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Expression and Dynamics of Podoplanin in Cultured Osteoblasts with Mechanostress and Mineralization Stimulus.

Takenawa T, Kanai T, Kitamura T, Yoshimura Y, Sawa Y, Iida J.

Acta Histochem Cytochem. 2018 Feb 27;51(1):41-52. doi: 10.1267/ahc.17031. Epub 2018 Jan 30.


Gimeracil enhances the antitumor effect of cisplatin in oral squamous cell carcinoma cells in vitro and in vivo.

Harada K, Ferdous T, Harada T, Takenawa T, Ueyama Y.

Oncol Lett. 2017 Sep;14(3):3349-3356. doi: 10.3892/ol.2017.6602. Epub 2017 Jul 18.


Calreticulin is a novel independent prognostic factor for oral squamous cell carcinoma.

Harada K, Takenawa T, Ferdous T, Kuramitsu Y, Ueyama Y.

Oncol Lett. 2017 Jun;13(6):4857-4862. doi: 10.3892/ol.2017.6062. Epub 2017 Apr 20.


PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells.

Fukumoto M, Ijuin T, Takenawa T.

Cancer Sci. 2017 May;108(5):941-951. doi: 10.1111/cas.13215. Epub 2017 May 11.


Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer.

Ijuin T, Takeuchi Y, Shimono Y, Fukumoto M, Tokuda E, Takenawa T.

Cancer Sci. 2016 Jul;107(7):981-90. doi: 10.1111/cas.12968. Epub 2016 Jun 24.


Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.

Ijuin T, Hatano N, Takenawa T.

Genes Cells. 2016 May;21(5):457-65. doi: 10.1111/gtc.12353. Epub 2016 Mar 4.


IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.

Ando H, Hirose M, Gainche L, Kawaai K, Bonneau B, Ijuin T, Itoh T, Takenawa T, Mikoshiba K.

PLoS One. 2015 Oct 28;10(10):e0141569. doi: 10.1371/journal.pone.0141569. eCollection 2015.


Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.

Ijuin T, Hosooka T, Takenawa T.

Mol Cell Biol. 2015 Oct 19;36(1):108-18. doi: 10.1128/MCB.00921-15. Print 2016 Jan 1.


Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78.

Ijuin T, Hatano N, Hosooka T, Takenawa T.

Biochim Biophys Acta. 2015 Dec;1853(12):3192-201. doi: 10.1016/j.bbamcr.2015.09.009. Epub 2015 Sep 14.


Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation.

Tsujita K, Takenawa T, Itoh T.

Nat Cell Biol. 2015 Jun;17(6):749-58. doi: 10.1038/ncb3162. Epub 2015 May 4.


α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.

Fukumoto M, Kurisu S, Yamada T, Takenawa T.

PLoS One. 2015 Apr 10;10(4):e0120616. doi: 10.1371/journal.pone.0120616. eCollection 2015.


Osteogenic cell fractions isolated from mouse tongue muscle.

Harada K, Harada T, Ferdous T, Takenawa T, Ueyama Y.

Mol Med Rep. 2015 Jul;12(1):31-6. doi: 10.3892/mmr.2015.3350. Epub 2015 Feb 13.


Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy.

Yamashita K, Sasaki T, Itoh R, Kato D, Hatano N, Soejima T, Ishii K, Takenawa T, Hiromatsu K, Yamashita Y.

J Hepatobiliary Pancreat Sci. 2015 Jun;22(6):454-62. doi: 10.1002/jhbp.223. Epub 2015 Feb 11.


Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain.

Ijuin T, Takenawa T.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):41-6. doi: 10.1016/j.bbrc.2014.11.031. Epub 2014 Nov 18.


Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins.

Suetsugu S, Kurisu S, Takenawa T.

Physiol Rev. 2014 Oct;94(4):1219-48. doi: 10.1152/physrev.00040.2013. Review.


Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.

Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T.

Cancer Res. 2014 Jun 1;74(11):3054-66. doi: 10.1158/0008-5472.CAN-13-2441. Epub 2014 Apr 4.


GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients.

Saegusa J, Irino Y, Yoshida M, Tanaka S, Kogata Y, Kageyama G, Tsuji G, Takenawa T, Kawano S, Kumagai S, Morinobu A.

Clin Exp Rheumatol. 2014 Jan-Feb;32(1):148. Epub 2014 Jan 3. No abstract available.


