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Evaluation of the functional effects of genetic variants‒missense and nonsense SNPs, indels and copy number variations‒in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity.

Ueki M, Kimura-Kataoka K, Fujihara J, Iida R, Kawai Y, Kusaka A, Sasaki T, Takeshita H, Yasuda T.

Sci Rep. 2019 Sep 20;9(1):13660. doi: 10.1038/s41598-019-49935-y.


Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.

Nozato S, Yamamoto K, Takeshita H, Nozato Y, Imaizumi Y, Fujimoto T, Yokoyama S, Nagasawa M, Takeda M, Hongyo K, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Mogi M, Horiuchi M, Rakugi H.

Clin Sci (Lond). 2019 Sep 24;133(18):2005-2018. doi: 10.1042/CS20190573. Print 2019 Sep 30.


Measurement of Serum Tenascin-X in Joint Hypermobility Syndrome Patients.

Yamada K, Watanabe A, Takeshita H, Fujita A, Miyake N, Matsumoto N, Matsumoto KI.

Biol Pharm Bull. 2019;42(9):1596-1599. doi: 10.1248/bpb.b19-00168.


Aspects of a Large Tsunami That Struck the Sunda Strait in Indonesia: Lessons for Japan and the Rest of the World.

Inoue K, Takeshita H, Hashioka S, Takeichi N, Fujita Y.

Asia Pac J Public Health. 2019 Sep;31(6):574-575. doi: 10.1177/1010539519867220. Epub 2019 Aug 6. No abstract available.


Circulating cell-free DNA fragment analysis by microchip electrophoresis and its relationship with DNase I in cardiac diseases.

Fujihara J, Takinami Y, Ueki M, Kimura-Kataoka K, Yasuda T, Takeshita H.

Clin Chim Acta. 2019 Oct;497:61-66. doi: 10.1016/j.cca.2019.07.014. Epub 2019 Jul 11.


Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data.

Morioka T, Blyth BJ, Imaoka T, Nishimura M, Takeshita H, Shimomura T, Ohtake J, Ishida A, Schofield P, Grosche B, Kulka U, Shimada Y, Yamada Y, Kakinuma S.

Int J Radiat Biol. 2019 Oct;95(10):1372-1377. doi: 10.1080/09553002.2019.1625458. Epub 2019 Jun 26.


Low genetic heterogeneity of copy number variations (CNVs) in the genes encoding the human deoxyribonucleases 1-like 3 and II potentially relevant to autoimmunity.

Ueki M, Fujihara J, Kimura-Kataoka K, Yamada K, Takinami Y, Takeshita H, Iida R, Yasuda T.

PLoS One. 2019 Apr 25;14(4):e0215479. doi: 10.1371/journal.pone.0215479. eCollection 2019.


The Need to Develop a Strategy With an Evidence-Based Guideline for the Prevention of Gaming Disorder.

Hashioka S, Inoue K, Takeshita H, Kamura M, Fujita Y.

Asia Pac J Public Health. 2019 Apr;31(3):267-268. doi: 10.1177/1010539519844079. Epub 2019 Apr 21. No abstract available.


Neutralizing antibodies for Helicobacter pylori urease inhibit bacterial colonization in the murine stomach in vivo.

Takeshita H, Watanabe E, Norose Y, Ito Y, Takahashi H.

Biomed Res. 2019;40(2):87-95. doi: 10.2220/biomedres.40.87.


Diagnosis of Lymph Node Metastasis in Colorectal Cancer by a Semi-dry Dot-blot Method.

Hamada K, Otsubo R, Takeshita H, Nonaka T, Tominaga T, Hidaka S, Sumida Y, Abe K, Sawai T, Nagayasu T.

Anticancer Res. 2019 Apr;39(4):2069-2076. doi: 10.21873/anticanres.13318.


Initial 3-month dynamics of dehydroepiandrosterone sulfate can predict responsiveness to primary androgen deprivation therapy in patients with metastatic prostate cancer.

Yano A, Kagawa M, Takeshita H, Okada Y, Morozumi M, Kawakami S.

Asian J Androl. 2019 Mar 26. doi: 10.4103/aja.aja_9_19. [Epub ahead of print] No abstract available.


Effects of Low-Dose Sacubitril/Valsartan on Different Stages of Cardiac Hypertrophy in Salt-Loaded Hypertensive Rats.

Hamano G, Yamamoto K, Takami Y, Takeshita H, Shimosato T, Moritani T, Rakugi H.

J Cardiovasc Pharmacol. 2019 May;73(5):282-289. doi: 10.1097/FJC.0000000000000662.


Analysis of copy number variation in the NEDD4L gene potentially implicated in body height in the Japanese population.

Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Yasuda T.

