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Items: 1 to 50 of 120

1.

Monitoring of Glutamate-Induced Excitotoxicity by Mitochondrial Oxygen Consumption.

Kumagai A, Sasaki T, Matsuoka K, Abe M, Tabata T, Itoh Y, Fuchino H, Wugangerile S, Suga M, Yamaguchi T, Kawahara H, Nagaoka Y, Kawabata K, Furue MK, Takemori H.

Synapse. 2018 Aug 18. doi: 10.1002/syn.22067. [Epub ahead of print]

PMID:
30120794
2.

Carnosol suppresses IL-6 production in mouse lungs injured by ischemia-reperfusion operation and in RAW264.7 macrophages treated with lipopolysaccharide.

Momozane T, Kawamura T, Itoh Y, Sanosaka M, Sasaki T, Kanzaki R, Ose N, Funaki S, Shintani Y, Minami M, Okumura M, Takemori H.

Biochem Cell Biol. 2018 Jun 29. doi: 10.1139/bcb-2017-0339. [Epub ahead of print]

PMID:
29958095
3.

Coordination-Mediated Synthesis of Purification-Free Bivalent 99mTc-Labeled Probes for in Vivo Imaging of Saturable System.

Taira Y, Uehara T, Tsuchiya M, Takemori H, Mizuno Y, Takahashi S, Suzuki H, Hanaoka H, Akizawa H, Arano Y.

Bioconjug Chem. 2018 Feb 21;29(2):459-466. doi: 10.1021/acs.bioconjchem.7b00788. Epub 2018 Jan 31.

PMID:
29320158
4.

LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.

Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T.

Cancer Res. 2018 Jan 15;78(2):516-527. doi: 10.1158/0008-5472.CAN-17-0910. Epub 2017 Nov 29.

PMID:
29187404
5.

PCDD/PCDF formation in the chlor-alkali process-laboratory study and comparison with patterns from contaminated sites.

Yamamoto T, Higashino K, Abe T, Takasuga T, Takemori H, Weber R, Sasaki Y.

Environ Sci Pollut Res Int. 2017 Nov 25. doi: 10.1007/s11356-017-0777-5. [Epub ahead of print]

PMID:
29178004
6.

The Importance of 11α-OH, 15-oxo, and 16-en Moieties of 11α-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis.

Kuroi A, Sugimura K, Kumagai A, Kohara A, Nagaoka Y, Kawahara H, Yamahara M, Kawahara N, Takemori H, Fuchino H.

Skin Pharmacol Physiol. 2017;30(4):205-215. doi: 10.1159/000475471. Epub 2017 Jul 12.

7.

Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.

Zhang Y, Takemori H, Wang C, Fu J, Xu M, Xiong L, Li N, Wen X.

Life Sci. 2017 Mar 15;173:107-115. doi: 10.1016/j.lfs.2017.02.001. Epub 2017 Feb 6.

PMID:
28174122
8.

Maintenance treatment using abatacept with dose reduction after achievement of low disease activity in patients with rheumatoid arthritis (MATADOR) - A prospective, multicenter, single arm pilot clinical trial.

Yasuda S, Ohmura K, Kanazawa H, Kurita T, Kon Y, Ishii T, Fujieda Y, Jodo S, Tanimura K, Minami M, Izumiyama T, Matsumoto T, Amasaki Y, Suzuki Y, Kasahara H, Yamauchi N, Kato M, Kamishima T, Tsutsumi A, Takemori H, Koike T, Atsumi T.

Mod Rheumatol. 2017 Nov;27(6):930-937. doi: 10.1080/14397595.2017.1286714. Epub 2017 Feb 16.

PMID:
28150514
9.

Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.

Watanabe A, Sasaki T, Yukami T, Kanki H, Sakaguchi M, Takemori H, Kitagawa K, Mochizuki H.

Neuroscience. 2016 Dec 17;339:139-149. doi: 10.1016/j.neuroscience.2016.09.036. Epub 2016 Sep 28.

PMID:
27693471
10.

Potentiality of syringetin for preferential radiosensitization to cancer cells.

Bando SI, Hatano O, Takemori H, Kubota N, Ohnishi K.

Int J Radiat Biol. 2017 Mar;93(3):286-294. doi: 10.1080/09553002.2017.1242815. Epub 2016 Nov 9.

PMID:
27707083
11.

A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel.

Zhou J, Alfraidi A, Zhang S, Santiago-O'Farrill JM, Yerramreddy Reddy VK, Alsaadi A, Ahmed AA, Yang H, Liu J, Mao W, Wang Y, Takemori H, Vankayalapati H, Lu Z, Bast RC Jr.