Involvement of histidine in complex formation of PriB and single-stranded DNA.

Fujiyama S, Abe Y, Takenawa T, Aramaki T, Shioi S, Katayama T, Ueda T.

Biochim Biophys Acta. 2014 Feb;1844(2):299-307. doi: 10.1016/j.bbapap.2013.10.015. Epub 2013 Nov 5.


Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1.

Funato Y, Hayashi T, Irino Y, Takenawa T, Miki H.

Biochem Biophys Res Commun. 2013 Nov 1;440(4):737-42. doi: 10.1016/j.bbrc.2013.09.138. Epub 2013 Oct 8.


srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity.

Yamazaki D, Itoh T, Miki H, Takenawa T.

Mol Biol Cell. 2013 Nov;24(21):3393-405. doi: 10.1091/mbc.E13-04-0178. Epub 2013 Sep 4.


Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion.

Uenishi E, Shibasaki T, Takahashi H, Seki C, Hamaguchi H, Yasuda T, Tatebe M, Oiso Y, Takenawa T, Seino S.

J Biol Chem. 2013 Sep 6;288(36):25851-64. doi: 10.1074/jbc.M113.464420. Epub 2013 Jul 18.


IRSp53 mediates podosome formation via VASP in NIH-Src cells.

Oikawa T, Okamura H, Dietrich F, Senju Y, Takenawa T, Suetsugu S.

PLoS One. 2013;8(3):e60528. doi: 10.1371/journal.pone.0060528. Epub 2013 Mar 26.


A novel serum metabolomics-based diagnostic approach to pancreatic cancer.

Kobayashi T, Nishiumi S, Ikeda A, Yoshie T, Sakai A, Matsubara A, Izumi Y, Tsumura H, Tsuda M, Nishisaki H, Hayashi N, Kawano S, Fujiwara Y, Minami H, Takenawa T, Azuma T, Yoshida M.

Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):571-9. doi: 10.1158/1055-9965.EPI-12-1033. Epub 2013 Mar 29.


Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation.

Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T.

J Cell Sci. 2013 May 15;126(Pt 10):2267-78. doi: 10.1242/jcs.122515. Epub 2013 Mar 22.


Actin filament reorganization is necessary to facilitate dynamic cellular events. Preface.

Takenawa T, Suetsugu S.

Semin Cell Dev Biol. 2013 Apr;24(4):257. doi: 10.1016/j.semcdb.2013.03.005. Epub 2013 Mar 15. No abstract available.


Proteomic analysis showed down-regulation of nucleophosmin in progressive tumor cells compared to regressive tumor cells.

Takenawa T, Kuramitsu Y, Wang Y, Okada F, Tokuda K, Kitagawa T, Ueyama Y, Nakamura K.

Anticancer Res. 2013 Jan;33(1):153-60.


RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.

Koizumi K, Takano K, Kaneyasu A, Watanabe-Takano H, Tokuda E, Abe T, Watanabe N, Takenawa T, Endo T.

Mol Biol Cell. 2012 Dec;23(23):4647-61. doi: 10.1091/mbc.E12-04-0315. Epub 2012 Oct 3.


A novel serum metabolomics-based diagnostic approach for colorectal cancer.

Nishiumi S, Kobayashi T, Ikeda A, Yoshie T, Kibi M, Izumi Y, Okuno T, Hayashi N, Kawano S, Takenawa T, Azuma T, Yoshida M.

PLoS One. 2012;7(7):e40459. doi: 10.1371/journal.pone.0040459. Epub 2012 Jul 11.


Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.

Ijuin T, Takenawa T.

Mol Cell Biol. 2012 Sep;32(17):3570-84. doi: 10.1128/MCB.00636-12. Epub 2012 Jul 2.


The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.

Kato K, Yazawa T, Taki K, Mori K, Wang S, Nishioka T, Hamaguchi T, Itoh T, Takenawa T, Kataoka C, Matsuura Y, Amano M, Murohara T, Kaibuchi K.

Mol Biol Cell. 2012 Jul;23(13):2593-604. doi: 10.1091/mbc.E11-11-0958. Epub 2012 May 16.


ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.

Hasegawa J, Tsujita K, Takenawa T, Itoh T.

Mol Biol Cell. 2012 Jul;23(13):2481-9. doi: 10.1091/mbc.E12-01-0017. Epub 2012 May 9.


Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes.

Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T.

J Lipid Res. 2012 Apr;53(4):810-9. doi: 10.1194/jlr.D019547. Epub 2012 Feb 3.


Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry.

Yoshida M, Hatano N, Nishiumi S, Irino Y, Izumi Y, Takenawa T, Azuma T.

J Gastroenterol. 2012 Jan;47(1):9-20. doi: 10.1007/s00535-011-0493-8. Epub 2011 Nov 2. Review.


Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry.

Kondo Y, Nishiumi S, Shinohara M, Hatano N, Ikeda A, Yoshie T, Kobayashi T, Shiomi Y, Irino Y, Takenawa T, Azuma T, Yoshida M.

Biomark Med. 2011 Aug;5(4):451-60. doi: 10.2217/bmm.11.41.


Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer.

Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M.

Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.


Characterization of the EFC/F-BAR domain protein, FCHO2.

Uezu A, Umeda K, Tsujita K, Suetsugu S, Takenawa T, Nakanishi H.

Genes Cells. 2011 Aug;16(8):868-78. doi: 10.1111/j.1365-2443.2011.01536.x. Epub 2011 Jul 18.


Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.

Tsutsumi K, Matsuda M, Kotani M, Mizokami A, Murakami A, Takahashi I, Terada Y, Kanematsu T, Fukami K, Takenawa T, Jimi E, Hirata M.

J Biol Chem. 2011 Sep 2;286(35):31032-42. doi: 10.1074/jbc.M111.235903. Epub 2011 Jul 11.


SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.

Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T.

J Cell Biol. 2011 May 30;193(5):901-16. doi: 10.1083/jcb.201012161.


Neural Wiskott-Aldrich syndrome protein is required for accurate chromosome congression and segregation.

Park SJ, Takenawa T.

Mol Cells. 2011 Jun;31(6):515-21. doi: 10.1007/s10059-011-2292-8. Epub 2011 Apr 20.


GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis.

Ooi M, Nishiumi S, Yoshie T, Shiomi Y, Kohashi M, Fukunaga K, Nakamura S, Matsumoto T, Hatano N, Shinohara M, Irino Y, Takenawa T, Azuma T, Yoshida M.

Inflamm Res. 2011 Sep;60(9):831-40. doi: 10.1007/s00011-011-0340-7. Epub 2011 Apr 27.


Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin.

Wang F, Ijuin T, Itoh T, Takenawa T.

J Biochem. 2011 Jul;150(1):83-93. doi: 10.1093/jb/mvr037. Epub 2011 Mar 23.


A metabolomic approach to lung cancer.

Hori S, Nishiumi S, Kobayashi K, Shinohara M, Hatakeyama Y, Kotani Y, Hatano N, Maniwa Y, Nishio W, Bamba T, Fukusaki E, Azuma T, Takenawa T, Nishimura Y, Yoshida M.

Lung Cancer. 2011 Nov;74(2):284-92. doi: 10.1016/j.lungcan.2011.02.008. Epub 2011 Mar 15.


[The challenge of disease diagnosis by metabolomics].

Yoshida M, Hatano N, Shinohara M, Nishiumi S, Irino Y, Azuma T, Takenawa T.

Fukuoka Igaku Zasshi. 2010 Nov;101(11):231-7. Review. Japanese. No abstract available.


Phosphoinositides regulate clathrin-dependent endocytosis at the tip of pollen tubes in Arabidopsis and tobacco.

Zhao Y, Yan A, Feijó JA, Furutani M, Takenawa T, Hwang I, Fu Y, Yang Z.

Plant Cell. 2010 Dec;22(12):4031-44. doi: 10.1105/tpc.110.076760. Epub 2010 Dec 28.


Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation.

Takano K, Watanabe-Takano H, Suetsugu S, Kurita S, Tsujita K, Kimura S, Karatsu T, Takenawa T, Endo T.

Science. 2010 Dec 10;330(6010):1536-40. doi: 10.1126/science.1197767.


WASP and WAVE family proteins: friends or foes in cancer invasion?

Kurisu S, Takenawa T.

Cancer Sci. 2010 Oct;101(10):2093-104. doi: 10.1111/j.1349-7006.2010.01654.x. Epub 2010 Aug 12. Review.


Phosphoinositide-binding interface proteins involved in shaping cell membranes.

Takenawa T.

Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):509-23. Review.

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