Y, Taketo MM.

Oncotarget. 2018 Apr 24;9(31):21950-21964. doi: 10.18632/oncotarget.25134. eCollection 2018 Apr 24.

16.

Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.

Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM.

Genes Cells. 2018 Jul;23(7):580-589. doi: 10.1111/gtc.12592. Epub 2018 May 11.

17.

Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.

Vidal R, Garro-Martínez E, Díaz Á, Castro E, Florensa-Zanuy E, Taketo MM, Pazos Á, Pilar-Cuéllar F.

Mol Neurobiol. 2019 Jan;56(1):553-566. doi: 10.1007/s12035-018-1100-2. Epub 2018 May 8.

PMID:
29737454
18.

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria.

Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW.

Kidney Int. 2018 Jun;93(6):1367-1383. doi: 10.1016/j.kint.2017.12.017. Epub 2018 Mar 28.

PMID:
29605095
19.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice.

Lemberger UJ, Fuchs CD, Schöfer C, Bileck A, Gerner C, Stojakovic T, Taketo MM, Trauner M, Egger G, Österreicher CH.

Oncotarget. 2018 Jan 30;9(13):11243-11257. doi: 10.18632/oncotarget.24346. eCollection 2018 Feb 16.

20.

Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing.

Sun Q, Rabbani P, Takeo M, Lee SH, Lim CH, Noel ES, Taketo MM, Myung P, Millar S, Ito M.

J Invest Dermatol. 2018 Jul;138(7):1591-1600. doi: 10.1016/j.jid.2018.01.030. Epub 2018 Feb 8.

PMID:
29428355
21.

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.

Reichman DE, Park L, Man L, Redmond D, Chao K, Harvey RP, Taketo MM, Rosenwaks Z, James D.

Development. 2018 Jan 8;145(1). pii: dev159905. doi: 10.1242/dev.159905.

22.

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.

Wu CC, Hou S, Orr BA, Kuo BR, Youn YH, Ong T, Roth F, Eberhart CG, Robinson GW, Solecki DJ, Taketo MM, Gilbertson RJ, Roussel MF, Han YG.

Dev Cell. 2017 Dec 18;43(6):673-688.e5. doi: 10.1016/j.devcel.2017.10.011. Epub 2017 Nov 2.

23.

Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation.

Osmundsen AM, Keisler JL, Taketo MM, Davis SW.

Endocrinology. 2017 Oct 1;158(10):3339-3353. doi: 10.1210/en.2017-00581.

PMID:
28938441
24.

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.

Neumann JE, Wefers AK, Lambo S, Bianchi E, Bockstaller M, Dorostkar MM, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider MR, Renner-Müller I, Merk DJ, Shakarami M, Sharma T, Chavez L, Glass R, Chan JA, Taketo MM, Neumann P, Kool M, Schüller U.

Nat Med. 2017 Oct;23(10):1191-1202. doi: 10.1038/nm.4402. Epub 2017 Sep 11.

PMID:
28892064
25.

Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.

Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7697-E7706. doi: 10.1073/pnas.1710366114. Epub 2017 Aug 28.

26.

Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.

Fujishita T, Kojima Y, Kajino-Sakamoto R, Taketo MM, Aoki M.

Oncogene. 2017 Nov 16;36(46):6480-6489. doi: 10.1038/onc.2017.242. Epub 2017 Jul 31.

PMID:
28759045
27.

Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD.

Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS.

J Am Soc Nephrol. 2017 Dec;28(12):3490-3503. doi: 10.1681/ASN.2016121351. Epub 2017 Jul 12.

28.

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C.

Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26.

PMID:
28650479
29.

A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.

Li MY, Miao WY, Wu QZ, He SJ, Yan G, Yang Y, Liu JJ, Taketo MM, Yu X.

Neuron. 2017 Jun 21;94(6):1155-1172.e8. doi: 10.1016/j.neuron.2017.05.022.

30.

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.

Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M.

Oncogene. 2017 Oct 19;36(42):5885-5896. doi: 10.1038/onc.2017.194. Epub 2017 Jun 19.

31.

Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.

Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H.

Cancer Res. 2017 Jul 1;77(13):3442-3454. doi: 10.1158/0008-5472.CAN-16-3192. Epub 2017 May 23.

32.

Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.

Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM.

J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629. Epub 2017 May 2.

33.

Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion.

Chassot AA, Le Rolle M, Jourden M, Taketo MM, Ghyselinck NB, Chaboissier MC.

Dev Biol. 2017 Jun 1;426(1):17-27. doi: 10.1016/j.ydbio.2017.04.010. Epub 2017 Apr 26.

34.

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.

