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Items: 1 to 50 of 188

1.

Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial-onset seizures.

Takenaka O, Ferry J, Saeki K, Laurenza A.

Acta Neurol Scand. 2018 Apr;137(4):400-408. doi: 10.1111/ane.12874. Epub 2017 Nov 23.

PMID:
29171002
2.

Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.

Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2678-2687. doi: 10.1016/j.xphs.2017.02.012. Epub 2017 Feb 24.

PMID:
28238896
3.

Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats.

Nagaya Y, Nozaki Y, Takenaka O, Watari R, Kusano K, Yoshimura T, Kusuhara H.

Drug Metab Pharmacokinet. 2016 Feb;31(1):57-66. doi: 10.1016/j.dmpk.2015.10.003. Epub 2015 Nov 5.

4.

Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.

Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.

Mol Pharm. 2016 Feb 1;13(2):438-48. doi: 10.1021/acs.molpharmaceut.5b00664. Epub 2016 Jan 7.

PMID:
26696140
5.

HPLC with fluorescence detection assay of perampanel, a novel AMPA receptor antagonist, in human plasma for clinical pharmacokinetic studies.

Mano Y, Takenaka O, Kusano K.

Biomed Chromatogr. 2015 Oct;29(10):1589-93. doi: 10.1002/bmc.3463. Epub 2015 Mar 31.

PMID:
25828925
6.
7.

Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions.

Izumi S, Nozaki Y, Maeda K, Komori T, Takenaka O, Kusuhara H, Sugiyama Y.

Drug Metab Dispos. 2015 Feb;43(2):235-47. doi: 10.1124/dmd.114.059105. Epub 2014 Nov 20.

PMID:
25414411
8.

Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists.

Yoshida Y, Terauchi T, Naoe Y, Kazuta Y, Ozaki F, Beuckmann CT, Nakagawa M, Suzuki M, Kushida I, Takenaka O, Ueno T, Yonaga M.

Bioorg Med Chem. 2014 Nov 1;22(21):6071-88. doi: 10.1016/j.bmc.2014.08.034. Epub 2014 Sep 8. Erratum in: Bioorg Med Chem. 2015 Jul 1;23(13):3870.

PMID:
25267004
9.

Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.

Nagaya Y, Nozaki Y, Kobayashi K, Takenaka O, Nakatani Y, Kusano K, Yoshimura T, Kusuhara H.

Drug Metab Pharmacokinet. 2014;29(5):419-26. Epub 2014 May 6.

10.

Genetic analysis of group composition and relatedness in white-headed langurs.

Liu Z, Huang C, Zhou Q, Li Y, Wang Y, Li M, Takenaka O, Takenaka A.

Integr Zool. 2013 Dec;8(4):410-6. doi: 10.1111/1749-4877.12048.

PMID:
24344965
11.

A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder.

Nakatani Y, Suzuki M, Tokunaga M, Maeda J, Sakai M, Ishihara H, Yoshinaga T, Takenaka O, Zhang MR, Suhara T, Higuchi M.

PLoS One. 2013 Sep 23;8(9):e75040. doi: 10.1371/journal.pone.0075040. eCollection 2013.

12.

Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17β-glucuronide, estrone-3-sulfate, and sulfobromophthalein.

Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H, Sugiyama Y.

Drug Metab Dispos. 2013 Oct;41(10):1859-66. doi: 10.1124/dmd.113.052290. Epub 2013 Aug 6.

PMID:
23920221
13.

Species difference in the mechanism of nonlinear pharmacokinetics of E2074, a novel sodium channel inhibitor, in rats, dogs, and monkeys.

Nagaya Y, Takenaka O, Kusano K, Yoshimura T.

Drug Metab Dispos. 2013 May;41(5):1004-11. doi: 10.1124/dmd.112.050062. Epub 2013 Feb 11.

PMID:
23401471
14.

Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist.

Hibi S, Ueno K, Nagato S, Kawano K, Ito K, Norimine Y, Takenaka O, Hanada T, Yonaga M.

