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Detoxification of the solanaceous phytoalexins rishitin, lubimin, oxylubimin and solavetivone via a cytochrome P450 oxygenase.

Camagna M, Ojika M, Takemoto D.

Plant Signal Behav. 2020;15(2):1707348. doi: 10.1080/15592324.2019.1707348. Epub 2019 Dec 28.


Transcriptional induction of capsidiol synthesis genes by wounding can promote pathogen signal-induced capsidiol synthesis.

Kojima T, Asakura N, Hasegawa S, Hirasawa T, Mizuno Y, Takemoto D, Katou S.

BMC Plant Biol. 2019 Dec 21;19(1):576. doi: 10.1186/s12870-019-2204-1.


Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice.

Shimoyoshi S, Takemoto D, Ono Y, Kitagawa Y, Shibata H, Tomono S, Unno K, Wakabayashi K.

Nutrients. 2019 Jul 12;11(7). pii: E1582. doi: 10.3390/nu11071582.


Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferon β and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells.

Abe-Kanoh N, Kunimoto Y, Takemoto D, Ono Y, Shibata H, Ohnishi K, Kawai Y.

J Agric Food Chem. 2019 Jul 10;67(27):7640-7649. doi: 10.1021/acs.jafc.8b07227. Epub 2019 Apr 16.


Nicotiana benthamiana RanBP1-1 Is Involved in the Induction of Disease Resistance via Regulation of Nuclear-Cytoplasmic Transport of Small GTPase Ran.

Mizuno Y, Ohtsu M, Shibata Y, Tanaka A, Camagna M, Ojika M, Mori H, Sato I, Chiba S, Kawakita K, Takemoto D.

Front Plant Sci. 2019 Mar 8;10:222. doi: 10.3389/fpls.2019.00222. eCollection 2019.


Sesamin suppresses aging phenotypes in adult muscular and nervous systems and intestines in a Drosophila senescence-accelerated model.

Le TD, Nakahara Y, Ueda M, Okumura K, Hirai J, Sato Y, Takemoto D, Tomimori N, Ono Y, Nakai M, Shibata H, Inoue YH.

Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1826-1839. doi: 10.26355/eurrev_201902_17146.


Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma.

Takeshima S, Higashide T, Kimura M, Udagawa S, Yamada Y, Takemoto D, Ohkubo S, Sugiyama K.

Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):677-684. doi: 10.1167/iovs.18-25694.


Intraocular pressure and visual field changes in normal-tension glaucoma patients treated using either unoprostone or latanoprost: a prospective comparative study.

Takemoto D, Higashide T, Saito Y, Ohkubo S, Udagawa S, Takeda H, Sugiyama K.

Clin Ophthalmol. 2017 Sep 1;11:1617-1624. doi: 10.2147/OPTH.S144344. eCollection 2017.


EIN2-mediated signaling is involved in pre-invasion defense in Nicotiana benthamiana against potato late blight pathogen, Phytophthora infestans.

Rin S, Mizuno Y, Shibata Y, Fushimi M, Katou S, Sato I, Chiba S, Kawakita K, Takemoto D.

Plant Signal Behav. 2017 Apr 3;12(4):e1300733. doi: 10.1080/15592324.2017.1300733.


Cateteres venosos centrais de inserção periférica: alternativa ou primeira escolha em acesso vascular?

Di Santo MK, Takemoto D, Nascimento RG, Nascimento AM, Siqueira É, Duarte CT, Jovino MAC, Kalil JA.

J Vasc Bras. 2017 Apr-Jun;16(2):104-112. doi: 10.1590/1677-5449.011516. Portuguese. No abstract available.

Free PMC Article

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.

Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK.

Elife. 2017 Mar 20;6. pii: e20873. doi: 10.7554/eLife.20873.


SymB and SymC, two membrane associated proteins, are required for Epichloë festucae hyphal cell-cell fusion and maintenance of a mutualistic interaction with Lolium perenne.

Green KA, Becker Y, Tanaka A, Takemoto D, Fitzsimons HL, Seiler S, Lalucque H, Silar P, Scott B.

Mol Microbiol. 2017 Feb;103(4):657-677. doi: 10.1111/mmi.13580. Epub 2016 Dec 14.


The Full-Size ABCG Transporters Nb-ABCG1 and Nb-ABCG2 Function in Pre- and Postinvasion Defense against Phytophthora infestans in Nicotiana benthamiana.

Shibata Y, Ojika M, Sugiyama A, Yazaki K, Jones DA, Kawakita K, Takemoto D.

Plant Cell. 2016 May;28(5):1163-81. doi: 10.1105/tpc.15.00721. Epub 2016 Apr 21.


What's Normal? Accurately and Efficiently Assessing Menstrual Function.

Takemoto DM, Beharry MS.

Pediatr Ann. 2015 Sep;44(9):e213-7. doi: 10.3928/00904481-20150910-08. Review.


Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes.