Cancer Discov. 2017 May;7(5):522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15.

35.

SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.

Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.

Stem Cell Reports. 2017 Mar 14;8(3):561-575. doi: 10.1016/j.stemcr.2017.01.006. Epub 2017 Feb 9.

36.

Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.

Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo MM.

Cancer Sci. 2017 Apr;108(4):744-752. doi: 10.1111/cas.13187. Epub 2017 Apr 12.

37.

Beta-catenin and estrogen signaling collaborate to drive cyclin D1 expression in developing mouse prostate.

Mulligan WA, Wegner KA, Keil KP, Mehta V, Taketo MM, Vezina CM.

Differentiation. 2017 Jan - Feb;93:66-71. doi: 10.1016/j.diff.2016.11.002. Epub 2016 Dec 2.

38.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.

Lemberger UJ, Fuchs CD, Karer M, Haas S, Stojakovic T, Schöfer C, Marschall HU, Wrba F, Taketo MM, Egger G, Trauner M, Österreicher CH.

Oncotarget. 2016 Dec 27;7(52):86985-86998. doi: 10.18632/oncotarget.13521.

39.

Manipulating Wnt signaling at different subcellular levels affects the fate of neonatal neural stem/progenitor cells.

Kriska J, Honsa P, Dzamba D, Butenko O, Kolenicova D, Janeckova L, Nahacka Z, Andera L, Kozmik Z, Taketo MM, Korinek V, Anderova M.

Brain Res. 2016 Nov 15;1651:73-87. doi: 10.1016/j.brainres.2016.09.026. Epub 2016 Sep 19.

PMID:
27659965
40.

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.

Muñoz-Bravo JL, Flores-Martínez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA.

PLoS One. 2016 Oct 13;11(10):e0164714. doi: 10.1371/journal.pone.0164714. eCollection 2016.

41.

Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis.

Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo MM, Nagayama S, Sakai Y, Matsuda M.

PLoS One. 2016 Sep 2;11(9):e0162300. doi: 10.1371/journal.pone.0162300. eCollection 2016.

42.

Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.

Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM.

Cancer Sci. 2016 Nov;107(11):1622-1631. doi: 10.1111/cas.13063.

43.

Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis.

Yamamoto T, Kawada K, Itatani Y, Inamoto S, Okamura R, Iwamoto M, Miyamoto E, Chen-Yoshikawa TF, Hirai H, Hasegawa S, Date H, Taketo MM, Sakai Y.

Clin Cancer Res. 2017 Feb 1;23(3):833-844. doi: 10.1158/1078-0432.CCR-16-0520. Epub 2016 Aug 4.

44.

Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.

Mašek J, Machoň O, Kořínek V, Taketo MM, Kozmik Z.

Development. 2016 Jun 15;143(12):2206-16. doi: 10.1242/dev.132357.

45.

The WNT/MYB pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation.

Matsumoto S, Kurimoto T, Taketo MM, Fujii S, Kikuchi A.

Development. 2016 Jul 1;143(13):2311-24. doi: 10.1242/dev.134486. Epub 2016 May 9.

46.

The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis.

Itatani Y, Kawada K, Inamoto S, Yamamoto T, Ogawa R, Taketo MM, Sakai Y.

Int J Mol Sci. 2016 Apr 28;17(5). pii: E643. doi: 10.3390/ijms17050643. Review.

47.

β-Catenin Activation in Muscle Progenitor Cells Regulates Tissue Repair.

Rudolf A, Schirwis E, Giordani L, Parisi A, Lepper C, Taketo MM, Le Grand F.

Cell Rep. 2016 May 10;15(6):1277-90. doi: 10.1016/j.celrep.2016.04.022. Epub 2016 Apr 28.

48.

Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.

Liu L, Chen Y, Qi J, Zhang Y, He Y, Ni W, Li W, Zhang S, Sun S, Taketo MM, Wang L, Chai R, Li H.

Cell Death Dis. 2016 Mar 10;7:e2136. doi: 10.1038/cddis.2016.35.

49.

Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.

Kumar M, Syed SM, Taketo MM, Tanwar PS.

Dev Biol. 2016 Apr 15;412(2):234-49. doi: 10.1016/j.ydbio.2016.02.025. Epub 2016 Mar 2.

50.

Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15-CCR1 Chemokine Axis.

Inamoto S, Itatani Y, Yamamoto T, Minamiguchi S, Hirai H, Iwamoto M, Hasegawa S, Taketo MM, Sakai Y, Kawada K.

Clin Cancer Res. 2016 Jan 15;22(2):492-501. doi: 10.1158/1078-0432.CCR-15-0726. Epub 2015 Sep 4.

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