J Med Chem. 2012 Dec 13;55(23):10584-600. doi: 10.1021/jm301268u. Epub 2012 Dec 4.

PMID:
23181587
15.

Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy.

Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y.

Epilepsia. 2011 Jul;52(7):1331-40. doi: 10.1111/j.1528-1167.2011.03109.x. Epub 2011 Jun 2.

16.

Lineage-specific duplication and loss of pepsinogen genes in hominoid evolution.

Narita Y, Oda S, Takenaka O, Kageyama T.

J Mol Evol. 2010 Apr;70(4):313-24. doi: 10.1007/s00239-010-9320-8. Epub 2010 Mar 27.

PMID:
20349055
17.

Relic of ancient recombinations in gibbon ABO blood group genes deciphered through phylogenetic network analysis.

Kitano T, Noda R, Takenaka O, Saitou N.

Mol Phylogenet Evol. 2009 Jun;51(3):465-71. doi: 10.1016/j.ympev.2009.02.023. Epub 2009 Mar 17.

PMID:
19298858
18.

Relatedness in wild chimpanzees: influence of paternity, male philopatry, and demographic factors.

Inoue E, Inoue-Murayama M, Vigilant L, Takenaka O, Nishida T.

Am J Phys Anthropol. 2008 Nov;137(3):256-62. doi: 10.1002/ajpa.20865.

PMID:
18512686
19.

Synthesis and pharmacological profile of serofendic acids A and B.

Terauchi T, Asai N, Doko T, Taguchi R, Takenaka O, Sakurai H, Yonaga M, Kimura T, Kajiwara A, Niidome T, Kume T, Akaike A, Sugimoto H.

Bioorg Med Chem. 2007 Nov 15;15(22):7098-107. Epub 2007 Aug 22.

PMID:
17804246
20.
21.

Comparison of efficacies of a dipeptidyl peptidase IV inhibitor and alpha-glucosidase inhibitors in oral carbohydrate and meal tolerance tests and the effects of their combination in mice.

Yamazaki K, Inoue T, Yasuda N, Sato Y, Nagakura T, Takenaka O, Clark R, Saeki T, Tanaka I.

J Pharmacol Sci. 2007 May;104(1):29-38. Epub 2007 May 8.

22.

Female long-tailed macaques with scrotum-like structure.

Malaivijitnond S, Hamada Y, Suryobroto B, Takenaka O.

Am J Primatol. 2007 Jul;69(7):721-35.

PMID:
17245765
23.

Wild chimpanzee infant urine and saliva sampled noninvasively usable for DNA analyses.

Inoue E, Inoue-Murayama M, Takenaka O, Nishida T.

Primates. 2007 Apr;48(2):156-9. Epub 2006 Nov 17.

PMID:
17111091
24.

Comparative analysis of estrogen receptor gene polymorphisms in apes.

Hong KW, Iwatsuki H, Takenaka O, Hayasaka I, Murayama Y, Ito S, Inoue-Murayama M.

Primates. 2007 Apr;48(2):151-5. Epub 2006 Sep 21.

PMID:
17024513
25.

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor.

Yasuda N, Nagakura T, Inoue T, Yamazaki K, Katsutani N, Takenaka O, Clark R, Matsuura F, Emori E, Yoshikawa S, Kira K, Ikuta H, Okada T, Saeki T, Asano O, Tanaka I.

Eur J Pharmacol. 2006 Oct 24;548(1-3):181-7. Epub 2006 Aug 16.

PMID:
16973152
26.

Molecular evolution of the periphilin gene in relation to human endogenous retrovirus m element.

Huh JW, Kim TH, Yi JM, Park ES, Kim WY, Sin HS, Kim DS, Min DS, Kim SS, Kim CB, Hyun BH, Kang SK, Jung JS, Lee WH, Takenaka O, Kim HS.

J Mol Evol. 2006 Jun;62(6):730-7. Epub 2006 Apr 11.

PMID:
16612547
27.