Takada S, Kinugawa S, Matsushima S, Takemoto D, Furihata T, Mizushima W, Fukushima A, Yokota T, Ono Y, Shibata H, Okita K, Tsutsui H.

Exp Physiol. 2015 Nov;100(11):1319-30. doi: 10.1113/EP085251. Epub 2015 Oct 1.


Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue.

Takemoto D, Yasutake Y, Tomimori N, Ono Y, Shibata H, Hayashi J.

Glob J Health Sci. 2015 Mar 25;7(6):1-10. doi: 10.5539/gjhs.v7n6p1.


[Two cases of Vogt-Koyanagi-Harada disease presenting shallow anterior chamber].

Takemoto D, Ijiri S, Shimizu M, Higashide T, Sugiyama K.

Nippon Ganka Gakkai Zasshi. 2015 May;119(5):354-62. Japanese.


Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.

Itoh Y, Sanosaka M, Fuchino H, Yahara Y, Kumagai A, Takemoto D, Kagawa M, Doi J, Ohta M, Tsumaki N, Kawahara N, Takemori H.

J Biol Chem. 2015 Jul 17;290(29):17879-93. doi: 10.1074/jbc.M115.640821. Epub 2015 Jun 5.


Induced resistance in Solanum lycopersicum by algal elicitor extracted from Sargassum fusiforme.

Sbaihat L, Takeyama K, Koga T, Takemoto D, Kawakita K.

ScientificWorldJournal. 2015;2015:870520. doi: 10.1155/2015/870520. Epub 2015 Feb 24.


Methanol extract of mycelia from Phytophthora infestans-induced resistance in potato.

Monjil MS, Nozawa T, Shibata Y, Takemoto D, Ojika M, Kawakita K.

C R Biol. 2015 Mar;338(3):185-96. doi: 10.1016/j.crvi.2015.01.004. Epub 2015 Feb 13.


Nucleoporin 75 is involved in the ethylene-mediated production of phytoalexin for the resistance of Nicotiana benthamiana to Phytophthora infestans.

Ohtsu M, Shibata Y, Ojika M, Tamura K, Hara-Nishimura I, Mori H, Kawakita K, Takemoto D.

Mol Plant Microbe Interact. 2014 Dec;27(12):1318-30. doi: 10.1094/MPMI-06-14-0181-R.


Dissecting tumour heterogeneity in flies: genetic basis of interclonal oncogenic cooperation.

Ohsawa S, Takemoto D, Igaki T.

J Biochem. 2014 Sep;156(3):129-36. doi: 10.1093/jb/mvu045. Epub 2014 Jul 9. Review.


Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970.

Hall AB, Newsome D, Wang Y, Boucher DM, Eustace B, Gu Y, Hare B, Johnson MA, Milton S, Murphy CE, Takemoto D, Tolman C, Wood M, Charlton P, Charrier JD, Furey B, Golec J, Reaper PM, Pollard JR.

Oncotarget. 2014 Jul 30;5(14):5674-85.


ProA, a transcriptional regulator of fungal fruiting body development, regulates leaf hyphal network development in the Epichloë festucae-Lolium perenne symbiosis.

Tanaka A, Cartwright GM, Saikia S, Kayano Y, Takemoto D, Kato M, Tsuge T, Scott B.

Mol Microbiol. 2013 Nov;90(3):551-68. doi: 10.1111/mmi.12385. Epub 2013 Sep 18.


Differential roles of NADPH oxidases and associated regulators in polarized growth, conidiation and hyphal fusion in the symbiotic fungus Epichloë festucae.

Kayano Y, Tanaka A, Akano F, Scott B, Takemoto D.

Fungal Genet Biol. 2013 Jul;56:87-97. doi: 10.1016/j.fgb.2013.05.001. Epub 2013 May 15.


Nicotiana benthamiana calreticulin 3a is required for the ethylene-mediated production of phytoalexins and disease resistance against oomycete pathogen Phytophthora infestans.

Matsukawa M, Shibata Y, Ohtsu M, Mizutani A, Mori H, Wang P, Ojika M, Kawakita K, Takemoto D.

Mol Plant Microbe Interact. 2013 Aug;26(8):880-92. doi: 10.1094/MPMI-12-12-0301-R.


Bis-aryl methanone compound is a candidate of nitric oxide producing elicitor and induces resistance in Nicotiana benthamiana against Phytophthora infestans.

Monjil MS, Shibata Y, Takemoto D, Kawakita K.

Nitric Oxide. 2013 Feb 28;29:34-45. doi: 10.1016/j.niox.2012.12.004. Epub 2013 Jan 3.


Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment.

Bartels DJ, Sullivan JC, Zhang EZ, Tigges AM, Dorrian JL, De Meyer S, Takemoto D, Dondero E, Kwong AD, Picchio G, Kieffer TL.

J Virol. 2013 Feb;87(3):1544-53. doi: 10.1128/JVI.02294-12. Epub 2012 Nov 14.


Proteomic analysis of S-nitrosylated proteins in potato plant.