Leg Med (Tokyo). 2019 Mar;37:83-85. doi: 10.1016/j.legalmed.2019.02.003. Epub 2019 Feb 11.


Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis.

Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, Takeshita H, Wang C, Yokoyama S, Hayashi H, Hongyo K, Akasaka H, Takeya Y, Sugimoto K, Nakagami H, Rakugi H.

Biochem Biophys Res Commun. 2019 Jan 22;508(4):1168-1174. doi: 10.1016/j.bbrc.2018.12.025. Epub 2018 Dec 13.


Schnitzler's syndrome: A female elderly case presenting intractable non-pruritic febrile urticarial rush.

Kimura N, Takeshita H, Kai T, Inoue Y, Furue M.

Asian Pac J Allergy Immunol. 2018 Dec 9. doi: 10.12932/AP-150818-0394. [Epub ahead of print]


Relationship between oral stereognostic ability and dietary intake in older Japanese adults with complete dentures.

Fukutake M, Ikebe K, Okubo H, Matsuda KI, Enoki K, Inomata C, Takeshita H, Mihara Y, Hatta K, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Maeda Y.

J Prosthodont Res. 2019 Jan;63(1):105-109. doi: 10.1016/j.jpor.2018.10.001. Epub 2018 Oct 30.


Association of SNPs in transferrin and transferrin receptor genes with blood iron levels in human.

Fujihara J, Yasuda T, Kimura-Kataoka K, Takeshita H.

Leg Med (Tokyo). 2019 Feb;36:17-20. doi: 10.1016/j.legalmed.2018.09.022. Epub 2018 Oct 4.


Influence of lack of posterior occlusal support on cognitive decline among 80-year-old Japanese people in a 3-year prospective study.

Hatta K, Ikebe K, Gondo Y, Kamide K, Masui Y, Inagaki H, Nakagawa T, Matsuda KI, Ogawa T, Inomata C, Takeshita H, Mihara Y, Fukutake M, Kitamura M, Murakami S, Kabayama M, Ishizaki T, Arai Y, Sugimoto K, Rakugi H, Maeda Y.

Geriatr Gerontol Int. 2018 Oct;18(10):1439-1446. doi: 10.1111/ggi.13508. Epub 2018 Sep 16.


Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.

Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H.

J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):975-986. doi: 10.1002/jcsm.12334. Epub 2018 Sep 11.


Discrimination Between Infant and Adult Bloodstains Using Micro-Raman Spectroscopy: A Preliminary Study.

Fujihara J, Nishimoto N, Yasuda T, Takeshita H.

J Forensic Sci. 2019 May;64(3):698-701. doi: 10.1111/1556-4029.13904. Epub 2018 Aug 31.


Infrared spectroscopic and computational studies on formamide solutions of Ca2+. Vibrational frequencies of formamide and modes of coordination to Ca2.

Ohashi K, Hikiishi N, Takeshita H.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jan 5;206:112-119. doi: 10.1016/j.saa.2018.07.089. Epub 2018 Aug 1.


Association of handgrip strength with various oral functions in 82- to 84-year-old community-dwelling Japanese.

Mihara Y, Matsuda KI, Ikebe K, Hatta K, Fukutake M, Enoki K, Ogawa T, Takeshita H, Inomata C, Gondo Y, Masui Y, Kamide K, Sugimoto K, Kabayama M, Ishizaki T, Arai Y, Maeda Y.

Gerodontology. 2018 May 15. doi: 10.1111/ger.12341. [Epub ahead of print]


Foreign-body granuloma mimicking post-chemotherapy residual seminoma: A case of true-negative findings using diffusion-weighted whole-body magnetic resonance imaging with background suppression.

Takeshita H, Kawakami S, Takahara T, Tachibana K, Hiranuma S, Sugiyama H, Kagawa M, Yano A, Okada Y, Morozumi M.

Eur J Radiol Open. 2018 Mar 15;5:41-44. doi: 10.1016/j.ejro.2018.03.003. eCollection 2018.


Limited influence of dutasteride on individual prostate-specific antigen variability in men with clinical benign prostatic hyperplasia.

Takeshita H, Kawakami S, Kagawa M, Yano A, Okada Y, Morozumi M.

Int J Urol. 2018 Jun;25(6):633-634. doi: 10.1111/iju.13557. Epub 2018 Apr 25. No abstract available.


[A Case of Intraductal Pancreatic Mallignant Tumor with Difficulty in Differentiating between IPMN and ITPN].

Fukami T, Noguchi A, Ishii H, Watanabe A, Sugimoto R, Tada H, Takeshita H, Umehara S, Izumi H, Tani N, Yamaguchi M, Kawabata K, Yamane T.

Gan To Kagaku Ryoho. 2018 Mar;45(3):566-568. Japanese.


Impact of cognitive function on oral perception in independently living older people.