Clin Cancer Res. 2017 Apr 15;23(8):1945-1954. doi: 10.1158/1078-0432.CCR-16-1562. Epub 2016 Sep 27.

12.

Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.

Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N.

Nat Commun. 2016 Jun 27;7:12117. doi: 10.1038/ncomms12117. No abstract available.

13.

Simple chronic colitis model using hypopigmented mice with a Hermansky-Pudlak syndrome 5 gene mutation.

Itoh Y, Nagaoka Y, Katakura Y, Kawahara H, Takemori H.

Pigment Cell Melanoma Res. 2016 Sep;29(5):578-82. doi: 10.1111/pcmr.12504. Epub 2016 Aug 8.

PMID:
27333462
14.

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.

Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N.

Nat Commun. 2016 Mar 24;7:10959. doi: 10.1038/ncomms10959. Erratum in: Nat Commun. 2016 Jun 27;7:12117.

15.

Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling.

Itoh Y, Fuchino H, Sanosaka M, Kako K, Hada K, Fukamizu A, Takemori H, Kawahara N.

Biochem Biophys Res Commun. 2016 Apr 29;473(2):415-20. doi: 10.1016/j.bbrc.2016.03.016. Epub 2016 Mar 9.

PMID:
26970301
16.

Clinical and structural remission rates increased annually and radiographic progression was continuously inhibited during a 3-year administration of tocilizumab in patients with rheumatoid arthritis: A multi-center, prospective cohort study by the Michinoku Tocilizumab Study Group.

Hirabayashi Y, Munakata Y, Miyata M, Urata Y, Saito K, Okuno H, Yoshida M, Kodera T, Watanabe R, Miyamoto S, Ishii T, Nakazawa S, Takemori H, Ando T, Kanno T, Komagamine M, Kato I, Takahashi Y, Komatsuda A, Endo K, Murai C, Takakubo Y, Miura T, Sato Y, Ichikawa K, Konta T, Chiba N, Muryoi T, Kobayashi H, Fujii H, Sekiguchi Y, Hatakeyama A, Ogura K, Sakuraba H, Asano T, Kanazawa H, Suzuki E, Takasaki S, Asakura K, Sugisaki K, Suzuki Y, Takagi M, Nakayama T, Watanabe H, Miura K, Mori Y; Michinoku Tocilizumab Study Group.

Mod Rheumatol. 2016 Nov;26(6):828-835. doi: 10.3109/14397595.2016.1160991. Epub 2016 Apr 21.

PMID:
26934116
17.

A Simple Method for Labeling Human Embryonic Stem Cells Destined to Lose Undifferentiated Potency.

Kumagai A, Suga M, Yanagihara K, Itoh Y, Takemori H, Furue MK.

Stem Cells Transl Med. 2016 Mar;5(3):275-81. doi: 10.5966/sctm.2015-0145. Epub 2016 Jan 27.

18.

Carnosol Is a Potent Lung Protective Agent: Experimental Study on Mice.

Kawamura T, Momozane T, Sanosaka M, Sugimura K, Iida O, Fuchino H, Funaki S, Shintani Y, Inoue M, Minami M, Kawahara N, Takemori H, Okumura M.

Transplant Proc. 2015 Jul-Aug;47(6):1657-61. doi: 10.1016/j.transproceed.2015.05.004.

PMID:
26293030
19.

Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.

Yamahara M, Sugimura K, Kumagai A, Fuchino H, Kuroi A, Kagawa M, Itoh Y, Kawahara H, Nagaoka Y, Iida O, Kawahara N, Takemori H, Watanabe H.

J Nat Med. 2016 Jan;70(1):28-35. doi: 10.1007/s11418-015-0933-5. Epub 2015 Aug 13.

PMID:
26267810
20.

Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.

Itoh Y, Sanosaka M, Fuchino H, Yahara Y, Kumagai A, Takemoto D, Kagawa M, Doi J, Ohta M, Tsumaki N, Kawahara N, Takemori H.

J Biol Chem. 2015 Jul 17;290(29):17879-93. doi: 10.1074/jbc.M115.640821. Epub 2015 Jun 5.

21.

The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis.

Chinen I, Nakahama T, Kimura A, Nguyen NT, Takemori H, Kumagai A, Kayama H, Takeda K, Lee S, Hanieh H, Ripley B, Millrine D, Dubey PK, Nyati KK, Fujii-Kuriyama Y, Chowdhury K, Kishimoto T.

Int Immunol. 2015 Aug;27(8):405-15. doi: 10.1093/intimm/dxv015. Epub 2015 Apr 10.

PMID:
25862525
22.

Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons.

Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takemori H, Okuno H, Bito H, Tsuda M.