How costly are ejaculates for Japanese macaques?

Thomsen R, Soltis J, Matsubara M, Matsubayashi K, Onuma M, Takenaka O.

Primates. 2006 Jul;47(3):272-4. Epub 2006 Feb 9.

PMID:
16467956
28.

Comparison of androgen receptor CAG and GGN repeat length polymorphism in humans and apes.

Hong KW, Hibino E, Takenaka O, Hayasaka I, Murayama Y, Ito S, Inoue-Murayama M.

Primates. 2006 Jul;47(3):248-54. Epub 2006 Feb 9.

PMID:
16467955
29.

Nucleotide sequence analyses of human complement 6 (C6) gene suggest balancing selection.

Soejima M, Tachida H, Tsuneoka M, Takenaka O, Kimura H, Koda Y.

Ann Hum Genet. 2005 May;69(Pt 3):239-52.

30.

Molecular cloning and phylogeny of HERV-E family that is expressed in Japanese monkey (Macaca fuscata) tissues.

Yi JM, Takenaka O, Kim HS.

Arch Virol. 2005 May;150(5):869-82. Epub 2005 Jan 27.

PMID:
15834513
31.

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

Go Y, Satta Y, Takenaka O, Takahata N.

Genetics. 2005 May;170(1):313-26. Epub 2005 Mar 2.

32.

Identification of a protanomalous chimpanzee by molecular genetic and electroretinogram analyses.

Terao K, Mikami A, Saito A, Itoh S, Ogawa H, Takenaka O, Sakai T, Onishi A, Teramoto M, Udono T, Emi Y, Kobayashi H, Imai H, Shichida Y, Koike S.

Vision Res. 2005 May;45(10):1225-35. Epub 2004 Dec 16.

33.

Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population.

Iwasaki M, Yoshimura Y, Asahi S, Saito K, Sakai S, Morita S, Takenaka O, Inoda T, Kashiyama E, Aoyama A, Nakabayashi T, Omori S, Kuwabara T, Izumi T, Nakamura K, Takanaka K, Nakayama Y, Takeuchi M, Nakamura H, Kametani S, Terauchi Y, Hashizume T, Nagayama S, Kume T, Achira M, Kawai H, Kawashiro T, Nakamura A, Nakai Y, Kagayama A, Shiraga T, Niwa T, Yoshimura T, Morita J, Ohsawa F, Tani M, Osawa N, Ida K, Noguchi K.

Drug Metab Pharmacokinet. 2004 Dec;19(6):444-52.

34.

Species and sex identification of western lowland gorillas (Gorilla gorilla gorilla), eastern lowland gorillas (Gorilla beringei graueri) and humans.

Matsubara M, Basabose AK, Omari I, Kaleme K, Kizungu B, Sikubwabo K, Kahindo M, Yamagiwa J, Takenaka O.

Primates. 2005 Jul;46(3):199-202. Epub 2005 Jan 6.

PMID:
15635453
35.

Expression and identification of HERV-W family in Japanese monkeys (Macaca fuscata).

Yi JM, Takenaka O, Kim HS.

Zoolog Sci. 2004 Jun;21(6):649-59.

PMID:
15226587
36.

Piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4]benzothiazine as orally-active adhesion molecule inhibitors.

Kaneko T, Clark RS, Ohi N, Ozaki F, Kawahara T, Kamada A, Okano K, Yokohama H, Ohkuro M, Muramoto K, Takenaka O, Kobayashi S.

Chem Pharm Bull (Tokyo). 2004 Jun;52(6):675-87.

37.

A prevalent POLG CAG microsatellite length allele in humans and African great apes.

Rovio AT, Abel J, Ahola AL, Andres AM, Bertranpetit J, Blancher A, Bontrop RE, Chemnick LG, Cooke HJ, Cummins JM, Davis HA, Elliott DJ, Fritsche E, Hargreave TB, Hoffman SM, Jequier AM, Kao SH, Kim HS, Marchington DR, Mehmet D, Otting N, Poulton J, Ryder OA, Schuppe HC, Takenaka O, Wei YH, Wichmann L, Jacobs HT.