Fukutake M, Ogawa T, Ikebe K, Mihara Y, Inomata C, Takeshita H, Matsuda K, Hatta K, Gondo Y, Masui Y, Inagaki H, Arai Y, Kamide K, Ishizaki T, Maeda Y.

Clin Oral Investig. 2019 Jan;23(1):267-271. doi: 10.1007/s00784-018-2433-y. Epub 2018 Apr 10.


The Charlson Comorbidity Index as an Independent Prognostic Factor in Older Colorectal Cancer Patients.

Tominaga T, Nonaka T, Takeshita H, Kunizaki M, Sumida Y, Hidaka S, Sawai T, Nagayasu T.

Indian J Surg. 2018 Feb;80(1):54-60. doi: 10.1007/s12262-016-1544-4. Epub 2016 Aug 24.


Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.

Jin Y, Takeda Y, Kondo Y, Tripathi LP, Kang S, Takeshita H, Kuhara H, Maeda Y, Higashiguchi M, Miyake K, Morimura O, Koba T, Hayama Y, Koyama S, Nakanishi K, Iwasaki T, Tetsumoto S, Tsujino K, Kuroyama M, Iwahori K, Hirata H, Takimoto T, Suzuki M, Nagatomo I, Sugimoto K, Fujii Y, Kida H, Mizuguchi K, Ito M, Kijima T, Rakugi H, Mekada E, Tachibana I, Kumanogoh A.

Sci Rep. 2018 Mar 23;8(1):5145. doi: 10.1038/s41598-018-23338-x.


Predictors of portal and splenic vein thrombosis after laparoscopic splenectomy: a retrospective analysis of a single-center experience.

Kuroki T, Kitasato A, Tokunaga T, Takeshita H, Taniguchi K, Maeda S, Fujioka H.

Surg Today. 2018 Aug;48(8):804-809. doi: 10.1007/s00595-018-1655-6. Epub 2018 Mar 22.


[Metastatic Pancreatic Carcinoma from Renal Cell Carcinoma Indistinguishable from Primary Pancreatic Endocrine Tumor - A Case Report].

Tada H, Noguchi A, Watanabe A, Fukami T, Sugimoto R, Takeshita H, Umehara S, Ishii H, Izumi H, Tani N, Yamaguchi M, Yamane T.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1928-1929. Japanese.


Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study.

Ikebe K, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Inagaki H, Nakagawa T, Kabayama M, Ryuno H, Okubo H, Takeshita H, Inomata C, Kurushima Y, Mihara Y, Hatta K, Fukutake M, Enoki K, Ogawa T, Matsuda KI, Sugimoto K, Oguro R, Takami Y, Itoh N, Takeya Y, Yamamoto K, Rakugi H, Murakami S, Kitamura M, Maeda Y.

PLoS One. 2018 Jan 5;13(1):e0190741. doi: 10.1371/journal.pone.0190741. eCollection 2018.


Elevated neutrophil-to-lymphocyte ratio is associated with nutritional impairment, immune suppression, resistance to S-1 plus cisplatin, and poor prognosis in patients with stage IV gastric cancer.

Gonda K, Shibata M, Sato Y, Washio M, Takeshita H, Shigeta H, Ogura M, Oka S, Sakuramoto S.

Mol Clin Oncol. 2017 Dec;7(6):1073-1078. doi: 10.3892/mco.2017.1438. Epub 2017 Oct 4.


The long-term survival in primary retroperitoneal mucinous cystadenocarcinoma: a case report.

Tokai H, Nagata Y, Taniguchi K, Matsumura N, Kitasato A, Tokunaga T, Takeshita H, Kuroki T, Maeda S, Ito M, Fujioka H.

Surg Case Rep. 2017 Nov 25;3(1):117. doi: 10.1186/s40792-017-0394-z.


Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans.

Fujihara J, Yasuda T, Kimura-Kataoka K, Takinami Y, Nagao M, Takeshita H.

Leg Med (Tokyo). 2018 Jan;30:28-33. doi: 10.1016/j.legalmed.2017.10.009. Epub 2017 Nov 9.


Improved survival of men with metastatic prostate cancer treated with androgen deprivation therapy plus radiotherapy to the prostate.

Yano A, Kagawa M, Takeshita H, Okada Y, Morozumi M, Kawakami S.

Int J Urol. 2017 Dec;24(12):863-865. doi: 10.1111/iju.13479. Epub 2017 Oct 23. No abstract available.


Baseline low serum dehydroepiandrosterone sulfate can predict poor responsiveness to hormone therapy in patients with hormone-naïve prostate cancer with skeletal metastases.

Yano A, Kagawa M, Takeshita H, Okada Y, Morozumi M, Kawakami S.