Kato H, Takemoto D, Kawakita K.

Physiol Plant. 2013 Jul;148(3):371-86. doi: 10.1111/j.1399-3054.2012.01684.x. Epub 2012 Sep 17.


The role of Connexin 46 promoter in lens and other hypoxic tissues.

Molina SA, Takemoto DJ.

Commun Integr Biol. 2012 Mar 1;5(2):114-7. doi: 10.4161/cib.18715.


Functional analysis of an indole-diterpene gene cluster for lolitrem B biosynthesis in the grass endosymbiont Epichloë festucae.

Saikia S, Takemoto D, Tapper BA, Lane GA, Fraser K, Scott B.

FEBS Lett. 2012 Jul 30;586(16):2563-9. doi: 10.1016/j.febslet.2012.06.035. Epub 2012 Jun 29.


Fungal endophytes of grasses.

Tanaka A, Takemoto D, Chujo T, Scott B.

Curr Opin Plant Biol. 2012 Aug;15(4):462-8. doi: 10.1016/j.pbi.2012.03.007. Epub 2012 Mar 30. Review.


N-terminal motifs in some plant disease resistance proteins function in membrane attachment and contribute to disease resistance.

Takemoto D, Rafiqi M, Hurley U, Lawrence GJ, Bernoux M, Hardham AR, Ellis JG, Dodds PN, Jones DA.

Mol Plant Microbe Interact. 2012 Mar;25(3):379-92. doi: 10.1094/MPMI-11-10-0272.


Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43.

Banerjee D, Das S, Molina SA, Madgwick D, Katz MR, Jena S, Bossmann LK, Pal D, Takemoto DJ.

J Biol Chem. 2011 Jul 8;286(27):24519-33. doi: 10.1074/jbc.M110.217208. Epub 2011 May 23.


PKCγ, role in lens differentiation and gap junction coupling.

Das S, Wang H, Molina SA, Martinez-Wittinghan FJ, Jena S, Bossmann LK, Miller KA, Mathias RT, Takemoto DJ.

Curr Eye Res. 2011 Jul;36(7):620-31. doi: 10.3109/02713683.2011.573899. Epub 2011 May 20.


Treatment with connexin 46 siRNA suppresses the growth of human Y79 retinoblastoma cell xenografts in vivo.

Burr DB, Molina SA, Banerjee D, Low DM, Takemoto DJ.

Exp Eye Res. 2011 Apr;92(4):251-9. doi: 10.1016/j.exer.2011.02.003. Epub 2011 Feb 12.


Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex.

Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, Scott B.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2861-6. doi: 10.1073/pnas.1017309108. Epub 2011 Jan 31.


NMR structure/function relationships of peptides corresponding to the C1B1 Region of PKC gamma.

Lauer J, Banerjee D, Shanks D, Dai H, Gong YX, Prakash O, Takemoto D.

Protein Pept Lett. 2010 Jan;17(1):1-10.


A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia.

Banerjee D, Gakhar G, Madgwick D, Hurt A, Takemoto D, Nguyen TA.

Int J Cancer. 2010 Aug 15;127(4):839-48. doi: 10.1002/ijc.25107.


Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen.

Yevseyenkov VV, Das S, Lin D, Willard L, Davidson H, Sitaramayya A, Giblin FJ, Dang L, Takemoto DJ.

Arch Ophthalmol. 2009 Apr;127(4):500-6. doi: 10.1001/archophthalmol.2009.31.


Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse.

Zhang Y, Snider A, Willard L, Takemoto DJ, Lin D.

Biochem Biophys Res Commun. 2009 Jan 16;378(3):524-8. doi: 10.1016/j.bbrc.2008.11.082. Epub 2008 Dec 3.


Hypoxia-regulated activity of PKCepsilon in the lens.

Akoyev V, Das S, Jena S, Grauer L, Takemoto DJ.

Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1271-82. doi: 10.1167/iovs.08-2599. Epub 2008 Nov 7.


Protection of retinal cells from ischemia by a novel gap junction inhibitor.

Das S, Lin D, Jena S, Shi A, Battina S, Hua DH, Allbaugh R, Takemoto DJ.

Biochem Biophys Res Commun. 2008 Sep 5;373(4):504-8. doi: 10.1016/j.bbrc.2008.06.069. Epub 2008 Jun 30.


Synthesis and anti-breast cancer activities of substituted quinolines.

Shi A, Nguyen TA, Battina SK, Rana S, Takemoto DJ, Chiang PK, Hua DH.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3364-8. doi: 10.1016/j.bmcl.2008.04.024. Epub 2008 Apr 13.


NoxA activation by the small GTPase RacA is required to maintain a mutualistic symbiotic association between Epichloë festucae and perennial ryegrass.

Tanaka A, Takemoto D, Hyon GS, Park P, Scott B.

Mol Microbiol. 2008 Jun;68(5):1165-78. doi: 10.1111/j.1365-2958.2008.06217.x. Epub 2008 Apr 8.

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