Mamm Genome. 2004 Jun;15(6):492-502.

PMID:
15181541
38.

Polymorphism in the second intron of dopamine receptor D4 gene in humans and apes.

Shimada MK, Inoue-Murayama M, Ueda Y, Maejima M, Murayama Y, Takenaka O, Hayasaka I, Ito S.

Biochem Biophys Res Commun. 2004 Apr 16;316(4):1186-90.

PMID:
15044110
39.

Radiation and phylogeography in the Japanese macaque, Macaca fuscata.

Marmi J, Bertranpetit J, Terradas J, Takenaka O, Domingo-Roura X.

Mol Phylogenet Evol. 2004 Mar;30(3):676-85.

PMID:
15012947
40.

Population differences in DNA sequence variation and linkage disequilibrium at the PON1 gene.

Koda Y, Tachida H, Soejima M, Takenaka O, Kimura H.

Ann Hum Genet. 2004 Mar;68(Pt 2):110-9.

PMID:
15008790
41.

Molecular cloning of protamine-2 and expression with aging in Japanese monkey (Macaca fuscata).

Yu SS, Takenaka O.

Primates. 2004 Apr;45(2):147-50. Epub 2004 Feb 24.

PMID:
14986146
42.

Endogenous retrovirus HC2 pol fragments in the squirrel monkey: expression, evolution, and phylogeny.

Yi JM, Kim TH, Huh JI, Nakamura S, Takenaka O, Lee WH, Hyun BH, Kim HS.

Arch Virol. 2003 Nov;148(11):2257-65.

PMID:
14579182
43.

Molecular characterization and phylogenetic relationship of HERV-W family in the Macaca fuscata.

Yi JM, Takenaka O, Kim HS.

Arch Virol. 2003 Aug;148(8):1613-22.

PMID:
12898334
44.

Comparative study of urinary reproductive hormones in great apes.

Shimizu K, Udono T, Tanaka C, Narushima E, Yoshihara M, Takeda M, Tanahashi A, van Elsackar L, Hayashi M, Takenaka O.

Primates. 2003 Apr;44(2):183-90. Epub 2003 Feb 14.

PMID:
12687484
45.

Behavioral evidence of color vision deficiency in a protanomalia chimpanzee (Pan troglodytes).

Saito A, Mikami A, Hasegawa T, Koida K, Terao K, Koike S, Onishi A, Takenaka O, Teramoto M, Mori Y.

Primates. 2003 Apr;44(2):171-6. Epub 2003 Feb 27.

PMID:
12687482
46.

Genetic mechanism and property of a whole-arm translocation (WAT) between chromosomes 8 and 9 of agile gibbons (Hylobates agilis).

Hirai H, Mootnick AR, Takenaka O, Suryobroto B, Mouri T, Kamanaka Y, Katoh A, Kimura N, Katoh A, Maeda N.

Chromosome Res. 2003;11(1):37-50.

PMID:
12675304
47.

Molecular phylogeny and evolution of the human endogenous retrovirus HERV-W LTR family in hominoid primates.

Huh JW, Hong KW, Yi JM, Kim TH, Takenaka O, Lee WH, Kim HS.

Mol Cells. 2003 Feb 28;15(1):122-6.

49.

Variation of variable number of tandem repeat sequences in the 3'-untranslated region of primate dopamine transporter genes that affects reporter gene expression.

Inoue-Murayama M, Adachi S, Mishima N, Mitani H, Takenaka O, Terao K, Hayasaka I, Ito S, Murayama Y.

Neurosci Lett. 2002 Dec 16;334(3):206-10.

PMID:
12453630
50.

Y-chromosomal red-green opsin genes of nocturnal New World monkey.

Kawamura S, Takenaka N, Hiramatsu C, Hirai M, Takenaka O.

FEBS Lett. 2002 Oct 23;530(1-3):70-2.

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