J Neurosci. 2015 Apr 8;35(14):5606-24. doi: 10.1523/JNEUROSCI.3650-14.2015.

23.

Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.

Lee J, Tong T, Takemori H, Jefcoate C.

Mol Cell Endocrinol. 2015 Jun 15;408:80-9. doi: 10.1016/j.mce.2015.01.022. Epub 2015 Feb 7.

24.

Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice.

Sanosaka M, Fujimoto M, Ohkawara T, Nagatake T, Itoh Y, Kagawa M, Kumagai A, Fuchino H, Kunisawa J, Naka T, Takemori H.

Immunology. 2015 Jun;145(2):268-78. doi: 10.1111/imm.12445.

25.

Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.

Kumagai A, Fujita A, Yokoyama T, Nonobe Y, Hasaba Y, Sasaki T, Itoh Y, Koura M, Suzuki O, Adachi S, Ryo H, Kohara A, Tripathi LP, Sanosaka M, Fukushima T, Takahashi H, Kitagawa K, Nagaoka Y, Kawahara H, Mizuguchi K, Nomura T, Matsuda J, Tabata T, Takemori H.

Genes (Basel). 2014 Dec 11;5(4):1095-114. doi: 10.3390/genes5041095.

26.

Prevalence of hepatitis B virus infection in patients with rheumatic diseases in Tohoku area: a retrospective multicenter survey.

Watanabe R, Ishii T, Kobayashi H, Asahina I, Takemori H, Izumiyama T, Oguchi Y, Urata Y, Nishimaki T, Chiba K, Komatsuda A, Chiba N, Miyata M, Takagi M, Kawamura O, Kanno T, Hirabayashi Y, Konta T, Ninomiya Y, Abe Y, Murata Y, Saito Y, Ohira H, Harigae H, Sasaki T.

Tohoku J Exp Med. 2014 Jun;233(2):129-33.

27.

Pericardial fat volume is an independent risk factor for the severity of coronary artery disease in patients with preserved ejection fraction.

Okura K, Maeno K, Okura S, Takemori H, Toya D, Tanaka N, Miyayama S.

J Cardiol. 2015 Jan;65(1):37-41. doi: 10.1016/j.jjcc.2014.03.015. Epub 2014 May 17.

28.

Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.

Popov S, Takemori H, Tokudome T, Mao Y, Otani K, Mochizuki N, Pires N, Pinho MJ, Franco-Cereceda A, Torielli L, Ferrandi M, Hamsten A, Soares-da-Silva P, Eriksson P, Bertorello AM, Brion L.

PLoS One. 2014 Apr 21;9(4):e95771. doi: 10.1371/journal.pone.0095771. eCollection 2014.

29.

Associations between levels of hydroxylated PCBs and PCBs in serum of pregnant women and blood thyroid hormone levels and body size of neonates.

Hisada A, Shimodaira K, Okai T, Watanabe K, Takemori H, Takasuga T, Koyama M, Watanabe N, Suzuki E, Shirakawa M, Noda Y, Komine Y, Ariki N, Kato N, Yoshinaga J.

Int J Hyg Environ Health. 2014 Apr-May;217(4-5):546-53. doi: 10.1016/j.ijheh.2013.10.004. Epub 2013 Nov 4.

PMID:
24269188
30.

Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway.

Yu J, Hu X, Yang Z, Takemori H, Li Y, Zheng H, Hong S, Liao Q, Wen X.

Int J Mol Med. 2013 Jul;32(1):151-7. doi: 10.3892/ijmm.2013.1377. Epub 2013 May 10.

PMID:
23670276
31.

LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.

Tang HM, Gao WW, Chan CP, Siu YT, Wong CM, Kok KH, Ching YP, Takemori H, Jin DY.

Retrovirology. 2013 Apr 11;10:40. doi: 10.1186/1742-4690-10-40.

32.

Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.

Yao C, Hirata T, Soontrapa K, Ma X, Takemori H, Narumiya S.

Nat Commun. 2013;4:1685. doi: 10.1038/ncomms2684.

33.

Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.

Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y.

J Nat Med. 2013 Oct;67(4):705-10. doi: 10.1007/s11418-012-0727-y. Epub 2012 Dec 4.

PMID:
23208771
34.

Serum levels of hydroxylated PCBs, PCBs and thyroid hormone measures of Japanese pregnant women.

Hisada A, Shimodaira K, Okai T, Watanabe K, Takemori H, Takasuga T, Noda Y, Shirakawa M, Kato N, Yoshinaga J.

Environ Health Prev Med. 2013 May;18(3):205-14. doi: 10.1007/s12199-012-0306-6. Epub 2012 Sep 30.

35.