Int J Urol. 2017 Dec;24(12):861-862. doi: 10.1111/iju.13445. Epub 2017 Sep 11. No abstract available.


Sequence analysis of ABO and its homologues is valid for species identification.

Sano R, Fukuda H, Takahashi Y, Takahashi K, Kubo R, Kobayashi M, Fujihara J, Takeshita H, Kominato Y.

Transfus Med. 2017 Dec;27(6):428-436. doi: 10.1111/tme.12455. Epub 2017 Aug 29.


Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study.

Tada S, Ikebe K, Kamide K, Gondo Y, Inomata C, Takeshita H, Matsuda KI, Kitamura M, Murakami S, Kabayama M, Oguro R, Nakama C, Kawai T, Yamamoto K, Sugimoto K, Shintani A, Ishihara T, Arai Y, Masui Y, Takahashi R, Rakugi H, Maeda Y.

PLoS One. 2017 Aug 17;12(8):e0182563. doi: 10.1371/journal.pone.0182563. eCollection 2017.


Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H.

J Stroke Cerebrovasc Dis. 2017 Nov;26(11):2587-2594. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.012. Epub 2017 Jun 29.


Preoperative evaluation of accessory hepatic ducts by drip infusion cholangiography with CT.

Ishii H, Noguchi A, Fukami T, Sugimoto R, Tada H, Takeshita H, Umehara S, Izumi H, Tani N, Yamaguchi M, Yamane T.

BMC Surg. 2017 May 8;17(1):52. doi: 10.1186/s12893-017-0251-9.


Simple screening method for copy number variations associated with physical features.

Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Yasuda T.

Leg Med (Tokyo). 2017 Mar;25:71-74. doi: 10.1016/j.legalmed.2017.01.006. Epub 2017 Jan 24.


Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.

Ueki M, Takeshita H, Utsunomiya N, Chino T, Oyama N, Hasegawa M, Kimura-Kataoka K, Fujihara J, Iida R, Yasuda T.

PLoS One. 2017 Apr 10;12(4):e0175083. doi: 10.1371/journal.pone.0175083. eCollection 2017.


Dietary Intake Is Associated with Occlusal Force Rather Than Number of Teeth in 80-y-Old Japanese.

Inomata C, Ikebe K, Okubo H, Takeshita H, Mihara Y, Hatta K, Tada S, Enoki K, Ogawa T, Matsuda K, Gondo Y, Masui Y, Kamide K, Takahashi R, Arai Y, Maeda Y.

JDR Clin Trans Res. 2017 Apr;2(2):187-197. doi: 10.1177/2380084416673963. Epub 2016 Oct 21.


Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.

Takeshita H, Yamamoto K, Nozato S, Inagaki T, Tsuchimochi H, Shirai M, Yamamoto R, Imaizumi Y, Hongyo K, Yokoyama S, Takeda M, Oguro R, Takami Y, Itoh N, Takeya Y, Sugimoto K, Fukada SI, Rakugi H.

Sci Rep. 2017 Feb 8;7:42323. doi: 10.1038/srep42323.


Pheochromocytoma Multisystem Crisis Behaving Like Interstitial Pneumonia: An Autopsy Case.

Nomoto Y, Kawano K, Fujisawa N, Yoshida K, Yamashita T, Makita N, Takeshita H, Kamimori K, Yanagi S, Yoshiyama M.

Intern Med. 2017;56(2):149-152. doi: 10.2169/internalmedicine.56.7449. Epub 2017 Jan 15.



Cho E, Morozumi M, Yano A, Tachibana K, Hiranuma S, Sugiyama H, Takeshita H, Okada Y, Kawakami S, Osada H, Yamashita T, Tamaru J.

Nihon Hinyokika Gakkai Zasshi. 2017;108(2):96-100. doi: 10.5980/jpnjurol.108.96. Japanese.


An autopsy case of prolonged asphyxial death caused by the impacted denture in the esophagus.

Funayama K, Fujihara J, Takeshita H, Takatsuka H.

Leg Med (Tokyo). 2016 Nov;23:95-98. doi: 10.1016/j.legalmed.2016.10.006. Epub 2016 Oct 20.


An autopsy case of spontaneous esophageal perforation (Boerhaave syndrome).

Kimura-Kataoka K, Fujihara J, Kurata S, Takinami Y, Inoue K, Yasuda T, Takeshita H.

Leg Med (Tokyo). 2016 Nov;23:5-9. doi: 10.1016/j.legalmed.2016.08.009. Epub 2016 Aug 26.


Erratum: Carcinoma-like nonfunctional pheochromocytoma in the right adrenal gland: A case report.

Moriyama S, Takeshita H, Araki S, Tokairin T, Kagawa M, Chiba K, Adachi A, Noro A.

Oncol Lett. 2016 Nov;12(5):4277. Epub 2016 Sep 16.

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