Involvement of SIK3 in glucose and lipid homeostasis in mice.

Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H.

PLoS One. 2012;7(5):e37803. doi: 10.1371/journal.pone.0037803. Epub 2012 May 25.

36.

Novel repressor regulates insulin sensitivity through interaction with Foxo1.

Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H.

EMBO J. 2012 May 16;31(10):2275-95. doi: 10.1038/emboj.2012.97. Epub 2012 Apr 17.

37.

Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line.

Popov S, Venetsanou K, Chedrese PJ, Pinto V, Takemori H, Franco-Cereceda A, Eriksson P, Mochizuki N, Soares-da-Silva P, Bertorello AM.

Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H57-65. doi: 10.1152/ajpheart.00512.2011. Epub 2012 Mar 30.

38.

SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.

Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, Tsumaki N.

Development. 2012 Mar;139(6):1153-63. doi: 10.1242/dev.072652. Epub 2012 Feb 8.

39.

Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats.

Liu Y, Poon V, Sanchez-Watts G, Watts AG, Takemori H, Aguilera G.

Endocrinology. 2012 Jan;153(1):223-33. doi: 10.1210/en.2011-1404. Epub 2011 Nov 22.

40.

Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.

Popov S, Silveira A, Wågsäter D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, Metoki H, Kikuya M, Ohkubo T, Katsuya T, Rakugi H, Imai Y, Sanchez F, Leosdottir M, Syvänen AC, Hamsten A, Melander O, Bertorello AM.

J Hypertens. 2011 Dec;29(12):2395-403. doi: 10.1097/HJH.0b013e32834d3d55.

PMID:
22045124
41.

A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y.

PLoS One. 2011;6(10):e26148. doi: 10.1371/journal.pone.0026148. Epub 2011 Oct 13.

42.

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.

Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M.

J Biol Chem. 2011 Dec 9;286(49):42162-79. doi: 10.1074/jbc.M111.299727. Epub 2011 Oct 14.

43.

Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5.

Dietrich JB, Takemori H, Grosch-Dirrig S, Bertorello A, Zwiller J.

Synapse. 2012 Jan;66(1):61-70. doi: 10.1002/syn.20988. Epub 2011 Nov 3.

PMID:
21954104
44.

Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.

Eneling K, Chen J, Welch LC, Takemori H, Sznajder JI, Bertorello AM.

Biochem Biophys Res Commun. 2011 May 27;409(1):28-33. doi: 10.1016/j.bbrc.2011.04.100. Epub 2011 Apr 28.

45.

SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB.

Sasaki T, Takemori H, Yagita Y, Terasaki Y, Uebi T, Horike N, Takagi H, Susumu T, Teraoka H, Kusano K, Hatano O, Oyama N, Sugiyama Y, Sakoda S, Kitagawa K.

Neuron. 2011 Jan 13;69(1):106-19. doi: 10.1016/j.neuron.2010.12.004.

46.

cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover.

Jefcoate CR, Lee J, Cherradi N, Takemori H, Duan H.

Mol Cell Endocrinol. 2011 Apr 10;336(1-2):53-62. doi: 10.1016/j.mce.2010.12.006. Epub 2010 Dec 13. Review.

47.

Downregulation of SIK2 expression promotes the melanogenic program in mice.

Horike N, Kumagai A, Shimono Y, Onishi T, Itoh Y, Sasaki T, Kitagawa K, Hatano O, Takagi H, Susumu T, Teraoka H, Kusano K, Nagaoka Y, Kawahara H, Takemori H.

Pigment Cell Melanoma Res. 2010 Dec;23(6):809-19. doi: 10.1111/j.1755-148X.2010.00760.x. Epub 2010 Aug 31.

PMID:
20819186
48.

Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.

Uebi T, Tamura M, Horike N, Hashimoto YK, Takemori H.

Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E413-25. doi: 10.1152/ajpendo.00525.2009. Epub 2010 Jun 15.

49.

Blocking the salt-inducible kinase 1 network prevents the increases in cell sodium transport caused by a hypertension-linked mutation in human alpha-adducin.

Stenström K, Takemori H, Bianchi G, Katz AI, Bertorello AM.

J Hypertens. 2009 Dec;27(12):2452-7. doi: 10.1097/HJH.0b013e328330cf15.

PMID:
19657284
50.

Expression and regulated nuclear transport of transducers of regulated CREB 1 in retinal ganglion cells.

Deng J, Zhang XL, Wang JW, Teng LL, Ge J, Takemori H, Xiong ZQ, Zhou Y.

Neuroscience. 2009 Mar 31;159(3):1023-31. doi: 10.1016/j.neuroscience.2009.01.073. Epub 2009 Feb 6.

PMID:
19356686

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